The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The elusive function of metallothioneins
Open accessAbstract
Biochemistry and genetics are both required to elucidate the function of macromolecules. There is no question that metallothioneins (MTs) have unique biochemical properties, but genetic experiments have not substantiated the importance of MTs under physiological conditions. Even after thousands of studies describing the structure, biochemical characteristics, tissue distribution, induction, and consequences of genetic disruption and deliberate overexpression, the evolutionary forces that led to the initial appearance, gene duplications, and nearly ubiquitous expression of MTs remain enigmatic.
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Cites
Thinking about genetic redundancy
Thomas, J. H. (1993) · Trends in Genetics · doi:10.1016/0168-9525(93)90140-d · Cited by 239
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Molecular mechanisms of plant metal tolerance and homeostasis
Clemens, S. (2001) · Planta · doi:10.1007/s004250000458 · Cited by 1,417
UNRAVELING THE MECHANISMS INVOLVED IN MOTOR NEURON DEGENERATION IN ALS
Bruijn, L. I., Miller, T. M., & Cleveland, D. W. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.27.070203.144244 · Cited by 1,185
Okuda, M., Li, K., Beard, M. R., Showalter, L. A., Scholle, F., Lemon, S. M., & Weinman, S. A. (2002) · Gastroenterology · doi:10.1053/gast.2002.30983 · Cited by 926
Sacheck, J. M., Hyatt, J. K., Raffaello, A., Thomas Jagoe, R., Roy, R. R., Reggie Edgerton, V., Lecker, S. H., & Goldberg, A. L. (2007) · The FASEB Journal · doi:10.1096/fj.06-6604com · Cited by 585
Metadata
- Authors
- Palmiter, R. D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1998-07-21
- Volume
- 95
- Issue
- 15
- Pages
- 8428-8430
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2034900642
- Cited by
- 679
- References
- 1
- FWCI
- 26.58
- Type
- journal article
- Language
- en
- Open access
- green
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- Palmiter, R. D. (1998). The elusive function of metallothioneins. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.95.15.8428
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
