The DOI matches its Crossref record; 123 of the 123 references it cites were found in a registry or an index.
Drug‐Induced Torsades de Pointes and Implications for Drug Development
Abstract
Torsades de pointes is a potentially lethal arrhythmia that occasionally appears as an adverse effect of pharmacotherapy. Recently developed understanding of the underlying electrophysiology allows better estimation of the drug‐induced risks and explains the failures of older approaches through the surface ECG. This article expresses a consensus reached by an independent academic task force on the physiologic understanding of drug‐induced repolarization changes, their preclinical and clinical evaluation, and the risk‐to‐benefit interpretation of drug‐induced torsades de pointes. The consensus of the task force includes suggestions on how to evaluate the risk of torsades within drug development programs. Individual sections of the text discuss the techniques and limitations of methods directed at drug‐related ion channel phenomena, investigations aimed at action potentials changes, preclinical studies of phenomena seen only in the whole (or nearly whole) heart, and interpretation of human ECGs obtained in clinical studies. The final section of the text discusses drug‐induced torsades within the larger evaluation of drug‐related risks and benefits. (J Cardiovasc Electrophysiol, Vol. 15, pp. 475‐495, April 2004)
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Cites
Risk Stratification in the Long-QT Syndrome
Priori, S. G., Schwartz, P. J., Napolitano, C., Bloise, R., Ronchetti, E., Grillo, M., Vicentini, A., Spazzolini, C., Nastoli, J., Bottelli, G., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022147 · Cited by 1,459
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Self-citationMiRP1 Forms IKr Potassium Channels with HERG and Is Associated with Cardiac Arrhythmia
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Complete Remission after Treatment of Acute Promyelocytic Leukemia with Arsenic Trioxide
Soignet, S. L., Maslak, P., Wang, Z.-G., Jhanwar, S., Calleja, E., Dardashti, L. J., Corso, D., DeBlasio, A., Gabrilove, J., Scheinberg, D. A., et al. (1998) · New England Journal of Medicine · doi:10.1056/nejm199811053391901 · Cited by 1,213
Molecular and Cellular Mechanisms of Cardiac Arrhythmias
Keating, M. T., & Sanguinetti, M. C. (2001) · Cell · doi:10.1016/s0092-8674(01)00243-4 · Cited by 1,001
Self-citationDie Systolendauer im Elektrokardiogramm bei normalen Menschen und bei Herzkranken
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Self-citationAnkyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death
Mohler, P. J., Schott, J.-J., Gramolini, A. O., Dilly, K. W., Guatimosim, S., duBell, W. H., Song, L.-S., Haurogné, K., Kyndt, F., Ali, M. E., et al. (2003) · Nature · doi:10.1038/nature01335 · Cited by 957
A structural basis for drug-induced long QT syndrome
Mitcheson, J. S., Chen, J., Lin, M., Culberson, C., & Sanguinetti, M. C. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.210244497 · Cited by 944
Self-citationSudden death associated with short-QT syndrome linked to mutations in HERG
Brugada, R., Hong, K., Dumaine, R., Cordeiro, J., Gaita, F., Borggrefe, M., Menendez, T. M., Brugada, J., Pollevick, G. D., Wolpert, C., et al. (2004) · Circulation · doi:10.1161/01.cir.0000109482.92774.3a · Cited by 847
Cited by
Drew, B. J., Ackerman, M. J., Funk, M., Gibler, W. B., Kligfield, P., Menon, V., Philippides, G. J., Roden, D. M., & Zareba, W. (2010) · Circulation · doi:10.1161/circulationaha.109.192704 · Cited by 821
Self-citationIdentifying genetic risk factors for serious adverse drug reactions: current progress and challenges
Wilke, R. A., Lin, D. W., Roden, D. M., Watkins, P. B., Flockhart, D., Zineh, I., Giacomini, K. M., & Krauss, R. M. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2423 · Cited by 391
Self-citationPredicting drug–hERG channel interactions that cause acquired long QT syndrome
Sanguinetti, M. C., & Mitcheson, J. S. (2005) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2005.01.003 · Cited by 300
Self-citationhERG channel trafficking: Novel targets in drug-induced long QT syndrome
Dennis, A., Wang, L., Wan, X., & Ficker, E. (2007) · Biochemical Society Transactions · doi:10.1042/bst0351060 · Cited by 134
Sarkar, A. X., & Sobie, E. A. (2011) · Heart Rhythm · doi:10.1016/j.hrthm.2011.05.023 · Cited by 101
Metadata
- Authors
- FENICHEL, R. R., MALIK, M., ANTZELEVITCH, C., SANGUINETTI, M., RODEN, D. M., PRIORI, S. G., RUSKIN, J. N., LIPICKY, R. J., CANTILENA, L. R., & Independent Academic Task Force
- Venue
- Journal of Cardiovascular Electrophysiology
- Publisher
- Wiley
- Published
- 2004-04
- Volume
- 15
- Issue
- 4
- Pages
- 475-495
- ISSN
- 1045-3873 (ISSN-L)
- 1540-8167
- OpenAlex
- W2163863644
- Cited by
- 346
- References
- 123
- FWCI
- 19.83
- Type
- journal article
- Language
- en
- Open access
- closed
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- FENICHEL, R. R., MALIK, M., ANTZELEVITCH, C., SANGUINETTI, M., RODEN, D. M., PRIORI, S. G., RUSKIN, J. N., LIPICKY, R. J., CANTILENA, L. R., & Independent Academic Task Force. (2004). Drug‐Induced Torsades de Pointes and Implications for Drug Development. Journal of Cardiovascular Electrophysiology. https://doi.org/10.1046/j.1540-8167.2004.03534.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
