The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Oral naltrexone treatment for cholestatic pruritus: A double-blind, placebo-controlled study
Open accessAbstract
Background & aims The efficacy of currently available therapeutic agents for cholestatic pruritus is often disappointing. The aim of this study was to assess the antipruritic effect of naltrexone, an oral opiate receptor antagonist. Methods Sixteen patients with pruritus of chronic cholestasis were randomized to receive naltrexone (4-week course of 50 mg naltrexone daily) or placebo. Pruritus, quality of sleep, fatigue (using visual analogue scales), side effects, and liver function were assessed every 2 weeks. Serum naltrexone and 6 beta-naltrexol concentrations in all patients and 5 healthy controls were measured during the first day of naltrexone treatment. Results Mean changes with respect to baseline were significantly different, in favor of the naltrexone group, for daytime itching (-54% vs. 8%; P < 0.001) and nighttime itching (-44% vs. 7%, P = 0.003). In 4 naltrexone-treated patients, side effects (transient in 3 cases) consistent with an opiate withdrawal syndrome were noted. No deterioration of the underlying disease was observed. Naltrexone and 6 beta-naltrexol levels did not differ between patients and controls, and there was no significant association with treatment response. Conclusions For patients with cholestatic liver disease and itching, refractory to regular antipruritic therapy, oral naltrexone may be an effective and well-tolerated alternative.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Opiate antagonists (oral naltrexone and parenteral naloxone) are increasingly used as third-line therapy as they reduce the sensation of itching and scratching activity.186 190–192”
From The British Society of Gastroenterology/UK-PBC primary biliary cholangitis treatment and management guidelines (2018) · cites this paper as [191]
Citations
Cites
Opioid peptides and primary biliary cirrhosis
Thornton, J. R., & Losowsky, M. S. (1988) · BMJ · doi:10.1136/bmj.297.6662.1501 · Cited by 300
Treatment of pruritus of primary biliary cirrhosis with rifampin
Podesta, A., Lopez, P., Terg, R., Villamil, F., Flores, D., Mastai, R., Udaondo, C. B., & Companc, J. P. (1991) · Digestive Diseases and Sciences · doi:10.1007/bf01300759 · Cited by 267
Effects of long-term rifampicin administration in primary biliary cirrhosis
Bachs, L., Parés, A., Elena, M., Piera, C., & Rodés, J. (1992) · Gastroenterology · doi:10.1016/0016-5085(92)90335-v · Cited by 235
Cholestyramine for long term relief of the pruritus complicating intrahepatic cholestasis
Datta, D. V., & Sherlock, S. (1966) · Gastroenterology · doi:10.1016/s0016-5085(66)80071-9 · Cited by 181
Liver transplantation: An overview
Maddrey, W. C., & Thiel, D. H. V. (1988) · Hepatology · doi:10.1002/hep.1840080440 · Cited by 154
Nalmefene: Intravenous safety and kinetics of a new opioid antagonist
Dixon, R., Howes, J. F., Gentile, J., Hsu, H., Hsiao, J. H., Garg, D. C., Weidler, D. J., Meyer, M. C., & Tuttle, R. R. (1986) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.1986.9 · Cited by 98
Pruritus in hepatic cholestasis. Pathogenesis and therapy
Garden, J. M. (1985) · Archives of Dermatology · doi:10.1001/archderm.121.11.1415 · Cited by 57
Pruritis associated with cholestasis
Khandelwal, M., & Malet, P. F. (1994) · Digestive Diseases and Sciences · doi:10.1007/bf02090052 · Cited by 46
Bergasa, N. V., & Jones, E. A. (1993) · Seminars in Liver Disease · doi:10.1055/s-2007-1007360 · Cited by 36
Bergasa, N. V. (1993) · Hepatology · doi:10.1016/0270-9139(93)92233-p · Cited by 8
Cited by
Sorted by citations
Hirschfield, G. M., Beuers, U., Corpechot, C., Invernizzi, P., Jones, D., Marzioni, M., & Schramm, C. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2017.03.022 · Cited by 1,480
Schwab, M. (2011) · Springer eBooks · doi:10.1007/978-3-642-16483-5_4730 · Cited by 1,241
Lindor, K. D., Gershwin, E. M., Poupon, R., Kaplan, M., Bergasa, N. V., & Heathcote, J. E. (2009) · Hepatology · doi:10.1002/hep.22906 · Cited by 1,099
AASLD practice guidance on primary sclerosing cholangitis and cholangiocarcinoma
Bowlus, C. L., Arrivé, L., Bergquist, A. M., Deneau, M. R., Forman, L., Ilyas, S. I., Lunsford, K. E., Martínez, M., Sapisochín, G., Shroff, R. T., et al. (2022) · Hepatology · doi:10.1002/hep.32771 · Cited by 462
Management of primary biliary cirrhosis
Heathcote, J. (2000) · Hepatology · doi:10.1053/he.2000.5984 · Cited by 412
Itch: scratching more than the surface
Twycross, R. (2003) · QJM · doi:10.1093/qjmed/hcg002 · Cited by 412
European S2k Guideline on Chronic Pruritus
Weißhaar, E., Szepietowski, J. C., Dalgard, F. J., Garcovich, S., Gieler, U., Giménez‐Arnau, A. M., Lambert, J., Leslie, T. A., Mettang, T., Misery, L., et al. (2019) · Acta Dermato Venereologica · doi:10.2340/00015555-3164 · Cited by 405
Chemical Response Pattern of Different Classes of C-Nociceptors to Pruritogens and Algogens
Schmelz, M., Schmidt, R., Weidner, C., Hilliges, M., Torebjörk, H. E., & Handwerker, H. O. (2003) · Journal of Neurophysiology · doi:10.1152/jn.01139.2002 · Cited by 399
Diagnosis and Management of Cirrhosis and Its Complications
Tapper, E. B., & Parikh, N. D. (2023) · JAMA · doi:10.1001/jama.2023.5997 · Cited by 422
Padda, M. S., Sanchez, M. J., Akhtar, A. J., & Boyer, J. L. (2011) · Hepatology · doi:10.1002/hep.24229 · Cited by 399
Hirschfield, G. M., Dyson, J. K., Alexander, G. J. M., Chapman, M. H., Collier, J., Hübscher, S., Patanwala, I., Pereira, S. P., Thain, C., Thorburn, D., et al. (2018) · Gut · doi:10.1136/gutjnl-2017-315259 · Cited by 362
Hirschfield, G. M., & Heathcote, E. J. (2010) · Wiley eBooks · doi:10.1002/9781444314403.ch32 · Cited by 261
European Guideline on Chronic Pruritus
Weißhaar, E., Szepietowski, J. C., Darsow, U. G., Misery, L., Wallengren, J., Mettang, T., Gieler, U., Lotti, T., Lambert, J., Maisel, P., et al. (2012) · Acta Dermato Venereologica · doi:10.2340/00015555-1400 · Cited by 249
Butorphanol for treatment of intractable pruritus
Dawn, A. G., & Yosipovitch, G. (2006) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2005.12.010 · Cited by 219
AASLD Practice Guidance: Palliative care and symptom‐based management in decompensated cirrhosis
Rogal, S. S., Hansen, L., Patel, A., Ufere, N. N., Verma, M., Woodrell, C. D., & Kanwal, F. (2022) · Hepatology · doi:10.1002/hep.32378 · Cited by 226
Hepatitis and liver dysfunction with rifampicin therapy for pruritus in primary biliary cirrhosis
Prince, M. I., Burt, A. D., & Jones, D. E. J. (2002) · Gut · doi:10.1136/gut.50.3.436 · Cited by 202
Jones, A. E., & Bergasa, N. V. (1999) · Hepatology · doi:10.1002/hep.510290450 · Cited by 202
Terg, R., Coronel, E., Sordá, J., Muñoz, A. E., & Findor, J. (2002) · Journal of Hepatology · doi:10.1016/s0168-8278(02)00318-5 · Cited by 199
Open‐label trial of oral nalmefene therapy for the pruritus of cholestasis
Bergasa, N. V., Schmitt, J. M., Talbot, T. L., Alling, D. W., Swain, M. G., Turner, M. L., Jenkins, J. B., & Jones, A. E. (1998) · Hepatology · doi:10.1002/hep.510270307 · Cited by 182
Metze, D., Reimann, S., Beissert, S., & Luger, T. A. (1999) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(99)80048-6 · Cited by 181
Antipruritic treatment with systemic μ-opioid receptor antagonists: A review
Phan, N. Q., Bernhard, J. D., Luger, T. A., & Ständer, S. (2010) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2009.08.052 · Cited by 178
Tandon, P., Rowe, B. H., Vandermeer, B., & Bain, V. G. (2007) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2007.01200.x · Cited by 176
Bergasa, N. V., Alling, D. W., Talbot, T. L., Wells, M. C., & Jones, E. A. (1999) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(99)70117-9 · Cited by 163
Understanding Pruritus in Systemic Disease
Krajnik, M., & Żylicz, Z. (2001) · Journal of Pain and Symptom Management · doi:10.1016/s0885-3924(00)00256-6 · Cited by 162
Primary biliary cholangitis: Epidemiology, prognosis, and treatment
Trivella, J., John, B. V., & Levy, C. (2023) · Hepatology Communications · doi:10.1097/hc9.0000000000000179 · Cited by 159
The Role of Central μ Opioid Receptors in Opioid-Induced Itch in Primates
Ko, M., Song, M. S., Edwards, T. M., Lee, H., & Naughton, N. N. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.061101 · Cited by 137
Neff, G. W., OʼBrien, C., Reddy, K. R., Bergasa, N. V., Regev, A., Molina, E. G., Amaro, R., Rodriguez, M. J., Chase, V., Jeffers, L. J., et al. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.05852.x · Cited by 133
Kuiper, E. M. M., van Erpecum, K. J., Beuers, U., Hansen, B. E., Thio, B. H., de Man, R. A., Janssen, H. L. A., & van Buuren, H. R. (2010) · Hepatology · doi:10.1002/hep.23821 · Cited by 132
Pruritus in cholestatic and other liver diseases
Mela, M. G., Mancuso, A., & Burroughs, A. K. (2003) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2003.01458.x · Cited by 129
Pathogenesis and Treatment of Pruritus in Cholestasis
Kremer, A. E., Beuers, U. H., Elferink, R. P. J. O., & Pusl, T. (2008) · Drugs · doi:10.2165/00003495-200868150-00006 · Cited by 128
Treatment of pruritus with topically applied opiate receptor antagonist
Bigliardi, P. L., Stammer, H., Jost, G., Rufli, T., Büchner, S. A., & Bigliardi‐Qi, M. (2007) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2007.01.007 · Cited by 124
Primary Sclerosing Cholangitis
Talwalkar, J. A., & Lindor, K. D. (2005) · Inflammatory Bowel Diseases · doi:10.1097/00054725-200501000-00009 · Cited by 123
Novel therapeutic targets in primary biliary cirrhosis
Dyson, J. K., Hirschfield, G. M., Adams, D. H., Beuers, U., Mann, D. A., Lindor, K. D., & Jones, D. E. J. (2015) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2015.12 · Cited by 120
Parés, A. R., Herrera, M., Avilés, J., Sanz, M., & Mas, A. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2010.02.031 · Cited by 116
Ikoma, A., Rukwied, R., Ständer, S., Steinhoff, M. S., Miyachi, Y., & Schmelz, M. (2003) · Archives of Dermatology · doi:10.1001/archderm.139.11.1475 · Cited by 113
Pares, A., Cisneros, L., Salmeron, J. M., Caballeria, L., Mas, A., Torras, A., & Rodes, J. (2004) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2004.30204.x · Cited by 112
Schmelz, M. (2002) · Journal of Dermatological Science · doi:10.1016/s0923-1811(01)00167-0 · Cited by 112
Bergasa, N. V. (2005) · Journal of Hepatology · doi:10.1016/j.jhep.2005.09.004 · Cited by 112
Jones, E. A. (2002) · QJM · doi:10.1093/qjmed/95.8.547 · Cited by 107
Benign recurrent intrahepatic cholestasis
Luketic, V. A., & Shiffman, M. L. (2004) · Clinics in Liver Disease · doi:10.1016/s1089-3261(03)00133-8 · Cited by 110
Bergasa, N. V., McGee, M., Ginsburg, I. H., & Engler, D. (2006) · Hepatology · doi:10.1002/hep.21370 · Cited by 107
Itch in primary biliary cirrhosis: a patients' perspective
Rishe, E., Azarm, A., & Bergasa, N. (2008) · Acta Dermato-Venereologica · doi:10.2340/00015555-0350 · Cited by 107
Pathophysiology and current management of pruritus in liver disease
Kremer, A. E., Elferink, R. P. J. O., & Beuers, U. H. (2011) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2010.10.007 · Cited by 107
Use of Rifampin for Severe Pruritus in Children with Chronic Cholestasis
Yerushalmi, B., Sokol, R. J., Narkewicz, M. R., Smith, D. J., & Karrer, F. M. (1999) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-199910000-00013 · Cited by 103
Weißhaar, E., Kucenic, M., & Fleischer, A. B. (2003) · Acta Dermato Venereologica · doi:10.1080/00015555-0369 · Cited by 99
Saliba, F., Bañares, R., Larsen, F. S., Wilmer, A. P., Parés, A. R., Mitzner, S. R., Stange, J., Fuhrmann, V., Gilg, S., Hassanein, T., et al. (2022) · Intensive Care Medicine · doi:10.1007/s00134-022-06802-1 · Cited by 104
Receptors, cells and circuits involved in pruritus of systemic disorders
Kremer, A. E., Feramisco, J. D., Reeh, P. W., Beuers, U. H., & Elferink, R. P. J. O. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.02.007 · Cited by 97
Primary sclerosing cholangitis
Silveira, M. G., & Lindor, K. D. (2008) · Canadian Journal of Gastroenterology · doi:10.1155/2008/824168 · Cited by 94
Effect of oral naltrexone on pruritus in cholestatic patients
Mansour-Ghanaei, F. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i7.1125 · Cited by 89
Pharmacological interventions for pruritus in adult palliative care patients
Siemens, W., Xander, C. J., Meerpohl, J. J., Buroh, S., Antes, G., Schwarzer, G., & Becker, G. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008320.pub3 · Cited by 88
Alcoholism Treatment After Liver Transplantation: Lessons Learned From a Clinical Trial That Failed
Weinrieb, R. M., Horn, D. H. A. V., McLellan, A. T., Alterman, A. I., Calarco, J. S., O’Brien, C. P., & Lucey, M. R. (2001) · Psychosomatics · doi:10.1176/appi.psy.42.2.110 · Cited by 89
Pruritus and fatigue in primary biliary cirrhosis
Bergasa, N. V., Mehlman, J. K., & Jones, E. A. (2000) · Best Practice & Research Clinical Gastroenterology · doi:10.1053/bega.2000.0109 · Cited by 83
Pathogenesis and Management of Pruritus in PBC and PSC
Kremer, A. E., Namer, B., Bolier, R., Fischer, M. J. M., Elferink, R. P. J. O., & Beuers, U. H. (2015) · Digestive Diseases · doi:10.1159/000440829 · Cited by 84
Advances in Pathogenesis and Management of Pruritus in Cholestasis
Kremer, A. E., Bolier, R., van Dijk, R., Elferink, R. P. J. O., & Beuers, U. H. (2014) · Digestive Diseases · doi:10.1159/000360518 · Cited by 81
Jones, E. A., & Dekker, L. R. C. (2000) · Gastroenterology · doi:10.1016/s0016-5085(00)70225-3 · Cited by 78
Primer of Postoperative Pruritus for Anesthesiologists
Waxler, B., Dadabhoy, Z. P., Stojiljković, L., Rabito, S. F., & Warltier, D. C. (2005) · Anesthesiology · doi:10.1097/00000542-200507000-00025 · Cited by 77
Pain as a complication of use of opiate antagonists for symptom control in cholestasis
Mcrae, C. A., Prince, M. I., Hudson, M., Day, C. P., James, O. F. W., & Jones, D. E. J. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00879-5 · Cited by 73
Gossard, A. A., & Talwalkar, J. A. (2013) · Medical Clinics of North America · doi:10.1016/j.mcna.2013.09.002 · Cited by 75
Pruritus in Chronic Cholestatic Liver Disease
Bunchorntavakul, C., & Reddy, K. R. (2012) · Clinics in Liver Disease · doi:10.1016/j.cld.2012.03.010 · Cited by 71
Pruritus in systemic disease: mechanisms and management
Etter, L., & Myers, S. A. (2002) · Dermatologic Clinics · doi:10.1016/s0733-8635(02)00011-6 · Cited by 67
Razykov, I., Levis, B., Hudson, M., Baron, M. G., & Thombs, B. D. (2013) · Lara D. Veeken · doi:10.1093/rheumatology/ket275 · Cited by 66
Pruritus: Management Algorithms and Experimental Therapies
Steinhoff, M. S., Cevikbas, F., Ikoma, A., & Berger, T. G. (2011) · Seminars in Cutaneous Medicine and Surgery · doi:10.1016/j.sder.2011.05.001 · Cited by 65
Management of Primary Sclerosing Cholangitis
Lee, Y., & Kaplan, M. M. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.05585.x · Cited by 66
Ständer, S., Raap, U., Weißhaar, E., Schmelz, M., Mettang, T., Handwerker, H. O., & Luger, T. A. (2011) · JDDG Journal der Deutschen Dermatologischen Gesellschaft · doi:10.1111/j.1610-0387.2011.07585.x · Cited by 65
Olson, G. A., Olson, R. D., Vaccarino, A. L., & Kastin, A. J. (1998) · Peptides · doi:10.1016/s0196-9781(98)00137-5 · Cited by 64
Efficacy of oral naltrexone on pruritus in atopic eczema: a double‐blind, placebo‐controlled study
Malekzad, F., Arbabi, M., Mohtasham, N., Toosi, P., Jaberian, M., Mohajer, M., Mohammadi, M., Rahmati-Roodsari, M., & Nasiri, S. (2009) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2009.03129.x · Cited by 61
Neuberger, J., & Jones, E. A. (2001) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-200111000-00022 · Cited by 60
Serum time course of naltrexone and 6β-naltrexol levels during long term treatment in drug addicts
Ferrari, A., Bertolotti, M., Dell'Utri, A., Avico, U., & Sternieri, E. (1998) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(98)00098-2 · Cited by 60
Self-citationBigliardi‐Qi, M., Gavériaux‐Ruff, C., Pfaltz, K., Bady, P., Baumann, T., Rufli, T., Kieffer, B. L., & Bigliardi, P. L. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700661 · Cited by 59
Utility of Naltrexone Treatment for Chronic Inflammatory Dermatologic Conditions
Ekelem, C., Juhász, M. L. W., Khera, P., & Mesinkovska, N. A. (2018) · JAMA Dermatology · doi:10.1001/jamadermatol.2018.4093 · Cited by 59
Pruritus in Primary Biliary Cirrhosis: Pathogenesis and Therapy
Bergasa, N. V. (2008) · Clinics in Liver Disease · doi:10.1016/j.cld.2008.02.013 · Cited by 57
Villamil, A., Bandi, J. C., Galdame, O., Gerona, S., & Gadano, A. C. (2005) · The American Journal of Medicine · doi:10.1016/j.amjmed.2005.05.031 · Cited by 58
Clinical features and management of primary sclerosing Cholangitis
Silveira, M. G., & Lindor, K. D. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.3338 · Cited by 59
Springer, S. A., Azar, M. M., & Altice, F. L. (2010) · The American Journal of Drug and Alcohol Abuse · doi:10.3109/00952990.2010.540280 · Cited by 57
Antipruritische Therapie mit dem oralen Opiatrezeptorantagonisten Naltrexon
Brune, A., Metze, D., Luger, T. A., & St�nder, S. (2004) · Der Hautarzt · doi:10.1007/s00105-004-0802-8 · Cited by 56
Pathogenesis and management of pruritus in cholestatic liver disease
Imam, M. H., Gossard, A. A., Sinakos, E., & Lindor, K. D. (2012) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2012.07109.x · Cited by 56
Culver, E. L., & Chapman, R. W. (2011) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2011.04658.x · Cited by 57
Bergasa, N. V. (2011) · Seminars in Cutaneous Medicine and Surgery · doi:10.1016/j.sder.2011.04.009 · Cited by 56
Itch in systemic disease: therapeutic options
Greaves, M. W. (2005) · Dermatologic Therapy · doi:10.1111/j.1529-8019.2005.00036.x · Cited by 56
Levy, C., & Lindor, K. D. (2003) · Clinics in Liver Disease · doi:10.1016/s1089-3261(03)00032-1 · Cited by 56
Cholestasis and Endogenous Opioids
Davis, M. P. (2007) · Clinical Pharmacokinetics · doi:10.2165/00003088-200746100-00002 · Cited by 53
Palliative Care for Patients with End-Stage Liver Disease Ineligible for Liver Transplantation
Sánchez, W., & Talwalkar, J. A. (2006) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2005.12.007 · Cited by 53
Treatment of Pruritus Secondary to Liver Disease
Düll, M. M., & Kremer, A. E. (2019) · Current Gastroenterology Reports · doi:10.1007/s11894-019-0713-6 · Cited by 53
Recent advances in the management of pruritus in chronic liver diseases
Tajiri, K., & Shimizu, Y. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i19.3418 · Cited by 55
Cholestatic pruritus: Emerging mechanisms and therapeutics
Patel, S. P., Vasavda, C., Ho, B. K., Meixiong, J., Dong, X., & Kwatra, S. G. (2019) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2019.04.035 · Cited by 56
Prince, M. I., Mitchison, H. C., Ashley, D., Burke, D., Edwards, N., Bramble, M. G., James, O., & Jones, D. E. J. (2002) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2003.01398.x · Cited by 52
‘Out‐patient’ albumin dialysis for cholestatic patients with intractable pruritus
Leckie, P., Tritto, G., Mookerjee, R., Davies, N., Jones, D., & Jalan, R. (2012) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2012.04994.x · Cited by 51
NEUROTROPIC AND PSYCHOTROPIC DRUGS IN DERMATOLOGY
Tennyson, H., & Levine, N. S. (2001) · Dermatologic Clinics · doi:10.1016/s0733-8635(05)70239-4 · Cited by 51
Jaundice associated pruritis: A review of pathophysiology and treatment
Bassari, R. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i5.1404 · Cited by 50
Naltrexone for the management of post-burn pruritus: A preliminary report
LaSalle, L., Rachelska, G., & Nedelec, B. (2008) · Burns · doi:10.1016/j.burns.2007.10.009 · Cited by 49
Pruritus and fatigue in primary biliary cirrhosis
Bergasa, N. V. (2003) · Clinics in Liver Disease · doi:10.1016/s1089-3261(03)00105-3 · Cited by 48
Clinical features and management of primary biliary cirrhosis
Crosignani, A., Battezzati, P. M., Invernizzi, P., Selmi, C. F., Prina, E., & Podda, M. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.3313 · Cited by 46
Efficacy of naltrexone on acetylcholine‐induced alloknesis in atopic eczema
Heyer, G., Groene, D., & Martus, P. (2002) · Experimental Dermatology · doi:10.1034/j.1600-0625.2002.110508.x · Cited by 46
PRIMARY BILIARY CIRRHOSIS AND PRIMARY SCLEROSING CHOLANGITIS
Angulo, P., & Lindor, K. D. (1999) · Clinics in Liver Disease · doi:10.1016/s1089-3261(05)70084-2 · Cited by 46
Are Peripheral Opioid Antagonists the Solution to Opioid Side Effects?
Bates, J. J., Foss, J. F., & Murphy, D. B. (2004) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000090147.97636.77 · Cited by 46
Management of Pruritus in Primary Biliary Cholangitis: A Narrative Review
Trivedi, H. D., Lizaola‐Mayo, B., Tapper, E. B., & Bonder, A. (2017) · The American Journal of Medicine · doi:10.1016/j.amjmed.2017.01.037 · Cited by 46
Sleep disorder in patients with chronic liver disease: a narrative review
Shah, N. M., Malhotra, A. M., & Kaltsakas, G. (2020) · Journal of Thoracic Disease · doi:10.21037/jtd-cus-2020-012 · Cited by 44
Brewer, C. L., & Wong, V. S. (2004) · Addiction Biology · doi:10.1080/13556210410001674130 · Cited by 44
Diagnosis and management of chronic pruritus: An expert consensus review
Rajagopalan, M., Saraswat, A., Godse, K. V., Shankar, D. K., Kandhari, S., Shenoi, S. D., Tahiliani, S. T., & Zawar, V. (2017) · Indian Journal of Dermatology · doi:10.4103/0019-5154.198036 · Cited by 43
The pruritus of cholestasis: From bile acids to opiate agonists: Relevant after all these years
Bergasa, N. V. (2017) · Medical Hypotheses · doi:10.1016/j.mehy.2017.11.002 · Cited by 43
Metadata
- Authors
- Wolfhagen, F., Sternieri, E., Hop, W., Vitale, G., Bertolotti, M., & Van Buuren, H.
- Affiliations
- Erasmus MC (NL)
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 1997-10
- Volume
- 113
- Issue
- 4
- Pages
- 1264-1269
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W2008756039
- Cited by
- 343
- References
- 10
- Citations by year
- 2026: 7 · 2025: 4 · 2024: 10 · 2023: 12 · 2022: 12 · 2021: 9 · 2020: 7 · 2019: 9 · 2018: 11 · 2017: 9 · 2016: 15 · 2015: 15 · 2014: 14 · 2013: 5 · 2012: 7
- FWCI
- 6.93
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion, other-oa)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion, other-oa)
- RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
- IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Surgery › Pediatric Hepatobiliary Diseases and Treatments
- Keywords
- naltrexone, cholestatic pruritus, chronic cholestasis, antipruritic therapy, opioid antagonists, opioid withdrawal, sleep quality, fatigue, drug tolerability
- MeSH terms
- Administration, Oral, Adult, Aged, Cholestasis, Double-Blind Method, Fatigue, Female, Humans, Liver Cirrhosis, Biliary, Male, Middle Aged, Naltrexone, Narcotic Antagonists, Placebos, Pruritus, Cholangitis, Sclerosing
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review