The effects of rearing environment and chronic methylphenidate administration on behavior and dopamine receptors in adolescent rats

Gill, Kathryn E.; Beveridge, Thomas J.R.; Smith, Hilary R.; Porrino, Linda J.

doi:10.1016/j.brainres.2013.06.021

Cited by 30Neurotransmitter Receptor Influence on BehaviorAttention Deficit Hyperactivity DisorderNeuroscience and Neuropharmacology Research

The effects of rearing environment and chronic methylphenidate administration on behavior and dopamine receptors in adolescent rats

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Gill, Kathryn E., Beveridge, Thomas J.R., Smith, Hilary R., Porrino, Linda J.·2013·Brain Research

DOI 10.1016/j.brainres.2013.06.021PMC PMC3775327

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Abstract

Rearing young rodents in socially isolated or environmentally enriched conditions has been shown to affect numerous components of the dopamine system as well as behavior. Methylphenidate (MPH), a commonly used dopaminergic agent, may affect animals differently based on rearing environment. Here we examined the interaction between environment and chronic MPH treatment at clinically relevant doses, administered via osmotic minipump. Young Sprague Dawley rats (PND 21) were assigned to environmentally enriched, pair-housed, or socially isolated rearing conditions, and treated with either 0, 2, 4, or 8 mg/kg/day MPH for 3 weeks. At the end of the treatment period, animals were tested for locomotor activity and anxiety-like behavior. The densities of D1-like and D2-like receptors were measured in the striatum using in vitro receptor autoradiography. Locomotor activity and anxiety-like behavior were increased in isolated animals compared to pair-housed and enriched animals. The density of D1-like receptors was greater in isolated animals, but there were no differences between groups in D2-like receptor density. Finally, there were no effects of MPH administration on any reported measure. This study provides evidence for an effect of early rearing environment on the dopamine system and behavior, and also suggests that MPH administration may not have long-term consequences.

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Early exposure to low quality maternal care may alter the development of dopaminergic pathways associated with reward-related behaviors and response to drugs.
“Early exposure to low quality maternal care may also alter the development of dopaminergic pathways associated with reward-related behaviors, and response to drugs.”
From The maternal brain and its plasticity in humans (2016) · cites this paper as Gill et al., 2013
Rodents reared in isolation showed changes in distribution of dopamine receptors.
“For example, rodents who were reared in isolation showed changes in distribution of DA receptors (Gill et al., 2013),”
From The maternal brain and its plasticity in humans (2016) · cites this paper as Gill et al., 2013

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Background
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Authors: Gill, K. E., Beveridge, T. J. R., Smith, H. R., & Porrino, L. J.
Affiliations: Wake Forest University Health Sciences (US)
Corresponding author: Porrino, Linda J.
ORCID: Smith, Hilary R.
Porrino, Linda J.
Venue: Brain Research
Publisher: Elsevier BV
Published: 2013-08
Volume: 1527
Pages: 67-78
ISSN: 0006-8993 (ISSN-L)
DOI: 10.1016/j.brainres.2013.06.021
PMC: PMC3775327
OpenAlex: W1977803285
Cited by: 30
References: 120
Citations by year: 2026: 1 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 3 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 3 · 2014: 3
FWCI: 1.31
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Brain Research (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Alcohol Abuse and Alcoholism (T32-AA00756)
National Institute on Drug Abuse (R01DA020648, DA20648, P50DA006634, DA 06634)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: methylphenidate, rearing conditions, social isolation, environmental enrichment, pair housing, dopamine receptors, D1-like receptors, D2-like receptors, striatum, locomotor activity, anxiety-like behavior, adolescent rats, early life experience, chronic drug administration
MeSH terms: Aging, Central Nervous System Stimulants, Animals, Autoradiography, Behavior, Animal, Brain, Housing, Animal, Male, Methylphenidate, Motor Activity, Receptors, Dopamine, Social Isolation, Rats, Sprague-Dawley, Rats

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The effects of rearing environment and chronic methylphenidate administration on behavior and dopamine receptors in adolescent rats

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