The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Enhancement of Hippocampal Neurogenesis by Lithium
Abstract
Abstract: Increasing evidence suggests that mood disorders are associated with a reduction in regional CNS volume and neuronal and glial cell atrophy or loss. Lithium, a mainstay in the treatment of mood disorders, has recently been demonstrated to robustly increase the levels of the cytoprotective B‐cell lymphoma protein‐2 (bcl‐2) in areas of rodent brain and in cultured cells. In view of bcl‐2's antiapoptotic and neurotrophic effects, the present study was undertaken to determine if lithium affects neurogenesis in the adult rodent hippocampus. Mice were chronically treated with lithium, and 5‐bromo‐2‐deoxyuridine (BrdU) labeling of dividing cells was conducted over 12 days. Immunohistochemical analysis was undertaken 1 day after the last injection, and three‐dimensional stereological cell counting revealed that lithium produced a significant 25% increase in the BrdU‐labeled cells in the dentate gyrus. Double‐labeling immunofluorescence studies were undertaken to co‐localize BrdU‐positive cells with neuron‐specific nuclear protein and showed that ∼65% of the cells were double‐labeled. These results add to the growing body of evidence suggesting that mood stabilizers and antidepressants exert neurotrophic effects and may therefore be of use in the long‐term treatment of other neuropsychiatric disorders.
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Citations
Cites
Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus
van Praag, H., Kempermann, G., & Gage, F. H. (1999) · Nature Neuroscience · doi:10.1038/6368 · Cited by 3,880
Subgenual prefrontal cortex abnormalities in mood disorders
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NeuN, a neuronal specific nuclear protein in vertebratesxs
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A molecular and cellular theory of depression
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Ca2+ Influx Regulates BDNF Transcription by a CREB Family Transcription Factor-Dependent Mechanism
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Glial reduction in the subgenual prefrontal cortex in mood disorders
Öngür, D., Drevets, W. C., & Price, J. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13290 · Cited by 1,525
Rajkowska, G., Miguel-Hidalgo, J. J., Wei, J., Dilley, G., Pittman, S. D., Meltzer, H. Y., Overholser, J. C., Roth, B. L., & Stockmeier, C. A. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00041-4 · Cited by 1,477
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“…have demonstrated an enlargement of the third and lateral ventricles as well as reduced gray matter volumes in parts of the orbital and medial prefrontal cortex, the ventral stiatum, and the mesiotemporal cortex (Sheline et al., 1996, 1999; Drevets et al., 1997, 1999; Soares and Mann, 1997).”
BackgroundLithium-induced increase in human brain grey matter
Moore, G. J., Bebchuk, J. M., Wilds, I. B., Chen, G., & Menji, H. K. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02793-8 · Cited by 649
Self-citationStress inhibits the proliferation of granule cell precursors in the developing dentate gyrus
Tanapat, P., Galea, L. A. M., & Gould, E. (1998) · International Journal of Developmental Neuroscience · doi:10.1016/s0736-5748(98)00029-x · Cited by 330 · cited 1×
“In adulthood, precursor cells in the hilus and subgranular zone of the dentate gyrus (DG) divide and produce daughter cells that are capable of ultimately differentiating into mature granule neurons (Tanapat et al., 1998).”
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Cited by
The cellular neurobiology of depression
Manji, H. K., Drevets, W. C., & Charney, D. S. (2001) · Nature Medicine · doi:10.1038/87865 · Cited by 1,182
Self-citationDepression: Perspectives from Affective Neuroscience
Davidson, R. J., Pizzagalli, D., Nitschke, J. B., & Putnam, K. (2002) · Annual Review of Psychology · doi:10.1146/annurev.psych.53.100901.135148 · Cited by 1,138
Jin, K., Minami, M., Lan, J. Q., Mao, X. O., Batteur, S., Simon, R. P., & Greenberg, D. A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.081011098 · Cited by 1,051
Adult neurogenesis: from precursors to network and physiology
Abrous, D. N., Koehl, M., & Le Moal, M. (2005) · Physiological Reviews · doi:10.1152/physrev.00055.2003 · Cited by 971
Postmortem studies in mood disorders indicate altered numbers of neurons and glial cells
Rajkowska, G. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00950-1 · Cited by 822
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Metadata
- Authors
- Chen, G., Rajkowska, G., Du, F., Seraji‐Bozorgzad, N., & Manji, H. K.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 2000-10
- Volume
- 75
- Issue
- 4
- Pages
- 1729-1734
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W2088601627
- Cited by
- 599
- References
- 10
- FWCI
- 6.66
- Type
- journal article
- Language
- en
- Open access
- closed
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