The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Identification of a novel member of the T1R family of putative taste receptors
Abstract
In the gustatory system, the recognition of sugars, amino acids and bitter‐tasting compounds is the function of specialized G protein‐coupled receptors. Recently, two members of novel subfamily of G protein‐coupled receptors were proposed to function as taste receptors based on their specific expression in taste receptor cells. Here, we report the identification of a third member, T1R3, of this family of receptors. T1R3 maps near the telomere of mouse chromosome 4 rendering it a candidate for the Sac locus, a primary determinant of sweet preference in mice. Consistent with its candidacy for the Sac locus, T1R3 displays taste receptor cell‐specific expression. In addition, taster and non‐taster strains of mouse harbor different alleles of T1R3.
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Citations
Cites
A Multigene Family Encoding a Diverse Array of Putative Pheromone Receptors in Mammals
Matsunami, H., & Buck, L. B. (1997) · Cell · doi:10.1016/s0092-8674(00)80537-1 · Cited by 706
Cited by
Mammalian sweet taste receptors
Nelson, G., Hoon, M. A., Chandrashekar, J., Zhang, Y., Ryba, N. J. P., & Zuker, C. S. (2001) · Cell · doi:10.1016/s0092-8674(01)00451-2 · Cited by 1,702
Human receptors for sweet and umami taste
Li, X., Staszewski, L., Xu, H., Durick, K., Zoller, M., & Adler, E. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.072090199 · Cited by 1,378
Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors
Pin, J.-P., Galvez, T., & Prézeau, L. (2003) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(03)00038-x · Cited by 662
Detection of Sweet and Umami Taste in the Absence of Taste Receptor T1r3
Damak, S., Rong, M., Yasumatsu, K., Kokrashvili, Z., Varadarajan, V., Zou, S., Jiang, P., Ninomiya, Y., & Margolskee, R. F. (2003) · Science · doi:10.1126/science.1087155 · Cited by 632
An overview of binary taste–taste interactions
Keast, R. S. J., & Breslin, P. A. S. (2003) · Food Quality and Preference · doi:10.1016/s0950-3293(02)00110-6 · Cited by 615
Metadata
- Authors
- Sainz, E., Korley, J. N., Battey, J. F., & Sullivan, S. L.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 2001-05
- Volume
- 77
- Issue
- 3
- Pages
- 896-903
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W1517221659
- Cited by
- 323
- References
- 1
- FWCI
- 19.84
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sainz, E., Korley, J. N., Battey, J. F., & Sullivan, S. L. (2001). Identification of a novel member of the T1R family of putative taste receptors. Journal of Neurochemistry. https://doi.org/10.1046/j.1471-4159.2001.00292.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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