Cited by 280Celiac Disease Research and ManagementGastrointestinal motility and disordersInflammatory Bowel Disease

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Celiac disease–like abnormalities in a subgroup of patients with irritable bowel syndrome

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Wahnschaffe, Ulrich, Ullrich, R., Riecken, E.O., Schulzke, J.D.·2001·Gastroenterology

DOI 10.1053/gast.2001.29572

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Abstract

Background & aims Abdominal symptoms in the absence of mucosal abnormalities are features of both the irritable bowel syndrome (IBS) and latent/potential celiac disease (cd). To identify a possible subgroup of IBS patients with latent/potential cd, surrogate markers of cd were investigated in IBS patients.Methods IBS patients suffering from diarrhea (n = 102), and patients with active cd (n = 10), treated cd (n = 26), and latent cd (n = 5) were included in the study. We measured serum immunoglobulin (Ig) A against gliadin and tissue-transglutaminase, and IgA and IgM against gliadin, tissue-transglutaminase (intestinal cd-associated antibodies), and the dietary proteins beta-lactoglobulin and ovalbumin in duodenal aspirate by enzyme-linked immunosorbent assay. Intraepithelial lymphocytes (IELs) were counted in histology sections, and the expression of HLA-DQ2 (A1*0501/B1*0201) was investigated by polymerase chain reaction. In 26 IBS patients, the effect of 6 months of gluten withdrawal was examined.Results Most cd patients expressed HLA-DQ2 and had increased intestinal cd-associated antibodies, whereas cd-associated serum IgA and IEL counts were increased in active cd in contrast to treated or latent cd. In IBS patients, 35% were HLA-DQ2-positive, 23% had increased IEL counts, and 0% and 30% had increased cd-associated antibodies in serum and duodenal aspirate, respectively. Furthermore, stool frequency and intestinal IgA decreased significantly under a gluten-free diet in the subgroups of HLA-DQ2-positive and intestinal antibody-positive IBS patients when compared with IBS patients without these markers.Conclusions HLA-DQ2 expression and increased intestinal cd-associated antibodies are markers that can identify latent/potential cd in a subgroup of IBS patients who consequently appear to profit from a gluten-free diet.

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Dieterich, W., Ehnis, T., Bauer, M., Donner, P., Volta, U., Riecken, E. O., & Schuppan, D. (1997) · Nature Medicine · doi:10.1038/nm0797-797 · Cited by 2,021
Self-citation
Evidence for a primary association of celiac disease to a particular HLA-DQ alpha/beta heterodimer.
Sollid, L. M., Markussen, G., Ek, J., Gjerde, H., Vartdal, F., & Thorsby, E. (1989) · The Journal of Experimental Medicine · doi:10.1084/jem.169.1.345 · Cited by 929
Functional bowel disorders in apparently healthy people
Thompson, W., & Heaton, K. W. (1980) · Gastroenterology · doi:10.1016/0016-5085(80)90142-0 · Cited by 654
Tissue transglutaminase autoantibody enzyme-linked immunosorbent assay in detecting celiac disease
Sulkanen, S., Halttunen, T., Laurila, K., Kolho, K., Korponay-Szabo, I. R., Sarnesto, A., Savilahti, E., Collin, P., & Mäki, M. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70008-3 · Cited by 589
HLA‐DQB1 and ‐DQA1 typing by PCR amplification with sequence‐specific primers (PCR‐SSP) in 2 hours
Olerup, O., Aldener, A., & Fogdell, A. (1993) · Tissue Antigens · doi:10.1111/j.1399-0039.1993.tb01991.x · Cited by 547
Medical costs in community subjects with irritable bowel syndrome
Talley, N. J., Gabriel, S. E., Harmsen, W. S., Zinsmeister, A. R., & Evans, R. W. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90738-6 · Cited by 460
Effects of stressful life events on bowel symptoms: subjects with irritable bowel syndrome compared with subjects without bowel dysfunction.
Whitehead, W. E., Crowell, M. D., Robinson, J. C., Heller, B. R., & Schuster, M. M. (1992) · Gut · doi:10.1136/gut.33.6.825 · Cited by 432
Clinical and pathological spectrum of coeliac disease--active, silent, latent, potential.
Ferguson, A., Arranz, E. M., & O'Mahony, S. (1993) · Gut · doi:10.1136/gut.34.2.150 · Cited by 404
Quantitation of intraepithelial lymphocytes in human jejunum
Ferguson, A., & Murray, D. J. (1971) · Gut · doi:10.1136/gut.12.12.988 · Cited by 399
FOOD INTOLERANCE: A MAJOR FACTOR IN THE PATHOGENESIS OF IRRITABLE BOWEL SYNDROME
Jones, V. A., Shorthouse, M., McLaughlan, P., Workman, E., & Hunter, J. O. (1982) · The Lancet · doi:10.1016/s0140-6736(82)92782-9 · Cited by 333

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Changing face of irritable bowel syndrome
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Gluten-free and low-FODMAP sourdoughs for patients with coeliac disease and irritable bowel syndrome: A clinical perspective
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Absence of somatization in non-coeliac gluten sensitivity
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Gluten‐Free Diet in Nonceliac Disease
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Epithelial transport and deamidation of gliadin peptides: a role for coeliac disease patient immunoglobulin A
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Non-coeliac gluten/wheat sensitivity: advances in knowledge and relevant questions
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Immunopathogenesis of celiac disease
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Current and emerging therapies in irritable bowel syndrome: from pathophysiology to treatment
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Effect of gluten-free diet and co-morbidity of irritable bowel syndrome-type symptoms on health-related quality of life in adult coeliac patients
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Irritable bowel syndrome and chronic gastritis, hemorrhoid, urolithiasis.
Helvacı, M. R., Algın, M. C., & Kaya, H. (2009) · PubMed Central · Cited by 48
Non-celiac gluten sensitivity. Is it in the gluten or the grain?
Nijeboer, P., Bontkes, H. J., Mulder, C. J. J., & Bouma, G. (2013) · PubMed · Cited by 47
Current Concepts of the Irritable Bowel Syndrome
Quigley, E. M. M. (2003) · Scandinavian Journal of Gastroenterology · doi:10.1080/00855910310001403 · Cited by 46
Celiac disease: clinical, endoscopic, and histopathologic review
Harris, L. A., Park, J. Y., Voltaggio, L., & Lam-Himlin, D. M. (2012) · Gastrointestinal Endoscopy · doi:10.1016/j.gie.2012.04.473 · Cited by 46
Neurologic Complications of Celiac Disease
Chin, R. L., Latov, N., Green, P. H. R., Brannagan, T. H., Alaedini, A., & Sander, H. W. (2004) · Journal of Clinical Neuromuscular Disease · doi:10.1097/00131402-200403000-00004 · Cited by 46
Small bowel bacterial overgrowth, celiac disease, and IBS: what are the real associations?
O’Leary, C., & Quigley, E. M. M. (2003) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2003.07395.x · Cited by 46
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A Physiologic Events' Cascade, Irritable Bowel Syndrome, may Even Terminate with Urolithiasis
Helvacı, M. R., Kabay, Ş., & Gülcan, E. (2006) · Eisei kagaku · doi:10.1248/jhs.52.478 · Cited by 43
Testing for Gluten-Related Disorders in Clinical Practice: The Role of Serology in Managing the Spectrum of Gluten Sensitivity
Armstrong, D., Don-Wauchope, A., & Verdu, E. F. (2011) · Canadian Journal of Gastroenterology · doi:10.1155/2011/642452 · Cited by 43
Diet in the Irritable Bowel Syndrome
Floch, M., & Narayan, R. (2002) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-200207001-00009 · Cited by 24

Authors: Wahnschaffe, U., Ullrich, R., Riecken, E. O., & Schulzke, J. D.
Affiliations: Freie Universität Berlin (DE)
ORCID: Schulzke, J.D.
Venue: Gastroenterology
Publisher: Elsevier BV
Published: 2001-12
Volume: 121
Issue: 6
Pages: 1329-1338
ISSN: 0016-5085 (ISSN-L)
DOI: 10.1053/gast.2001.29572
OpenAlex: W2169133758
Cited by: 280
References: 35
Citations by year: 2025: 2 · 2024: 1 · 2023: 23 · 2022: 5 · 2021: 10 · 2020: 4 · 2019: 7 · 2018: 10 · 2017: 5 · 2016: 9 · 2015: 13 · 2014: 16 · 2013: 17 · 2012: 15
FWCI: 13.18
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Gastroenterology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Gastroenterology › Celiac Disease Research and Management
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
Keywords: irritable bowel syndrome, celiac disease, latent celiac disease, HLA-DQ2, intraepithelial lymphocytes, anti-tissue transglutaminase antibodies, anti-gliadin antibodies, duodenal aspirate, gluten-free diet, gluten withdrawal, intestinal IgA, β-lactoglobulin, ovalbumin, diarrhea, surrogate markers
MeSH terms: Adolescent, Adult, Aged, Aged, 80 and over, Antibodies, Antigens, Celiac Disease, Colonic Diseases, Functional, Diet, Duodenum, Female, Gliadin, Humans, Immunoglobulin A, Immunoglobulin M, Lactoglobulins, Male, Middle Aged, Ovalbumin, Transglutaminases, Reticulin

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Celiac disease–like abnormalities in a subgroup of patients with irritable bowel syndrome

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