Oral naltrexone treatment for cholestatic pruritus: A double-blind, placebo-controlled study

Opioid peptides and primary biliary cirrhosis

Thornton, J. R., & Losowsky, M. S. (1988) · BMJ · doi:10.1136/bmj.297.6662.1501 · Cited by 300

Treatment of pruritus of primary biliary cirrhosis with rifampin

Podesta, A., Lopez, P., Terg, R., Villamil, F., Flores, D., Mastai, R., Udaondo, C. B., & Companc, J. P. (1991) · Digestive Diseases and Sciences · doi:10.1007/bf01300759 · Cited by 267

Effects of long-term rifampicin administration in primary biliary cirrhosis

Bachs, L., Parés, A., Elena, M., Piera, C., & Rodés, J. (1992) · Gastroenterology · doi:10.1016/0016-5085(92)90335-v · Cited by 235

Cholestyramine for long term relief of the pruritus complicating intrahepatic cholestasis

Datta, D. V., & Sherlock, S. (1966) · Gastroenterology · doi:10.1016/s0016-5085(66)80071-9 · Cited by 181

Liver transplantation: An overview

Maddrey, W. C., & Thiel, D. H. V. (1988) · Hepatology · doi:10.1002/hep.1840080440 · Cited by 154

Nalmefene: Intravenous safety and kinetics of a new opioid antagonist

Dixon, R., Howes, J. F., Gentile, J., Hsu, H., Hsiao, J. H., Garg, D. C., Weidler, D. J., Meyer, M. C., & Tuttle, R. R. (1986) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.1986.9 · Cited by 98

Pruritus in hepatic cholestasis. Pathogenesis and therapy

Garden, J. M. (1985) · Archives of Dermatology · doi:10.1001/archderm.121.11.1415 · Cited by 57

Pruritis associated with cholestasis

Khandelwal, M., & Malet, P. F. (1994) · Digestive Diseases and Sciences · doi:10.1007/bf02090052 · Cited by 46

The Pruritus of Cholestasis

Bergasa, N. V., & Jones, E. A. (1993) · Seminars in Liver Disease · doi:10.1055/s-2007-1007360 · Cited by 36

Nalmefene therapy is associated with the relief of the pruritus of cholestasis: Results of a doubleblind randomized placebo-controlled trial

Bergasa, N. V. (1993) · Hepatology · doi:10.1016/0270-9139(93)92233-p · Cited by 8

The cannabinoid agonist WIN 55, 212-2 increases nociception threshold in cholestatic rats: implications for the treatment of the pruritus of cholestasis

Gingold, A. R., & Bergasa, N. V. (2003) · Life Sciences · doi:10.1016/s0024-3205(03)00668-4 · Cited by 43

Extrahepatic manifestations of cholestasis

Glasová, H., & Beuers, U. H. (2002) · Journal of Gastroenterology and Hepatology · doi:10.1046/j.1440-1746.2002.02717.x · Cited by 43

Clinical Efficacy and Safety of Naltrexone Combination Therapy in Older Patients with Severe Pruritus

Lee, J., Shin, J. U., Noh, S., Park, C. O., & Lee, K. H. (2016) · Annals of Dermatology · doi:10.5021/ad.2016.28.2.159 · Cited by 42

Psyche, opioids, and itch: therapeutic consequences

Krishnan, A., & Koo, J. Y. M. (2005) · Dermatologic Therapy · doi:10.1111/j.1529-8019.2005.00038.x · Cited by 41

Exaggerated levothyroxine malabsorption due to calcium carbonate supplementation in gastrointestinal disorders

Csako, G., McGriff, N. J., Rotman-Pikielny, P., Sarlis, N. J., & Pucino, F. (2001) · Annals of Pharmacotherapy · doi:10.1345/aph.1a031 · Cited by 40

Current diagnosis and management of primary sclerosing cholangitis

Tischendorf, J. J. W., Geier, A., & Trautwein, C. (2008) · Liver Transplantation · doi:10.1002/lt.21456 · Cited by 40

Evaluation and Management of Pruritus in Primary Biliary Cholangitis

Düll, M. M., & Kremer, A. E. (2022) · Clinics in Liver Disease · doi:10.1016/j.cld.2022.06.009 · Cited by 41

Medical and Nutritional Management of Cholestasis in Infants and Children

Feranchak, A. P., & Sokol, R. J. (2007) · Cambridge University Press eBooks · doi:10.1017/cbo9780511547409.012 · Cited by 40

Pharmacological interventions for pruritus in adult palliative care patients

Xander, C. J., Meerpohl, J. J., Galandi, D., Buroh, S., Schwarzer, G., Antes, G., & Becker, G. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008320.pub2 · Cited by 40

BAT117213: Ileal bile acid transporter (IBAT) inhibition as a treatment for pruritus in primary biliary cirrhosis: study protocol for a randomised controlled trial

Hegade, V. S., Kendrick, S. F. W., Dobbins, R. L., Miller, S. R., Richards, D. B., Storey, J. R., Dukes, G. E., Gilchrist, K., Vallow, S., Alexander, G., et al. (2016) · BMC Gastroenterology · doi:10.1186/s12876-016-0481-9 · Cited by 39

Pruritus in advanced internal diseases Pathogenesis and treatment

Krajnik, M. (2001) · The Netherlands Journal of Medicine · doi:10.1016/s0300-2977(00)00084-x · Cited by 39

Innovative Management of Pruritus

Feramisco, J. D., Berger, T. G., & Steinhoff, M. S. (2010) · Dermatologic Clinics · doi:10.1016/j.det.2010.03.004 · Cited by 39

An evidence‐based review of systemic treatments for itch

Pongcharoen, P., & Fleischer, A. B. (2015) · European Journal of Pain · doi:10.1002/ejp.766 · Cited by 38

Newer Approaches to the Management of Pruritus in Cholestatic Liver Disease

Düll, M. M., & Kremer, A. E. (2020) · Current Hepatology Reports · doi:10.1007/s11901-020-00517-x · Cited by 42

Review article: current and emerging therapies for the management of cirrhosis and its complications

Tapper, E. B., Ufere, N. N., Huang, D. Q., & Loomba, R. S. (2022) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.16831 · Cited by 41

Opioid Antagonists in the Treatment of Pruritus from Cholestatic Liver Disease

Terra, S. G., & Tsunoda, S. M. (1998) · Annals of Pharmacotherapy · doi:10.1345/aph.18115 · Cited by 38

Pruritus in cancer patients

Lidstone, V., & Thorns, A. (2001) · Cancer Treatment Reviews · doi:10.1053/ctrv.2001.0231 · Cited by 38

Fosinopril-induced prolonged cholestatic jaundice and pruritus: first case report

Nunes, A. C. R., Amaro, P., Maçôas, F., Cipriano, A., Martins, I., Rosa, A., Pimenta, I., Donato, A., & Freitas, D. (2001) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-200103000-00011 · Cited by 38

Primary biliary cirrhosis: new perspectives in diagnosis and treatment

Prince, M. I., & Jones, D. E. J. (2000) · Postgraduate Medical Journal · doi:10.1136/pmj.76.894.199 · Cited by 37

Difelikefalin in the Treatment of Chronic Kidney Disease-Associated Pruritus: A Systematic Review

Wala, K., & Szepietowski, J. C. (2022) · Pharmaceuticals · doi:10.3390/ph15080934 · Cited by 35

Pruritus in patients with chronic human immunodeficiency virus, hepatitis B and C virus infections

Bonacini, M. (2000) · Digestive and Liver Disease · doi:10.1016/s1590-8658(00)80847-6 · Cited by 35

Management of Pruritus in Chronic Liver Disease

Bhalerao, A., & Mannu, G. (2015) · Dermatology Research and Practice · doi:10.1155/2015/295891 · Cited by 35

Spontaneous scratching behavior in MRL/lpr mice, a possible model for pruritus in autoimmune diseases, and antipruritic activity of a novel κ-opioid receptor agonist nalfurafine hydrochloride

Umeuchi, H., Kawashima, Y., Aoki, C. A., Kurokawa, T., Nakao, K., Itoh, M., Kikuchi, K., Kato, T., Okano, K., Gershwin, M. E., et al. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.06.019 · Cited by 34

Update on the Treatment of the Pruritus of Cholestasis

Bergasa, N. V. (2008) · Clinics in Liver Disease · doi:10.1016/j.cld.2007.11.009 · Cited by 33

Current management of primary biliary cirrhosis and primary sclerosing cholangitis

Levy, C., & Lindor, K. D. (2003) · Journal of Hepatology · doi:10.1016/s0168-8278(03)00006-0 · Cited by 32

Medical Treatment of Primary Biliary Cirrhosis and Primary Sclerosing Cholangitis

Holtmeier, J., & Leuschner, U. (2001) · Digestion · doi:10.1159/000048854 · Cited by 33

Cholestatic Pruritus Treatments in Primary Biliary Cholangitis and Primary Sclerosing Cholangitis: A Systematic Literature Review

Smith, H. T., de Souza, A. R., Thompson, A. H., McLaughlin, M., Dever, J. J., Myers, J. A., & Chen, J. V. (2023) · Digestive Diseases and Sciences · doi:10.1007/s10620-023-07862-z · Cited by 34

Fibrates for the treatment of cholestatic itch (FITCH): study protocol for a randomized controlled trial

Bolier, R., de Vries, E. S., Parés, A. R., Helder, J., Kemper, E. M., Zwinderman, K. H., Elferink, R. P. J. O., & Beuers, U. H. (2017) · Trials · doi:10.1186/s13063-017-1966-8 · Cited by 32

Use of Oral Naltrexone for Severe Pruritus Due to Cholestatic Liver Disease in Children

Zellos, A., Roy, A., & Schwarz, K. B. (2010) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e3181eb5ac0 · Cited by 30

Effective Treatment of Pruritus with Naltrexone, an Orally Active Opiate Antagonist

Metze, D., Reimann, S., & Luger, T. A. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb08705.x · Cited by 30

Cholestatic Itch: Our Current Understanding of Pathophysiology and Treatments

Does, A. V., Levy, C., & Yosipovitch, G. (2022) · American Journal of Clinical Dermatology · doi:10.1007/s40257-022-00710-2 · Cited by 32

Medical Palliation of the Jaundiced Patient with Pruritus

Bergasa, N. V. (2006) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2005.12.008 · Cited by 29

Advances in Pathogenesis and Treatment of Pruritus

Bolier, R., Elferink, R. P. J. O., & Beuers, U. H. (2012) · Clinics in Liver Disease · doi:10.1016/j.cld.2012.11.006 · Cited by 29

Peripheral Neuronal Mechanism of Itch: Histamine and Itch

Histamine and Itch Robin L. Thurmond, K. K. (2014) · CRC Press eBooks · doi:10.1201/b16573-14 · Cited by 28

Primary sclerosing cholangitis

Worthington, J., & Chapman, R. W. (2006) · Orphanet Journal of Rare Diseases · doi:10.1186/1750-1172-1-41 · Cited by 28

Multidisciplinary approach to benign biliary strictures

Costamagna, G., Familiari, P., Tringali, A., & Mutignani, M. (2007) · Current Treatment Options in Gastroenterology · doi:10.1007/s11938-007-0061-8 · Cited by 28

The molecular adsorbent recirculating system as a liver support system. Summary of Mexican experience

Cisneros-Garza, L. E., Muñoz-Ramírez, M. D. R., Muñoz-Espinosa, L. E., Velasco, J. A. V.-R., Moreno-Alcantar, R., Marín-López, E., & Méndez‐Sánchez, N. (2014) · Annals of Hepatology · doi:10.1016/s1665-2681(19)30887-7 · Cited by 27

European Guideline on Chronic Pruritus. In cooperation with the European Dermatology Forum (EDF)

Weißhaar, E., Müller, S., Szepietowski, J. C., Dalgard, F. J., Garcovich, S., Kupfer, J. P., Giménez‐Arnau, A. M., Lambert, J. R., Mettang, T., Misery, L., et al. (2025) · Acta Dermato Venereologica · doi:10.2340/actadv.v105.44220 · Cited by 33

Treatment of Pruritus Associated with Systemic Disorders in the Elderly

Lonsdale-Eccles, A. A., & Carmichael, A. (2003) · Drugs & Aging · doi:10.2165/00002512-200320030-00004 · Cited by 26

Treatment options for chronic cholestasis in infancy and childhood

Ng, V. L., & Balistreri, W. F. (2005) · Current Treatment Options in Gastroenterology · doi:10.1007/s11938-005-0045-5 · Cited by 26

Cutaneous Manifestations of Chronic Liver Disease

Patel, A. D., Katz, K. L., & Gordon, K. B. (2020) · Clinics in Liver Disease · doi:10.1016/j.cld.2020.04.003 · Cited by 25

Treatment of the pruritus of cholestasis

Bergasa, N. V. (2004) · Current Treatment Options in Gastroenterology · doi:10.1007/s11938-004-0009-1 · Cited by 25

Evaluation of Chronic Pruritus in Older Patients

Grundmann, S. A., & Ständer, S. (2010) · Aging Health · doi:10.2217/ahe.09.84 · Cited by 24

Understanding and Treating Pruritus in Primary Biliary Cholangitis

Carrion, A. F., Rosen, J. D., & Levy, C. (2018) · Clinics in Liver Disease · doi:10.1016/j.cld.2018.03.005 · Cited by 24

Inhibition of Passive Cutaneous Anaphylaxis-Associated Scratching Behavior by μ-Opioid Receptor Antagonists in ICR Mice

Inagaki, N., Nakamura, N., Nagao, M., Kawasaki, H., & Nagai, H. (2000) · International Archives of Allergy and Immunology · doi:10.1159/000053650 · Cited by 24

Targets and study design for symptom-focused trials aimed at patients with cirrhosis: An expert consensus

Patel, A., Tapper, E. B., Kanwal, F., Woodrell, C. D., Hansen, L., Lai, J. C., Rogal, S. S., McDermott, C. L., Rakoski, M. O., & Ufere, N. N. (2023) · Hepatology Communications · doi:10.1097/hc9.0000000000000135 · Cited by 24

Successful use of the Molecular Adsorbent Recirculating System (MARS) in a patient with primary biliary cirrhosis (PBC) and treatment refractory pruritus

Müllhaupt, B. (2003) · Hepatology Research · doi:10.1016/s1386-6346(02)00310-8 · Cited by 23

Endogenous opioid peptides and chronic liver disease: From bedside to bench

Marzioni, M., Svegliati‐Baroni, G., Alpini, G. D., & Benedetti, A. (2007) · Journal of Hepatology · doi:10.1016/j.jhep.2007.01.006 · Cited by 23

Update on Primary Biliary Cirrhosis

Heathcote, J. (2000) · Canadian Journal of Gastroenterology · doi:10.1155/2000/989486 · Cited by 23

Opioid Antagonists

Barnett, V., Twycross, R., Mihalyo, M., & Wilcock, A. (2014) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2013.12.223 · Cited by 22

Transport of Maternally Administered Pharmaceutical Agents Across the Placental Barrier In Vitro

Pemathilaka, R. L., Alimoradi, N., Reynolds, D. E., & Hashemi, N. N. (2022) · ACS Applied Bio Materials · doi:10.1021/acsabm.2c00121 · Cited by 22

Psoriasis as the marker of underlying systemic disease.

Kourosh, A. S., Miner, A. G., & Menter, A. (2008) · PubMed · Cited by 22

High-performance liquid chromatographic determination of naltrexone in plasma of hemodialysis patients

Kambia, K., Bah, S., Dine, T., Azar, R., Odou, P., Gressier, B., Luyckx, M., Brunet, C., Ballester, L., CAZIN, M., et al. (2000) · Biomedical Chromatography · doi:10.1002/1099-0801(200005)14:3 · Cited by 22

Management of pre–liver transplantation patient—Part 2

Sharma, P., & Rakela, J. L. (2005) · Liver Transplantation · doi:10.1002/lt.20379 · Cited by 22

Multidisciplinary Care of Alcohol-related Liver Disease and Alcohol Use Disorder: A Narrative Review for Hepatology and Addiction Clinicians

Shroff, H., & Gallagher, H. (2023) · Clinical Therapeutics · doi:10.1016/j.clinthera.2023.09.016 · Cited by 23

Recent advances in understanding the molecular mechanisms of cholestatic pruritus: A review

Sanjel, B., & Shim, W. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165958 · Cited by 23

Endogenous Opioid Levels Do Not Correlate With Itch Intensity and Therapeutic Interventions in Hepatic Pruritus

Düll, M. M., Wolf, K., Vetter, M., Dietrich, P., Neurath, M. F., & Kremer, A. E. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.641163 · Cited by 21

Pruritus of Cholestasis

Bergasa, N. V. (2014) · CRC Press eBooks · doi:10.1201/b16573-10 · Cited by 21

Treatment of Pruritus Caused by Cholestasis with Opioid Antagonists

Jones, E. A., & Żylicz, Z. (2005) · Journal of Palliative Medicine · doi:10.1089/jpm.2005.8.1290 · Cited by 21

Pruritus in chronic liver disease: Mechanisms and treatment

Bergasa, N. V. (2004) · Current Gastroenterology Reports · doi:10.1007/s11894-004-0020-7 · Cited by 21

What are new treatment concepts in systemic itch?

Kremer, A. E. (2019) · Experimental Dermatology · doi:10.1111/exd.14024 · Cited by 20

Extrahepatic Manifestations of Cholestatic Liver Diseases: Pathogenesis and Therapy

Pusl, T., & Beuers, U. H. (2005) · Clinical Reviews in Allergy & Immunology · doi:10.1385/criai:28:2:147 · Cited by 20

Treatment options for primary sclerosing cholangitis

Sinakos, E., & Lindor, K. D. (2010) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/egh.10.33 · Cited by 19

Therapy for pruritus in the elderly: a review of treatment developments

Pereira, M. P., & Ständer, S. (2018) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2018.1444752 · Cited by 18

Pruritis: scratching the surface

Bosonnet, L. (2003) · European Journal of Cancer Care · doi:10.1046/j.1365-2354.2003.00395.x · Cited by 18

Sclerosing Cholangitis and Recurrent Pyogenic Cholangitis

Ross, A. S., & Kowdley, K. V. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-6189-2.00068-8 · Cited by 17

Pharmacological interventions for pruritus in adult palliative care patients

Boehlke, C. S., Joos, L., Couné, B., Becker, C., Meerpohl, J. J., Buroh, S., Hercz, D., Schwarzer, G., & Becker, G. (2023) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008320.pub4 · Cited by 19

Cholestatic Itch Management

Mittal, A. K. (2016) · Current problems in dermatology · doi:10.1159/000446057 · Cited by 17

Charcoal hemoperfusion in the treatment of medically refractory pruritus in cholestatic liver disease

Kittanamongkolchai, W., Zoghby, Z., Hay, J., Wiesner, R. H., Kamath, P. S., LaRusso, N. F., Watt, K. D. S., Cramer, C. H., & Leung, N. (2016) · Hepatology International · doi:10.1007/s12072-016-9775-9 · Cited by 18

Role of Methotrexate in the Treatment of Chronic Cholestatic Disorders

Novak, K. L., & Swain, M. G. (2008) · Clinics in Liver Disease · doi:10.1016/j.cld.2007.11.011 · Cited by 17

Drug Treatments for Pruritus in Adult Palliative Care

Siemens, W., Xander, C. J., Meerpohl, J. J., Antes, G., & Becker, G. (2014) · Deutsches Ärzteblatt international · doi:10.3238/arztebl.2014.0863 · Cited by 16

Systematic review: efficacy of therapies for cholestatic pruritus

Ebhohon, E., & Chung, R. T. (2023) · Therapeutic Advances in Gastroenterology · doi:10.1177/17562848231172829 · Cited by 16

Relationship between pruritus and sleep in participants with primary biliary cholangitis in the Phase 2b GLIMMER trial

von Maltzahn, R., Mayo, M. J., Smith, H. T., Thompson, A. H., Das, S., de Souza, A. R., Lisi, E., Levy, C., McLaughlin, M., & Jones, D. E. (2024) · Journal of Patient-Reported Outcomes · doi:10.1186/s41687-024-00722-y · Cited by 16

Plasma Dynorphin A Concentration Reflects the Degree of Pruritus in Chronic Liver Disease: A Preliminary Report

Moniaga, C. S., Iwamoto, S., Kitamura, T., Fujishiro, M., Takahashi, N., Kina, K., Ogawa, H., Tominaga, M., & Takamori, K. (2019) · Acta Dermato Venereologica · doi:10.2340/00015555-3139 · Cited by 16

Complications of Cholestasis

Patil, A., & Mayo, M. J. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-118-5_9 · Cited by 16

Medical Management of Chronic Liver Diseases (CLD) in Children (Part II)

El-Shabrawi, M. H. F., & Kamal, N. M. (2011) · Pediatric Drugs · doi:10.2165/11591620-000000000-00000 · Cited by 16

Treatment of pediatric cholestatic liver disease

Cohran, V. C., & Heubi, J. E. (2003) · Current Treatment Options in Gastroenterology · doi:10.1007/s11938-003-0043-4 · Cited by 16

A Study of the Mu Opioid Receptor Gene Polymorphism A118G in Patients with Primary Biliary Cirrhosis with and without Pruritus

Wei, L. X., Floreani, A., Variola, A., Younis, C. M. E., & Bergasa, N. V. (2008) · Acta Dermato Venereologica · doi:10.2340/00015555-0436 · Cited by 16

Opioid receptor antagonist promotes angiogenesis in bile duct ligated rats

Faramarzi, N., Abbasi, A., Tavangar, S. M., Mazouchi, M., & Dehpour, A. R. (2009) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2009.05794.x · Cited by 15

Blood Cytokine, Chemokine and Gene Expression in Cholestasis Patients with Intractable Pruritus Treated with a Molecular Adsorbent Recirculating System: A Case Series

Lisboa, L. F., Asthana, S., Kremer, A. E., Swain, M. G., Bagshaw, S. M., Gibney, R. T. N., & Karvellas, C. J. (2012) · Canadian Journal of Gastroenterology · doi:10.1155/2012/623862 · Cited by 15

Trials of opiate antagonists for the pruritus of cholestasis: primary efficacy endpoints and opioid withdrawal-like reactions

Jones, E. A. (2002) · Journal of Hepatology · doi:10.1016/s0168-8278(02)00347-1 · Cited by 15

Developmental Considerations for the Use of Naltrexone in Children and Adolescents

Stancil, S. L., Abdel‐Rahman, S. M., & Wagner, J. (2021) · The Journal of Pediatric Pharmacology and Therapeutics · doi:10.5863/1551-6776-26.7.675 · Cited by 14

Treatment of primary biliary cirrhosis

Szalay, F. (2001) · Journal of Physiology-Paris · doi:10.1016/s0928-4257(01)00055-9 · Cited by 14

Symptom Management in Children with Cancer

Ullrich, C., Berde, C. B., & Billett, A. L. (2009) · Elsevier eBooks · doi:10.1016/b978-1-4160-3431-5.00031-5 · Cited by 13

The Use of Naltrexone in Dermatology. Current Evidence and Future Directions

Sikora, M., Rakowska, A., Olszewska, M., & Rudnicka, L. (2019) · Current Drug Targets · doi:10.2174/1389450120666190318121122 · Cited by 13

Current and emerging systemic treatments targeting the neural system for chronic pruritus

Golpanian, R. S., & Yosipovitch, G. (2020) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2020.1775815 · Cited by 13

Rifampin (INN Rifampicin)

Howard, P. D., Twycross, R., Grove, G. L., Charlesworth, S. A., Mihalyo, M., & Wilcock, A. (2015) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2015.09.004 · Cited by 13

An approach to the management of the pruritus of cholestasis

Bergasa, N. V. (2004) · Clinics in Liver Disease · doi:10.1016/s1089-3261(03)00128-4 · Cited by 13

Management and treatment of pruritus.

Lovell, P. A., & Vender, R. B. (2007) · PubMed · Cited by 13

LIVER TRANSPLANTATION

Saab, S., Han, S., & Martin, P. (2000) · Clinics in Liver Disease · doi:10.1016/s1089-3261(05)70124-0 · Cited by 13

Delayed opioid withdrawal-like reaction in primary biliary cirrhosis following naloxone therapy

Shawcross, D. L., & Jalan, R. (2001) · Gastroenterology · doi:10.1053/gast.2001.27714 · Cited by 12

Primary biliary cirrhosis

Lazaridis, K. N., & Lindor, K. D. (1999) · Current Treatment Options in Gastroenterology · doi:10.1007/s11938-999-0051-0 · Cited by 12

Benign Cutaneous Adverse Reactions to Drugs

Ardern‐Jones, M. R., & Lee, H. Y. (2016) · Wiley eBooks · doi:10.1002/9781118441213.rtd0119 · Cited by 12

Sleep disturbances in chronic liver disease

Busebee, B. T., Watt, K. D. S., Dupuy-McCauley, K. L., & DuBrock, H. M. (2024) · Liver Transplantation · doi:10.1097/lvt.0000000000000369 · Cited by 11

Naltrexone for cholestatic itch: a systematic review

Murray-Brown, F. L. (2021) · BMJ Supportive & Palliative Care · doi:10.1136/bmjspcare-2020-002801 · Cited by 12

Management of primary biliary cirrhosis

Levy, C., & Lindor, K. D. (2003) · Current Treatment Options in Gastroenterology · doi:10.1007/s11938-003-0051-4 · Cited by 11

Pruritus

Franco, J. (1999) · Current Treatment Options in Gastroenterology · doi:10.1007/s11938-999-0048-8 · Cited by 11

Methylnaltrexone to Palliate Pruritus in Terminal Hepatic Disease

Hohl, C. M., Wong, J. K., & Harlos, M. (2015) · Journal of Palliative Care · doi:10.1177/082585971503100209 · Cited by 10

Complications of Cholestasis

Ahmed, A., & Mayo, M. J. (2014) · Clinical gastroenterology · doi:10.1007/978-1-4939-1013-7_9 · Cited by 10

The Central Opioid System in Liver Disease and Its Complications

Yurdaydın, C. (2001) · Metabolic Brain Disease · doi:10.1023/a:1011618729660 · Cited by 10

20 Oral naltrexone for the treatment of cholestatic itch

Murray-Brown, F. L. (2020) · Oral Presentations · doi:10.1136/spcare-2020-pcc.20

Naltrexone for cholestatic itch: a systematic review

Murray-Brown, F. L. (2021) · BMJ Supportive & Palliative Care · doi:10.1136/bmjspcare-2020-002801 · Cited by 12

Treatment of the pruritus of cholestasis: From unbearable lightness to substance

Bergasa, N. V., Jaeschke, H., Mullen, K. D., & Moradpour, D. (2004) · Hepatology · doi:10.1002/hep.20171

Effect of oral naltrexone on pruritus in cholestatic patients

Mansour-Ghanaei, F. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i7.1125 · Cited by 89

www.wjgnet.com

Mansour-ghanaei, F., Taheri, A., Froutan, H., Ghofrani, H., Nasiri-toosi, M., Farahvash, M.-J., Mirmomen, S., Ebrahimi-Daryani, N., Farhangi, E., Pourrasouli, Z., et al. (2015)