Endothelial-Specific Knockdown of Interleukin-1 (IL-1) Type 1 Receptor Differentially Alters CNS Responses to IL-1 Depending on Its Route of Administration

Interleukin-1 stimulates the secretion of hypothalamic corticotropin-releasing factor

Sapolsky, R., Rivier, C., Yamamoto, G., Plotsky, P., & Vale, W. (1987) · Science · doi:10.1126/science.2821621 · Cited by 1,504 · see citing works

Interleukin-1β-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity

Samad, T. A., Moore, K. A., Sapirstein, A., Billet, S. E., Allchorne, A. J., Poole, S., Bonventre, J. V., & Woolf, C. J. (2001) · Nature · doi:10.1038/35068566 · Cited by 1,282 · see citing works

Corticotropin-releasing factor-producing neurons in the rat activated by interleukin-1

Berkenbosch, F., van Oers, J., del Rey, A., Tilders, F., & Besedovsky, H. (1987) · Science · doi:10.1126/science.2443979 · Cited by 1,151 · see citing works

Interleukin-1 Mediates Pathological Effects of Microglia on Tau Phosphorylation and on Synaptophysin Synthesis in Cortical Neurons through a p38-MAPK Pathway

Li, Y., Liu, L., Barger, S. W., & Griffin, W. S. T. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-05-01605.2003 · Cited by 563 · see citing works

Type 1 interleukin‐1 receptor in the rat brain: Distribution, regulation, and relationship to sites of IL‐1–induced cellular activation

Ericsson, A., Liu, C., Hart, R. P., & Sawchenko, P. E. (1995) · Journal of Comparative Neurology · doi:10.1002/cne.903610410 · Cited by 471 · see citing works

Uniform vascular-endothelial-cell-specific gene expression in both embryonic and adult transgenic mice

Schlaeger, T. M., Bartunkova, S., Lawitts, J. A., Teichmann, G., Risau, W., Deutsch, U., & Sato, T. N. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.7.3058 · Cited by 469 · see citing works

The Role of the Vagus Nerve in Cytokine‐to‐Brain Communication

Maier, S. F., Goehler, L. E., Fleshner, M., & Watkins, L. R. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb09569.x · Cited by 439 · see citing works

Endothelial cells of the rat brain vasculature express cyclooxygenase-2 mRNA in response to systemic interleukin-1β: a possible site of prostaglandin synthesis responsible for fever

Cao, C., Matsumura, K., Yamagata, K., & Watanabe, Y. (1996) · Brain Research · doi:10.1016/0006-8993(96)00575-6 · Cited by 308 · see citing works

Intravenous lipopolysaccharide induces cyclooxygenase 2-like immunoreactivity in rat brain perivascular microglia and meningeal macrophages

Elmquist, J. K., Breder, C. D., Sherin, J. E., Scammell, T. E., Hickey, W. F., DeWitt, D. L., & Saper, C. B. (1997) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19970505)381:2 · Cited by 282 · see citing works

Effect of acute systemic inflammatory response and cytokines on the transcription of the genes encoding cyclooxygenase enzymes (COX-1 and COX-2) in the rat brain.

Lacroix, S., & Rivest, S. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.70020452.x · Cited by 280 · see citing works

Distinct roles for CD4 and CD8 as co-receptors in antigen receptor signalling

Julius, M., Maroun, C. R., & Haughn, L. (1993) · Immunology Today · doi:10.1016/0167-5699(93)90282-p · Cited by 275 · see citing works

Rat brain vascular distribution of interleukin‐1 type‐1 receptor immunoreactivity: Relationship to patterns of inducible cyclooxygenase expression by peripheral inflammatory stimuli

Konsman, J. P., Vigues, S., Mackerlova, L., Bristow, A., & Blomqvist, A. G. (2004) · The Journal of Comparative Neurology · doi:10.1002/cne.20052 · Cited by 259 · see citing works

Interleukin 1 receptors in the brain and endocrine tissues

Cunningham, E. T., & Souza, E. B. D. (1993) · Immunology Today · doi:10.1016/0167-5699(93)90281-o · Cited by 230 · see citing works

Expression of inducible cyclooxygenase mRNA in the mouse brain after systemic administration of bacterial lipopolysaccharide

Breder, C. D., & Saper, C. B. (1996) · Brain Research · doi:10.1016/0006-8993(95)01474-8 · Cited by 198 · see citing works

Distinct Brain Vascular Cell Types Manifest Inducible Cyclooxygenase Expression as a Function of the Strength and Nature of Immune Insults

Schiltz, J. C., & Sawchenko, P. E. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-13-05606.2002 · Cited by 195 · see citing works

Fever induction pathways: evidence from responses to systemic or local cytokine formation

Roth, J., & de Souza, G. E. P. (2001) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2001000300003 · Cited by 194 · see citing works

IL‐6 and IL‐1β in Fever: Studies Using Cytokine‐Deficient (Knockout) Mice ^a

KOZAK, W., KLUGER, M. J., SOSZYNSKI, D., CONN, C. A., RUDOLPH, K., LEON, L. R., & ZHENG, H. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb08310.x · Cited by 189 · see citing works

Circulating interleukin-6 induces fever through a STAT3-linked activation of COX-2 in the brain

Rummel, C. D., Sachot, C., Poole, S., & Luheshi, G. N. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00301.2006 · Cited by 179 · see citing works

Cyclooxygenase 2 mRNA expression in rat brain after peripheral injection of lipopolysaccharide

Quan, N., Whiteside, M. B., & Herkenham, M. A. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00402-8 · Cited by 172 · see citing works

The contribution of the vagus nerve in interleukin-1β-induced fever is dependent on dose

Hansen, M. K., O'Connor, K. A., Goehler, L. E., Watkins, L. R., & Maier, S. F. (2001) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.280.4.r929 · Cited by 169 · see citing works

Expression of the Alzheimer amyloid-promoting factor antichymotrypsin is induced in human astrocytes by IL-1

Das, S., & Potter, H. (1995) · Neuron · doi:10.1016/0896-6273(95)90300-3 · Cited by 166 · see citing works

Systemic interleukin-1 induces early and late patterns of c-fos mRNA expression in brain

Brady, L. S., Lynn, A. B., Herkenham, M. A., & Gottesfeld, Z. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-08-04951.1994 · Cited by 165 · see citing works

Inactivation of the Cerebral NFκB Pathway Inhibits Interleukin-1β-Induced Sickness Behavior and c-Fos Expression in Various Brain Nuclei

Nadjar, A., Bluthé, R.-M., May, M. J., Dantzer, R., & Parnet, P. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300755 · Cited by 120 · see citing works

Interleukin-1β Enhances Survival and Interleukin-6 Protects against MPP+ Neurotoxicity in Cultures of Fetal Rat Dopaminergic Neurons

Akaneya, Y., Takahashi, M., & Hatanaka, H. (1995) · Experimental Neurology · doi:10.1006/exnr.1995.1082 · Cited by 110 · see citing works

Vagotomy attenuates the behavioural but not the pyrogenic effects of interleukin-1 in rats

Luheshi, G. N., Bluthé, R.-M., Rushforth, D. A., MULCAHY, N., Konsman, J. P., Goldbach, M., & Dantzer, R. (2000) · Autonomic Neuroscience · doi:10.1016/s1566-0702(00)00231-9 · Cited by 106 · see citing works

Cyclooxygenase-2 mediates the febrile response of mice to interleukin-1β

Li, S., Ballou, L. R., Morham, S. G., & Blatteis, C. M. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02707-x · Cited by 105 · see citing works

Connecting cytokines and brain: a review of current issues.

Quan, N., & Herkenham, M. A. (2002) · PubMed · doi:10.14670/hh-17.273 · Cited by 101 · see citing works

Intracerebroventricular but not intravenous interleukin-1β induces widespread vascular-mediated leukocyte infiltration and immune signal mRNA expression followed by brain-wide glial activation

Proescholdt, M. G., Chakravarty, S., Foster, J. A., Foti, S., Briley, E. M., & Herkenham, M. A. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00048-9 · Cited by 95 · see citing works

A Functional Analysis of EP4 Receptor‐Expressing Neurons in Mediating the Action of Prostaglandin E2 Within Specific Nuclei of the Brain in Response to Circulating Interleukin‐1β

Zhang, J., & Rivest, S. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0742134.x · Cited by 73 · see citing works

Interleukin-1β exerts a myriad of effects in the brain and in particular in the hippocampus: Analysis of some of these actions

Lynch, M. A. (2002) · Vitamins and hormones · doi:10.1016/s0083-6729(02)64006-3 · Cited by 71 · see citing works

IL-1 type I receptor plays a key role in mediating the recruitment of leukocytes into the central nervous system

Ching, S., He, L., Lai, W., & Quan, N. (2004) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2004.06.001 · Cited by 70 · see citing works

Endothelial activation is an intermediate step for peripheral lipopolysaccharide induced activation of paraventricular nucleus

Quan, N., He, L., & Lai, W. (2003) · Brain Research Bulletin · doi:10.1016/s0361-9230(02)00951-6 · Cited by 70 · see citing works

Effects of the Inhibition of Cyclo‐Oxygenase 1 or 2 or 5‐Lipoxygenase on the Activation of the Hypothalamic‐Pituitary‐Adrenal Axis Induced by Interleukin‐1β in the Male Rat

Parsadaniantz, S. M., Lebeau, A., Duval, P., Grimaldi, B., Terlain, B., & Kerdelhué, B. (2000) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2000.00517.x · Cited by 57 · see citing works

Localized vs. systemic inflammation in guinea pigs: a role for prostaglandins at distinct points of the fever induction pathways?

Rummel, C. D., Barth, S. W., Voß, T., Korte, S., Gerstberger, R., Hübschle, T., & Roth, J. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00104.2005 · Cited by 37 · see citing works

Inducible and selective transgene expression in murine vascular endothelium.

Teng, P. I., Dichiara, M., Kömüves, L., Abe, K., Quertermous, T., & Topper, J. (2002) · Physiological Genomics · doi:10.1152/physiolgenomics.00059.2002 · Cited by 33 · see citing works

Tumor Necrosis Factor-α, Interleukin-1β, and Interleukin-6 Levels in Febrile, Young Children With and Without Occult Bacteremia

Strait, R. T., Kelly, K. J., & Kurup, V. P. (1999) · PEDIATRICS · doi:10.1542/peds.104.6.1321 · Cited by 22 · see citing works

Elevation of serum IL-6 levels in patients with acute bacterial infection.

Chen, Y. M., Whang‐Peng, J., Chern, C.-L., Kuo, B. I., Wang, S. Y., & Perng, R.-P. (1995) · PubMed · Cited by 3 · see citing works

Neuroinflammation: The Devil Is in the Details

DiSabato, D. J., Quan, N., & Godbout, J. P. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13607 · Cited by 1,640 · see citing works

The blood–brain barrier in systemic infection and inflammation

Galea, I. (2021) · Cellular and Molecular Immunology · doi:10.1038/s41423-021-00757-x · Cited by 764 · see citing works

Minocycline attenuates lipopolysaccharide (LPS)-induced neuroinflammation, sickness behavior, and anhedonia

Henry, C. J., Huang, Y., Wynne, A., Hanke, M., Himler, J., Bailey, M. T., Sheridan, J. F., & Godbout, J. P. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-15 · Cited by 678 · see citing works

Sequential activation of microglia and astrocyte cytokine expression precedes increased iba‐1 or GFAP immunoreactivity following systemic immune challenge

Norden, D. M., Trojanowski, P. J., Villanueva, E., Navarro, E., & Godbout, J. P. (2015) · Glia · doi:10.1002/glia.22930 · Cited by 596 · see citing works

Neurogenic neuroinflammation: inflammatory CNS reactions in response to neuronal activity

Xanthos, D. N., & Sandkühler, J. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3617 · Cited by 580 · see citing works

Stress-Induced Recruitment of Bone Marrow-Derived Monocytes to the Brain Promotes Anxiety-Like Behavior

Wohleb, E. S., Powell, N. D., Godbout, J. P., & Sheridan, J. F. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.1671-13.2013 · Cited by 563 · see citing works

Neuromodulation by the immune system: a focus on cytokines

Salvador, A. F., de Lima, K. A., & Kipnis, J. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-021-00508-z · Cited by 389 · see citing works

Neuroimmune Axes of the Blood–Brain Barriers and Blood–Brain Interfaces: Bases for Physiological Regulation, Disease States, and Pharmacological Interventions

Erickson, M. A., & Banks, W. A. (2018) · Pharmacological Reviews · doi:10.1124/pr.117.014647 · Cited by 394 · see citing works

Aging, microglial cell priming, and the discordant central inflammatory response to signals from the peripheral immune system

Dilger, R. N., & Johnson, R. W. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.0208108 · Cited by 391 · see citing works

Autonomic Nervous System and Immune System Interactions

Kenney, M., & Ganta, C. K. (2014) · Comprehensive physiology · doi:10.1002/cphy.c130051 · Cited by 383 · see citing works

The anatomy and immunology of vasculature in the central nervous system

Mastorakos, P., & McGavern, D. (2019) · Science Immunology · doi:10.1126/sciimmunol.aav0492 · Cited by 333 · see citing works

The regulation of muscle mass by endogenous glucocorticoids

Braun, T. P., & Marks, D. L. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00012 · Cited by 273 · see citing works

Dual Roles for Perivascular Macrophages in Immune-to-Brain Signaling

Serrats, J., Schiltz, J. C., García-Bueno, B., van Rooijen, N., Reyes, T. M., & Sawchenko, P. E. (2010) · Neuron · doi:10.1016/j.neuron.2009.11.032 · Cited by 253 · see citing works

Cell-Type-Specific Interleukin 1 Receptor 1 Signaling in the Brain Regulates Distinct Neuroimmune Activities

Liu, X., Nemeth, D. P., McKim, D. B., Zhu, L., DiSabato, D. J., Berdysz, O., Gorantla, G., Oliver, B., Witcher, K. G., Wang, Y., et al. (2019) · Immunity · doi:10.1016/j.immuni.2018.12.012 · Cited by 218 · see citing works

Central nervous system inflammation induces muscle atrophy via activation of the hypothalamic–pituitary–adrenal axis

Braun, T. P., Zhu, X., Szumowski, M., Scott, G. D., Grossberg, A. J., Levasseur, P. R., Graham, K., Khan, S., Damaraju, S., Colmers, W. F., et al. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20111020 · Cited by 213 · see citing works

Knockdown of Interleukin-1 Receptor Type-1 on Endothelial Cells Attenuated Stress-Induced Neuroinflammation and Prevented Anxiety-Like Behavior

Wohleb, E. S., Patterson, J. M., Sharma, V., Quan, N., Godbout, J. P., & Sheridan, J. F. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.3723-13.2014 · Cited by 209 · see citing works

Vertebrate sickness behaviors: Adaptive and integrated neuroendocrine immune responses

Adelman, J. S., & Martin, L. B. (2009) · Integrative and Comparative Biology · doi:10.1093/icb/icp028 · Cited by 205 · see citing works

Neural Mechanisms of Inflammation-Induced Fever

Blomqvist, A. G., & Engblom, D. (2018) · The Neuroscientist · doi:10.1177/1073858418760481 · Cited by 197 · see citing works

Neuroinflammation and Infection: Molecular Mechanisms Associated with Dysfunction of Neurovascular Unit

Tohidpour, A., Morgun, A. V., Boitsova, E. B., Malinovskaya, N. A., Martynova, G. P., Хилажева, Е. Д., Kopylevich, N. V., Gertsog, G. E., & Salmina, A. B. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00276 · Cited by 179 · see citing works

Mechanisms of Fever Production and Lysis: Lessons from Experimental LPS Fever

Roth, J., & Blatteis, C. M. (2014) · Comprehensive physiology · doi:10.1002/cphy.c130033 · Cited by 196 · see citing works

A critical review of human endotoxin administration as an experimental paradigm of depression.

DellaGioia, N., & Hannestad, J. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.07.014 · Cited by 175 · see citing works

Platelet interleukin-1α drives cerebrovascular inflammation

Thornton, P., McColl, B. W., Greenhalgh, A. D., Dénes, Á., Allan, S. M., & Rothwell, N. J. (2010) · Blood · doi:10.1182/blood-2009-11-252643 · Cited by 163 · see citing works

Hypothalamic mechanisms in cachexia

Grossberg, A. J., Scarlett, J. M., & Marks, D. L. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.03.011 · Cited by 160 · see citing works

The central role of hypothalamic inflammation in the acute illness response and cachexia

Burfeind, K. G., Michaelis, K. A., & Marks, D. L. (2016) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2015.10.038 · Cited by 156 · see citing works

Fingolimod may support neuroprotection via blockade of astrocyte nitric oxide

Colombo, E., Dario, M. D., Capitolo, E., Chaabane, L., Newcombe, J., Martino, G., & Farina, C. (2014) · Annals of Neurology · doi:10.1002/ana.24217 · Cited by 150 · see citing works

Inflammasome activation in multiple sclerosis and experimental autoimmune encephalomyelitis ( EAE )

Barclay, W., & Shinohara, M. L. (2016) · Brain Pathology · doi:10.1111/bpa.12477 · Cited by 150 · see citing works

Immunological Control of Viral Infections in Bats and the Emergence of Viruses Highly Pathogenic to Humans

Schountz, T., Baker, M. L., Butler, J. E., & Munster, V. J. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01098 · Cited by 147 · see citing works

Interleukin‐1β: a bridge between inflammation and excitotoxicity?

Fogal, B., & Hewett, S. J. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05315.x · Cited by 145 · see citing works

Immune-Induced Fever Is Mediated by IL-6 Receptors on Brain Endothelial Cells Coupled to STAT3-Dependent Induction of Brain Endothelial Prostaglandin Synthesis

Eskilsson, A., Mirrasekhian, E., Dufour, S., Schwaninger, M., Engblom, D., & Blomqvist, A. G. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.3520-14.2014 · Cited by 142 · see citing works

Oxidative and Nitrosative Stress and Immune-inflammatory Pathways in Patients with Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS)

Morris, G., & Maes, M. H. J. (2014) · Current Neuropharmacology · doi:10.2174/1570159x11666131120224653 · Cited by 139 · see citing works

Blood-Brain Barrier Disruption Induced by Chronic Sleep Loss: Low-Grade Inflammation May Be the Link

Hurtado‐Alvarado, G., Domı́nguez-Salazar, E., Pavón, L., Velázquez‐Moctezuma, J., & Gómez‐González, B. (2016) · Journal of Immunology Research · doi:10.1155/2016/4576012 · Cited by 142 · see citing works

Prostaglandins and sickness behavior: Old story, new insights

Pecchi, E., Dallaporta, M., Jean, A., Thirion, S., & Troadec, J.-D. (2009) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.02.040 · Cited by 135 · see citing works

TAK1 in brain endothelial cells mediates fever and lethargy

Ridder, D. A., Lang, M., Salinin, S., Roederer, J.-P., Struss, M., Maser‐Gluth, C., & Schwaninger, M. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20110398 · Cited by 133 · see citing works

Liver–brain interactions in inflammatory liver diseases: Implications for fatigue and mood disorders

D’Mello, C., & Swain, M. G. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.10.009 · Cited by 129 · see citing works

Stress responses: the contribution of prostaglandin E2 and its receptors

Furuyashiki, T., & Narumiya, S. (2010) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2010.194 · Cited by 128 · see citing works

Anti-Inflammatory Effects of Angiotensin Receptor Blockers in the Brain and the Periphery

Benický, J., Sánchez-Lemus, E., Pavel, J., & Saavedra, J. M. (2009) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-009-9368-4 · Cited by 126 · see citing works

Neuroinflammation as an etiological trigger for depression comorbid with inflammatory bowel disease

Craig, C. F., Filippone, R. T., Stavely, R., Bornstein, J. C., Apostolopoulos, V., & Nurgali, K. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02354-1 · Cited by 124 · see citing works

Lipopolysaccharide-Induced Fever Depends on Prostaglandin E2 Production Specifically in Brain Endothelial Cells

Engström, L., Ruud, J., Eskilsson, A., Larsson, A. O., Mackerlova, L., Kugelberg, U. Ö., Qian, H., Vasilache, A. M., Larsson, P., Engblom, D., et al. (2012) · Endocrinology · doi:10.1210/en.2012-1375 · Cited by 118 · see citing works

Immunology of Bats and Their Viruses: Challenges and Opportunities

Schountz, T. (2014) · Viruses · doi:10.3390/v6124880 · Cited by 117 · see citing works

Acrylamide-induced neurotoxicity in primary astrocytes and microglia: Roles of the Nrf2-ARE and NF-κB pathways

Zhao, M., Wang, F. S. L., Hu, X., Chen, F., & Chan, H. M. (2017) · Food and Chemical Toxicology · doi:10.1016/j.fct.2017.05.007 · Cited by 111 · see citing works

Interleukin-1 and Stroke: Biomarker, Harbinger of Damage, and Therapeutic Target

Dénes, Á., Pinteaux, E., Rothwell, N. J., & Allan, S. M. (2011) · Cerebrovascular Diseases · doi:10.1159/000332205 · Cited by 109 · see citing works

Deletion of Prostaglandin E2Synthesizing Enzymes in Brain Endothelial Cells Attenuates Inflammatory Fever

Wilhelms, D., Kirilov, M., Mirrasekhian, E., Eskilsson, A., Kugelberg, U. Ö., Klar, C., Ridder, D. A., Herschman, H. R., Schwaninger, M., Blomqvist, A. G., et al. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.1838-14.2014 · Cited by 106 · see citing works

Immune-To-Brain Signaling: How Important are the Blood–Brain Barrier-independent Pathways?

Quan, N. (2008) · Molecular Neurobiology · doi:10.1007/s12035-008-8026-z · Cited by 94 · see citing works

Central nervous system inflammation in disease related conditions: Mechanistic prospects

Fung, A., Vizcaychipi, M. P., Lloyd, D. G., Wan, Y., & Ma, D. (2012) · Brain Research · doi:10.1016/j.brainres.2012.01.061 · Cited by 93 · see citing works

Interleukin-1 promotes autoimmune neuroinflammation by suppressing endothelial heme oxygenase-1 at the blood–brain barrier

Hauptmann, J., Johann, L., Marini, F., Kitic, M., Colombo, E., Mufazalov, I. A., Krueger, M. W., Karram, K., Moos, S., Wanke, F., et al. (2020) · Acta Neuropathologica · doi:10.1007/s00401-020-02187-x · Cited by 80 · see citing works

Interleukin-1 mediates ischaemic brain injury via distinct actions on endothelial cells and cholinergic neurons

Wong, R., Lénárt, N., Hill, L., Toms, L., Coutts, G., Martinecz, B., Császár, E., Nyíri, G., Papaemmanouil, A., Waisman, A., et al. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.11.012 · Cited by 78 · see citing works

Focus on the Role of the NLRP3 Inflammasome in Multiple Sclerosis: Pathogenesis, Diagnosis, and Therapeutics

Cui, Y., Yu, H., Bu, Z., Wen, L., Yan, L.-L., & Feng, J. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.894298 · Cited by 79 · see citing works

Prostaglandin-dependent modulation of dopaminergic neurotransmission elicits inflammation-induced aversion in mice

Fritz, M., Klawonn, A. M., Nilsson, A., Singh, A. K., Zajdel, J., Wilhelms, D., Lazarus, M., Löfberg, A., Jaarola, M., Kugelberg, U. Ö., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci83844 · Cited by 72 · see citing works

Electroacupuncture pretreatment with different waveforms prevents brain injury in rats subjected to cecal ligation and puncture via inhibiting microglial activation, and attenuating inflammation, oxidative stress and apoptosis

Chen, Y., Yu, L., Mo, L., Li, J., Wang, M.-H., Wei, J., & Zhou, J. F. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.10.009 · Cited by 72 · see citing works

Inflammasome Signaling, Thromboinflammation, and Venous Thromboembolism

Potere, N., Abbate, A., Kanthi, Y. M., Carrier, M., Toldo, S. A., Porreca, E., & Nisio, M. D. (2023) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2023.03.017 · Cited by 70 · see citing works

Inflammatory transcription factors as activation markers and functional readouts in immune-to-brain communication

Rummel, C. D. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.09.003 · Cited by 70 · see citing works

Neurobiology of inflammation-associated anorexia

Gautron, L. (2009) · Frontiers in Neuroscience · doi:10.3389/neuro.23.003.2009 · Cited by 72 · see citing works

First inducible transgene expression in porcine large animal models

Klymiuk, N., Böcker, W., Schönitzer, V., Bähr, A., Radic, T., Fröhlich, T., Wünsch, A., Keßler, B., Kurome, M., Schilling, E., et al. (2011) · The FASEB Journal · doi:10.1096/fj.11-185041 · Cited by 68 · see citing works

Interleukin 1 Type 1 Receptor Restore: A Genetic Mouse Model for Studying Interleukin 1 Receptor-Mediated Effects in Specific Cell Types

Liu, X., Yamashita, T., Chen, Q., Belevych, N., McKim, D. B., Tarr, A. J., Coppola, V., Nath, N., Nemeth, D. P., Syed, Z. W., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.3199-14.2015 · Cited by 68 · see citing works

Etazolate abrogates the lipopolysaccharide (LPS)-induced downregulation of the cAMP/pCREB/BDNF signaling, neuroinflammatory response and depressive-like behavior in mice

Guo, J., Lin, P., Zhao, X., Zhang, J., Wei, X., Wang, Q., & Wang, C. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.01.008 · Cited by 67 · see citing works

In-depth conversation: Spectrum and kinetics of neuroimmune afferent pathways

Quan, N. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.02.006 · Cited by 66 · see citing works

Neural control of the spleen as an effector of immune responses to inflammation: mechanisms and treatments

Mota, C. M. D., & Madden, C. J. (2022) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00151.2022 · Cited by 65 · see citing works

Venlafaxine inhibits the upregulation of plasma tumor necrosis factor-alpha (TNF-α) in the Chinese patients with major depressive disorder: A prospective longitudinal study

Li, Z., Qi, D., Chen, J., Zhang, C., Yi, Z., Yuan, C., Wang, Z., Hong, W., Yu, S., Cui, D., et al. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.05.005 · Cited by 63 · see citing works

IL-1R1 Signaling Regulates CXCL12-Mediated T Cell Localization and Fate within the Central Nervous System during West Nile Virus Encephalitis

Durrant, D. M., Daniels, B. P., & Klein, R. S. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1401192 · Cited by 63 · see citing works

The Cytokine Basis of Cachexia and its Treatment: Are They Ready for Prime Time?

Yeh, S., Blackwood, K., & Schuster, M. W. (2008) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2008.01.003 · Cited by 63 · see citing works

Inflammatory Regulation of CNS Barriers After Traumatic Brain Injury: A Tale Directed by Interleukin-1

Garnett, C. N., Watson, J. B., Higgins, E. K., Quan, N., & Bachstetter, A. D. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.688254 · Cited by 60 · see citing works

Amplification and propagation of interleukin-1β signaling by murine brain endothelial and glial cells

Krasnow, S. M., Knoll, J. G., Verghese, S. C., Levasseur, P. R., & Marks, D. L. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0908-4 · Cited by 60 · see citing works

Immunoregulatory effect of mast cells influenced by microbes in neurodegenerative diseases

Girolamo, F., Coppola, C., & Ribatti, D. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.06.017 · Cited by 60 · see citing works

Immune and behavioral consequences of microglial reactivity in the aged brain

Wynne, A. M., Henry, C. J., & Godbout, J. P. (2009) · Integrative and Comparative Biology · doi:10.1093/icb/icp009 · Cited by 58 · see citing works

Autonomic Nervous System and Immune System Interactions

Kenney, M., & Ganta, C. K. (2014) · Comprehensive physiology · doi:10.1002/j.2040-4603.2014.tb00574.x · Cited by 56 · see citing works

Inducible Prostaglandin E2Synthesis Interacts in a Temporally Supplementary Sequence with Constitutive Prostaglandin-Synthesizing Enzymes in Creating the Hypothalamic–Pituitary–Adrenal Axis Response to Immune Challenge

Elander, L., Engström, L., Ruud, J., Mackerlova, L., Jakobsson, P., Engblom, D., Nilsberth, C., & Blomqvist, A. G. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5247-08.2009 · Cited by 53 · see citing works

The transcription factor nuclear factor interleukin 6 mediates pro- and anti-inflammatory responses during LPS-induced systemic inflammation in mice

Schneiders, J., Fuchs, F., Damm, J., Herden, C., Gerstberger, R., Soares, D. D. M., Roth, J., & Rummel, C. D. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.03.008 · Cited by 53 · see citing works

Endothelial IL-1R1 is a critical mediator of EAE pathogenesis

Li, Q., Powell, N. D., Zhang, H., Belevych, N., Ching, S., Chen, Q., Sheridan, J. F., Whitacre, C. C., & Quan, N. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.09.009 · Cited by 49 · see citing works

Immune challenge by intraperitoneal administration of lipopolysaccharide directs gene expression in distinct blood–brain barrier cells toward enhanced prostaglandin E2 signaling

Vasilache, A. M., Qian, H., & Blomqvist, A. G. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.02.003 · Cited by 49 · see citing works

Generation and Characterization of Mice Expressing a Conditional Allele of the Interleukin-1 Receptor Type 1

Robson, M. J., Zhu, C.-B., Quinlan, M. A., Botschner, D. A., Baganz, N. L., Lindler, K. M., Thome, J. G., Hewlett, W. A., & Blakely, R. (2016) · PLoS ONE · doi:10.1371/journal.pone.0150068 · Cited by 47 · see citing works

Interleukin-1β induced activation of the hypothalamus–pituitary–adrenal axis is dependent on interleukin-1 receptors on non-hematopoietic cells

Matsuwaki, T., Eskilsson, A., Kugelberg, U. Ö., Jönsson, J., & Blomqvist, A. G. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.03.015 · Cited by 45 · see citing works

Feeding the beast: Can microglia in the senescent brain be regulated by diet?

Johnson, R. W. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.09.022 · Cited by 44 · see citing works

Chronic systemic IL-1β exacerbates central neuroinflammation independently of the blood–brain barrier integrity

Murta, V., Farías, M. I., Pitossi, F. J., & Ferrari, C. C. (2014) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2014.11.023 · Cited by 44 · see citing works

TLR4 Signaling Selectively and Directly Promotes CGRP Release from Vagal Afferents in the Mouse

Jia, L., Lee, S., Tierney, J. A., Elmquist, J. K., Burton, M. D., & Gautron, L. (2020) · eNeuro · doi:10.1523/eneuro.0254-20.2020 · Cited by 44 · see citing works

Farnesol attenuates lipopolysaccharide-induced neurodegeneration in Swiss albino mice by regulating intrinsic apoptotic cascade

Rajasekaran, S., & Sudhandiran, G. (2015) · Brain Research · doi:10.1016/j.brainres.2015.04.043 · Cited by 43 · see citing works

Research Progress on Main Symptoms of Novel Coronavirus Pneumonia Improved by Traditional Chinese Medicine

Luo, C., Ma, L., Liu, H., Liao, W., Xu, R., Ci, Z., Lin, J., Han, L., & Zhang, D. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.556885 · Cited by 43 · see citing works

Sleep Disruption and Cancer: Chicken or the Egg?

Berisha, A., Shutkind, K., & Borniger, J. C. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.856235 · Cited by 42 · see citing works

Regulation of cytokine signaling and T-cell recruitment in the aging mouse brain in response to central inflammatory challenge

Xu, Y., Nygård, M., Kristensson, K., & Bentivoglio, M. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.09.006 · Cited by 41 · see citing works

The crosstalk between brain and periphery: Implications for brain health and disease

Gonçalves, R. A., & Felice, F. G. D. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108728 · Cited by 41 · see citing works

Selective contributions of neuronal and astroglial interleukin-1 receptor 1 to the regulation of sleep

Ingiosi, A. M., Raymond, R. M., Pavlova, M. N., & Opp, M. R. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.03.014 · Cited by 39 · see citing works

Reduced ENA78 levels as novel biomarker for major depressive disorder and venlafaxine efficiency: Result from a prospective longitudinal study

Li, Z., Wang, Z., Zhang, C., Chen, J., Su, Y., Huang, J., Yi, Z., Yuan, C., Hong, W., Wang, Y., et al. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.03.015 · Cited by 38 · see citing works

Broad and Temperature Independent Replication Potential of Filoviruses on Cells Derived From Old and New World Bat Species

Miller, M. R., McMinn, R. J., Misra, V., Schountz, T., Müller, M. A., Kurth, A. A., & Munster, V. J. (2016) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiw199 · Cited by 38 · see citing works

Neuroprotective and Antiinflammatory Properties of a Novel Demethylated Curcuminoid

Khanna, S., Park, H., Sen, C. K., Golakoti, T., Sengupta, K., Venkateswarlu, S., & Roy, S. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2230 · Cited by 37 · see citing works

Sex difference in the interrelationship between TNF-α and oxidative stress status in first-episode drug-naïve schizophrenia

Zhu, M., Liu, Z., Guo, Y., Sultana, S., Wu, K., Lang, X., Lv, Q., Huang, X., Yi, Z., & Li, Z. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02261-5 · Cited by 36 · see citing works

Targeting IL-1α in cancer cachexia: a narrative review

McDonald, J. J., McMillan, D. C., & Laird, B. J. A. (2018) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0000000000000398 · Cited by 35 · see citing works

Fever and Antipyretic Supported by Traditional Chinese Medicine: A Multi-Pathway Regulation

Ma, L.-L., Liu, H., Luo, C., He, Y., Wang, F., Huang, H., Han, L., Yang, M., Xu, R., & Zhang, D. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.583279 · Cited by 35 · see citing works

Future Biomarkers for Infection and Inflammation in Febrile Children

Zandstra, J., Jongerius, I., & Kuijpers, T. W. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.631308 · Cited by 32 · see citing works

Interleukin-1 exerts distinct actions on different cell types of the brain in vitro

Quan, N., An, ., & Chen, Q. (2011) · Journal of Inflammation Research · doi:10.2147/jir.s15357 · Cited by 32 · see citing works

IL-1R1 signaling in TBI: assessing chronic impacts and neuroinflammatory dynamics in a mouse model of mild closed-head injury

Vincent, J. C., Garnett, C. N., Watson, J. B., Higgins, E. K., Macheda, T., Sanders, L. G., Roberts, K. N., Shahidehpour, R. K., Blalock, E. M., Quan, N., et al. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02934-3 · Cited by 31 · see citing works

Can consuming flavonoids restore old microglia to their youthful state?

Jang, S., & Johnson, R. W. (2010) · Nutrition Reviews · doi:10.1111/j.1753-4887.2010.00336.x · Cited by 31 · see citing works

Involvement of interleukin-1 type 1 receptors in lipopolysaccharide-induced sickness responses

Matsuwaki, T., Shionoya, K., Ihnatko, R., Eskilsson, A., Kakuta, S., Dufour, S., Schwaninger, M., Waisman, A., Müller, W., Pinteaux, E., et al. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.06.013 · Cited by 30 · see citing works

Cytokines in the perinatal period – Part I

Chau, A. M. T., Markley, J. C., Juang, J., & Tsen, L. C. (2016) · International Journal of Obstetric Anesthesia · doi:10.1016/j.ijoa.2015.12.005 · Cited by 30 · see citing works

Inflammation- and tumor-induced anorexia and weight loss require MyD88 in hematopoietic/myeloid cells but not in brain endothelial or neural cells

Ruud, J., Wilhelms, D. B., Nilsson, A., Eskilsson, A., Tang, Y., Ströhle, P., Caesar, R., Schwaninger, M., Wunderlich, T., Bäckhed, F., et al. (2013) · The FASEB Journal · doi:10.1096/fj.12-225433 · Cited by 29 · see citing works

Suppression of Locomotor Activity in Female C57Bl/6J Mice Treated with Interleukin-1β: Investigating a Method for the Study of Fatigue in Laboratory Animals

Bonsall, D. R., Kim, H., Tocci, C., Ndiaye, A., Petronzio, A., McKay-Corkum, G. B., Molyneux, P. C., Scammell, T. E., & Harrington, M. E. (2015) · PLoS ONE · doi:10.1371/journal.pone.0140678 · Cited by 29 · see citing works

Cytokines in the perinatal period – Part II

Chau, A. M. T., Markley, J. C., Juang, J., & Tsen, L. C. (2016) · International Journal of Obstetric Anesthesia · doi:10.1016/j.ijoa.2015.12.006 · Cited by 28 · see citing works

Examining the relationship between astrocyte dysfunction and neurodegeneration in ALS using hiPSCs

Halpern, M., Brennand, K., & Gregory, J. A. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104562 · Cited by 28 · see citing works

Interferon-ɣ mediated signaling in the brain endothelium is critical for inflammation-induced aversion

Fritz, M., Klawonn, A. M., Jaarola, M., & Engblom, D. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.08.020 · Cited by 27 · see citing works

Age-associated suppression of exploratory activity during sickness is linked to meningeal lymphatic dysfunction and microglia activation

Goldman, D. H., Dykstra, T., Smirnov, I., Blackburn, S. M., Mesquita, S. D., Kipnis, J., & Herz, J. (2022) · Nature Aging · doi:10.1038/s43587-022-00268-y · Cited by 24 · see citing works

Serum levels of chemokines in adolescents with major depression treated with fluoxetine.

Peña, F. R. D. L., Cruz-Fuentes, C., Palacios, L., Girón-Pérez, M. I., Medina-Rivero, E., Ponce-Regalado, M. D., Alvarez-Herrera, S., Pérez-Sánchez, G., Becerril-Villanueva, E., Maldonado-García, J. L., et al. (2020) · World Journal of Psychiatry · doi:10.5498/wjp.v10.i8.175 · Cited by 24 · see citing works

Mechanisms of Fever Production and Lysis: Lessons from Experimental LPS Fever

Roth, J., & Blatteis, C. M. (2014) · Comprehensive physiology · doi:10.1002/j.2040-4603.2014.tb00582.x · Cited by 24 · see citing works

Cell-Type-Specific Interleukin 1 Receptor 1 Signaling in the Brain Regulates Distinct Neuroimmune Activities

Liu, X., Nemeth, D. P., McKim, D. B., Zhu, L., DiSabato, D. J., Berdysz, O., Gorantla, G., Oliver, B., Witcher, K. G., Wang, Y., et al. (2019) · Immunity · doi:10.1016/j.immuni.2018.12.012 · Cited by 218 · see citing works

73. Cell type-specific interleukin-1 receptor 1 mediates distinct downstream effects in the central nervous system following an intracerebralventricular injection of interleukin-1 beta

Liu, X., Chen, Q., Coppola, V., Quan, N., & Zuo, J. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.06.093

Interleukin 1 Type 1 Receptor Restore: A Genetic Mouse Model for Studying Interleukin 1 Receptor-Mediated Effects in Specific Cell Types

Liu, X., Yamashita, T., Chen, Q., Belevych, N., McKim, D. B., Tarr, A. J., Coppola, V., Nath, N., Nemeth, D. P., Syed, Z. W., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.3199-14.2015 · Cited by 68 · see citing works

Interleukin-1 exerts distinct actions on different cell types of the brain in vitro

Quan, N., An, ., & Chen, Q. (2011) · Journal of Inflammation Research · doi:10.2147/jir.s15357 · Cited by 32 · see citing works

Brain endothelial IL-1R1 mediates central IL-1 induced neuroinflammation and anxiety-like behavior

Liu, X., Belevych, N., Quan, N., Chen, Q., Zuo, J., Nemeth, D. P., Tarr, A. J., & Ismail, A. S. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.06.071