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The DOI matches its Crossref record; 87 of the 87 references it cites were found in a registry or an index.

Zoonotic hepatitis E: animal reservoirs and emerging risks

Open access
Pavio, Nicole, Meng, Xiang-Jin, Renou, Christophe·2010·Veterinary Research

Abstract

Hepatitis E virus (HEV) is responsible for enterically-transmitted acute hepatitis in humans with two distinct epidemiological patterns. In endemic regions, large waterborne epidemics with thousands of people affected have been observed, and, in contrast, in non-endemic regions, sporadic cases have been described. Although contaminated water has been well documented as the source of infection in endemic regions, the modes of transmission in non-endemic regions are much less known. HEV is a single-strand, positive-sense RNA virus which is classified in the Hepeviridae family with at least four known main genotypes (1-4) of mammalian HEV and one avian HEV. HEV is unique among the known hepatitis viruses, in which it has an animal reservoir. In contrast to humans, swine and other mammalian animal species infected by HEV generally remain asymptomatic, whereas chickens infected by avian HEV may develop a disease known as Hepatitis-Splenomegaly syndrome. HEV genotypes 1 and 2 are found exclusively in humans while genotypes 3 and 4 are found both in humans and other mammals. Several lines of evidence indicate that, in some cases involving HEV genotypes 3 and 4, animal to human transmissions occur. Furthermore, individuals with direct contact with animals are at higher risk of HEV infection. Cross-species infections with HEV genotypes 3 and 4 have been demonstrated experimentally. However, not all sources of human infections have been identified thus far and in many cases, the origin of HEV infection in humans remains unknown.

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Metadata

Authors
Pavio, N., Meng, X.-J., & Renou, C.
Venue
Veterinary Research
Publisher
EDP Sciences
Published
2010-04-02
Volume
41
Issue
6
Pages
46
ISSN
  • 0928-4249 (ISSN-L)
  • 1297-9716
OpenAlex
W2111132338
Cited by
344
References
87
FWCI
17.50
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Zoonotic hepatitis E: animal reservoirs and emerging risks. https://app.cochat.ai/papers/10.1051/vetres/2010018
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Pavio, N., Meng, X.-J., & Renou, C. (2010). Zoonotic hepatitis E: animal reservoirs and emerging risks. Veterinary Research. https://doi.org/10.1051/vetres/2010018

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