The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
Zinc inhibition of cellular energy production: implications for mitochondria and neurodegeneration
Open accessAbstract
An increasing body of evidence suggests that high intracellular free zinc promotes neuronal death by inhibiting cellular energy production. A number of targets have been postulated, including complexes of the mitochondrial electron transport chain, components of the tricarboxylic acid cycle, and enzymes of glycolysis. Consequences of cellular zinc overload may include increased cellular reactive oxygen species (ROS) production, loss of mitochondrial membrane potential, and reduced cellular ATP levels. Additionally, zinc toxicity might involve zinc uptake by mitochondria and zinc induction of mitochondrial permeability transition. The present review discusses these processes with special emphasis on their potential involvement in brain injury.
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Cites
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Cited by
The Essential Toxin: Impact of Zinc on Human Health
Plum, L. M., Rink, L., & Haase, H. (2010) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph7041342 · Cited by 1,577
Zinc in the physiology and pathology of the CNS
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Kahlson, M. A., & Dixon, S. J. (2022) · Science · doi:10.1126/science.abo3959 · Cited by 521
Critical Role of Zinc as Either an Antioxidant or a Prooxidant in Cellular Systems
Lee, S. R. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/9156285 · Cited by 458
Alpha-ketoglutarate dehydrogenase: a target and generator of oxidative stress
Tretter, L., & Adam-Vizi, V. (2005) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2005.1764 · Cited by 434
Metadata
- Authors
- Dineley, K. E., Votyakova, T. V., & Reynolds, I. J.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 2003-04-04
- Volume
- 85
- Issue
- 3
- Pages
- 563-570
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W1941267787
- Cited by
- 362
- References
- 59
- FWCI
- 5.79
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Dineley, K. E., Votyakova, T. V., & Reynolds, I. J. (2003). Zinc inhibition of cellular energy production: implications for mitochondria and neurodegeneration. Journal of Neurochemistry. https://doi.org/10.1046/j.1471-4159.2003.01678.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
