Cited by 234Neurotransmitter Receptor Influence on BehaviorEstrogen and related hormone effectsNeuroscience and Neuropharmacology Research

Estrogen Regulation of Dopamine Release in the Nucleus Accumbens: Genomic‐and Nongenomic‐Mediated Effects

Thompson, Tina L., Moss, Robert L.·1994·Journal of Neurochemistry

Abstract

Abstract:The ability of estrogen to modulate mesolimbic dopamine (DA) was examined using in vivo voltammetry. Estrogen priming (5 μ g, 48 h) of ovariectomized (ovx) female rats resulted in a slight decrease in K+‐stimulated DA release measured in the nucleus accumbens: this decrease was accompanied by a significant increase in both DA reuptake and DA clearance times. Following estrogen priming nomifensine, a potent inhibitor of the DA uptake carrier, was still able to potentiate K+‐stimulated DA release and alter the time course of DA availability, but the response was attenuated compared with ovx controls. Direct infusion of 17β‐estradiol hemisuccinate (17β‐E, 20–50 pg) into the nucleus accumbens resulted in a biphasic potentiation of K+‐stimulated release. An initial increase in release was observed 2 min after 17β‐E infusion; this increase, although reduced by 15 min, was still significantly higher than control values. A subsequent potentiation was observed 60 min after the initial 17β‐E infusion; this response remained for at least an additional 60 min. Nomifensine did not significantly alter K+‐stimulated DA release following 17β‐E infusion, but was still able to potentiate the total time DA was available extracellularly. These data suggest that the mesolimbic A10 DA neurons that terminate in the nucleus accumbens can be modulated in vivo by estrogen and that this modulation may be mediated by both genomic (long term) and nongenomic (short term) mechanisms.

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Crossref · 10.1046/j.1471-4159.1994.62051750.x

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Authors
Thompson, T. L., & Moss, R. L.
Affiliations
The University of Texas Southwestern Medical Center (US)
Corresponding author
Thompson, Tina L.
Venue
Journal of Neurochemistry
Publisher
Wiley
Published
1994-05
Volume
62
Issue
5
Pages
1750-1756
ISSN
  • 0022-3042 (ISSN-L)
  • 1471-4159
OpenAlex
W2019626637
Cited by
234
References
53
Citations by year
2026: 3 · 2025: 6 · 2024: 2 · 2023: 2 · 2022: 14 · 2021: 8 · 2020: 8 · 2019: 5 · 2018: 11 · 2017: 9 · 2016: 10 · 2015: 9 · 2014: 6 · 2013: 9 · 2012: 4
FWCI
2.33
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Neurochemistry (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01mh047418-06)
  • National Institute of Mental Health (MH47418-03)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD07062-15)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
estrogen, dopamine release, nucleus accumbens, mesolimbic dopamine neurons, estradiol, ovariectomy, estrogen priming, non-genomic estrogen signaling, genomic estrogen signaling, dopamine reuptake, nomifensine, potassium-evoked release, dopamine clearance
MeSH terms
Analysis of Variance, Animals, Dopamine, Estradiol, Female, Infusions, Parenteral, Kinetics, Nomifensine, Nucleus Accumbens, Ovariectomy, Potassium, Stereotaxic Techniques, Time Factors, Rats, Sprague-Dawley, Rats

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