Cited by 280Inflammatory mediators and NSAID effectsNeuroinflammation and Neurodegeneration MechanismsPain Mechanisms and Treatments

The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.

Effect of acute systemic inflammatory response and cytokines on the transcription of the genes encoding cyclooxygenase enzymes (COX-1 and COX-2) in the rat brain.

Lacroix, Steve, Rivest, Serge·1998·Journal of Neurochemistry

DOI 10.1046/j.1471-4159.1998.70020452.x

Open this paper in CoChat — free account

Abstract

The aim of this study was to investigate the influence of the acute-phase response and the proinflammatory cytokines on the transcription of the genes encoding the limiting enzymes for the production of prostaglandins, cyclooxygenase (COX)-1 and COX-2, in the rat brain. The bacterial endotoxin lipopolysaccharide (intravenous and intraperitoneal) and turpentine (intramuscular) were used as different models of inflammation in adult male rats. Animals were also killed at various times after intravenous administration of interleukin-1beta, tumor necrosis factor-alpha, and interleukin-6, and mRNAs encoding COX-1 and COX-2 were assayed by in situ hybridization histochemistry. A profound transcriptional activation of the gene encoding COX-2 was detected over blood vessels of the entire brain microvasculature, choroid plexus, and leptomeninges of lipopolysaccharide-challenged rats. Injection of the endotoxin intravenously also increased COX-2 gene expression within parvocellular division of the hypothalamic paraventricular nucleus. It is interesting that intramuscular turpentine injection stimulated transcription of COX-2 along endothelium of brain capillaries, and the signal of this transcript paralleled the inflammation of the left hind limb. A robust COX-2 mRNA signal was detected rapidly in the brain microvessels of interleukin-1beta-injected rats, whereas tumor necrosis factor-alpha administration caused a modest but significant induction of this transcript. In contrast, intravenous injection of interleukin-6 did not alter genetic expression of COX-2, and none of the above described models affected the synthesis of COX-1 gene in the rat brain. These results indicate that specific cell populations, in particular vascular- and/or perivascular-associated cells, are responsible for the central production of prostaglandins during systemic inflammation, and circulating interleukin-1beta is likely to be a potent mediator of this response.

Integrity signals

Registry

Crossref · 10.1046/j.1471-4159.1998.70020452.x

Cites

70 of 70 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein
Wright, S. D., Ramos, R., Tobias, P. S., Ulevitch, R. J., & Mathison, J. C. (1990) · Science · doi:10.1126/science.1698311 · Cited by 3,996
Secretory products of macrophages.
Nathan, C. F. (1987) · Journal of Clinical Investigation · doi:10.1172/jci112815 · Cited by 2,615
Interleukin-1 stimulates the secretion of hypothalamic corticotropin-releasing factor
Sapolsky, R., Rivier, C., Yamamoto, G., Plotsky, P., & Vale, W. (1987) · Science · doi:10.1126/science.2821621 · Cited by 1,504
THE PHENOMENON OF THE ACUTE PHASE RESPONSE*
Kushner, I. (1982) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1982.tb22124.x · Cited by 1,494
Biology of multifunctional cytokines: IL 6 and related molecules (IL 1 and TNF)
Akira, S., Hirano, T., Taga, T., & Kishimoto, T. (1990) · The FASEB Journal · doi:10.1096/fasebj.4.11.2199284 · Cited by 1,306
Expression of a mitogen-inducible cyclooxygenase in brain neurons: Regulation by synaptic activity and glucocorticoids
Yamagata, K., Andreasson, K. I., Kaufmann, W. E., Barnes, C. A., & Worley, P. F. (1993) · Neuron · doi:10.1016/0896-6273(93)90192-t · Cited by 1,231
Interleukin-1 and Its Biologically Related Cytokines
Dinarello, C. A. (1989) · Advances in immunology · doi:10.1016/s0065-2776(08)60642-2 · Cited by 1,145
A Complete Protocol for In Situ Hybridization of Messenger RNAs in Brain and Other Tissues With Radio-labeled Single-Stranded RNA Probes
Simmons, D. M., Arriza, J. L., & Swanson, L. W. (1989) · Journal of Histotechnology · doi:10.1179/his.1989.12.3.169 · Cited by 921
Selective expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide.
Lee, S., Soyoola, E., Chanmugam, P., Hart, S., Sun, W., Zhong, H., Liou, S., Simmons, D., & Hwang, D. H. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)35698-9 · Cited by 811
Cyclo-Oxygenase-2 Gene Expression in Neurons Contributes to Ischemic Brain Damage
Nogawa, S., Zhang, F., Ross, M. E., & Iadecola, C. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-08-02746.1997 · Cited by 715

Show all 70 references

Sorted by citations

Regulation of the Hypothalamic-Pituitary-Adrenal Axis by Cytokines: Actions and Mechanisms of Action
TURNBULL, A. V., & RIVIER, C. L. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.1.1 · Cited by 1,297
Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications
Felger, J. C., & Lotrich, F. E. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.04.060 · Cited by 1,180
Neuroinflammation: The role and consequences
Lyman, M., Lloyd, D. G., Ji, X., Vizcaychipi, M. P., & Ma, D. (2013) · Neuroscience Research · doi:10.1016/j.neures.2013.10.004 · Cited by 776
Proinflammatory cytokine synthesis in the injured mouse spinal cord: Multiphasic expression pattern and identification of the cell types involved
Pineau, I., & Lacroix, S. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.21149 · Cited by 592
Cytokine effects on the basal ganglia and dopamine function: The subcortical source of inflammatory malaise
Felger, J. C., & Miller, A. H. (2012) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2012.09.003 · Cited by 413
Coexpression of Microsomal-Type Prostaglandin E Synthase with Cyclooxygenase-2 in Brain Endothelial Cells of Rats during Endotoxin-Induced Fever
Yamagata, K., Matsumura, K., Inoue, W., Shiraki, T., Suzuki, K., Yasuda, S., Sugiura, H., Cao, C., Watanabe, Y., & Kobayashi, S. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-08-02669.2001 · Cited by 372
LPS-induced Murine Neuroinflammation Model: Main Features and Suitability for Pre-clinical Assessment of Nutraceuticals
Catorce, M. N., & Gevorkian, G. (2016) · Current Neuropharmacology · doi:10.2174/1570159x14666151204122017 · Cited by 368
A potential role for pro-inflammatory cytokines in regulating synaptic plasticity in major depressive disorder
Khairova, R. A., Machado-Vieira, R., Du, J., & Manji, H. K. (2009) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145709009924 · Cited by 350
DNA Damage in Nasal and Brain Tissues of Canines Exposed to Air Pollutants Is Associated with Evidence of Chronic Brain Inflammation and Neurodegeneration
Calderón‐Garcidueñas, L., Maronpot, R. R., Torres‐Jardón, R., Henríquez-Roldán, C. F., Schoonhoven, R., Acuña-Ayala, H., Villarreal-Calderón, A., Nakamura, J., Fernando, R. A., Reed, W., et al. (2003) · Toxicologic Pathology · doi:10.1080/01926230390226645 · Cited by 363
Ectopic and Abnormal Hormone Receptors in Adrenal Cushing's Syndrome
Lacroix, A., N’Diaye, N., Tremblay, J., & Hamet, P. (2001) · Endocrine Reviews · doi:10.1210/edrv.22.1.0420 · Cited by 350
Cytokine, sickness behavior, and depression
Dantzer, R. (2006) · Neurologic Clinics · doi:10.1016/j.ncl.2006.03.003 · Cited by 340
Choroid plexus and the blood–cerebrospinal fluid barrier in disease
Solár, P., Zamani, A., Kubíčková, L., Dubový, P., & Joukal, M. (2020) · Fluids and Barriers of the CNS · doi:10.1186/s12987-020-00196-2 · Cited by 365
The Spinal Phospholipase-Cyclooxygenase-Prostanoid Cascade in Nociceptive Processing
Svensson, C. I., & Yaksh, T. L. (2002) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.42.092401.143905 · Cited by 302
An Essential Role of Interleukin-1β in Mediating NF-κB Activity and COX-2 Transcription in Cells of the Blood–Brain Barrier in Response to a Systemic and Localized Inflammation But Not During Endotoxemia
Laflamme, N., Lacroix, S., & Rivest, S. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-24-10923.1999 · Cited by 287
Effects of circulating tumor necrosis factor on the neuronal activity and expression of the genes encoding the tumor necrosis factor receptors (p55 and p75) in the rat brain: a view from the blood–brain barrier
Nadeau, S., & Rivest, S. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00225-0 · Cited by 279
A Systematic Analysis of the Peripheral and CNS Effects of Systemic LPS, IL-1Β, TNF-α and IL-6 Challenges in C57BL/6 Mice
Skelly, D., Hennessy, E., Dansereau, M., & Cunningham, C. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069123 · Cited by 289
How the Blood Talks to the Brain Parenchyma and the Paraventricular Nucleus of the Hypothalamus During Systemic Inflammatory and Infectious Stimuli
Rivest, S., Lacroix, S., Vallières, L., Nadeau, S., Zhang, J., & Laflamme, N. (2000) · Proceedings of The Society for Experimental Biology and Medicine · doi:10.1046/j.1525-1373.2000.22304.x · Cited by 277
Expression of cyclooxygenase 2 (COX-2) in human glioma and in vitro inhibition by a specific COX-2 inhibitor, NS-398.
Joki, T., Heese, O., Nikas, D. C., Bello, L., Zhang, J., Kraeft, S., Seyfried, N. T., Abe, T., Chen, L. B., Carroll, R. S., et al. (2000) · PubMed · Cited by 265
Rat brain vascular distribution of interleukin‐1 type‐1 receptor immunoreactivity: Relationship to patterns of inducible cyclooxygenase expression by peripheral inflammatory stimuli
Konsman, J. P., Vigues, S., Mackerlova, L., Bristow, A., & Blomqvist, A. G. (2004) · The Journal of Comparative Neurology · doi:10.1002/cne.20052 · Cited by 259
Autonomic neural regulation of immunity
CZURA, C. J., & TRACEY, K. J. (2005) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2004.01442.x · Cited by 255
Dual Roles for Perivascular Macrophages in Immune-to-Brain Signaling
Serrats, J., Schiltz, J. C., García-Bueno, B., van Rooijen, N., Reyes, T. M., & Sawchenko, P. E. (2010) · Neuron · doi:10.1016/j.neuron.2009.11.032 · Cited by 253
Development of the choroid plexus
Dzięgielewska, K. M., Ek, C. J., Habgood, M. D., & Saunders, N. R. (2000) · Microscopy Research and Technique · doi:10.1002/1097-0029(20010101)52:1 · Cited by 245
Prostaglandin E2 as a mediator of fever: synthesis and catabolism
Andrei, I. I. (2004) · Frontiers in bioscience · doi:10.2741/1383 · Cited by 239
Circulating interleukin‐6 mediates the febrile response to localised inflammation in rats
Cartmell, T., Poole, S., Turnbull, A. V., Rothwell, N. J., & Luheshi, G. N. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00653.x · Cited by 233
The Bacterial Endotoxin Lipopolysaccharide has the Ability to Target the Brain in Upregulating Its Membrane CD14 Receptor Within Specific Cellular Populations
Lacroix, S., Feinstein, D., & Rivest, S. (1998) · Brain Pathology · doi:10.1111/j.1750-3639.1998.tb00189.x · Cited by 223
Induction of COX‐2 and PGE2 biosynthesis by IL‐1β is mediated by PKC and mitogen‐activated protein kinases in murine astrocytes
Molina‐Holgado, E., Ortiz, S., Molina‐Holgado, F., & Guaza, C. (2000) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703557 · Cited by 229
Distribution, regulation and colocalization of the genes encoding the EP2‐ and EP4‐PGE2 receptors in the rat brain and neuronal responses to systemic inflammation
Zhang, J., & Rivest, S. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00682.x · Cited by 220
Immune-to-Brain Communication Pathways in Inflammation-Associated Sickness and Depression
D’Mello, C., & Swain, M. G. (2016) · Current topics in behavioral neurosciences · doi:10.1007/7854_2016_37 · Cited by 226
How circulating cytokines trigger the neural circuits that control the hypothalamic–pituitary–adrenal axis
Rivest, S. (2001) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(01)00064-6 · Cited by 195
Distinct Brain Vascular Cell Types Manifest Inducible Cyclooxygenase Expression as a Function of the Strength and Nature of Immune Insults
Schiltz, J. C., & Sawchenko, P. E. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-13-05606.2002 · Cited by 197
Effects of Systemic Immunogenic Insults and Circulating Proinflammatory Cytokines on the Transcription of the Inhibitory Factor κBα Within Specific Cellular Populations of the Rat Brain
Laflamme, N., & Rivest, S. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0730309.x · Cited by 182
Circulating interleukin-6 induces fever through a STAT3-linked activation of COX-2 in the brain
Rummel, C. D., Sachot, C., Poole, S., & Luheshi, G. N. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00301.2006 · Cited by 180
Endotoxic fever: New concepts of its regulation suggest new approaches to its management
Blatteis, C. M. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.10.013 · Cited by 173
Prostaglandins as inflammatory messengers across the blood-brain barrier
Engblom, D., Ek, M., Saha, S., Ericsson‐Dahlstrand, A., Jakobsson, P., & Blomqvist, A. G. (2002) · Journal of Molecular Medicine · doi:10.1007/s00109-001-0289-z · Cited by 167
Cyclooxygenase-2 immunoreactivity in the human brain following cerebral ischemia
Iadecola, C., Forster, C. L., Nogawa, S., Clark, H. B., & Ross, M. E. (1999) · Acta Neuropathologica · doi:10.1007/s004010051045 · Cited by 164
Major Depression: One Brain, One Disease, One Set of Intertwined Processes
Filatova, E. V., Shadrina, M. I., & Slominsky, P. A. (2021) · Cells · doi:10.3390/cells10061283 · Cited by 186
Interleukin-6 Is a Needed Proinflammatory Cytokine in the Prolonged Neural Activity and Transcriptional Activation of Corticotropin-Releasing Factor during Endotoxemia1
Vallières, L., & Rivest, S. (1999) · Endocrinology · doi:10.1210/endo.140.9.6983 · Cited by 157
Endothelial-Specific Knockdown of Interleukin-1 (IL-1) Type 1 Receptor Differentially Alters CNS Responses to IL-1 Depending on Its Route of Administration
Ching, S., Zhang, H., Belevych, N., He, L., Lai, W., Pu, X.-A., Jaeger, L. B., Chen, Q., & Quan, N. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3357-07.2007 · Cited by 156
Cytokines, PGE2 and endotoxic fever: a re-assessment
Blatteis, C. M., Li, S., Li, Z., Feleder, C., & Perlík, V. (2005) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2005.01.001 · Cited by 153
Cyclooxygenase-2 modulates brain inflammation-related gene expression in central nervous system radiation injury
Kyrkanides, S., Moore, A. H., Olschowka, J. A., Daeschner, J., Williams, J. P., Hansen, J. T., & O’Banion, M. K. (2002) · Molecular Brain Research · doi:10.1016/s0169-328x(02)00353-4 · Cited by 151
Prostaglandin E2-synthesizing enzymes in fever: differential transcriptional regulation
Ivanov, A. I., Pero, R. S., Scheck, A. C., & Romanovsky, A. A. (2002) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00347.2002 · Cited by 152
Inhibition of cyclooxygenase-2 prevents inflammation-mediated preterm labor in the mouse.
Gross, G., Imamura, T., Vogt, S. K., Wozniak, D. F., Nelson, D., Sadovsky, Y., & Muglia, L. J. (2000) · American Journal of Physiology. Regulatory Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.278.6.r1415 · Cited by 150
Prostaglandins and sickness behavior: Old story, new insights
Pecchi, E., Dallaporta, M., Jean, A., Thirion, S., & Troadec, J.-D. (2009) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.02.040 · Cited by 135
Liver-brain inflammation axis
D’Mello, C., & Swain, M. G. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00184.2011 · Cited by 136
TAK1 in brain endothelial cells mediates fever and lethargy
Ridder, D. A., Lang, M., Salinin, S., Roederer, J.-P., Struss, M., Maser‐Gluth, C., & Schwaninger, M. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20110398 · Cited by 133
Liver–brain interactions in inflammatory liver diseases: Implications for fatigue and mood disorders
D’Mello, C., & Swain, M. G. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.10.009 · Cited by 133
Regulation of the gene encoding the monocyte chemoattractant protein 1 (MCP‐1) in the mouse and rat brain in response to circulating LPS and proinflammatory cytokines
Thibeault, I., Laflamme, N., & Rivest, S. (2001) · The Journal of Comparative Neurology · doi:10.1002/cne.1187 · Cited by 129
Signaling the brain in systemic inflammation the role of perivascular cells
Sawchenko, P. E. (2003) · Frontiers in bioscience · doi:10.2741/1211 · Cited by 126
The role of neuroinflammation on pathogenesis of affective disorders
Rhie, S. J., Jung, E.-Y., & Shim, I. (2020) · Journal of Exercise Rehabilitation · doi:10.12965/jer.2040016.008 · Cited by 126
The Encephalopathy in Sepsis
Siami, S., Annane, D., & Sharshar, T. (2008) · Critical Care Clinics · doi:10.1016/j.ccc.2007.10.001 · Cited by 127
Molecular Anti-inflammatory Mechanisms of Retinoids and Carotenoids in Alzheimer’s Disease: a Review of Current Evidence
Honarvar, N. M., Saedisomeolia, A., Abdolahi, M., Shayeganrad, A., Sangsari, G. T., Rad, B. H., & Muench, G. W. (2016) · Journal of Molecular Neuroscience · doi:10.1007/s12031-016-0857-x · Cited by 123
Prolonged Cyclooxygenase-2 Induction in Neurons and Glia Following Traumatic Brain Injury in the Rat
Strauss, K. I., Barbe, M. F., Marshall, R. M., Raghupathi, R., Mehta, S. D., & Narayan, R. K. (2000) · Journal of Neurotrauma · doi:10.1089/089771500415436 · Cited by 120
Pyrogen Sensing and Signaling: Old Views and New Concepts
Blatteis, C. M., SEHIC, E., & Li, S. (2000) · Clinical Infectious Diseases · doi:10.1086/317522 · Cited by 120
Cyclo-Oxygenase-2 Inhibitors
McGeer, P. L. (2000) · Drugs & Aging · doi:10.2165/00002512-200017010-00001 · Cited by 115
Science review: The brain in sepsis--culprit and victim.
Sharshar, T., Hopkinson, N. S., Orlikowski, D., & Annane, D. (2004) · Critical Care · doi:10.1186/cc2951 · Cited by 115
Mechanisms of the Behavioural Effects of Cytokines
Dantzer, R., Aubert, A., Bluthé, R.-M., Gheusi, G., Cremona, S., Layé, S., Konsman, J. P., Parnet, P., & Kelley, K. W. (1999) · Advances in experimental medicine and biology · doi:10.1007/978-0-585-37970-8_6 · Cited by 112
Cellular mechanisms by which tumor necrosis factor-α produces disruption of the blood–brain barrier
Mayhan, W. G. (2002) · Brain Research · doi:10.1016/s0006-8993(01)03348-0 · Cited by 109
Patterns of cyclooxygenase-1 and -2 expression in human gliomas in vivo
Deininger, M., Weller, M., Streffer, J. R., Mittelbronn, M. G. A., & Meyermann, R. (1999) · Acta Neuropathologica · doi:10.1007/s004010051075 · Cited by 107
Interactions Between the Immune and Neuroendocrine Systems
Rivest, S. (2010) · Progress in brain research · doi:10.1016/s0079-6123(08)81004-7 · Cited by 106
TNF‐α–secreting monocytes are recruited into the brain of cholestatic mice†‡
Kerfoot, S. M., D’Mello, C., Nguyen, H. H., Ajuebor, M. N., Kubes, P., Le, T. P., & Swain, M. G. (2005) · Hepatology · doi:10.1002/hep.21003 · Cited by 105
Central nervous system recognition of peripheral inflammation: a neural, hormonal collaboration.
Hopkins, S. J. (2007) · Acta bio-medica dell'Ateneo parmense/Acta biomedica · Cited by 102
MCP-1-deficient mice show reduced neuroinflammatory responses and increased peripheral inflammatory responses to peripheral endotoxin insult
Thompson, W. L., Karpus, W. J., & Eldik, L. J. V. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-35 · Cited by 107
Specific roles of cyclooxygenase‐1 and cyclooxygenase‐2 in lipopolysaccharide‐induced fever and fos expression in rat brain
Zhang, Y., Lu, J., Elmquist, J. K., & Saper, C. B. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10743 · Cited by 102
Cyclooxygenase inhibition in nerve-injury- and TNF-induced hyperalgesia in the rat
Schäfers, M., Marziniak, M., Sorkin, L. S., Yaksh, T. L., & Sommer, C. (2003) · Experimental Neurology · doi:10.1016/j.expneurol.2003.09.015 · Cited by 99
Systemic injections of lipopolysaccharide accelerates myelin phagocytosis during Wallerian degeneration in the injured mouse spinal cord
Vallières, N., Berard, J. L., David, S., & Lacroix, S. (2005) · Glia · doi:10.1002/glia.20266 · Cited by 95
A role for cyclooxygenase-2 in lipopolysaccharide-induced anorexia in rats
Lugarini, F., Hrupka, B. J., Schwartz, G. J., Plata‐Saláman, C. R., & Langhans, W. (2002) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00200.2002 · Cited by 95
Anti‐inflammatory effects of prostaglandin E2 in the central nervous system in response to brain injury and circulating lipopolysaccharide
Zhang, J., & Rivest, S. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00080.x · Cited by 92
The Role of Interleukin-6 in Lipopolysaccharide-Induced Fever by Mechanisms Independent of Prostaglandin E2
Nilsberth, C., Elander, L., Hamzic, N., Norell, M., Lönn, J., Engström, L., & Blomqvist, A. G. (2008) · Endocrinology · doi:10.1210/en.2008-0806 · Cited by 92
Brain-specific endothelial induction of prostaglandin E2 synthesis enzymes and its temporal relation to fever
Inoue, W., Matsumura, K., Yamagata, K., Takemiya, T., Shiraki, T., & Kobayashi, S. (2002) · Neuroscience Research · doi:10.1016/s0168-0102(02)00083-4 · Cited by 91
Colony-stimulating factor 1 receptor inhibition prevents disruption of the blood-retina barrier during chronic inflammation
Kokona, D., Ebneter, A., Escher, P., & Zinkernagel, M. S. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1373-4 · Cited by 93
Cerebrovascular Cyclooxygenase-1 Expression, Regulation, and Role in Hypothalamic-Pituitary-Adrenal Axis Activation by Inflammatory Stimuli
García‐Bueno, B., Serrats, J., & Sawchenko, P. E. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.2373-09.2009 · Cited by 92
NFκB Activates in vivo the Synthesis of Inducible Cox-2 in the Brain
Nadjar, A., Tridon, V., May, M. J., Ghosh, S., Dantzer, R., Amédée, T., & Parnet, P. (2005) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600106 · Cited by 88
Effect of Mechanical Compression on the Lumbar Nerve Root: Localization and Changes of Intraradicular Inflammatory Cytokines, Nitric Oxide, and Cyclooxygenase
Kobayashi, S., Baba, H., Uchida, K., Kokubo, Y., Kubota, C., Yamada, S., Suzuki, Y., & Yoshizawa, H. (2005) · Spine · doi:10.1097/01.brs.0000171910.97937.0e · Cited by 88
Evaluation of [11C]rofecoxib as PET tracer for cyclooxygenase 2 overexpression in rat models of inflammation
de Vries, E. F. J., Doorduin, J., Dierckx, R., & van Waarde, A. (2007) · Nuclear Medicine and Biology · doi:10.1016/j.nucmedbio.2007.07.015 · Cited by 87
Temporal and spatial patterns ofc-fos mRNA induced by intravenous interleukin-1: A cascade of non-neuronal cellular activation at the blood-brain barrier
Herkenham, M. A., Lee, H. Y., & Baker, R. A. (1998) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19981019)400:2 · Cited by 87
Signaling the brain in inflammation: the role of endothelial cells
Matsumura, K. (2004) · Frontiers in bioscience · doi:10.2741/1439 · Cited by 87
Cyclooxygenase-2 (COX-2) is frequently expressed in multiple myeloma and is an independent predictor of poor outcome
Ladetto, M., Vallet, S., Trojan, A., Dell'Aquila, M., Monitillo, L., Rosato, R., Santo, L., Drandi, D., Bertola, A., Falco, P., et al. (2005) · Blood · doi:10.1182/blood-2004-11-4201 · Cited by 85
Chronic overexpression of proinflammatory cytokines and histopathology in the brains of rats infected withTrypanosoma brucei
Quan, N., Mhlanga, J., Whiteside, M. B., McCoy, A. N., Kristensson, K., & Herkenham, M. A. (1999) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19991108)414:1 · Cited by 85
Signaling the brain in systemic inflammation: the role of complement
Clark, M. B. (2004) · Frontiers in bioscience · doi:10.2741/1297 · Cited by 80
COX-2 inhibition attenuates anorexia during systemic inflammation without impairing cytokine production.
Johnson, P. M., Vogt, S., Burney, M., & Muglia, L. (2002) · American Journal of Physiology. Endocrinology and Metabolism · doi:10.1152/ajpendo.00388.2001 · Cited by 84
Lipopolysaccharide-initiated persistent rhinitis causes gliosis and synaptic loss in the olfactory bulb
Hasegawa‐Ishii, S., Shimada, A., & Imamura, F. (2017) · Scientific Reports · doi:10.1038/s41598-017-10229-w · Cited by 79
Correction: A Systematic Analysis of the Peripheral and CNS Effects of Systemic LPS, IL-1Β, TNF-α and IL-6 Challenges in C57BL/6 Mice
Skelly, D. T., Hennessy, E., Dansereau, M.-A., & Cunningham, C. (2013) · PLoS ONE · doi:10.1371/annotation/90c76048-2edd-4315-8404-4d9d8cbd411e · Cited by 77
A Novel Antipyretic Action of 15-Deoxy-Δ12,14-Prostaglandin J2in the Rat Brain
Mouihate, A., Lomax, L. B., & Pittman, Q. J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.3145-03.2004 · Cited by 76
Selective Involvement of Interleukin-6 in the Transcriptional Activation of the Suppressor of Cytokine Signaling-3 in the Brain during Systemic Immune Challenges.
Lebel, E., Vallières, L., & Rivest, S. (2000) · Endocrinology · doi:10.1210/endo.141.10.7695 · Cited by 31
A Functional Analysis of EP4 Receptor‐Expressing Neurons in Mediating the Action of Prostaglandin E2 Within Specific Nuclei of the Brain in Response to Circulating Interleukin‐1β
Zhang, J., & Rivest, S. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0742134.x · Cited by 75
Cyclooxygenase 2 (COX-2) inhibition increases the inflammatory response in the brain during systemic immune stimuli
Blais, V., Turrin, N. P., & Rivest, S. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03480.x · Cited by 72
Self-citation
Inflammatory transcription factors as activation markers and functional readouts in immune-to-brain communication
Rummel, C. D. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.09.003 · Cited by 73
Expression profile of receptors for myelin-associated inhibitors of axonal regeneration in the intact and injured mouse central nervous system
Barrette, B., Vallières, N., Dubé, M., & Lacroix, S. (2007) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2006.12.004 · Cited by 70
Cyclooxygenases-1 and -2 are differentially localized to microglia and endothelium in rat EAE and glioma
Deininger, M. H., & Schluesener, H. J. (1999) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(98)00257-4 · Cited by 70
Stress and Cytokine-elicited Neuroendocrine and Neurotransmitter Sensitization: Implications for Depressive Illness
Hayley, S. P., Merali, Z., & Anisman, H. (2003) · Stress · doi:10.1080/1025389031000091167 · Cited by 70
Interleukin-6 is an afferent signal to the hypothalamo-pituitary-adrenal axis during local inflammation in mice
Turnbull, A. V., Prehar, S., Kennedy, A. R., Little, R. A., & Hopkins, S. J. (2003) · Endocrinology · doi:10.1210/en.2002-220964 · Cited by 66
Regulation of the hypothalamo–pituitary–adrenal axis by cytokines
Mulla, A., & Buckingham, J. C. (1999) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1053/beem.1999.0041 · Cited by 66
Windows into stress: a glimpse at emerging roles for CRH PVN neurons
Rasiah, N. P., Loewen, S. P., & Bains, J. S. (2023) · Physiological Reviews · doi:10.1152/physrev.00056.2021 · Cited by 62
Endotoxemia-induced cytokine-mediated responses of hippocampal astrocytes transmitted by cells of the brain–immune interface
Hasegawa‐Ishii, S., Inaba, M., Umegaki, H., Unno, K., Wakabayashi, K., & Shimada, A. (2016) · Scientific Reports · doi:10.1038/srep25457 · Cited by 65
Neuroimmune Response to Endogenous and Exogenous Pyrogens Is Differently Modulated by Sex Steroids
Mouihate, A., & Pittman, Q. J. (2003) · Endocrinology · doi:10.1210/en.2002-0093 · Cited by 63
Embryonic exposure to PFOS induces immunosuppression in the fish larvae of marine medaka
Fang, C., Huang, Q., Ye, T., Chen, Y., Liu, L., Kang, M., Lin, Y., Shen, H., & Dong, S. (2013) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2013.03.005 · Cited by 64
Inhibitory Action of Nitric Oxide on Circulating Tumor Necrosis Factor-Induced NF-κB Activity and COX-2 Transcription in the Endothelium of the Brain Capillaries
Blais, V., & Rivest, S. (2001) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/60.9.893 · Cited by 63
Cerebral Blood Flow in Acute Liver Failure: A Finding in Search of a Mechanism
Vaquero, J., Chung, C., & Blei, A. T. (2004) · Metabolic Brain Disease · doi:10.1023/b:mebr.0000043968.04313.e7 · Cited by 60
Immune‐Induced Expression of Lipocalin‐2 in Brain Endothelial Cells: Relationship with Interleukin‐6, Cyclooxygenase‐2 and the Febrile Response
Hamzic, N., Blomqvist, A. G., & Nilsberth, C. (2012) · Journal of Neuroendocrinology · doi:10.1111/jne.12000 · Cited by 60
Interleukin-6 is a candidate molecule that transmits inflammatory information to the CNS
Oka, Y., Ibuki, T., Matsumura, K., Namba, M., Yamazaki, Y., Poole, S., Tanaka, Y., & Kobayashi, S. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2006.10.055 · Cited by 60

Authors: Lacroix, S., & Rivest, S.
Affiliations: Centre hospitalier de l'Université Laval (CA)
Corresponding author: Rivest, Serge
ORCID: Lacroix, Steve
Rivest, Serge
Venue: Journal of Neurochemistry
Publisher: Wiley
Published: 1998-02
Volume: 70
Issue: 2
Pages: 452-466
ISSN: 0022-3042 (ISSN-L)
1471-4159
DOI: 10.1046/j.1471-4159.1998.70020452.x
OpenAlex: W2063310609
Cited by: 280
References: 70
Citations by year: 2025: 1 · 2024: 4 · 2023: 3 · 2022: 6 · 2021: 6 · 2020: 3 · 2019: 2 · 2018: 3 · 2017: 4 · 2016: 6 · 2015: 5 · 2014: 5 · 2013: 12 · 2012: 5
FWCI: 17.58
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 1747 d)
Locations: Journal of Neurochemistry (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Keywords: cyclooxygenase-2, cyclooxygenase-1, acute systemic inflammation, inflammatory cytokines, IL-1β, TNF-α, interleukin-6, lipopolysaccharide, turpentine, prostaglandin synthesis, cerebral microvasculature, choroid plexus, paraventricular nucleus, hypothalamus, gene transcription, neuroinflammation
MeSH terms: Acute Disease, Animals, Brain, Escherichia coli, Humans, Inflammation, Injections, Intramuscular, Injections, Intraperitoneal, Injections, Intravenous, Interleukin-1, Isoenzymes, Lipopolysaccharides, Male, Membrane Proteins, Paraventricular Hypothalamic Nucleus, Prostaglandin-Endoperoxide Synthases, Recombinant Proteins, RNA, Messenger, Transcription, Genetic, Tumor Necrosis Factor-alpha, Turpentine, Interleukin-6, Gene Expression Regulation, Enzymologic, Cytokines, Rats, Sprague-Dawley, Rats, Cyclooxygenase 1, Cyclooxygenase 2

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Effect of acute systemic inflammatory response and cytokines on the transcription of the genes encoding cyclooxygenase enzymes (COX-1 and COX-2) in the rat brain.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks