Haptoglobin and serum amyloid A as putative biomarker candidates of naturally occurring bovine respiratory disease in dairy calves

Joshi, Vivek; Gupta, V.K.; Bhanuprakash, A.G.; Mandal, R.S.K.; Dimri, U.; Ajith, Y.

doi:10.1016/j.micpath.2018.01.001

Cited by 75Animal health and immunologyMicrobial infections and disease researchInflammation biomarkers and pathways

Haptoglobin and serum amyloid A as putative biomarker candidates of naturally occurring bovine respiratory disease in dairy calves

Joshi, Vivek, Gupta, V.K., Bhanuprakash, A.G., Mandal, R.S.K., Dimri, U., Ajith, Y.·2018·Microbial Pathogenesis

DOI 10.1016/j.micpath.2018.01.001

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Abstract

Bovine respiratory disease (BRD) is one of the leading causes of morbidity and mortality in dairy calves. Identification of reliable biomarkers of naturally occurring BRD is essential for ensuring early diagnosis and treatment of calves and monitoring treatment efficacy. This need is punctuated, especially in mild to moderate cases that would greatly help to decrease recurrence and the overall prevalence of BRD. The present study was conducted to investigate the changes in serum concentrations of haptoglobin (Hpt) and serum amyloid A (SAA) and association between oxidative stress and acute phase proteins (APPs) in BRD. Hpt and SAA levels significantly increased (P < .01) in BRD stressed calves as compared to healthy subjects. There was a significant decrease (P < .01) in serum albumin (Alb) concentration of infected calves as compared to controls. The oxidative stress markers revealed a significant (P < .01) increase in lipid peroxidation (LPO) and a concurrent decrease in activities of superoxide dismutase (SOD), reduced glutathione (R-GSH) and catalase (CAT) in BRD. A significant correlation among APPs, extent of oxidative stress and clinical score (CS) of calves was depicted. A stepwise decrease in Hpt and SAA and increase in Alb was observed in infected calves post-treatment. These results suggest implication of oxidative stress in enhancing APPs and monitoring of APPs as a potential complement to clinical assessment of treatment in calves with naturally occurring BRD. Hpt may be useful as the most sensitive biomarker in BRD. However, the combined use of Hpt and oxidative stress biomarkers would greatly improve the diagnostic accuracy.

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An acute phase response has been previously observed in calves coping with infection or in response to acute stress (such as transport).
“An acute phase response has been previously observed in calves coping with infection (41) or in response to acute stress (such as transport) (42).”
From Effect of source and journey on physiological variables in calves transported by road and ferry between Ireland and the Netherlands (2023) · cites this paper as [41]

Involvement of the Superoxide Anion Radical in the Autoxidation of Pyrogallol and a Convenient Assay for Superoxide Dismutase
Marklund, S. L., & MARKLUND, G. (1974) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1974.tb03714.x · Cited by 10,382 · see citing works
Albumin standards and the measurement of serum albumin with bromcresol green
Doumas, B. T., Watson, W. A., & Biggs, H. G. (1971) · Clinica Chimica Acta · doi:10.1016/0009-8981(71)90365-2 · Cited by 3,103 · see citing works
Albumin standards and the measurement of serum albumin with bromcresol green
Doumas, B. T., Watson, W. A., & Biggs, H. G. (1997) · Clinica Chimica Acta · doi:10.1016/s0009-8981(96)06447-9 · Cited by 2,774 · see citing works
Estimation of product of lipid peroxidation (malonyl dialdehyde) in biochemical systems
Placer, Z., Cushman, L. L., & Johnson, B. C. (1966) · Analytical Biochemistry · doi:10.1016/0003-2697(66)90167-9 · Cited by 2,330 · see citing works
HOW NEUTROPHILS KILL MICROBES
Segal, A. W. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115653 · Cited by 1,783 · see citing works
Measurement of catalase activity in tissue extracts
Cohen, G., Dembiec, D., & Marcus, J. (1970) · Analytical Biochemistry · doi:10.1016/0003-2697(70)90083-7 · Cited by 1,211 · see citing works
Current research on acute phase proteins in veterinary diagnosis: an overview
Murata, H., Shimada, N., & Yoshioka, M. (2003) · The Veterinary Journal · doi:10.1016/s1090-0233(03)00119-9 · Cited by 1,108 · see citing works
Application of acute phase protein measurements in veterinary clinical chemistry
Petersen, H. H., Nielsen, J. P., & Heegaard, P. M. H. (2004) · Veterinary Research · doi:10.1051/vetres:2004002 · Cited by 1,060 · see citing works
Acute phase proteins: Biomarkers of infection and inflammation in veterinary medicine
Eckersall, P. D., & Bell, R. (2010) · The Veterinary Journal · doi:10.1016/j.tvjl.2010.04.009 · Cited by 841 · see citing works
Oxidants and antioxidants in disease: Oxidative stress in farm animals
Lykkesfeldt, J., & Svendsen, O. (2006) · The Veterinary Journal · doi:10.1016/j.tvjl.2006.06.005 · Cited by 798 · see citing works
Disease Management of Dairy Calves and Heifers
McGuirk, S. M. (2008) · Veterinary Clinics of North America: Food Animal Practice · doi:10.1016/j.cvfa.2007.10.003 · Cited by 629 · see citing works
Acute phase proteins in ruminants
Ceciliani, F., Cerón, J. M. C., Eckersall, P. D., & Sauerwein, H. (2012) · Journal of Proteomics · doi:10.1016/j.jprot.2012.04.004 · Cited by 579 · see citing works
A simplified assay method of superoxide dismutase activity for clinical use
Masayasu, M., & Hiroshi, Y. (1979) · Clinica Chimica Acta · doi:10.1016/0009-8981(79)90211-0 · Cited by 557 · see citing works
Biochemical Methods in Red Cell Genetics
Lehmann, H. (1970) · Journal of Medical Genetics · doi:10.1136/jmg.7.3.303 · Cited by 461 · see citing works
Pathogenesis and Pathology of Bovine Pneumonia
Panciera, R. J., & Confer, A. W. (2010) · Veterinary Clinics of North America: Food Animal Practice · doi:10.1016/j.cvfa.2010.04.001 · Cited by 246 · see citing works
The Non-Invasive and Automated Detection of Bovine Respiratory Disease Onset in Receiver Calves Using Infrared Thermography
Schaefer, A. L., Cook, N. J., Bench, C., Chabot, J. B., Colyn, J., Liu, T., Okine, E. K., Stewart, M., & Webster, J. R. (2012) · Research in Veterinary Science · doi:10.1016/j.rvsc.2011.09.021 · Cited by 229 · see citing works
Acute phase proteins and their use in the diagnosis of diseases in ruminants: a review
Tóthová, C., Nagy, O., & Kovác, G. (2014) · Veterinární Medicína · doi:10.17221/7478-vetmed · Cited by 211 · see citing works
Effect of transport stress on respiratory disease, serum antioxidant status, and serum concentrations of lipid peroxidation biomarkers in beef cattle
Chirase, N. K., Greene, L. W., Purdy, C. W., Loan, R. W., Auvermann, B. W., Parker, D. B., Walborg, E. F., Stevenson, D. E., Xu, Y., & Klaunig, J. E. (2004) · American Journal of Veterinary Research · doi:10.2460/ajvr.2004.65.860 · Cited by 174 · see citing works
Respiratory disease in calves: Microbiological investigations on trans-tracheally aspirated bronchoalveolar fluid and acute phase protein response
Angen, Ø., Thomsen, J., Larsen, L. E., Larsen, J., Kokotovic, B., Heegaard, P. M. H., & Enemark, J. M. D. (2009) · Veterinary Microbiology · doi:10.1016/j.vetmic.2008.12.024 · Cited by 173 · see citing works
Etiology of respiratory disease in non-vaccinated, non-medicated calves in rearing herds.
Autio, T., Pohjanvirta, T., Holopainen, R., Rikula, U., Pentikäinen, J., Huovilainen, A., Rusanen, H., Soveri, T., Sihvonen, L., & Pelkonen, S. (2007) · Veterinary Microbiology · doi:10.1016/j.vetmic.2006.10.001 · Cited by 165 · see citing works
Dose Dependency and Individual Variability of the Lipopolysaccharide-Induced Bovine Acute Phase Protein Response
Jacobsen, S. E., Andersen, P. H., Toelboell, T., & Heegaard, P. M. H. (2004) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(04)73469-4 · Cited by 149 · see citing works
Acute phase proteins as indicators of calf herd health
Gånheim, C., Alenius, S., & Waller, K. P. (2006) · The Veterinary Journal · doi:10.1016/j.tvjl.2006.01.011 · Cited by 129 · see citing works
Association of bovine respiratory disease with clinical status and acute phase proteins in calves
Nikunen, S., Härtel, H., Orro, T., Neuvonen, E., Tanskanen, R., Kivelä, S.-L., Sankari, S., Aho, P., Pyörälä, S., Saloniemi, H., et al. (2007) · Comparative Immunology Microbiology and Infectious Diseases · doi:10.1016/j.cimid.2006.11.004 · Cited by 102 · see citing works
Acute phase proteins as promising biomarkers: Perspectives and limitations for human and veterinary medicine
Schrödl, W., Büchler, R., Wendler, S., Reinhold, P., Muckova, P., Reindl, J., & Rhode, H. (2016) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201600028 · Cited by 97 · see citing works
Pulmonary Expression of Tumor Necrosis Factor Alpha, Interleukin-1 Beta, and Interleukin-8 in the Acute Phase of Bovine Pneumonic Pasteurellosis
Malazdrewich, C., Ames, T. R., Abrahamsen, M. S., & Maheswaran, S. K. (2001) · Veterinary Pathology · doi:10.1354/vp.38-3-297 · Cited by 90 · see citing works
Acute phase protein changes in calves during an outbreak of respiratory disease caused by bovine respiratory syncytial virus
Orro, T., Pohjanvirta, T., Rikula, U., Huovilainen, A., Alasuutari, S., Sihvonen, L. H., Pelkonen, S., & Soveri, T. (2009) · Comparative Immunology Microbiology and Infectious Diseases · doi:10.1016/j.cimid.2009.10.005 · Cited by 82 · see citing works
Differential expression and secretion of bovine serum amyloid A3 (SAA3) by mammary epithelial cells stimulated with prolactin or lipopolysaccharide
Larson, M. A., Weber, A. M., Weber, A. T., & McDonald, T. L. (2005) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2005.05.006 · Cited by 70 · see citing works
Evaluation of antioxidant status and oxidative stress in sheep naturally infected with Babesia ovis
Esmaeilnejad, B., Tavassoli, M., Asri‐Rezaei, S., & Dalir‐Naghadeh, B. (2011) · Veterinary Parasitology · doi:10.1016/j.vetpar.2011.10.001 · Cited by 49 · see citing works
Inflammatory Mediators and Oxidative Stress in Animals Subjected to Smoke Inhalation: A Systematic Review
de Carvalho, F. O., Felipe, F. A., Costa, A. C. S. D. M., Teixeira, L. G. B., Silva, É. R., Nunes, P. S., Shanmugam, S., de Lucca, W., Quintans, J. D. S. S., & Araújo, A. A. D. S. (2016) · Lung · doi:10.1007/s00408-016-9879-y · Cited by 42 · see citing works
Membrane penicillinase of Bacillus licheniformis 749/C, a phospholipoprotein.
Yamamoto, S., & Lampen, J. (1975) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)41613-x · Cited by 41 · see citing works
Systematic Review of the Diagnostic Accuracy of Haptoglobin, Serum Amyloid A, and Fibrinogen versus Clinical Reference Standards for the Diagnosis of Bovine Respiratory Disease
Abdallah, A., Hewson, J., Francoz, D., Selim, H., & Buczinski, S. (2016) · Journal of Veterinary Internal Medicine · doi:10.1111/jvim.13975 · Cited by 39 · see citing works
Trypanosoma evansiin naturally infected Dromedary Camels: lipid profile, oxidative stress parameters, acute phase proteins and proinflammatory cytokines
El-Bahr, S. M., & El‐Deeb, W. (2016) · Parasitology · doi:10.1017/s0031182016000123 · Cited by 36 · see citing works
Effects of dystocia on plasma cortisol and cholesterol levels in holstein heifers and their newborn calves
Cıvelek, T., Çeli̇k, H. A., Gülcan, A. V. C. I., & Cıngı, C. Ç. (2008) · Cited by 31 · see citing works
The diagnostic accuracy of acute phase proteins and proinflammatory cytokines in sheep with pneumonic pasteurellosis
El‐Deeb, W., & Elmoslemany, A. M. (2016) · PeerJ · doi:10.7717/peerj.2161 · Cited by 28 · see citing works
Effects of dry period length and dietary energy source on inflammatory biomarkers and oxidative stress in dairy cows
Mayasari, N., Chen, J., Ferrari, A., Bruckmaier, R. M., Kemp, B., Parmentier, H. K., van Knegsel, A. T. M., & Trevisi, E. (2017) · Journal of Dairy Science · doi:10.3168/jds.2016-11857 · Cited by 26 · see citing works
Serum albumin level as a predictor of intensive respiratory or vasopressor support in influenza A (H1N1) virus infection
Wi, Y. M., Kim, J. M., & Peck, K. R. (2013) · International Journal of Clinical Practice · doi:10.1111/ijcp.12249 · Cited by 18 · see citing works
Neutrophil migration in the lung, general and bovine-specific aspects
Soethout, E. C., Müller, K. E., & Rutten, V. P. M. G. (2002) · Veterinary Immunology and Immunopathology · doi:10.1016/s0165-2427(02)00053-3 · Cited by 17 · see citing works
Haptoglobin and serum amyloid a responses in cattle persistently infected with bovine viral diarrhea virus
Ulutaş, B., Tan, T., Ulutaş, P. A., & Bayramlı, G. (2011) · Redalyc (Universidad Autónoma del Estado de México) · Cited by 16 · see citing works
Prophylactic nitric oxide treatment reduces incidence of bovine respiratory disease complex in beef cattle arriving at a feedlot
Regev-Shoshani, G., Church, J. S., Cook, N. J., Schaefer, A. L., & Miller, C. (2013) · Research in Veterinary Science · doi:10.1016/j.rvsc.2013.06.016 · Cited by 14 · see citing works
Haptoglobin and serum amyloid-A concentrations and their relationship with oocyst count in neonatal lambs experimentally infected with Cryptosporidium parvum
Dinler, C., Ulutaş, B., Voyvoda, H., Ulutaş, P. A., Ural, K., & Karagenç, T. (2017) · Veterinary Parasitology · doi:10.1016/j.vetpar.2017.09.023 · Cited by 14 · see citing works
Acute phase proteins, proteomics and metabolomics in the diagnosis of bovine mastitis
Thomas, F. C. (2015) · Enlighten: Theses (The University of Glasgow) · Cited by 11 · see citing works
Acute-phase proteins in immune response.
Tîrziu, E. (2009) · Lucrari Stiintifice - Universitatea de Stiinte Agricole a Banatului Timisoara, Medicina Veterinara · Cited by 9 · see citing works
Changes of acute phase protein levels in Saanen goat kids during neonatal period
Ulutaş, P. A., Ulutaş, B., Kıral, F. K., Aşıcı, G. S. E., & Gültekin, M. (2016) · Small Ruminant Research · doi:10.1016/j.smallrumres.2016.11.015 · Cited by 9 · see citing works
Bovine Respiratory Disease-An Updated Review
Joshi, V., Gupta, V. K., Kumar, O. R. V., Pruthvishree, B. S., Dimri, U., & Alam, S. (2016) · Journal of Immunology and Immunopathology · doi:10.5958/0973-9149.2016.00014.9 · Cited by 7 · see citing works
Self-citation
Tumour Necrosis Factor-alpha, Haptoglobin, Serum Amyloid A and Neopterin Levels in Cattle with Lumpy Skin Disease [1][2]
Başbuğ, O., Tuzcu, N., Çoşkun, A., Aydoğdu, U., Yiğin, A., & Ağaoğlu, Z. T. (2016) · Kafkas Universitesi Veteriner Fakultesi Dergisi · Cited by 3 · see citing works
Evaluating Serum Lipid Profile in Bacterial Bovine Respiratory Disease (BRD) Affected Calves
Joshi, V., Gupta, V., Dimri, U., Mandal, R. S. K., & Sharma, D. K. (2015) · INTAS POLIVET · Cited by 2 · see citing works
Self-citation
Current and future strategies of bovine respiratory disease diagnostics and treatments
Miller, S. L. (2016) · K-State Research Exchange (Kansas State University) · Cited by 2 · see citing works

Flagged first, then by citations

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Biomarkers in Stress Related Diseases/Disorders: Diagnostic, Prognostic, and Therapeutic Values
Dhama, K., Latheef, S. K., Dadar, M., Samad, H. A., Munjal, A. K., Khandia, R., Karthik, K., Tiwari, R., Yatoo, M. I., Bhatt, P., et al. (2019) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2019.00091 · Cited by 333 · see citing works
Acute phase proteins in cattle and swine: A review
Saco, Y., & Bassols, A. (2022) · Veterinary Clinical Pathology · doi:10.1111/vcp.13220 · Cited by 93 · see citing works
Review on bovine respiratory syncytial virus and bovine parainfluenza – usual suspects in bovine respiratory disease – a narrative review
Makoschey, B., & Berge, A. C. (2021) · BMC Veterinary Research · doi:10.1186/s12917-021-02935-5 · Cited by 88 · see citing works
Strategies for Bovine Respiratory Disease (BRD) Diagnosis and Prognosis: A Comprehensive Overview
Kamel, M. S., Davidson, J. L., & Verma, M. S. (2024) · Animals · doi:10.3390/ani14040627 · Cited by 76 · see citing works
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Cerón, J. M. C. (2019) · BMC Veterinary Research · doi:10.1186/s12917-019-1931-8 · Cited by 54 · see citing works
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El-Deeb, W., Elsohaby, I., Fayez, M., Mkrtchyan, H. V., El-Etriby, D., & ElGioushy, M. (2020) · Acta Tropica · doi:10.1016/j.actatropica.2020.105336 · Cited by 50 · see citing works
The use of inflammatory markers as a diagnostic and prognostic approach in neonatal calves with septicaemia
Kirbaş, A., Kandemır, F. M., Çelebi, D., Hanedan, B., & Timurkan, M. Ö. (2019) · Acta Veterinaria Hungarica · doi:10.1556/004.2019.037 · Cited by 47 · see citing works
Short term feeding of industrial hemp with a high cannabidiolic acid (CBDA) content increases lying behavior and reduces biomarkers of stress and inflammation in Holstein steers
Kleinhenz, M. D., Weeder, M. M., Montgomery, S. R., Martin, M. S., Curtis, A. K., Magnin, G., Lin, Z., Griffin, J., & Coetzee, J. F. (2022) · Scientific Reports · doi:10.1038/s41598-022-07795-z · Cited by 46 · see citing works
Macronutrient profile in milk replacer or a whole milk powder modulates growth performance, feeding behavior, and blood metabolites in ad libitum-fed calves
Wilms, J. N., Ghaffari, M. H., Steele, M. A., Sauerwein, H., Martín‐Tereso, J., & Leal, L. N. (2022) · Journal of Dairy Science · doi:10.3168/jds.2022-21870 · Cited by 33 · see citing works
Longitudinal blood transcriptomic analysis to identify molecular regulatory patterns of bovine respiratory disease in beef cattle
Sun, H., Srithayakumar, V., Jiminez, J. A., Jin, W., Hosseini, A., Raszek, M., Orsel, K., Guan, L. L., & Plastow, G. S. (2020) · Genomics · doi:10.1016/j.ygeno.2020.07.014 · Cited by 33 · see citing works
Biomarkers of sepsis in pigs, horses and cattle: from acute phase proteins to procalcitonin
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Martin, M. S., Kleinhenz, M. D., Montgomery, S. R., Blasi, D. A., Almes, K. M., Baysinger, A., & Coetzee, J. F. (2021) · Journal of Animal Science · doi:10.1093/jas/skab368 · Cited by 11 · see citing works
Dill tablet and Ocimum basilicum aqueous extract: Promising therapeutic agents for improving cognitive deficit in hypercholesterolemic rats
Mohammadali, S., Heshami, N., Komaki‬, A., Tayebinia, H., Oshaghi, E. A., Karimi, J., Hashemnia, M., & Khodadadi, I. (2020) · Journal of Food Biochemistry · doi:10.1111/jfbc.13485 · Cited by 11 · see citing works
Effect of source and journey on physiological variables in calves transported by road and ferry between Ireland and the Netherlands
van Dijk, L. L., Siegmann, S., Field, N. L., Sugrue, K., van Reenen, C. G., Bokkers, E. A. M., Sayers, G., & Conneely, M. (2023) · Frontiers in Veterinary Science · doi:10.3389/fvets.2023.1238734 · Cited by 10 · see citing works
“An acute phase response has been previously observed in calves coping with infection (41) or in response to acute stress (such as transport) (42).”
Background
The Effect of Metaphylactic Use of Tildipirosin for the Control of Respiratory Disease in Long-Distance Transported Dairy Calves
Celestino, M. L., Fernandes, L., Menta, P. R., Paiva, D., Ribeiro, T. L., Silva, T., Bilby, T. R., Neves, R. C., Ballou, M. A., & Machado, V. S. (2020) · Frontiers in Veterinary Science · doi:10.3389/fvets.2020.00632 · Cited by 10 · see citing works
Evaluation of haptoglobin concentration in clinically healthy dairy cows: correlation between serum and milk levels
Fouz, R., Rodríguez‐Bermúdez, R., Rodríguez-Godina, I. J., Domínguez, M. C. R., Rico, M., & Diéguez, F. J. (2024) · Journal of Applied Animal Research · doi:10.1080/09712119.2023.2300624 · Cited by 10 · see citing works
Comparison of physiological markers, behavior monitoring, and clinical illness scoring as indicators of an inflammatory response in beef cattle
Juge, A. E., Cooke, R. F., Ceja, G., Matt, M., & Daigle, C. (2024) · PLoS ONE · doi:10.1371/journal.pone.0302172 · Cited by 11 · see citing works
Treatment with 2 commercial antibiotics reduced clinical and systemic signs of pneumonia and the abundance of pathogenic bacteria in the upper respiratory tract of preweaning dairy calves
Tomazi, A. C. C. H., Tomazi, T., Bringhenti, L., Vinhal, A. P. A., Rodrigues, M. X., Bilby, T. R., Huson, H. J., & Bicalho, R. C. (2023) · Journal of Dairy Science · doi:10.3168/jds.2022-22451 · Cited by 10 · see citing works
Detection of haptoglobin and serum amyloid A as biomarkers in naturally infected Mycoplasma bovis calves
Saher, A. S., Raza, A., Qiu, F., Mehmood, K., Hussain, R., Qayyum, A., İdris, M., Almutairi, M. H., & Li, K. (2024) · Acta Tropica · doi:10.1016/j.actatropica.2024.107215 · Cited by 10 · see citing works
Comparative evaluation of different therapeutic protocols for contagious caprine pleuropneumonia in Himalayan Pashmina goats
Yatoo, M. I., Parray, O. R., Mir, M., Bhat, R. A., Malik, H. U., Fazili, M. R., Qureshi, S., Mir, M. S., Yousuf, R. W., Tufani, N. A., et al. (2019) · Tropical Animal Health and Production · doi:10.1007/s11250-019-01913-2 · Cited by 10 · see citing works
Associations between lung consolidation and serum amyloid A and haptoglobin, and the potential of acute phase proteins to differentiate primary respiratory tract pathogens in calves
Lowie, T., Jourquin, S., Stuyvaert, S., Hanley‐Cook, G., & Pardon, B. (2024) · Journal of Dairy Science · doi:10.3168/jds.2024-25093 · Cited by 9 · see citing works
Serum iron concentration is candidate inflammatory marker for respiratory diseases in beef cows
TSUKANO, K., FUKUDA, T., IKEDA, K., SATO, K., & SUZUKI, K. (2021) · Journal of Veterinary Medical Science · doi:10.1292/jvms.21-0051 · Cited by 8 · see citing works
l-Glutamine supplementation reduces gastrointestinal permeability and biomarkers of physiological stress in preweaning Holstein heifer calves
Ceja, G., Boerman, J. P., Neves, R. C., Jorgensen, M. W., & Johnson, J. S. (2023) · Journal of Dairy Science · doi:10.3168/jds.2023-23334 · Cited by 8 · see citing works
Oxidative stress in calves with enzootic pneumonia
Özbek, M. C., & Özkan, C. (2020) · TURKISH JOURNAL OF VETERINARY AND ANIMAL SCIENCES · doi:10.3906/vet-2007-17 · Cited by 8 · see citing works
Cattle Diseases - Molecular and Biochemical Approach
Kükürt, A., & Gelen, V. (2022) · Veterinary medicine and science · doi:10.5772/intechopen.104145 · Cited by 7 · see citing works
Ultrasonographic diagnosis of clinical and subclinical bovine respiratory disease in Holstein calves
Mahmoud, A. E., Fathy, A., Ahmed, E. A., Ali, A. O., Abdelaal, A. M., & El-Maghraby, M. M. (2022) · Veterinary World · doi:10.14202/vetworld.2022.1932-1942 · Cited by 6 · see citing works
Clinical Significance of Some Acute Phase Proteins in Cattle
Bozukluhan, K., & MERHAN, O. (2022) · Veterinary medicine and science · doi:10.5772/intechopen.108152 · Cited by 6 · see citing works
Association of Bovine Respiratory Disease during the Pre-Weaning Period with Blood Cell Counts and Circulating Concentration of Metabolites, Minerals, and Acute Phase Proteins in Dairy Calves Transported to a Calf Raising Facility
Bielamowicz, L. P., Celestino, M. L., Menta, P. R., Fernandes, L., Ballou, M., Neves, R. C., & Machado, V. S. (2024) · Animals · doi:10.3390/ani14131909 · Cited by 5 · see citing works
Associations of Neonatal Dairy Calf Faecal Microbiota with Inflammatory Markers and Future Performance
Loch, M., Dorbek-Kolin, E., Husso, A., Pessa‐Morikawa, T., Niine, T., Kaart, T., Mõtus, K., Niku, M., & Orro, T. (2024) · Animals · doi:10.3390/ani14172533 · Cited by 5 · see citing works
Evaluation of Fetal Heart Serum Amyloid a Concentrations in Infectious Cattle Abortion Cases
Aras, Z., & Yavuz, O. (2022) · Heliyon · doi:10.1016/j.heliyon.2022.e11330 · Cited by 5 · see citing works
Observational study: effect of varying transport durations and feed withdrawal on the physiological status and health of dairy calves
van Dijk, L. L., Siegmann, S., Field, N. L., Sugrue, K., van Reenen, C. G., Bokkers, E. A. M., Conneely, M., & Sayers, G. (2025) · Irish Veterinary Journal · doi:10.1186/s13620-025-00287-2 · Cited by 4 · see citing works
“SAA was lower in the INT group than in the NLD group at arrival, contrary to expectation; SAA has several physiological roles [37], and from a research perspective is commonly used as a biomarker of the primordial acute phase response and as a diagnostic tool for BRD [38].”
Identification of diagnostic biomarkers of and immune cell infiltration analysis in bovine respiratory disease
Sheng, H., Zhang, J., Shi, X., Zhang, L., Yao, D., Zhang, P., Li, Y., Zhang, J., Guo, X., & Zhang, X. (2025) · Frontiers in Veterinary Science · doi:10.3389/fvets.2025.1556676 · Cited by 4 · see citing works
Subcutaneous lysophosphatidylcholine administration promotes a febrile and immune response in Holstein heifer calves
Tate, B. N., Deys, M. M., Gutierrez-Oviedo, F. A., Ferguson, A. D., Zang, Y., Bradford, B. J., Deme, P., Haughey, N. J., & McFadden, J. W. (2023) · Journal of Dairy Science · doi:10.3168/jds.2023-23688 · Cited by 4 · see citing works
Structural characteristics of circulating immune complexes in calves with bronchopneumonia: Impact on the quiescent leukocytes
Kovačić, M. V., Fratrić, N. P., Arsić, A., Mojsilović, S. B., Drvenica, I. T., Marković, D. C., Maslovarić, I. S., Grujić-Milanović, J. D., Ivanov, M., & Ilić, V. L. (2020) · Research in Veterinary Science · doi:10.1016/j.rvsc.2020.09.004 · Cited by 4 · see citing works
Evaluation of local expressions of acute phase proteins in white muscle disease in lambs by the immunohistochemical method
Karataş, Ö., & Akçakavak, G. (2024) · Revista Científica de la Facultad de Ciencias Veterinarias · doi:10.52973/rcfcv-e34313 · Cited by 4 · see citing works
Clinical Efficacy of Antimicrobial Agents in Combination with Flunixin Meglumine and Phenylbutazone on Acute Phase Response in Respiratory Disease of Calves
El‐Deeb, W. (2021) · Pakistan Veterinary Journal · doi:10.29261/pakvetj/2020.078 · Cited by 4 · see citing works
Sığırların Solunum Sistemi Hastalığı Kompleksinde Kardiyak Hasarın Belirlenmesinde Serum H-FABP ve NT-proBNP Düzeylerinin Tanısal Değeri
Değirmençay, Ş. (2023) · Kafkas Universitesi Veteriner Fakultesi Dergisi · doi:10.9775/kvfd.2022.28624 · Cited by 3 · see citing works
Proteomic Serum Profiling of Holstein Friesian Cows with Different Pathological Forms of Bovine Paratuberculosis Reveals Changes in the Acute-Phase Response and Lipid Metabolism
León, A. I. N., Muñoz, M., Iglesias, N., Vázquez, C. B., Balseiro, A., Santos, F. M., Ciordia, S., Corrales, F. J., Iglesias, T., & Casais, R. (2023) · Journal of Proteome Research · doi:10.1021/acs.jproteome.3c00244 · Cited by 3 · see citing works
Self-Administration of Meloxicam via Medicated Molasses Lick Blocks May Improve Welfare of Castrated Calves
Rudd, S., Lomax, S., White, P., & der Saag, D. V. (2025) · Animals · doi:10.3390/ani15030442 · Cited by 3 · see citing works
Dogs' ability to detect an inflammatory immune response in cattle via olfaction
Juge, A. E., Hall, N. J., Richeson, J. T., Cooke, R. F., & Daigle, C. L. (2024) · Frontiers in Veterinary Science · doi:10.3389/fvets.2024.1393289 · Cited by 3 · see citing works
Review and comprehensive analysis of knowledge, tools, and implementation gaps for the control of contagious bovine pleuropneumonia
Manso-Silván, L., Amanfu, W., Apolloni, A., Comtet, L., Heller, M., Muuka, G. M., Rafi, L., Rich, K. M., Sacchini, F., Schieck, E., et al. (2025) · BMC Veterinary Research · doi:10.1186/s12917-025-04979-3 · Cited by 2 · see citing works
Assessment of pulmonary function test, acute phase proteins, cytokines and electrocardiographic changes in naturally occurring bovine respiratory disease of feedlot cattle calves
ramadan, M., Abdel-Raoof, Y., Zeineldin, M. M., Attar, H. E. E., abdelghany, A., & Ghanem, M. (2019) · Benha Veterinary Medical Journal · doi:10.21608/bvmj.2019.16768.1089 · Cited by 2 · see citing works
Modified-live versus inactivated respiratory viral vaccines for revaccinating beef calves at weaning
McNeff, C., Robison, C. A., Wilson, B. K., White, F. J., Cauble, R., Biggs, R. S., Salak‐Johnson, J. L., & Beck, P. A. (2023) · Applied Animal Science · doi:10.15232/aas.2022-02332 · Cited by 2 · see citing works
Overview on Brucellosis in Camels
(2023) · Egyptian Journal of Animal Health · doi:10.21608/ejah.2023.314382 · Cited by 2 · see citing works
Study of the Genetic Expression of Antiretroviral Restriction Factors and Acute Phase Proteins in Cattle Infected with Bovine Leukemia Virus
Méndez, A. S. G., Pérez, J., Anaya, E. R., & Álvarez, H. R. (2023) · Pathogens · doi:10.3390/pathogens12040529 · Cited by 2 · see citing works
A journey to improve robustness of veal calves
Marcato, F. (2021) · doi:10.18174/542457 · Cited by 2 · see citing works
Haptoglobin response in serum and pleural fluid of tuberculin reactor cattle assessed by culture and gross pathology
Didkowska, A., Klich, D., Matusik, K., Wilczek, M., Anusz, K., & Krajewska‐Wędzina, M. (2025) · The Veterinary Journal · doi:10.1016/j.tvjl.2025.106453 · Cited by 1 · see citing works
Comparison of thoracic ultrasonography (TUS), clinical respiratory scoring (CRS), and blood analysis to evaluate respiratory dysfunction in transported calves
van Dijk, L. L., Siegmann, S., Field, N. L., Sugrue, K., van Reenen, C. G., Bokkers, E. A. M., Sayers, G., & Conneely, M. (2026) · PLoS ONE · doi:10.1371/journal.pone.0337418 · Cited by 1 · see citing works
Acute Phase Proteins (Haptoglobin and Serum Amyloid A) and Pro-Inflammatory Cytokines (IL-12 and IL-10) in Cows Vaccinated with Prototype Killed S. aureus Mastitis Vaccine and Challenged with S. aureus Mastitis Infection.Preprint
Hambali, I. U., Jesse, F. F. A., Bhuttu, K. R., Лила, А. М., Zakaria, Z., Haron, A. W., & Jeferi, M. N. (2020) · doi:10.21203/rs.2.20378/v1
Bayesian Framework of the sensitivity and specificity of five pneumonia detection methods in pre weaning calves
Decaris, N. (2021) · doi:10.11606/d.10.2021.tde-16032022-092500
Tropical study on Clinical and Host Cell Responses of Acute Phase Proteins, Pro-Inflammatory Cytokines and Antibodies’ in Lactating Dairy Cows Vaccinated and Challenged with S. aureusPreprint
Hambali, I. U., Abdullah, F. F. J., Bhutto, K. R., Lila, M. A. M., Zakaria, Z., Haron, A. W., & Norsidin, M. J. (2022) · Research Square · doi:10.21203/rs.3.rs-2303938/v1
A STUDY ON DIAGNOSTIC AND PROGNOSTIC ROLE OF PERIOSTIN IN RESPIRATORY SYSTEM DISEASE COMPLEX IN CALVES
Baran, D., & Keleş, İ. (2024) · Sağlık Bilimleri Dergisi · doi:10.34108/eujhs.1367430
Serum Amyloid A and Haptoglobin concentrations in calves at first event of respiratory disease were not associated with subsequent risk of respiratory disease during the preweaning period
Møller, H. H., Petersen, M. B., Krogh, M. A., Nielsen, L. R., & Capion, N. (2024) · The Veterinary Journal · doi:10.1016/j.tvjl.2024.106188
Serum haptoglobin fluctuation in calves with bovine respiratory disease complex
Nakamura, M., Koyama, T., Matsui, Y., SAWAMUKAI, Y., Sugiura, T., & MORIYOSHI, M. (2022) · Japanese Journal of Large Animal Clinics · doi:10.4190/jjlac.12.188
Effects of a protocol with herbal-blend-based products on the health and growth performance of dairy and beef-on-dairy calves before weaning
Moreira, D. M., Rocha, C., Bringhenti, L., & Machado, V. S. (2025) · Applied Animal Science · doi:10.15232/aas.2025-02749
Peripheral leukocyte transcriptomic changes in preweaned Holstein heifer calves with varying stages of Bovine Respiratory Disease
Makratzakis, L. C., Velasco, J. A., Stegelmeier, N. C., Ficklin, S. P., Hinnant, H. R., Elder, L. A., Mandella, C. M., Leeson, R. A., Fisher, C. D., Slanzon, G. S., et al. (2026) · PLoS ONE · doi:10.1371/journal.pone.0349348

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Møller, H. H., Petersen, M. B., Krogh, M. A., Nielsen, L. R., & Capion, N. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4712474
Serum Amyloid A and Haptoglobin concentrations in calves at first event of respiratory disease were not associated with subsequent risk of respiratory disease during the preweaning period
Møller, H. H., Petersen, M. B., Krogh, M. A., Nielsen, L. R., & Capion, N. (2024) · The Veterinary Journal · doi:10.1016/j.tvjl.2024.106188
Association of Plasma Haptoglobin Concentration and Other Biomarkers with Bovine Respiratory Disease Status in Pre-Weaned Dairy Calves
Moisá, S. J., Aly, S. S., Lehenbauer, T. W., Love, W. J., Rossitto, P. V., Van Eenennaam, A. L., Trombetta, S. C., Bortoluzzi, E. M., & Hulbert, L. E. (2019) · Journal of Veterinary Diagnostic Investigation · doi:10.1177/1040638718807242 · Cited by 43 · see citing works
Use of procalcitonin, neopterin, haptoglobin, serum amyloid A and proinflammatory cytokines in diagnosis and prognosis of bovine respiratory disease in feedlot calves under field conditions
El-Deeb, W., Elsohaby, I., Fayez, M., Mkrtchyan, H. V., El-Etriby, D., & ElGioushy, M. (2020) · Acta Tropica · doi:10.1016/j.actatropica.2020.105336 · Cited by 50 · see citing works
Associations between lung consolidation and serum amyloid A and haptoglobin, and the potential of acute phase proteins to differentiate primary respiratory tract pathogens in calves
Lowie, T., Jourquin, S., Stuyvaert, S., Hanley‐Cook, G., & Pardon, B. (2024) · Journal of Dairy Science · doi:10.3168/jds.2024-25093 · Cited by 9 · see citing works

Authors: Joshi, V., Gupta, V. K., Bhanuprakash, A. G., Mandal, R. S. K., Dimri, U., & Ajith, Y.
Affiliations: Indian Council of Agricultural Research (IN)
Indian Veterinary Research Institute (IN)
Corresponding author: Joshi, Vivek
ORCID: Joshi, Vivek
Gupta, V.K.
Mandal, R.S.K.
Dimri, U.
Ajith, Y.
Venue: Microbial Pathogenesis
Publisher: Elsevier BV
Published: 2018-03
Volume: 116
Pages: 33-37
ISSN: 0882-4010 (ISSN-L)
DOI: 10.1016/j.micpath.2018.01.001
OpenAlex: W2783512097
Cited by: 75
References: 50
Citations by year: 2026: 2 · 2025: 6 · 2024: 12 · 2023: 11 · 2022: 14 · 2021: 12 · 2020: 12 · 2019: 6
FWCI: 10.99
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Microbial Pathogenesis (publishedVersion)
PubMed (publishedVersion)
Funders: ICAR-Indian Veterinary Research Institute, Izatnagar
Topics: Health Sciences › Veterinary › Small Animals › Animal health and immunology
Life Sciences › Immunology and Microbiology › Microbiology › Microbial infections and disease research
Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
Keywords: bovine respiratory disease, dairy calves, haptoglobin, serum amyloid A, biomarkers, oxidative stress, acute phase proteins, lipid peroxidation, superoxide dismutase, catalase, reduced glutathione, serum albumin, treatment monitoring, clinical scoring systems
MeSH terms: Acute-Phase Proteins, Serum Amyloid A Protein, Animals, Cattle, Cattle Diseases, Haptoglobins, Respiratory Tract Infections, Biomarkers, Oxidative Stress

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Haptoglobin and serum amyloid A as putative biomarker candidates of naturally occurring bovine respiratory disease in dairy calves

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