Serum haptoglobin concentrations in a population of feedlot cattle
Open accessAbstract
Objective: To determine serum haptoglobin concentrations in a population of feedlot cattle and evaluate their usefulness in predicting subsequent clinical respiratory tract disease. Design: Prospective longitudinal study. Animals: 366 beef calves. Procedure: Serum samples were obtained at feedlot entry and 40 and 65 days on feed (DOF). Calves were observed daily for clinical signs of respiratory tract disease. The lungs of 144 of the calves were evaluated at slaughter for the presence of gross lesions of pneumonia. Results: 58% of the calves had detectable serum haptoglobin concentration in at least 1 sample. The proportion of calves with detectable haptoglobin were similar at each sample collection time. A higher proportion of the calves had values > 10 mg/dl at 40 DOF. The prcportion of calves observed with clinical disease during the 10-day period after the 40 DOF sample increased (P < 0.10) as serum haptoglobin concentration increased. At 65 DOF, calves with serum haptoglobin value > 10 mg/dl had a higher (P < 0.05) rate of subsequent clinical respiratory tract disease than did calves with lower values. The proportion of calves with gross pulmonary lesions slaughter increased (P < 0.05) from 39% among calves without detectable serum haptoglobin concentration in any of the 3 samples to 63% among calves with at least 1 observed value > 10 mg/dl. Conclusions: We observed associations between serum haptoglobin concentration and subsequent clinical respiratory tract disease and pulmonary lesions at slaughter. However, serum haptoglobin concentration alone is not adequate for prediction of clinical disease. Clinical Relevance: The usefulness for cross-sectional sampling of serum haptoglobin concentration as a diagnostic tool for clinical respiratory tract disease in feedlot cattle appears to be limited.
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Contrasting studies challenge the reliability of Hp as an indicator for BRD diagnosis in cattle.
“However, contrasting studies challenge the reliability of Hp as an indicator for BRD diagnosis in cattle [216,264,265].”
From Strategies for Bovine Respiratory Disease (BRD) Diagnosis and Prognosis: A Comprehensive Overview (2024) · cites this paper as [264]
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Cites
Bovine haptoglobin response in clinically defined field conditions
Skinner, J., Brown, R., & Roberts, L. (1991) · Veterinary Record · doi:10.1136/vr.128.7.147 · Cited by 278 · see citing works
Bovine and canine acute phase proteins
Eckersall, P. D., & Conner, J. (1988) · Veterinary Research Communications · doi:10.1007/bf00362798 · Cited by 273 · see citing works
Alsemgeest, S. P. M., Kalsbeek, H. C., Wensing, T., Koeman, J. P., van Ederen, A. M., & Gruys, E. (1994) · Veterinary Quarterly · doi:10.1080/01652176.1994.9694410 · Cited by 231 · see citing works
Polymeric binding of haemoglobin in cattle
Goodger, B. V. (1970) · Clinica Chimica Acta · doi:10.1016/0009-8981(70)90013-6 · Cited by 9 · see citing works
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Research works printed but not linked: 1
- Panndorf H , Richter H , Oittrich B. Haptoglobin in domestic animals . V. Plasma haptoglobin levels in cattle under pathological conditions . Arch Exp Veterinarmed 1976 ; 30 : 193-202 .
Cited by
Sorted by citations
Application of acute phase protein measurements in veterinary clinical chemistry
Petersen, H. H., Nielsen, J. P., & Heegaard, P. M. H. (2004) · Veterinary Research · doi:10.1051/vetres:2004002 · Cited by 1,060 · see citing works
Acute phase proteins as indicators of calf herd health
Gånheim, C., Alenius, S., & Waller, K. P. (2006) · The Veterinary Journal · doi:10.1016/j.tvjl.2006.01.011 · Cited by 129 · see citing works
Cooke, R. F. (2017) · The Professional Animal Scientist · doi:10.15232/pas.2016-01573 · Cited by 119 · see citing works
Timsit, E., Dendukuri, N., Schiller, I., & Buczinski, S. (2016) · Preventive Veterinary Medicine · doi:10.1016/j.prevetmed.2016.11.006 · Cited by 112 · see citing works
Comparison of Various Antibiotic Treatments for Cows Diagnosed with Toxic Puerperal Metritis
Smith, B. I., Donovan, G. A., Risco, C. A., Littell, R. C., Young, C. R., Stanker, L. H., & Elliott, J. B. (1998) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(98)75721-2 · Cited by 105 · see citing works
Self-citationAssociation of bovine respiratory disease with clinical status and acute phase proteins in calves
Nikunen, S., Härtel, H., Orro, T., Neuvonen, E., Tanskanen, R., Kivelä, S.-L., Sankari, S., Aho, P., Pyörälä, S., Saloniemi, H., et al. (2007) · Comparative Immunology Microbiology and Infectious Diseases · doi:10.1016/j.cimid.2006.11.004 · Cited by 102 · see citing works
Theurer, M. E., Anderson, D. E., White, B. J., Miesner, M. D., Mosier, D. A., Coetzee, J. F., Lakritz, J., & Amrine, D. E. (2013) · Journal of Animal Science · doi:10.2527/jas.2012-5823 · Cited by 91 · see citing works
Berry, B. A., Confer, A. W., Krehbiel, C. R., Gill, D. R., Smith, R. A., & Montelongo, M. (2004) · Journal of Animal Science · doi:10.2527/2004.823845x · Cited by 91 · see citing works
Orro, T., Pohjanvirta, T., Rikula, U., Huovilainen, A., Alasuutari, S., Sihvonen, L. H., Pelkonen, S., & Soveri, T. (2009) · Comparative Immunology Microbiology and Infectious Diseases · doi:10.1016/j.cimid.2009.10.005 · Cited by 82 · see citing works
Carter, J. N., Meredith, G. L., Montelongo, M., Gill, D. R., Krehbiel, C. R., Payton, M. E., & Confer, A. W. (2002) · American Journal of Veterinary Research · doi:10.2460/ajvr.2002.63.1111 · Cited by 78 · see citing works
Strategies for Bovine Respiratory Disease (BRD) Diagnosis and Prognosis: A Comprehensive Overview
Kamel, M. S., Davidson, J. L., & Verma, M. S. (2024) · Animals · doi:10.3390/ani14040627 · Cited by 76 · see citing works
“However, contrasting studies challenge the reliability of Hp as an indicator for BRD diagnosis in cattle [216,264,265].”
ResultManagement of Periparturient Disorders in Dairy Cattle
Smith, B. I., & Risco, C. A. (2005) · Veterinary Clinics of North America Food Animal Practice · doi:10.1016/j.cvfa.2005.02.007 · Cited by 71 · see citing works
Serum haptoglobin concentrations in Holstein dairy cattle with toxic puerperal metritis
Smith, B. I., Donovan, G. A., Risco, C. A., Young, C. R., & Stanker, L. H. (1998) · Veterinary Record · doi:10.1136/vr.142.4.83 · Cited by 66 · see citing works
Self-citationHumblet, M., Coghe, J., Lekeux, P. M., & Godeau, J. (2004) · Research in Veterinary Science · doi:10.1016/j.rvsc.2004.02.009 · Cited by 62 · see citing works
Serum haptoglobin concentrations in dairy cattle with lameness due to claw disorders
Smith, B. I., Kauffold, J., & Sherman, L. (2009) · The Veterinary Journal · doi:10.1016/j.tvjl.2009.08.012 · Cited by 54 · see citing works
El-Deeb, W., Elsohaby, I., Fayez, M., Mkrtchyan, H. V., El-Etriby, D., & ElGioushy, M. (2020) · Acta Tropica · doi:10.1016/j.actatropica.2020.105336 · Cited by 50 · see citing works
Tadich, N., Tejeda, C., Bastias, S., Rosenfeld, C., & Green, L. E. (2013) · The Veterinary Journal · doi:10.1016/j.tvjl.2013.01.029 · Cited by 46 · see citing works
Moisá, S. J., Aly, S. S., Lehenbauer, T. W., Love, W. J., Rossitto, P. V., Van Eenennaam, A. L., Trombetta, S. C., Bortoluzzi, E. M., & Hulbert, L. E. (2019) · Journal of Veterinary Diagnostic Investigation · doi:10.1177/1040638718807242 · Cited by 43 · see citing works
Abdallah, A., Hewson, J., Francoz, D., Selim, H., & Buczinski, S. (2016) · Journal of Veterinary Internal Medicine · doi:10.1111/jvim.13975 · Cited by 39 · see citing works
Murray, G., More, S., Clegg, T., Earley, B., O'Neill, R., Johnston, D., Gilmore, J., Nosov, M., Mcelroy, M., Inzana, T., et al. (2018) · BMC Veterinary Research · doi:10.1186/s12917-018-1372-9 · Cited by 25 · see citing works
El‐Deeb, W., & Tharwat, M. (2014) · Comparative Clinical Pathology · doi:10.1007/s00580-014-1949-z · Cited by 33 · see citing works
El-Bahr, S. M. (2013) · American journal of biochemistry & biotechnology/American journal of biochemistry and biotechnology · doi:10.3844/ajbbsp.2013.34.40 · Cited by 32 · see citing works
Filipov, N. M., Thompson, F., Ja, S., Elsasser, T. H., Kahl, S., Rp, S., Young, C. R., Stanker, L. H., & Smith, C. (1999) · Journal of Endocrinology · doi:10.1677/joe.0.1630213 · Cited by 30 · see citing works
Self-citationHolland, B. P., Step, D. L., Burciaga-Robles, L. O., Fulton, R. W., Confer, A. W., Rose, T. K., Laidig, L. E., Richards, C., & Krehbiel, C. R. (2011) · American Journal of Veterinary Research · doi:10.2460/ajvr.72.10.1349 · Cited by 29 · see citing works
El‐Deeb, W., & Elmoslemany, A. M. (2016) · PeerJ · doi:10.7717/peerj.2161 · Cited by 28 · see citing works
Ostermann, C., Schroedl, W., Schubert, E., Sachse, K., & Reinhold, P. (2012) · The Veterinary Journal · doi:10.1016/j.tvjl.2012.10.035 · Cited by 27 · see citing works
Acute phase response in emergency slaughtered dairy cows
Hirvonen, J., Hietakorpi, S., & Saloniemi, H. (1997) · Meat Science · doi:10.1016/s0309-1740(97)00020-x · Cited by 25 · see citing works
Predictive Modeling of Bovine Respiratory Disease Outcomes in Feedlot Cattle: A Narrative Review
Wisnieski, L., Amrine, D. E., & Renter, D. G. (2021) · Livestock Science · doi:10.1016/j.livsci.2021.104666 · Cited by 23 · see citing works
Yamamoto, M., Katoh, N., & Adachi, Y. (1998) · Journal of Veterinary Medical Science · doi:10.1292/jvms.60.181 · Cited by 22 · see citing works
Acute phase proteins in relation to various inflammatory diseases of calves
Tóthová, C., Nagy, O., Seidel, H., & Kovác, G. (2011) · Comparative Clinical Pathology · doi:10.1007/s00580-011-1224-5 · Cited by 21 · see citing works
Crawford, R. G., Leslie, K. E., Bagg, R., Dick, C., & Duffield, T. F. (2005) · Europe PMC (PubMed Central) · Cited by 21 · see citing works
Tóthová, C., Nagy, O., Seidel, H., Paulíková, I., & Kovác, G. (2011) · Acta veterinaria · doi:10.2298/avb1103141t · Cited by 19 · see citing works
Bannikov, G. A., Mattoon, J. S., Abrahamsen, E. J., Premanandan, C., Green‐Church, K. B., Marsh, A. E., & Lakritz, J. (2007) · American Journal of Veterinary Research · doi:10.2460/ajvr.68.9.995 · Cited by 17 · see citing works
Katoh, N., Miyamoto, T., Nakagawa, H., & Watanabe, A. (1999) · American Journal of Veterinary Research · doi:10.2460/ajvr.1999.60.11.1390 · Cited by 16 · see citing works
The electrophoretic pattern of serum proteins in dairy cows with inflammatory diseases
Tóthová, C., Mudroň, P., & Nagy, O. (2017) · Acta veterinaria · doi:10.1515/acve-2017-0016 · Cited by 15 · see citing works
Anti-Inflammatory Effects of Ergotamine in Steers
Filipov, N. M., Thompson, F. N., Stuedemann, J. A., Elsasser, T. H., Kahl, S., Stanker, L. H., Young, C. R., Dawe, D. L., & Smith, C. K. (2000) · Proceedings of The Society for Experimental Biology and Medicine · doi:10.1046/j.1525-1373.2000.22517.x · Cited by 15 · see citing works
Self-citationBovine serum transferrin concentration during acuteinfection with Haemophilus somnus
McNair, J., Elliott, C., Bryson, D. G., & Mackie, D. P. (1998) · The Veterinary Journal · doi:10.1016/s1090-0233(05)80020-6 · Cited by 14 · see citing works
El‐Deeb, W., Fayez, M., Elsohaby, I., Salem, M. A., Alhaider, A., & Kandeel, M. K. (2020) · PeerJ · doi:10.7717/peerj.10394 · Cited by 13 · see citing works
Nakagawa, H., & Katoh, N. (1999) · Journal of Veterinary Medical Science · doi:10.1292/jvms.61.1101 · Cited by 13 · see citing works
Acute phase response and oxidative stress parameters in pneumonic camel calves (Camelus dromedarius)
El‐Deeb, W. (2015) · BULGARIAN JOURNAL OF VETERINARY MEDICINE · doi:10.15547/bjvm.853 · Cited by 13 · see citing works
Wright, C. L., Corah, L. R., Stokka, G. L., & Blecha, F. (2000) · The Professional Animal Scientist · doi:10.15232/s1080-7446(15)31673-9 · Cited by 12 · see citing works
Application of Functional Genomics for Bovine Respiratory Disease Diagnostics
Rai, A. N., Epperson, W. B., & Nanduri, B. (2015) · Bioinformatics and Biology Insights · doi:10.4137/bbi.s30525 · Cited by 9 · see citing works
Acute phase proteins in dairy calves and reindeer Changes after birth and in respiratory infections
Orro, T. (2008) · Työväentutkimus Vuosikirja · Cited by 8 · see citing works
Allam, T. S., Said, L., Elsayed, M. S. A. E., & Saleh, N. (2021) · Advances in Animal and Veterinary Sciences · doi:10.17582/journal.aavs/2021/9.6.792.801 · Cited by 6 · see citing works
Acute Phase Proteins as Markers of Diseases in Farm Animals
Tóthová, C., Nagy, O., Seidel, H., & Kova, G. (2011) · InTech eBooks · doi:10.5772/20484 · Cited by 5 · see citing works
Wottlin, L., Carstens, G., Kayser, W., Pinchak, W., Thomson, J., Copié, V., & O'Shea-Stone, G. (2020) · Journal of Animal Science · doi:10.1093/jas/skaa404 · Cited by 5 · see citing works
Acute-phase proteins in different pathological conditions at the lungs of buffaloes
Abdelbaset, A. E., Ellah, M. R. A., Abd‐Elghaffar, S. K., & Sadiek, A. H. (2013) · Comparative Clinical Pathology · doi:10.1007/s00580-013-1696-6 · Cited by 3 · see citing works
Fontes, P. L. P., Davis, D. G., Melo-Gonçalves, L., Burato, S., Smith, M. S., Stelzleni, A. M., Fluharty, F. F., Stewart, R. L., Cooke, R. F., Bromfield, J. J., et al. (2026) · Journal of Animal Science · doi:10.1093/jas/skag004 · Cited by 2 · see citing works
Prevalencia de niveles séricos de haptoglobina en bovinos adultos, de cuatro hatos de Antioquia
Ramírez, N., Molina, S., Sierra, G., & Pareja, J. (2016) · Revista Colombiana de Ciencias Pecuarias · doi:10.17533/udea.rccp.323810 · Cited by 2 · see citing works
OKAMOTO, K., HARADA, M., AKUZAWA, M., & DEGUCHI, E. (1998) · Nihon Chikusan Gakkaiho · doi:10.2508/chikusan.69.683 · Cited by 2 · see citing works
Use of Accelerometers to Characterize Behavior in Beef Cattle During Health and Subclinical Disease
Bayne, J. E. (2017) · Cited by 2 · see citing works
Filippo, P. A. D., de Lannes, S. T., Meireles, M. A. D., Nogueira, A. F. S., & Quirino, C. R. (2019) · Pesquisa Veterinária Brasileira · doi:10.1590/1678-5150-pvb-5817 · Cited by 2 · see citing works
Studies on the acute phase reaction during respiratory infections in calves
Gånheim, C. (2004) · Epsilon Open Archive (Sveriges lantbruksuniversitet biblioteket (Swedish University of Agricultural Sciences)) · Cited by 2 · see citing works
L'haptoglobine, marqueur protéique de l'inflammation aiguë, dans l'espèce bovine
Humblet, M., & Godeau, J. (2005) · ORBi (University of Liège) · Cited by 2 · see citing works
Flores, V. V., Gifford, J. A. H., Soto-Navarro, S. A., Matera, J., Wilson, B. K., Hartson, S. D., Byrum, S. D., & Gifford, C. A. (2023) · Journal of Animal Science · doi:10.1093/jas/skad221 · Cited by 1 · see citing works
Anti-Inflammatory Effects of Ergotamine in Steers (44562):
Filipov, N. M., Thompson, F. N., Stuedemann, J. A., Elsasser, T. H., Kahl, S., Stanker, L. H., Young, C. R., Dawe, D. L., & Smith, C. K. (2016) · Proceedings of The Society for Experimental Biology and Medicine · doi:10.1177/153537020022500205 · Cited by 1 · see citing works
Self-citationLes marqueurs de l'inflammation chez les bovins : nature, physiopathologie et intérêt diagnostique
Corbière, F. (2002) · HAL · Cited by 1 · see citing works
Gómez, L. M., Posada, S. L., Olivera, M., & Nutri-Solla, G. (2014)
Acute phase proteins in healthy and sick dairy and beef calves and their association with growth
Seppä‐Lassila, L. (2018) · Työväentutkimus Vuosikirja
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- Authors
- Young, C. R., Wittum, T. E., Stanker, L. H., Perino, L. J., Griffin, D. D., & Littledike, E. T.
- Affiliations
- University of Nebraska–Lincoln (US)
- Venue
- American Journal of Veterinary Research
- Published
- 1996-02-01
- Volume
- 57
- Issue
- 2
- Pages
- 138-141
- ISSN
- 0002-9645 (ISSN-L)
- OpenAlex
- W2302117756
- Cited by
- 61
- References
- 4
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 1 · 2021: 2 · 2020: 3 · 2019: 1 · 2018: 3 · 2017: 3 · 2016: 5 · 2015: 2 · 2014: 2 · 2013: 4 · 2012: 1
- FWCI
- 6.96
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal of Veterinary Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Veterinary › Small Animals › Animal health and immunology
- Life Sciences › Immunology and Microbiology › Microbiology › Microbial infections and disease research
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Effects of Environmental Stressors on Livestock
- Keywords
- haptoglobin, feedlot cattle, beef calves, respiratory diseases, bovine pneumonia, lung lesions, disease prediction, diagnostic biomarkers
- MeSH terms
- Animals, Cattle, Cattle Diseases, Female, Haptoglobins, Longitudinal Studies, Lung, Male, Pneumonia, Predictive Value of Tests, Prospective Studies, Reference Values, Respiratory Tract Infections
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