Dictyostelium discoideum: a new host model system for intracellular pathogens of the genus Legionella

Molecular Cloning: A Laboratory Manual

Sambrook, J., Fritsch, E., & Maniatis, T. (1989) · UCLA - Biblioteca de Ciencias de la Salud · Cited by 133,589

Molecular cloning: A laboratory manual

Deininger, P. L. (1990) · Analytical Biochemistry · doi:10.1016/0003-2697(90)90595-z · Cited by 84,684

Studies on transformation of Escherichia coli with plasmids

Hanahan, D. (1983) · Journal of Molecular Biology · doi:10.1016/s0022-2836(83)80284-8 · Cited by 11,194

Conjugative Transfer by the Virulence System of Legionella pneumophila

Vogel, J. P., Andrews, H. L., Wong, S. K., & Isberg, R. R. (1998) · Science · doi:10.1126/science.279.5352.873 · Cited by 721

The molecular ecology of legionellae

Fields, B. S. (1996) · Trends in Microbiology · doi:10.1016/0966-842x(96)10041-x · Cited by 543

Host cell killing and bacterial conjugation require overlapping sets of genes within a 22-kb region of the Legionella pneumophila genome

Segal, G., Purcell, M., & Shuman, H. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.4.1669 · Cited by 540

Resuscitation of viable but nonculturable Legionella pneumophila Philadelphia JR32 by Acanthamoeba castellanii

Steinert, M., Emödy, L., Amann, R., & Hacker, J. (1997) · Applied and Environmental Microbiology · doi:10.1128/aem.63.5.2047-2053.1997 · Cited by 371

Fluid-phase uptake by macropinocytosis in Dictyostelium

Hacker, U., Albrecht, R., & Maniak, M. (1997) · Journal of Cell Science · doi:10.1242/jcs.110.2.105 · Cited by 251

Invasion of Protozoa by Legionella pneumophila and Its Role in Bacterial Ecology and Pathogenesis

Kwaik, Y. A., Gao, L., Stone, B. J., Venkataraman, C., & Harb, O. S. (1998) · Applied and Environmental Microbiology · doi:10.1128/aem.64.9.3127-3133.1998 · Cited by 251

Utilization of similar mechanisms by Legionella pneumophila to parasitize two evolutionarily distant host cells, mammalian macrophages and protozoa

Gao, L., Harb, O. S., & Kwaik, Y. A. (1997) · Infection and Immunity · doi:10.1128/iai.65.11.4738-4746.1997 · Cited by 235

Legionella and Legionnaires' Disease: 25 Years of Investigation

Fields, B. S., Benson, R. F., & Besser, R. E. (2002) · Clinical Microbiology Reviews · doi:10.1128/cmr.15.3.506-526.2002 · Cited by 1,601

Microorganisms Resistant to Free-Living Amoebae

Greub, G., & Raoult, D. (2004) · Clinical Microbiology Reviews · doi:10.1128/cmr.17.2.413-433.2004 · Cited by 1,066

Amoebae as Training Grounds for Intracellular Bacterial Pathogens

Molmeret, M., Horn, M., Wagner, M., Šantić, M., & Kwaik, Y. A. (2005) · Applied and Environmental Microbiology · doi:10.1128/aem.71.1.20-28.2005 · Cited by 550

The phagosome: compartment with a license to kill

Haas, A. (2007) · Traffic · doi:10.1111/j.1600-0854.2006.00531.x · Cited by 450

Legionella pneumophila: an aquatic microbe goes astray

Steinert, M., Hentschel, U., & Hacker, J. H. (2002) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2002.tb00607.x · Cited by 292

Legionella pneumophila Exploits PI(4)P to Anchor Secreted Effector Proteins to the Replicative Vacuole

Weber, S. S., Ragaz, C., Reus, K., Nyfeler, Y., & Hilbi, H. (2006) · PLoS Pathogens · doi:10.1371/journal.ppat.0020046 · Cited by 292

The role of biofilms and protozoa inLegionellapathogenesis: implications for drinking water

Lau, H. Y., & Ashbolt, N. J. (2009) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2009.04208.x · Cited by 285

Pseudomonas aeruginosaVirulence Analyzed in aDictyostelium discoideumHost System

Cosson, P., Zulianello, L., Join‐Lambert, O., Faurisson, F., Gebbie, L. K., Benghezal, M., van Delden, C., Curty, L. K., & Köhler, T. (2002) · Journal of Bacteriology · doi:10.1128/jb.184.11.3027-3033.2002 · Cited by 268

Common molecular mechanisms of symbiosis and pathogenesis

Hentschel, U., Steinert, M., & Hacker, J. H. (2000) · Trends in Microbiology · doi:10.1016/s0966-842x(00)01758-3 · Cited by 250

The Icm/Dot type-IV secretion systems ofLegionella pneumophilaandCoxiella burnetii

Segal, G., Feldman, M., & Zusman, T. (2004) · FEMS Microbiology Reviews · doi:10.1016/j.femsre.2004.07.001 · Cited by 218

A star with stripes: zebrafish as an infection model

van der Sar, A. M., Appelmelk, B. J., Vandenbroucke‐Grauls, C. M. J. E., & Bitter, W. (2004) · Trends in Microbiology · doi:10.1016/j.tim.2004.08.001 · Cited by 216

From Many Hosts, One Accidental Pathogen: The Diverse Protozoan Hosts of Legionella

Boamah, D. K., Zhou, G., Ensminger, A. W., & O’Connor, T. J. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00477 · Cited by 201

Environmental predators as models for bacterial pathogenesis

Hilbi, H., Weber, S. S., Ragaz, C., Nyfeler, Y., & Urwyler, S. (2007) · Environmental Microbiology · doi:10.1111/j.1462-2920.2007.01238.x · Cited by 206

Proteomic Characterization of the Whole Secretome of Legionella pneumophila and Functional Analysis of Outer Membrane Vesicles

Galka, F., Wai, S. N., Kusch, H., Engelmann, S., Hecker, M., Schmeck, B., Hippenstiel, S., Uhlin, B. E., & Steinert, M. (2008) · Infection and Immunity · doi:10.1128/iai.01396-07 · Cited by 192

The Legionella pneumophila response regulator LqsR promotes host cell interactions as an element of the virulence regulatory network controlled by RpoS and LetA

Tiaden, A. N., Spirig, T., Weber, S. S., Brüggemann, H., Bosshard, R., Buchrieser, C., & Hilbi, H. (2007) · Cellular Microbiology · doi:10.1111/j.1462-5822.2007.01005.x · Cited by 185

Legionella, Protozoa, and Biofilms: Interactions Within Complex Microbial Systems

Taylor, M., Ross, K., & Bentham, R. (2009) · Microbial Ecology · doi:10.1007/s00248-009-9514-z · Cited by 170

Free-Living Amoebae as Hosts for and Vectors of Intracellular Microorganisms with Public Health Significance

Balczun, C., & Scheid, P. L. (2017) · Viruses · doi:10.3390/v9040065 · Cited by 170

Proteome Analysis of Legionella Vacuoles Purified by Magnetic Immunoseparation Reveals Secretory and Endosomal GTPases

Urwyler, S., Nyfeler, Y., Ragaz, C., Lee, H., Mueller, L. N., Aebersold, R. H., & Hilbi, H. (2008) · Traffic · doi:10.1111/j.1600-0854.2008.00851.x · Cited by 168

Dictyostelium discoideum—a model for many reasons

Annesley, S. J., & Fisher, P. R. (2009) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-009-0111-8 · Cited by 166

Dictyostelium as host model for pathogenesis

Steinert, M., & Heuner, K. (2005) · Cellular Microbiology · doi:10.1111/j.1462-5822.2005.00493.x · Cited by 144

Zebrafish (Danio rerio) as a model for the study of vaccination against viral haemorrhagic septicemia virus (VHSV)

Novoa, B., Romero, A., Mulero, V., Rodríguez-Nunez, I., Fernández, I., & Figueras, A. J. (2006) · Vaccine · doi:10.1016/j.vaccine.2006.05.015 · Cited by 141

Water ecology of Legionella and protozoan: environmental and public health perspectives

Borella, P., Guerrieri, E., Marchesi, I., Bondi, M., & Messi, P. (2005) · Biotechnology annual review · doi:10.1016/s1387-2656(05)11011-4 · Cited by 139

A Novel Sensor Kinase-Response Regulator Hybrid Controls Biofilm Formation and Type VI Secretion System Activity in Burkholderia cenocepacia

Aubert, D., Flannagan, R. S., & Valvano, M. A. (2008) · Infection and Immunity · doi:10.1128/iai.01338-07 · Cited by 132

Cellular microbiology and molecular ecology ofLegionella–amoeba interaction

Richards, A. M., Dwingelo, J. E. V., Price, C. T. D., & Kwaik, Y. A. (2013) · Virulence · doi:10.4161/viru.24290 · Cited by 129

Intracellular Replication of Mycobacterium marinum within Dictyostelium discoideum : Efficient Replication in the Absence of Host Coronin

Solomon, J. M., Leung, G. S., & Isberg, R. R. (2003) · Infection and Immunity · doi:10.1128/iai.71.6.3578-3586.2003 · Cited by 127

Intracellular Proliferation of Legionella pneumophila in Hartmannella vermiformis in Aquatic Biofilms Grown on Plasticized Polyvinyl Chloride

Kuiper, M. W., Wullings, B. A., Akkermans, A. D. L., Beumer, R. R., & van der Kooij, D. (2004) · Applied and Environmental Microbiology · doi:10.1128/aem.70.11.6826-6833.2004 · Cited by 126

Flotillin and RacH modulate the intracellular immunity of Dictyostelium to Mycobacterium marinum infection

Hagedorn, M., & Soldati, T. (2007) · Cellular Microbiology · doi:10.1111/j.1462-5822.2007.00993.x · Cited by 126

Distinct Network Interactions in Particle-Associated and Free-Living Bacterial Communities during a Microcystis aeruginosa Bloom in a Plateau Lake

Yang, C., Wang, Q., Simon, P. N., Liu, J., Liu, L., Dai, X., Zhang, X., Kuang, J., Igarashi, Y., Pan, X., et al. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01202 · Cited by 126

Macroautophagy is dispensable for intracellular replication of Legionella pneumophila in Dictyostelium discoideum

Otto, G. P., Wu, M., Clarke, M., Lu, H. X., Anderson, O. R., Hilbi, H., Shuman, H. A., & Kessin, R. H. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03826.x · Cited by 124

Towards a molecular understanding of human diseases using Dictyostelium discoideum

Williams, R. S. B., Boeckeler, K., Gräf, R., Müller‐Taubenberger, A., Li, Z., Isberg, R. R., Wessels, D. J., Soll, D. R., Alexander, H., & Alexander, S. (2006) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2006.07.003 · Cited by 125

Comparative analyses of Legionella species identifies genetic features of strains causing Legionnaires¿ disease

Gómez-Valero, L., Rusniok, C., Rolando, M., Néou, M., Ravault, D., Demirtas, J., Rouy, Z., Moore, R. J., Chen, H., Petty, N. K., et al. (2014) · Genome biology · doi:10.1186/preaccept-1086350395137407 · Cited by 133

The Professional Phagocyte Dictyostelium discoideum as a Model Host for Bacterial Pathogens

Bozzaro, S., & Eichinger, L. (2011) · Current Drug Targets · doi:10.2174/138945011795677782 · Cited by 122

Dynamic properties of Legionella-containing phagosomes in Dictyostelium amoebae

Lu, H. X., & Clarke, M. (2005) · Cellular Microbiology · doi:10.1111/j.1462-5822.2005.00528.x · Cited by 118

The natural alternative: protozoa as cellular models forLegionellainfection

Hoffmann, C., Harrison, C. F., & Hilbi, H. (2013) · Cellular Microbiology · doi:10.1111/cmi.12235 · Cited by 120

Dictyostelium transcriptional host cell response upon infection with Legionella

Farbrother, P., Wagner, C., Na, J., Tunggal, B., Morio, T., Urushihara, H., Tanaka, Y., Schleicher, M., Steinert, M., & Eichinger, L. (2006) · Cellular Microbiology · doi:10.1111/j.1462-5822.2005.00633.x · Cited by 112

Growth of Legionella pneumophila in Dictyostelium discoideum: a novel system for genetic analysis of host–pathogen interactions

Solomon, J. M., & Isberg, R. R. (2000) · Trends in Microbiology · doi:10.1016/s0966-842x(00)01852-7 · Cited by 112

Relevance of free-living amoebae as hosts for phylogenetically diverse microorganisms

Scheid, P. L. (2014) · Parasitology Research · doi:10.1007/s00436-014-3932-7 · Cited by 111

Factors Mediating Environmental Biofilm Formation by Legionella pneumophila

Khweek, A. A., & Amer, A. O. (2018) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2018.00038 · Cited by 111

Various bacterial pathogens and symbionts infect the amoeba Dictyostelium discoideum

Skriwan, C., Fajardo, M., Hägele, S., Horn, M., Wagner, M., Michel, R., Krohne, G., Schleicher, M., Hacker, J., & Steinert, M. (2002) · International Journal of Medical Microbiology · doi:10.1078/1438-4221-00177 · Cited by 109

The Ecology and Evolution of Amoeba-Bacterium Interactions

Shi, Y., Queller, D. C., Tian, Y., Zhang, S., Yan, Q., He, Z., He, Z., Wu, C., Wang, C., & Shu, L. (2020) · Applied and Environmental Microbiology · doi:10.1128/aem.01866-20 · Cited by 114

Acanthamoeba and Dictyostelium as Cellular Models for Legionella Infection

Swart, A. L., Harrison, C. F., Eichinger, L., Steinert, M., & Hilbi, H. (2018) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2018.00061 · Cited by 113

Legionella pathogenicity: Genome structure, regulatory networks and the host cell response

Steinert, M., Heuner, K., Buchrieser, C., Albert-Weißenberger, C., & Glöckner, G. (2007) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2007.03.009 · Cited by 118

Loss of Dictyostelium ATG9 results in a pleiotropic phenotype affecting growth, development, phagocytosis and clearance and replication of Legionella pneumophila

Tung, S. M., Ünal, C., Ley, A., Peña, C., Tunggal, B., Noegel, A. A., Krut, O., Steinert, M., & Eichinger, L. (2010) · Cellular Microbiology · doi:10.1111/j.1462-5822.2010.01432.x · Cited by 106

The Rise of Pathogens: Predation as a Factor Driving the Evolution of Human Pathogens in the Environment

Erken, M., Lutz, C., & McDougald, D. (2013) · Microbial Ecology · doi:10.1007/s00248-013-0189-0 · Cited by 106

New models for the study of Mycobacterium–host interactions

Pozos, T. C., & Ramakrishnan, L. (2004) · Current Opinion in Immunology · doi:10.1016/j.coi.2004.05.011 · Cited by 100

Function and Mechanism of Action of Dictyostelium Nramp1 (Slc11a1) in Bacterial Infection

Peracino, B., Wagner, C., Balest, A., Balbo, A., Pergolizzi, B., Noegel, A. A., Steinert, M., & Bozzaro, S. (2006) · Traffic · doi:10.1111/j.1600-0854.2005.00356.x · Cited by 96

Simple system – substantial share: The use of Dictyostelium in cell biology and molecular medicine

Müller‐Taubenberger, A., Kortholt, A., & Eichinger, L. (2012) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2012.10.003 · Cited by 96

Chapter 6 Phagocytosis and Host–Pathogen Interactions in Dictyostelium with a Look at Macrophages

Bozzaro, S., Bucci, C., & Steinert, M. (2008) · International review of cytology · doi:10.1016/s1937-6448(08)01206-9 · Cited by 96

Pathogen–host interactions in Dictyostelium, Legionella, Mycobacterium and other pathogens

Steinert, M. (2010) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2010.11.003 · Cited by 94

Proteomic analysis of Legionella-containing phagosomes isolated from Dictyostelium

Shevchuk, O., Batzilla, C. F., Hägele, S., Kusch, H., Engelmann, S., Hecker, M., Haas, A., Heuner, K., Glöckner, G., & Steinert, M. (2009) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2009.03.006 · Cited by 88

Evolution of the Zebrafish Model: From Development to Immunity and Infectious Disease

Phelps, H. A., & Neely, M. N. (2005) · Zebrafish · doi:10.1089/zeb.2005.2.87 · Cited by 86

Pathogenicity and virulence of Bordetella pertussis and its adaptation to its strictly human host

Belcher, T., Dubois, V., Rivera-Millot, A., Locht, C., & Jacob‐Dubuisson, F. (2021) · Virulence · doi:10.1080/21505594.2021.1980987 · Cited by 83

Potential role of bacteria packaging by protozoa in the persistence and transmission of pathogenic bacteria

Denoncourt, A. M., Paquet, V. E., & Charette, S. J. (2014) · Frontiers in Microbiology · doi:10.3389/fmicb.2014.00240 · Cited by 83

Antagonistic Microbial Interactions: Contributions and Potential Applications for Controlling Pathogens in the Aquatic Systems

Feichtmayer, J., Deng, L., & Griebler, C. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.02192 · Cited by 80

Intracellular survival strategies of mutualistic and parasitic prokaryotes

Goebel, W., & Gross, R. (2001) · Trends in Microbiology · doi:10.1016/s0966-842x(01)02040-6 · Cited by 76

Human Lung Tissue Explants Reveal Novel Interactions during Legionella pneumophila Infections

Jäger, J., Marwitz, S., Tiefenau, J. H. J., Rasch, J., Shevchuk, O., Kügler, C., Goldmann, T., & Steinert, M. (2013) · Infection and Immunity · doi:10.1128/iai.00703-13 · Cited by 73

Calnexin, calreticulin and cytoskeleton-associated proteins modulate uptake and growth of Legionella pneumophila in Dictyostelium discoideum

Fajardo, M., Schleicher, M., Noegel, A., Bozzaro, S., Killinger, S., Heuner, K., Hacker, J., & Steinert, M. (2004) · Microbiology · doi:10.1099/mic.0.27111-0 · Cited by 73

Dictyostelium discoideum strains lacking the RtoA protein are defective for maturation of the Legionella pneumophila replication vacuole

Li, Z., Solomon, J. M., & Isberg, R. R. (2005) · Cellular Microbiology · doi:10.1111/j.1462-5822.2004.00472.x · Cited by 72

Influence of the Alternative σ 28 Factor on Virulence and Flagellum Expression of Legionella pneumophila

Heuner, K., Dietrich, C., Skriwan, C., Steinert, M., & Hacker, J. H. (2002) · Infection and Immunity · doi:10.1128/iai.70.3.1604-1608.2002 · Cited by 71

RabD, aDictyosteliumRab14-related GTPase, regulates phagocytosis and homotypic phagosome and lysosome fusion

Harris, E. N., & Cardelli, J. A. (2002) · Journal of Cell Science · doi:10.1242/jcs.00050 · Cited by 70

Genome-wide transcriptional changes induced by phagocytosis or growth on bacteria in Dictyostelium

Sillo, A., Bloomfield, G., Balest, A., Balbo, A., Pergolizzi, B., Peracino, B., Skelton, J., Ivens, A., & Bozzaro, S. (2008) · BMC Genomics · doi:10.1186/1471-2164-9-291 · Cited by 69

Helicobacter pylori Resists Phagocytosis by Macrophages: Quantitative Assessment by Confocal Microscopy and Fluorescence-Activated Cell Sorting

Ramarao, N., & Meyer, T. F. (2001) · Infection and Immunity · doi:10.1128/iai.69.4.2604-2611.2001 · Cited by 68

Evolution of the Arsenal of Legionella pneumophila Effectors To Modulate Protist Hosts

Best, A., & Kwaik, Y. A. (2018) · mBio · doi:10.1128/mbio.01313-18 · Cited by 67

Free-living freshwater amoebae differ in their susceptibility to the pathogenic bacteriumLegionella pneumophila

Dey, R., Bodennec, J., Mameri, M. R., & Pernin, P. (2008) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2008.01387.x · Cited by 65

Genetic Models in Pathogenesis

Pradel, E., & Ewbank, J. J. (2004) · Annual Review of Genetics · doi:10.1146/annurev.genet.38.072902.092528 · Cited by 64

Legionella pneumophila adaptation to intracellular life and the host response: Clues from genomics and transcriptomics

Jules, M., & Buchrieser, C. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.05.026 · Cited by 70

Multiple Legionella pneumophila Type II Secretion Substrates, Including a Novel Protein, Contribute to Differential Infection of the Amoebae Acanthamoeba castellanii, Hartmannella vermiformis, and Naegleria lovaniensis

Tyson, J. Y., Pearce, M. M., Vargas, P., Bagchi, S., Mulhern, B. J., & Cianciotto, N. P. (2013) · Infection and Immunity · doi:10.1128/iai.00045-13 · Cited by 60

Ancient bacteria–amoeba relationships and pathogenic animal bacteria

Strassmann, J. E., & Shu, L. (2017) · PLoS Biology · doi:10.1371/journal.pbio.2002460 · Cited by 63

Deficiency of Huntingtin Has Pleiotropic Effects in the Social Amoeba Dictyostelium discoideum

Myre, M. A., Lumsden, A. L., Thompson, M. N., Wasco, W., MacDonald, M. E., & Gusella, J. F. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002052 · Cited by 57

Phosphoinositides differentially regulate bacterial uptake and Nramp1-induced resistance to Legionella infection in Dictyostelium

Peracino, B., Balest, A., & Bozzaro, S. (2010) · Journal of Cell Science · doi:10.1242/jcs.072124 · Cited by 63

Detection of Protozoan Hosts for Legionella pneumophila in Engineered Water Systems by Using a Biofilm Batch Test

Valster, R. M., Wullings, B. A., & van der Kooij, D. (2010) · Applied and Environmental Microbiology · doi:10.1128/aem.00926-10 · Cited by 54

Conserved features of endocytosis in Dictyostelium

Maniak, M. (2002) · International Review of Cytology · doi:10.1016/s0074-7696(02)21014-1 · Cited by 52

The many forms of a pleomorphic bacterial pathogen—the developmental network of Legionella pneumophila

Robertson, P., Abdelhady, H., & Garduño, R. A. (2014) · Frontiers in Microbiology · doi:10.3389/fmicb.2014.00670 · Cited by 51

Whole Genome Sequencing of Mutation Accumulation Lines Reveals a Low Mutation Rate in the Social Amoeba Dictyostelium discoideum

Saxer, G., Havlak, P., Fox, S. A., Quance, M. A., Gupta, S., Fofanov, Y., Strassmann, J. E., & Queller, D. C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046759 · Cited by 52

Balamuthia mandrillaris , Free-Living Ameba and Opportunistic Agent of Encephalitis, Is a Potential Host for Legionella pneumophila Bacteria

Shadrach, W. S., Rydzewski, K., Laube, U., Holland, G., Özel, M., Kiderlen, A. F., & Flieger, A. (2005) · Applied and Environmental Microbiology · doi:10.1128/aem.71.5.2244-2249.2005 · Cited by 50

The Nramp (Slc11) proteins regulate development, resistance to pathogenic bacteria and iron homeostasis in Dictyostelium discoideum

Peracino, B., Buracco, S., & Bozzaro, S. (2012) · Journal of Cell Science · doi:10.1242/jcs.116210 · Cited by 51

Legionella pneumophilamultiplication is enhanced by chronic AMPK signalling in mitochondrially diseased Dictyostelium cells

Francione, L. M., Smith, P. K., Accari, S. L., Taylor, P. E., Bokko, P. B., Bozzaro, S., Beech, P. L., & Fisher, P. R. (2009) · Disease Models & Mechanisms · doi:10.1242/dmm.003319 · Cited by 50

The amoebae plate test implicates a paralogue of lpxB in the interaction of Legionella pneumophila with Acanthamoeba castellanii

Albers, U., Reus, K., Shuman, H. A., & Hilbi, H. (2005) · Microbiology · doi:10.1099/mic.0.27563-0 · Cited by 50

Amoebae and Legionella pneumophila in saline environments

Gast, R. J., Moran, D. M., Dennett, M. R., Wurtsbaugh, W. A., & Amaral‐Zettler, L. (2011) · Journal of Water and Health · doi:10.2166/wh.2010.103 · Cited by 48

Bordetella bronchiseptica exploits the complex life cycle of Dictyostelium discoideum as an amplifying transmission vector

Taylor, D. L., Bendor, L., Linz, B., Rivera, I., Ryman, V. E., Dewan, K. K., Wagner, S. M., Wilson, E. F., Hilburger, L. J., Cuff, L. E., et al. (2017) · PLoS Biology · doi:10.1371/journal.pbio.2000420 · Cited by 50

Evidence that hsp90 Is Involved in the Altered Interactions ofAcanthamoeba castellaniiVariants with Bacteria

Yan, L., Cerny, R. L., & Cirillo, J. D. (2004) · Eukaryotic Cell · doi:10.1128/ec.3.3.567-578.2004 · Cited by 46

Free-Living Amoebae as Human Parasites and Hosts for Pathogenic Microorganisms

Scheid, P. L. (2018) · International Conference on Efficient & Sustainable Water Systems Management toward Worth Living Development (EWaS) · doi:10.3390/proceedings2110692 · Cited by 45

Recent insights into host-pathogen interactions fromDictyostelium

Clarke, M. (2009) · Cellular Microbiology · doi:10.1111/j.1462-5822.2009.01413.x · Cited by 44

Dictyostelium discoideum as a Model System for Identification of Burkholderia pseudomallei Virulence Factors

Hasselbring, B. M., Patel, M. K., & Schell, M. A. (2011) · Infection and Immunity · doi:10.1128/iai.01233-10 · Cited by 44

Cross-Species Infections and Their Analysis

Tan, M. (2002) · Annual Review of Microbiology · doi:10.1146/annurev.micro.56.012302.161110 · Cited by 42

Dictyostelium discoideum as a non‐mammalian biomedical model

Martín‐González, J., Montero‐Bullón, J., & Lacal, J. (2020) · Microbial Biotechnology · doi:10.1111/1751-7915.13692 · Cited by 43

The Neff strain of Acanthamoeba castellanii, a tool for testing the virulence of Mycobacterium kansasii

Goy, G., Thomas, V., Herrera-Rimann, K., Jaton, K., Prod’hom, G., & Greub, G. (2007) · Research in Microbiology · doi:10.1016/j.resmic.2007.01.003 · Cited by 40

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