The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Interleukin‐6 Production by Schwann Cells and Induction in Sciatic Nerve Injury
Abstract
Abstract: Interleukin‐6 (IL‐6) was produced by the spontaneously immortal Schwann cell clone, iSC, when cocultured with PC12 cells. The iSC cell‐derived IL‐6 in coculture conditioned media caused the neuronal differentiation of naive PC12 cells and this bioactivity was neutralized by preincubation of conditioned media with antisera to IL‐6. Cocultured iSC transcribe IL‐6 message as confirmed by northern analysis. Stimuli that induce IL‐6 production in the hematopoietic lineage induced transcription and production of IL‐6 by iSC cells. Lipopolysaccharide, tumor necrosis factor‐α, IL‐1α, IL‐6, and serum withdrawal induced iSC cell IL‐6 mRNA. The kinetics of IL‐6 production was confirmed in the mouse IL‐6‐dependent B9 bioassay and that activity could be neutralized with antisera to IL‐6. Expression of both the IL‐6 receptor and the gp130 signal transduction component by iSC as determined by northern analysis suggests an autocrine regulatory mechanism. The observed iSC production of IL‐6 in vitro led to an investigation of the sciatic nerve crush model of Schwann cell activation in vivo. In the initial 12 h after crush injury, IL‐6 message is induced. IL‐6 mRNA expression was highest distal to the crush injury. Our in vitro data demonstrate that iSC cells produce IL‐6 in response to PC12 cell coculture and to stimuli that induce IL‐6 production in the hematopoietic lineage. The induction of IL‐6 message distal to a crush injury suggests another mechanism by which Schwann cells facilitate peripheral nerve regeneration.
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Hirano, T., Yasukawa, K., Harada, H., Taga, T., Watanabe, Y., Matsuda, T., Kashiwamura, S.-I., Nakajima, K., Koyama, K., Iwamatsu, A., et al. (1986) · Nature · doi:10.1038/324073a0 · Cited by 2,139
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Watkins, L. R., & Maier, S. F. (2002) · Physiological Reviews · doi:10.1152/physrev.00011.2002 · Cited by 733
Austin, P. J., & Moalem-Taylor, G. (2010) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2010.08.013 · Cited by 607
The Pain of Being Sick: Implications of Immune-to-Brain Communication for Understanding Pain
Watkins, L. R., & Maier, S. F. (2000) · Annual Review of Psychology · doi:10.1146/annurev.psych.51.1.29 · Cited by 388
DeLEO, J. A., COLBURN, R. W., NICHOLS, M., & MALHOTRA, A. (1996) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.1996.16.695 · Cited by 373
Metadata
- Authors
- Bolin, L. M., Verity, A. N., Silver, J. E., Shooter, E. M., & Abrams, J. S.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 1995-02
- Volume
- 64
- Issue
- 2
- Pages
- 850-858
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W2063274987
- Cited by
- 256
- References
- 1
- FWCI
- 5.46
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bolin, L. M., Verity, A. N., Silver, J. E., Shooter, E. M., & Abrams, J. S. (1995). Interleukin‐6 Production by Schwann Cells and Induction in Sciatic Nerve Injury. Journal of Neurochemistry. https://doi.org/10.1046/j.1471-4159.1995.64020850.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
