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Cutaneous Injury Induces the Release of Cathelicidin Anti-Microbial Peptides Active Against Group A Streptococcus
Open accessAbstract
Cathelicidins are a family of peptides thought to provide an innate defensive barrier against a variety of potential microbial pathogens. The human and mouse cathelicidins (LL-37 and CRAMP, respectively) are expressed at select epithelial interfaces where they have been proposed to kill a number of gram-negative and gram-positive bacteria. To determine if these peptides play a part in the protection of skin against wound infections, the anti-microbial activity of LL-37 and CRAMP was determined against the common wound pathogen group A Streptococcus, and their expression was examined after cutaneous injury. We observed a large increase in the expression of cathelicidins in human and murine skin after sterile incision, or in mouse following infection by group A Streptococcus. The appearance of cathelicidins in skin was due to both synthesis within epidermal keratinocytes and deposition from granulocyctes that migrate to the site of injury. Synthesis and deposition in the wound was accompanied by processing from the inactive prostorage form to the mature C-terminal peptide. Analysis of anti-microbial activity of this C-terminal peptide against group A Streptococcus revealed that both LL-37 and CRAMP potently inhibited bacterial growth. Action against group A Streptococcus occurred in conditions that typically abolish the activity of anti-microbial peptides against other organisms. Thus, cathelicidins are well suited to provide defense against infections due to group A Streptococcus, and represent an important element of cutaneous innate immunity.
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“Early events in the innate immune response to skin injury include the recruitment of neutrophils and the induction of antimicrobial peptides, particularly, in humans, the cathelicidin LL-37.17”
From The Innate Immune System in Acute and Chronic Wounds (2016) · cites this paper as [17]
In the citing paper
“Interestingly, suction blister wounds, where the blister roof is still intact, do not show substantial inflammation,9 whereas excisional wounds, ultraviolet (UV)-induced skin damage, superficial tape stripping or chemical skin irritants, and contact sensitizers cause inflammatory infiltrates,17,23–26”
From The Innate Immune System in Acute and Chronic Wounds (2016) · cites this paper as [17]
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Self-citation
Metadata
- Authors
- Dorschner, R. A., Pestonjamasp, V. K., Tamakuwala, S., Ohtake, T., Rudisill, J., Nizet, V., Agerberth, B., Gudmundsson, G. H., & Gallo, R. L.
- Affiliations
- University of California San Diego (US)
- Karolinska Institutet (SE)
- Corresponding author
- Gallo, Richard L.
- Venue
- Journal of Investigative Dermatology
- Publisher
- Elsevier BV
- Published
- 2001-07
- Volume
- 117
- Issue
- 1
- Pages
- 91-97
- ISSN
- 0022-202X (ISSN-L)
- OpenAlex
- W2085793178
- Cited by
- 567
- References
- 56
- Citations by year
- 2026: 8 · 2025: 10 · 2024: 13 · 2023: 17 · 2022: 11 · 2021: 12 · 2020: 16 · 2019: 25 · 2018: 23 · 2017: 24 · 2016: 20 · 2015: 26 · 2014: 25 · 2013: 23 · 2012: 33
- FWCI
- 14.20
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Investigative Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (AI48176, R21AI048176)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR-44379)
- Topics
- Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
- Health Sciences › Medicine › Infectious Diseases › Streptococcal Infections and Treatments
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Keywords
- cathelicidin, LL-37, cramps, Streptococcus pyogenes, skin wounds, wound infection, antimicrobial peptides, innate immunity, keratinocytes, granulocytes, skin
- MeSH terms
- Amino Acid Sequence, Animals, Female, Humans, Male, Mice, Inbred C57BL, Molecular Sequence Data, Proteins, RNA, Messenger, Skin, Streptococcal Infections, Streptococcus pyogenes, Wound Healing, Keratinocytes, Gene Expression, Antimicrobial Cationic Peptides, Mice, Cathelicidins
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