The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Celiac disease–like abnormalities in a subgroup of patients with irritable bowel syndrome
Open accessAbstract
Background & aims Abdominal symptoms in the absence of mucosal abnormalities are features of both the irritable bowel syndrome (IBS) and latent/potential celiac disease (cd). To identify a possible subgroup of IBS patients with latent/potential cd, surrogate markers of cd were investigated in IBS patients.Methods IBS patients suffering from diarrhea (n = 102), and patients with active cd (n = 10), treated cd (n = 26), and latent cd (n = 5) were included in the study. We measured serum immunoglobulin (Ig) A against gliadin and tissue-transglutaminase, and IgA and IgM against gliadin, tissue-transglutaminase (intestinal cd-associated antibodies), and the dietary proteins beta-lactoglobulin and ovalbumin in duodenal aspirate by enzyme-linked immunosorbent assay. Intraepithelial lymphocytes (IELs) were counted in histology sections, and the expression of HLA-DQ2 (A1*0501/B1*0201) was investigated by polymerase chain reaction. In 26 IBS patients, the effect of 6 months of gluten withdrawal was examined.Results Most cd patients expressed HLA-DQ2 and had increased intestinal cd-associated antibodies, whereas cd-associated serum IgA and IEL counts were increased in active cd in contrast to treated or latent cd. In IBS patients, 35% were HLA-DQ2-positive, 23% had increased IEL counts, and 0% and 30% had increased cd-associated antibodies in serum and duodenal aspirate, respectively. Furthermore, stool frequency and intestinal IgA decreased significantly under a gluten-free diet in the subgroups of HLA-DQ2-positive and intestinal antibody-positive IBS patients when compared with IBS patients without these markers.Conclusions HLA-DQ2 expression and increased intestinal cd-associated antibodies are markers that can identify latent/potential cd in a subgroup of IBS patients who consequently appear to profit from a gluten-free diet.
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“Some patients with IBS lack tissue transglutaminase antibodies or histological markers of coeliac disease yet still respond symptomatically to a gluten-free diet.”
From Intestinal microbiota in functional bowel disorders: a Rome foundation report (2013) · cites this paper as [157]
In the citing paper
“Gluten causes coeliac disease in genetically susceptible people and causes gut dysfunction in mice and can generate IBS symptoms in the absence of coeliac disease.157”
From Intestinal microbiota in functional bowel disorders: a Rome foundation report (2013) · cites this paper as [157]
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Longstreth, G. F., Thompson, W. G., Chey, W. D., Houghton, L. A., Mearin, F., & Spiller, R. C. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.11.061 · Cited by 4,856
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Metadata
- Authors
- Wahnschaffe, U., Ullrich, R., Riecken, E. O., & Schulzke, J. D.
- Affiliations
- Freie Universität Berlin (DE)
- ORCID
- Schulzke, J.D.
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2001-12
- Volume
- 121
- Issue
- 6
- Pages
- 1329-1338
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W2169133758
- Cited by
- 280
- References
- 35
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 23 · 2022: 5 · 2021: 10 · 2020: 4 · 2019: 7 · 2018: 10 · 2017: 5 · 2016: 9 · 2015: 13 · 2014: 16 · 2013: 17 · 2012: 15
- FWCI
- 13.18
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Celiac Disease Research and Management
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Keywords
- irritable bowel syndrome, celiac disease, latent celiac disease, HLA-DQ2, intraepithelial lymphocytes, anti-tissue transglutaminase antibodies, anti-gliadin antibodies, duodenal aspirate, gluten-free diet, gluten withdrawal, intestinal IgA, β-lactoglobulin, ovalbumin, diarrhea, surrogate markers
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Antibodies, Antigens, Celiac Disease, Colonic Diseases, Functional, Diet, Duodenum, Female, Gliadin, Humans, Immunoglobulin A, Immunoglobulin M, Lactoglobulins, Male, Middle Aged, Ovalbumin, Transglutaminases, Reticulin
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