Cited by 115Muscle Physiology and DisordersNutrition and Health in AgingCardiovascular and exercise physiology

The Specific Force of Single Intact Extensor Digitorum Longus and Soleus Mouse Muscle Fibers Declines with Aging

González, E., Messi, M.L., Delbono, O.·2000·Journal of Membrane Biology

Abstract

In the present study we measured, for the first time, the isometric specific force (SF, force normalized to cross sectional area) generated by single intact fibers from fast- (extensor digitorum longus, EDL) and slow-twitch (soleus) muscles from young adult (2-6), middle-aged (12-14) and old (20-24 month-old) mice. SF has also been measured in single intact flexor digitorum brevis fibers from young mice. Muscle fibers have been classified into fast- or slow-twitch based on the contraction kinetics. Maximum SF recorded in EDL and soleus fibers from young and middle-aged mice did not differ significantly. A significant age-dependent decline in maximum SF was recorded in EDL and soleus fibers from young or middle-aged to old mice. The SF was 377 +/- 18, 417 +/- 20 and 279 +/- 18 kPa for EDL fibers from young, middle-aged and old mice, respectively and 397 +/- 17, 405 +/- 24 and 320 +/- 33 kPa for soleus fibers from age-matched mice, respectively. The frequency needed to elicit maximum force in EDL and soleus fibers from middle-aged to old mice did not differ significantly. In conclusion, the specific force developed by both fast and slow-twitch single intact muscle fibers declines with aging and more significantly in the former.

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Crossref · 10.1007/s002320010025

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  • Loss of muscle performance has a greater negative impact on older adults than loss of muscle mass.

    “the preponderance of evidence from years indicates that loss of muscle performance has a greater negative impact on older adults than loss of mass [18, 20–25, 37–39].”

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Authors
González, E., Messi, M. L., & Delbono, O.
Affiliations
Wake Forest University Health Sciences (US)
Venue
Journal of Membrane Biology
Published
2000-12-01
Volume
178
Issue
3
Pages
175-183
ISSN
  • 0022-2631 (ISSN-L)
  • 1432-1424
OpenAlex
W1965850822
Cited by
115
References
40
Citations by year
2026: 1 · 2025: 4 · 2024: 3 · 2023: 2 · 2022: 2 · 2021: 7 · 2020: 5 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 4 · 2015: 3 · 2014: 7 · 2013: 4 · 2012: 9
FWCI
1.93
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Membrane Biology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute on Aging (AG 15820, AG-10484, P60AG010484, AG00692, AG-13934, R01AG015820)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Keywords
muscle aging, extensor digitorum longus, soleus muscle, flexor digitorum brevis, fast-twitch muscle, slow-twitch muscle, isometric force, contraction kinetics
MeSH terms
Aging, Animals, Female, Isometric Contraction, Kinetics, Male, Mice, Inbred DBA, Muscle Contraction, Specific Pathogen-Free Organisms, Muscle, Skeletal, Muscle Fibers, Fast-Twitch, Muscle Fibers, Slow-Twitch, Myosin Heavy Chains, Protein Isoforms, Muscle Development, Mice

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