A whitened face woman with nephrotic syndrome
Abstract
Skin whitening cream from developing countries is a recognized source of chronic mercury poisoning. The authors report on a 34-year-old Indonesian domestic helper who presented with nephrotic syndrome secondary to membranous nephropathy. It was subsequently found that she used a skin whitening cream regularly that was found to contain a mercury level of almost 2,000 times above the allowable limit. Her blood and urinary mercury levels were both grossly elevated. Her symptoms improved after she stopped using the cream. However, she returned to her home country before chelating therapy could be arranged. Because mercury-containing skin products are still widely available in developing countries, the use of these products should be considered a possible cause of membranous nephropathy in immigrants from those countries.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Use of products like Deluxe Silken can lead to symptoms of mercury poisoning including Nephrotic Syndrome.
“Deluxe Silken is approximately 14,000 times the recommended limit for Mercury and use of products of this kind can lead to symptoms of Mercury poisoning including Nephrotic Syndrome as have been documented in the US,14,29 Barbados5 and Indonesia.30”
Cites
Goldfrank's Toxicologic Emergencies.
(1986) · Annals of Internal Medicine · doi:10.7326/0003-4819-105-2-323 · Cited by 1,279 · see citing works
Mercury poisoning associated with a Mexican beauty cream
Weldon, M. (2000) · Western Journal of Medicine · doi:10.1136/ewjm.173.1.15 · Cited by 127 · see citing works
Membranous nephropathy due to skin-lightening cream.
Kibukamusoke, J. W., Davies, D. E., & Hutt, M. S. R. (1974) · BMJ · doi:10.1136/bmj.2.5920.646 · Cited by 88 · see citing works
Fournié, G. J., Mas, M., Cautain, B., Savignac, M., Subra, J., Pelletier, L., Saoudi, A., Lagrange, D., Calise, M., & Druet, P. (2001) · Journal of Autoimmunity · doi:10.1006/jaut.2000.0482 · Cited by 83 · see citing works
Membranous nephropathy caused by mercury-containing skin lightening cream
Oliveira, D. B. G., Foster, G., Savill, J., et al. (1987) · Postgraduate Medical Journal · doi:10.1136/pgmj.63.738.303 · Cited by 74 · see citing works
The neurotoxicity of alkyl mercury compounds
Dales, L. G. (1972) · The American Journal of Medicine · doi:10.1016/0002-9343(72)90131-3 · Cited by 61 · see citing works
Short report: Mercury intoxication presenting with tics
Li, A. M. C. (2000) · Archives of Disease in Childhood · doi:10.1136/adc.83.2.174 · Cited by 59 · see citing works
Wide use of skin-lightening soap may cause mercury poisoning in Kenya
Harada, M., Nakachi, S., Tasaka, K., Sakashita, S., Muta, K., Yanagida, K., Doi, R., Kizaki, T., & Ohno, H. (2001) · The Science of The Total Environment · doi:10.1016/s0048-9697(00)00812-3 · Cited by 58 · see citing works
Membranous nephropathy from exposure to mercury in the fluorescent‐tube‐recycling industry
Aymaz, S., Groß, O., Krakamp, B., et al. (2001) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/16.11.2253 · Cited by 54 · see citing works
Magos, L. (1975) · British Medical Bulletin · doi:10.1093/oxfordjournals.bmb.a071293 · Cited by 54 · see citing works
Cytokine regulation of a rodent model of mercuric chloride-induced autoimmunity.
Bagenstose, L. M., Salgame, P., & Monestier, M. (1999) · Environmental Health Perspectives · doi:10.1289/ehp.99107s5807 · Cited by 37 · see citing works
Coers, W., Vos, J. T. W. M., van der Meide, P. H., et al. (1995) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.1995.tb03781.x · Cited by 34 · see citing works
An unusual case of mercury intoxication
Chan, M. H. M., Cheung, R. C. K., Chan, I. H. S., et al. (2001) · British Journal of Dermatology · doi:10.1046/j.1365-2133.2001.03978.x · Cited by 26 · see citing works
Self-citationIcard, P., Pelletier, L., Vial, M. C., et al. (1993) · Nephrology Dialysis Transplantation · doi:10.1093/oxfordjournals.ndt.a092403 · Cited by 24 · see citing works
Percutaneous mercury poisoning with a beauty cream in Mexico
Tlacuilo‐Parra, A., Guevara-Gutirrez, E., & Luna-Encinas, J. A. (2001) · Journal of the American Academy of Dermatology · doi:10.1067/mjd.2001.l17243 · Cited by 24 · see citing works
Nephrotic syndrome due to ammoniated mercury.
Jl, T., & Baker, H. (1968) · PubMed · Cited by 23 · see citing works
Zimmer, L. J., & Carter, D. E. (1978) · Life Sciences · doi:10.1016/0024-3205(78)90662-8 · Cited by 19 · see citing works
Charpentier, B., Moullot, P., Faux, N., et al. (1981) · PubMed · Cited by 10 · see citing works
(1996) · PubMed · Cited by 9 · see citing works
Nephrotic syndrome in two members of a family with mercury poisoning.
Meeks, A., Pr, K., & Ms, T. (1990) · PubMed · Cited by 8 · see citing works
Letter: Nephrotic syndrome due to cosmetics containing mercury.
Seedat, Y. K., Simjee, A. E., & Dv, N. (1974) · PubMed · Cited by 7 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Widespread Use of Toxic Skin Lightening Compounds: Medical and Psychosocial Aspects
Ladizinski, B., Mistry, N., & Kundu, R. V. (2011) · Dermatologic Clinics · doi:10.1016/j.det.2010.08.010 · Cited by 156 · see citing works
Mercury Levels in Locally Manufactured Mexican Skin-Lightening Creams
Peregrino, C. P., Moreno, M. V., Miranda, S. V., Rubio, A. D., & Leal, L. O. (2011) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph8062516 · Cited by 90 · see citing works
Irfan, M., Shafeeq, A., Siddiq, U., Bashir, F., Ahmad, T., Athar, M., Butt, M. T., Ullah, S., Mukhtar, A., Hussien, M., et al. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.128806 · Cited by 63 · see citing works
Mohammed, T., Mohammed, E., & Bascombe, S. (2017) · Journal of Public Health Research · doi:10.4081/jphr.2017.1097 · Cited by 50 · see citing works
Al-Saleh, I., El-Doush, I., Shinwari, N., Al-Baradei, R., Khogali, F., & Al-Amodi, M. (2005) · Cutaneous and Ocular Toxicology · doi:10.1081/cus-200046179 · Cited by 27 · see citing works
- Authors
- Soo, Y. O.-Y., Chow, K.-M., Lam, C. W.-K., Lai, F. M.-M., Szeto, C.-C., Chan, M. H.-M., & Li, P. K.-T.
- Affiliations
- Chinese University of Hong Kong (HK)
- Venue
- American Journal of Kidney Diseases
- Publisher
- Elsevier BV
- Published
- 2003-01
- Volume
- 41
- Issue
- 1
- Pages
- 250-253
- ISSN
- 0272-6386 (ISSN-L)
- OpenAlex
- W1988884276
- Cited by
- 69
- References
- 21
- Citations by year
- 2025: 1 · 2024: 2 · 2022: 6 · 2020: 3 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 3 · 2015: 7 · 2014: 7 · 2013: 4 · 2012: 2
- FWCI
- 2.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Kidney Diseases (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Nephrology › Renal Diseases and Glomerulopathies
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Mercury impact and mitigation studies
- Keywords
- nephrotic syndrome, membranous nephropathy, mercury toxicity, skin bleaching creams, urinary mercury, blood mercury, chelation therapy, immigrant health, developing countries
- MeSH terms
- Adult, Ankle, Cosmetics, Cultural Characteristics, Edema, Emigration and Immigration, Face, Female, Hong Kong, Humans, Mercury, Mercury Poisoning, Nephrotic Syndrome, Glomerulonephritis, Membranous
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review