Cited by 248Muscle Physiology and DisordersNutrition and Health in AgingNerve injury and regeneration

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Neural control of aging skeletal muscle

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Delbono, Osvaldo·2003·Aging Cell

DOI 10.1046/j.1474-9728.2003.00011.x

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Abstract

Summary: Functional and structural decline in the neuromuscular system with aging has been recognized as a cause of impairment in physical performance and loss of independence in the elderly. Alterations in spinal cord motor neurones and at the neuromuscular junction have been identified as evidence of denervation in skeletal muscles from aging mammals, including humans. However, the reciprocal influences of neurones on gene expression in muscle and of muscle on age‐related neurodegeneration are poorly understood, and, as a result, interventions aimed at delaying or preventing degeneration of the neural component in aging muscle have been largely unsuccessful. The present article discusses the evidence for neural influence on age‐related impairments of skeletal muscle, including a role in excitation–contraction uncoupling. The role of nerves in regulating the trophic actions of insulin‐like growth factor‐1 (IGF‐1) and other neurotrophic factors is considered as a novel influence on the effects of aging on the neuromuscular junction. A better understanding of nerve–muscle interactions will allow for more rational interventions in the aging neuromuscular system.

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See all 248

Authors: Delbono, O.
Affiliations: Wake Forest University Health Sciences (US)
Corresponding author: Delbono, Osvaldo
ORCID: Delbono, Osvaldo
Venue: Aging Cell
Publisher: Wiley
Published: 2003-01-28
Volume: 2
Issue: 1
Pages: 21-29
ISSN: 1474-9718 (ISSN-L)
1474-9726
DOI: 10.1046/j.1474-9728.2003.00011.x
OpenAlex: W2046854924
Cited by: 248
References: 97
Citations by year: 2026: 6 · 2025: 3 · 2024: 6 · 2023: 8 · 2022: 5 · 2021: 18 · 2020: 16 · 2019: 12 · 2018: 11 · 2017: 9 · 2016: 20 · 2015: 11 · 2014: 9 · 2013: 9 · 2012: 16
FWCI: 0.88
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Aging Cell (publishedVersion)
PubMed (publishedVersion)
Funders: Muscular Dystrophy Association
National Institutes of Health (AG13934)
National Institute on Aging (AG/AR 18755, AG 15820, AG-13934, R01AG015820)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Keywords: skeletal muscle aging, neuromuscular junction, spinal motoneurons, denervation, excitation-contraction uncoupling, insulin-like growth factor I, neurotrophic factors, nerve-muscle interaction, age-related neurodegeneration, muscle gene expression
MeSH terms: Aging, Animals, Humans, Insulin-Like Growth Factor I, Motor Neurons, Nerve Growth Factors, Neuromuscular Junction, Muscle, Skeletal

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