Estrogen Regulation of Dopamine Release in the Nucleus Accumbens: Genomic‐and Nongenomic‐Mediated Effects
Abstract
Abstract:The ability of estrogen to modulate mesolimbic dopamine (DA) was examined using in vivo voltammetry. Estrogen priming (5 μ g, 48 h) of ovariectomized (ovx) female rats resulted in a slight decrease in K+‐stimulated DA release measured in the nucleus accumbens: this decrease was accompanied by a significant increase in both DA reuptake and DA clearance times. Following estrogen priming nomifensine, a potent inhibitor of the DA uptake carrier, was still able to potentiate K+‐stimulated DA release and alter the time course of DA availability, but the response was attenuated compared with ovx controls. Direct infusion of 17β‐estradiol hemisuccinate (17β‐E, 20–50 pg) into the nucleus accumbens resulted in a biphasic potentiation of K+‐stimulated release. An initial increase in release was observed 2 min after 17β‐E infusion; this increase, although reduced by 15 min, was still significantly higher than control values. A subsequent potentiation was observed 60 min after the initial 17β‐E infusion; this response remained for at least an additional 60 min. Nomifensine did not significantly alter K+‐stimulated DA release following 17β‐E infusion, but was still able to potentiate the total time DA was available extracellularly. These data suggest that the mesolimbic A10 DA neurons that terminate in the nucleus accumbens can be modulated in vivo by estrogen and that this modulation may be mediated by both genomic (long term) and nongenomic (short term) mechanisms.
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17-Beta-estradiol directly potentiates dopamine release in the rat nucleus accumbens.
“17‐Beta‐estradiol has been shown to directly potentiate dopamine release in the rat nucleus accumbens 112.”
From History of early life adversity is associated with increased food addiction and sex-specific alterations in reward network connectivity in obesity (2019) · cites this paper as [112]
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- Authors
- Thompson, T. L., & Moss, R. L.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Thompson, Tina L.
- ORCID
- Moss, Robert L.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 1994-05
- Volume
- 62
- Issue
- 5
- Pages
- 1750-1756
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W2019626637
- Cited by
- 234
- References
- 53
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 2 · 2023: 2 · 2022: 14 · 2021: 8 · 2020: 8 · 2019: 5 · 2018: 11 · 2017: 9 · 2016: 10 · 2015: 9 · 2014: 6 · 2013: 9 · 2012: 4
- FWCI
- 2.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neurochemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01mh047418-06)
- National Institute of Mental Health (MH47418-03)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD07062-15)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- estrogen, dopamine release, nucleus accumbens, mesolimbic dopamine neurons, estradiol, ovariectomy, estrogen priming, non-genomic estrogen signaling, genomic estrogen signaling, dopamine reuptake, nomifensine, potassium-evoked release, dopamine clearance
- MeSH terms
- Analysis of Variance, Animals, Dopamine, Estradiol, Female, Infusions, Parenteral, Kinetics, Nomifensine, Nucleus Accumbens, Ovariectomy, Potassium, Stereotaxic Techniques, Time Factors, Rats, Sprague-Dawley, Rats
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