Improvements in GORE-TEX® vascular graft performance by Carmeda® bioactive surface heparin immobilization
Open accessAbstract
Objectives a performance improvement in small-diameter bypass grafts remains a clinical objective. The purpose of the present investigation was to evaluate the potential of enhancing the thromboresistance of ePTFE grafts using a bioactive heparinized graft luminal surface in a canine model.Material and methods this study investigated the utility of heparin immobilization onto expanded polytetrafluoroethylene using Carmeda BioActive Surface technology (CBAS-ePTFE) as a means of improving vascular graft thromboresistance. Graft luminal surfaces were covered uniformly with the stably bound, end-point immobilized heparin.Results acute canine (5 greyhounds) interposition experiments comparing CBAS-ePTFE grafts to control ePTFE grafts showed that CBAS-ePTFE grafts remained patent and had significantly greater thrombus-free luminal surface (p<0.05). In a chronic canine (16 greyhounds) interposition experiment, significantly improved patency (p<0.05) was observed with CBAS-ePTFE grafts compared to controls. Long-term in vivo heparin bioactivity was demonstrated on CBAS-ePTFE grafts explanted between 1 and 12 weeks. On all CBAS-ePTFE grafts, heparin activity levels ranged from 15-25pmol/cm(2) and did not differ significantly (p>0.05).Discussion these results support the conclusion that a stable, CBAS-ePTFE surface provides improved thromboresistance and improved patency in canine interposition models. Maintenance of heparin catalytic activity on the graft surface in vivo likely contributes to this outcome and holds promise for the utility of this graft surface for clinical applications.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Heparin covalently linked to vascular graft surfaces via end-point immobilization has been commercialized for ePTFE and Dacron grafts.
“Heparin has also been covalently linked to the surface of vascular grafts via end-point immobilization and this approach has been commercialized for expanded polytetrafluoroethylene (ePTFE) and Dacron grafts.37–39”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [38]
Cites
Veith, F. J., Gupta, S. K., Ascer, E., White-Flores, S. A., Samson, R. H., Scher, L. A., Towne, J. B., Bernhard, V. M., Bonier, P., Flinn, W. R., et al. (1986) · Journal of Vascular Surgery · doi:10.1016/0741-5214(86)90073-x · Cited by 1,105 · see citing works
Serruys, P. W. J. C., van Hout, B., Bonnier, H. J. R. M., Legrand, V., García, E., Macaya, C., Sousa, E., van der Giessen, W. J., Colombo, A., Seabra-Gomes, R. J., et al. (1998) · The Lancet · doi:10.1016/s0140-6736(97)11128-x · Cited by 649 · see citing works
Statistical Methods for Survival Data Analysis.
Saggu, P. S., & Lee, E. T. (1994) · Journal of the Royal Statistical Society Series D (The Statistician) · doi:10.2307/2348154 · Cited by 628 · see citing works
Guide to Anticoagulant Therapy: Heparin
Hirsh, J., Anand, S. S., Halperin, J. L., et al. (2001) · Circulation · doi:10.1161/01.cir.103.24.2994 · Cited by 567 · see citing works
Heparin-Coated Palmaz-Schatz Stents in Human Coronary Arteries
Serruys, P. W. J. C., Emanuelsson, H., van der Giessen, W. J., et al. (1996) · Circulation · doi:10.1161/01.cir.93.3.412 · Cited by 408 · see citing works
Vascular surgery : a comprehensive review
Moore, W. S. (1983) · Cited by 192 · see citing works
Endovascular surgery: Current concepts and its importance to the vascular surgeon
Ahn, S. S. (1992) · European Journal of Vascular Surgery · doi:10.1016/s0950-821x(05)80085-4 · Cited by 152 · see citing works
Quiñones‐Baldrich, W. J., Prego, A. A., Ucelay-Gómez, R., et al. (1992) · Journal of Vascular Surgery · doi:10.1016/0741-5214(92)90109-l · Cited by 128 · see citing works
Heparin-coated circuits reduce activation of granulocytes during cardiopulmonary bypass
Borowiec, J. W., Thelin, S., Bagge, L., et al. (1992) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(19)34730-0 · Cited by 125 · see citing works
Devine, C., Hons, B., & McCollum, C. N. (2001) · Journal of Vascular Surgery · doi:10.1067/mva.2001.113578 · Cited by 107 · see citing works
Studies of Adsorption, Activation, and Inhibition of Factor XII on Immobilized Heparin
Sánchez, J., Elgue, G., Riesenfeld, J., et al. (1998) · Thrombosis Research · doi:10.1016/s0049-3848(97)00310-1 · Cited by 96 · see citing works
Assay of plasma heparin using thrombin and the chromogenic substrate H-D-Phe-Pip-Arg-pNA (S-2238)
Larsen, M. L., Abildgaard, U., Teien, A. N., et al. (1978) · Thrombosis Research · doi:10.1016/0049-3848(78)90016-6 · Cited by 83 · see citing works
Fukutomi, M., Kobayashi, S., Niwaya, K., et al. (1996) · Artificial Organs · doi:10.1111/j.1525-1594.1996.tb04538.x · Cited by 77 · see citing works
Vroman, L. (1988) · PubMed · Cited by 76 · see citing works
Design of Nonthrombogenic Polymer Surfaces for Blood-Contacting Medical Devices
Kim, S. W., & Jacobs, H. A. (2008) · Blood Purification · doi:10.1159/000170288 · Cited by 73 · see citing works
Principles of heparin-coating techniques
Hsu, L.-C. (1991) · Perfusion · doi:10.1177/026765919100600310 · Cited by 52 · see citing works
Kocsis, J. F., Llanos, G. R., & Holmer, E. (2000) · Journal of Long-Term Effects of Medical Implants · doi:10.1615/jlongtermeffmedimplants.v10.i12.50 · Cited by 50 · see citing works
Surface modification with functionally active heparin.
Riesenfeld, J., Olsson, P.-I., Sánchez, J., et al. (1995) · PubMed · Cited by 37 · see citing works
Heparin coating of vascular prostheses reduces thromboemboli
Ritter, E. F., Kim, Y. B., Reischl, H. P., Serafín, D., Rudner, A. M., & Klitzman, B. M. (1997) · Surgery · doi:10.1016/s0039-6060(97)90329-9 · Cited by 34 · see citing works
Binding of antithrombin to immobilized heparin under varying flow conditions.
Pasche, B., Elgue, G., Olsson, P., et al. (1991) · PubMed · Cited by 34 · see citing works
Long-term stability in vivo of a thromboresistant heparinized surface
Arnander, C., Bagger‐Sjöbäck, D., Frebelius, S., et al. (1987) · Biomaterials · doi:10.1016/0142-9612(87)90088-3 · Cited by 33 · see citing works
Platelet Compatibility of an Artificial Surface Modified with Functionally Active Heparin
Videm, V., Christiansen, D., Bergseth, G., et al. (1999) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1614342 · Cited by 30 · see citing works
Bozdayi, M. A., Borowiec, J. W., Nilsson, L., et al. (1996) · Artificial Organs · doi:10.1111/j.1525-1594.1996.tb04588.x · Cited by 20 · see citing works
Serruys, P. W., Grines, C., Stone, G., et al. (1998) · International Journal of Cardiovascular Interventions · doi:10.1080/acc.1.1.19.27 · Cited by 18 · see citing works
Dzavik, V., Carere, R. G., Kk, T., et al. (1998) · PubMed · Cited by 14 · see citing works
Arterial substitutes in peripheral vascular surgery: a review.
Gl, M., & Porter, J. M. (1995) · PubMed · Cited by 14 · see citing works
Björck, C.-G., Bergqvist, D., Esquivel, C. O., et al. (1986) · Thrombosis Research · doi:10.1016/0049-3848(86)90339-7 · Cited by 8 · see citing works
Clinical evidence of improved biocompatibility using heparin-coated surfaces
Matheve, C. (1996) · Perfusion · doi:10.1177/026765919601100312 · Cited by 7 · see citing works
Heparinization of polytetrafluoroethylene (ePTFE) grafts. The effect on pseudointimal hyperplasia.
Bergqvist, D., Jensen, N., & Nh, P. (1988) · PubMed · Cited by 7 · see citing works
New methods for surface modification and covalent attachment of heparin.
Al-Lamee, K. G., & Taktak, Y. (1998) · PubMed · Cited by 3 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Wo, Y., Brisbois, E. J., Bartlett, R. H., & Meyerhoff, M. E. (2016) · Biomaterials Science · doi:10.1039/c6bm00271d · Cited by 251 · see citing works
Incorporation of heparin into biomaterials
Sakiyama-Elbert, S. E. (2014) · Acta Biomaterialia · doi:10.1016/j.actbio.2013.08.045 · Cited by 222 · see citing works
Novel thromboresistant materials
Jordan, S. W., & Chaikof, E. L. (2007) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2007.02.048 · Cited by 153 · see citing works
- Authors
- Begovac, P. C., Thomson, R. C., Fisher, J. L., Hughson, A., & Gällhagen, A.
- Affiliations
- W. L. Gore & Associates (United States) (US)
- Corresponding author
- Begovac, P.C.
- Venue
- European Journal of Vascular and Endovascular Surgery
- Publisher
- Elsevier BV
- Published
- 2003-05
- Volume
- 25
- Issue
- 5
- Pages
- 432-437
- ISSN
- 1078-5884 (ISSN-L)
- OpenAlex
- W1966905436
- Cited by
- 198
- References
- 30
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 8 · 2023: 8 · 2022: 14 · 2021: 10 · 2020: 16 · 2019: 6 · 2018: 11 · 2017: 10 · 2016: 14 · 2015: 12 · 2014: 10 · 2013: 7 · 2012: 12
- FWCI
- 3.32
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- European Journal of Vascular and Endovascular Surgery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Health Sciences › Medicine › Surgery › Peripheral Artery Disease Management
- Keywords
- expanded polytetrafluoroethylene, heparin immobilization, graft patency, interposition graft
- MeSH terms
- Analysis of Variance, Animals, Anticoagulants, Blood Vessel Prosthesis, Dogs, Graft Occlusion, Vascular, Heparin, Microscopy, Electron, Scanning, Polytetrafluoroethylene, Surface Properties, Vascular Patency, Coated Materials, Biocompatible
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
