Cited by 126Tryptophan and brain disordersNeuroinflammation and Neurodegeneration MechanismsStress Responses and Cortisol

The role of neuroinflammation on pathogenesis of affective disorders

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Rhie, Sung Ja, Jung, Eun-Yee, Shim, Insop·2020·Journal of Exercise Rehabilitation

Abstract

Accumulating evidence suggests that neuroinflammation plays an important role in etiology of psychiatric disorders. Neuronflammation involves a combination of psychological, neuroendocrine, and nervous systems resulting in changes of neurotransmitter metabolism, dysregulation of the hypothalamuspituitary-adrenal axis, pathologic microglial cell activation, impaired neuroplasticity, and structural and functional brain changes affecting cognition and emotional behavior. Inflammatory cytokines have been postulated to be the possible link and culprit in the disruption of these systems. The outcome of any type of dysregulation of the immune system in the brain might lead to occurrence of depression, anxiety. This review focuses on the possible impact of dysregulated cytokine networks which may cause pathogenesis of affective disorders such as depression and anxiety.

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Authors
Rhie, S. J., Jung, E.-Y., & Shim, I.
Affiliations
  • Halla University (KR)
  • Kyung Hee University (KR)
Corresponding author
Shim, Insop
Venue
Journal of Exercise Rehabilitation
Published
2020-02-26
Volume
16
Issue
1
Pages
2-9
ISSN
  • 2288-176X (ISSN-L)
  • 2288-1778
OpenAlex
W3008988734
Cited by
126
References
75
Citations by year
2026: 13 · 2025: 35 · 2024: 32 · 2023: 7 · 2022: 17 · 2021: 17 · 2020: 5
FWCI
0.74
Type
journal article
Language
en
Open access
Locations
  • Journal of Exercise Rehabilitation (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Funders
National Research Foundation of Korea (2016M3C7A1905384)
Topics
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
neuroinflammation, mood disorders, depression, anxiety, inflammatory cytokines, microglial activation, hypothalamic-pituitary-adrenal axis, neuroplasticity, neurotransmitter metabolism, immune dysregulation, pathogenesis

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