Cited by 371Blood Coagulation and Thrombosis MechanismsAdipokines, Inflammation, and Metabolic DiseasesProtease and Inhibitor Mechanisms

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Plasminogen activator inhibitor-1, inflammation, obesity, insulin resistance and vascular risk

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Juhan-Vague, I., Alessi, M-C., Mavri, A., Morange, P.E.·2003·Journal of Thrombosis and Haemostasis

DOI 10.1046/j.1538-7836.2003.00279.x

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Abstract

Elevated plasma plasminogen activator inhibitor-1 (PAI-1) level is a core feature of insulin-resistance syndrome (IRS). Atherothrombotic complications in IRS are partly attributed to impaired fibrinolysis caused by increased plasma PAI-1 levels. Although the etiology of IRS is far from being explained, the clustering of inflammation, adipose tissue accumulation and insulin resistance suggests an etiopathological link. Proinflammatory cytokines might regulate PAI-1 expression in IRS; however, more studies are needed to confirm this complex mechanism in humans. Furthermore, modifying PAI-1 expression by PAI-1 inhibitors provides a new challenge and may reveal the true role of PAI-1 in atherosclerotic and insulin resistance processes.

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Authors: Juhan-Vague, I., Alessi, M.-C., Mavri, A., & Morange, P. E.
Affiliations: Inserm (FR)
Corresponding author: Juhan-Vague, I.
ORCID: Alessi, M-C.
Mavri, A.
Morange, P.E.
Venue: Journal of Thrombosis and Haemostasis
Publisher: Elsevier BV
Published: 2003-07
Volume: 1
Issue: 7
Pages: 1575-1579
ISSN: 1538-7836 (ISSN-L)
DOI: 10.1046/j.1538-7836.2003.00279.x
OpenAlex: W2042742088
Cited by: 371
References: 95
Citations by year: 2026: 9 · 2025: 13 · 2024: 13 · 2023: 8 · 2022: 14 · 2021: 6 · 2020: 11 · 2019: 14 · 2018: 10 · 2017: 17 · 2016: 9 · 2015: 19 · 2014: 14 · 2013: 11 · 2012: 13
FWCI: 4.40
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 7104 d)
Locations: Journal of Thrombosis and Haemostasis (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
Keywords: plasminogen activator inhibitor-1, metabolic syndrome, inflammation, obesity, adipose tissue, inflammatory cytokines, impaired fibrinolysis, atherothrombosis, vascular risk, PAI-1 inhibitors, atherosclerosis
MeSH terms: Animals, Heart Diseases, Humans, Insulin Resistance, Obesity, Risk, Plasminogen Activator Inhibitor 1

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Plasminogen activator inhibitor-1, inflammation, obesity, insulin resistance and vascular risk

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