Cited by 1,138Neural and Behavioral Psychology StudiesAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesTreatment of Major Depression

Depression: Perspectives from Affective Neuroscience

Davidson, Richard J., Pizzagalli, Diego, Nitschke, Jack B., Putnam, Katherine·2002·Annual Review of Psychology

Abstract

Depression is a disorder of the representation and regulation of mood and emotion. The circuitry underlying the representation and regulation of normal emotion and mood is reviewed, including studies at the animal level, human lesion studies, and human brain imaging studies. This corpus of data is used to construct a model of the ways in which affect can become disordered in depression. Research on the prefrontal cortex, anterior cingulate, hippocampus, and amygdala is reviewed and abnormalities in the structure and function of these different regions in depression is considered. The review concludes with proposals for the specific types of processing abnormalities that result from dysfunctions in different parts of this circuitry and offers suggestions for the major themes upon which future research in this area should be focused.

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Crossref · 10.1146/annurev.psych.53.100901.135148

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178 of 178 references verified0 citation errors · 0 not checkable

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  • Heightened amygdala activity has been associated with deficient prefrontal cognitive control over limbic emotion processing, evidenced by diminished frontal regulatory activity and weaker amygdala-frontal connectivity during emotion processing in depression.

    “This increased amygdala activity has been linked to impaired cognitive control exerted by specific regions of the prefrontal cortex (Davidson, Pizzagalli, Nitschke, Putnam, 2002;Holmes & Pizzagalli, 2008) onto limbic emotion processing”
  • Depression involves reduced activation in cortical areas that support attentional control, and this reduction may relate to impaired emotion regulation.

    “Depression is associated with hypoactivation in cortical structures involved in attentional control which can be related to impaired emotion regulation.”
  • When connectivity is normal, the DLPFC can engage emotion regulation and inhibit the amygdala through links with other frontal areas, including the orbitofrontal cortex.

    “In the case of normal connectivity, the DLPFC can initiate emotion regulation, inhibiting the amygdala (Davidson et al., 2002) via connections with other frontal regions such as the orbitofrontal (OFC) cortex (Taylor & Fragopaganos, 2005).”
  • Changes in affective state and cognitive effects associated with depression alter mechanisms involved in speech production.

    “It was proven that changes in affective state and cognitive effects associated with depression have altered the mechanisms involved in speech production [57,58].”

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Authors
Davidson, R. J., Pizzagalli, D., Nitschke, J. B., & Putnam, K.
Affiliations
University of Wisconsin–Madison (US)
Venue
Annual Review of Psychology
Published
2002-02
Volume
53
Issue
1
Pages
545-574
ISSN
  • 0066-4308 (ISSN-L)
  • 1545-2085
OpenAlex
W2143380734
Cited by
1,138
References
178
Citations by year
2026: 16 · 2025: 19 · 2024: 25 · 2023: 27 · 2022: 29 · 2021: 32 · 2020: 40 · 2019: 50 · 2018: 46 · 2017: 49 · 2016: 64 · 2015: 54 · 2014: 62 · 2013: 77 · 2012: 59
FWCI
4.22
Type
journal article
Language
en
Open access
closed
Locations
  • Annual Review of Psychology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Alliance for Research on Schizophrenia and Depression
  • National Research Foundation
  • National Institutes of Health (5r01mh040747-14, 5k05mh000875-10)
  • National Institute of Mental Health (P50 MH61083, P50MH061083, T32MH18931, P50-MH 52354, P50MH052354, MH40747, MH 43454, K05-MH 00875, T32MH018931)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords
depression, emotion regulation, mood regulation, affective neuroscience, prefrontal cortex, anterior cingulate cortex, hippocampus, amygdala, brain lesions, neuroimaging
MeSH terms
Affect, Amygdala, Brain, Depressive Disorder, Gyrus Cinguli, Hippocampus, Humans, Neurosciences, Prefrontal Cortex, Mood Disorders

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