Cited by 79Prenatal Screening and DiagnosticsFetal and Pediatric Neurological DisordersCongenital Anomalies and Fetal Surgery

First‐trimester placental volume as a marker for chromosomal anomalies: preliminary results from an unselected population

Metzenbauer, M., Hafner, E., Schuchter, K., Philipp, K.·2002·Ultrasound in Obstetrics & Gynecology

Abstract

Objective: To compare first‐trimester placental volume in chromosomally abnormal and normal pregnancies. Methods: Placental volumes were routinely recorded at the time of nuchal translucency thickness measurement at 10–13 weeks of gestation. This was done using customized three‐dimensional ultrasound equipment and measurements were then converted to the placental quotient (placental volume/fetal crown–rump length). The possible difference in placental quotient between chromosomally normal and abnormal pregnancies was examined. Results: A total of 2863 pregnancies was evaluated, including 17 with major chromosomal defects (nine cases of trisomy 21, four of trisomy 18, two of trisomy 13, and one each of Turner syndrome and 48,XXY + 21). The median placental quotient in the chromosomally abnormal group (0.67) was significantly lower than that in the normal fetuses (0.98). In nine of the 17 affected pregnancies the quotient was below the 10th centile of the normal range. Conclusions: Assessment of placental volume may prove to be useful in first‐trimester risk assessment for chromosomal anomalies. Copyright © 2002 ISUOG

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Crossref · 10.1046/j.1469-0705.2002.00655.x

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Authors
Metzenbauer, M., Hafner, E., Schuchter, K., & Philipp, K.
Affiliations
Donauspital (AT)
Venue
Ultrasound in Obstetrics & Gynecology
Publisher
Wiley
Published
2002-03
Volume
19
Issue
3
Pages
240-242
ISSN
  • 0960-7692 (ISSN-L)
  • 1469-0705
OpenAlex
W2027238602
Cited by
79
References
13
Citations by year
2025: 2 · 2024: 2 · 2022: 2 · 2021: 2 · 2019: 1 · 2017: 5 · 2016: 2 · 2015: 7 · 2014: 5 · 2013: 8 · 2012: 3
FWCI
4.17
Type
journal article
Language
en
Open access
closed
Locations
  • Ultrasound in Obstetrics and Gynecology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Austrian Science Fund (P 13847)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Screening and Diagnostics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
  • Health Sciences › Medicine › Surgery › Congenital Anomalies and Fetal Surgery
Keywords
placental volume, first trimester, chromosomal abnormalities, Down syndrome, trisomy 18, trisomy 13, Turner syndrome, nuchal translucency, prenatal screening, 3D ultrasound, fetal crown-rump length
MeSH terms
Adolescent, Adult, Chromosomes, Human, Pair 13, Chromosomes, Human, Pair 18, Down Syndrome, Female, Follow-Up Studies, Genetic Markers, Humans, Middle Aged, Placenta, Placental Insufficiency, Pregnancy, Pregnancy Complications, Pregnancy Outcome, Pregnancy Trimester, First, Prenatal Care, Sampling Studies, Sensitivity and Specificity, Trisomy, Cohort Studies, Ultrasonography, Prenatal

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