Incorporation of heparin into biomaterials
Open accessAbstract
This review provides an overview of the incorporation of heparin into biomaterials with a focus on drug delivery and the use of heparin-based biomaterials for self-assembly of polymer networks. Heparin conjugation to biomaterials was originally explored to reduce the thrombogenicity of materials in contact with blood. Many of the conjugation strategies that were developed for these applications are still popular today for other applications. More recently heparin has been conjugated to biomaterials for drug delivery applications. Many of the delivery approaches have taken advantage of the ability of heparin to bind to a wide variety of growth factors, protecting them from degradation and potentiating interactions with cell surface receptors. More recently, the use of heparin as a base polymer for scaffold fabrication has also been explored, often utilizing non-covalent binding of heparin with peptides or proteins to promote self-assembly of hydrogel networks. This review will highlight recent advances in each of these areas.
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Heparin covalently linked to vascular graft surfaces via end-point immobilization has been commercialized for ePTFE and Dacron grafts.
“Heparin has also been covalently linked to the surface of vascular grafts via end-point immobilization and this approach has been commercialized for expanded polytetrafluoroethylene (ePTFE) and Dacron grafts.37–39”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [37]
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- Authors
- Sakiyama-Elbert, S. E.
- Venue
- Acta Biomaterialia
- Publisher
- Elsevier BV
- Published
- 2014-04
- Volume
- 10
- Issue
- 4
- Pages
- 1581-1587
- ISSN
- 1742-7061 (ISSN-L)
- PMC
- PMC3949739
- OpenAlex
- W2053179045
- Cited by
- 222
- References
- 98
- Citations by year
- 2026: 10 · 2025: 14 · 2024: 14 · 2023: 15 · 2022: 17 · 2021: 25 · 2020: 23 · 2019: 20 · 2018: 19 · 2017: 23 · 2016: 21 · 2015: 13 · 2014: 7 · 2013: 1
- FWCI
- 0.86
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Acta Biomaterialia (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS051454)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- heparin, biomaterials, drug delivery, thrombogenicity, heparin conjugation, growth factor binding, hydrogels, self-assembly, scaffolds, antithrombotic coatings
- MeSH terms
- Animals, Biocompatible Materials, Cell Differentiation, Heparin, Humans, Polymers, Drug Delivery Systems, Biomimetic Materials
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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