The role of neuroinflammation on pathogenesis of affective disorders
Open accessAbstract
Accumulating evidence suggests that neuroinflammation plays an important role in etiology of psychiatric disorders. Neuronflammation involves a combination of psychological, neuroendocrine, and nervous systems resulting in changes of neurotransmitter metabolism, dysregulation of the hypothalamuspituitary-adrenal axis, pathologic microglial cell activation, impaired neuroplasticity, and structural and functional brain changes affecting cognition and emotional behavior. Inflammatory cytokines have been postulated to be the possible link and culprit in the disruption of these systems. The outcome of any type of dysregulation of the immune system in the brain might lead to occurrence of depression, anxiety. This review focuses on the possible impact of dysregulated cytokine networks which may cause pathogenesis of affective disorders such as depression and anxiety.
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Pro-inflammatory factors released by peripheral immunocytes can drive neuroinflammation by activating astrocytes and microglia, thus modulating brain areas involved in mood regulation.
“Pro-inflammatory factors released by peripheral immunocytes (e.g., lymphocytes, monocytes, neutrophils) can drive neuroinflammation by activating astrocytes and microglia, thus modulating the brain areas participating in regulating mood.”
From Association between depression or anxiety symptoms and immune-inflammatory characteristics in in-patients with tuberculosis: A cross-sectional study (2022) · cites this paper as [43]
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- Authors
- Rhie, S. J., Jung, E.-Y., & Shim, I.
- Affiliations
- Halla University (KR)
- Kyung Hee University (KR)
- Corresponding author
- Shim, Insop
- ORCID
- Shim, Insop
- Venue
- Journal of Exercise Rehabilitation
- Published
- 2020-02-26
- Volume
- 16
- Issue
- 1
- Pages
- 2-9
- ISSN
- 2288-176X (ISSN-L)
- 2288-1778
- PMC
- PMC7056473
- OpenAlex
- W3008988734
- Cited by
- 126
- References
- 75
- Citations by year
- 2026: 13 · 2025: 35 · 2024: 32 · 2023: 7 · 2022: 17 · 2021: 17 · 2020: 5
- FWCI
- 0.74
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- Journal of Exercise Rehabilitation (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- National Research Foundation of Korea (2016M3C7A1905384)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- neuroinflammation, mood disorders, depression, anxiety, inflammatory cytokines, microglial activation, hypothalamic-pituitary-adrenal axis, neuroplasticity, neurotransmitter metabolism, immune dysregulation, pathogenesis
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