Effect of Moderate Aerobic Exercise Training on Endothelial Function and Arterial Stiffness in CKD Stages 3-4: A Randomized Controlled Trial
Abstract
Background Evidence of a beneficial effect of exercise training on mediators of vascular disease is accumulating in chronic kidney disease (CKD), but its effect on vascular function in vivo still has to be established. The present study was designed to investigate whether a formal aerobic exercise training program improves peripheral endothelial function in patients with CKD stages 3 to 4. Study design Randomized controlled trial with a parallel-group design. Setting & participants 48 patients with CKD stages 3 to 4 without established cardiovascular disease were randomly assigned to either an exercise training program or usual care. 40 patients completed the study (exercise training, 19; usual care, 21). Intervention The 3-month home-based aerobic training program consisted of 4 daily cycling sessions of 10 minutes each at a target heart rate, calculated as 90% of the heart rate achieved at the anaerobic threshold. Patients in the usual-care group were given standard therapy. Outcomes The primary outcome was peripheral endothelial function. Secondary outcomes were aerobic capacity, arterial stiffness, numbers of endothelial (EPCs) and osteogenic progenitor cells (OPCs), migratory function of circulatory angiogenic cells, and health-related quality of life. Measurements Endothelial function was assessed with flow-mediated dilation of the brachial artery, aerobic capacity by peak oxygen uptake (VO(2peak)), arterial stiffness by carotid-femoral pulse wave velocity, numbers of E…
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High risk of performance bias was granted to more than 75% of the included studies.
“high risk of performance bias was granted to more than 75% of the studies [7, 9, 10, 13, 15–18, 20, 21].”
From Exercise therapy improves eGFR, and reduces blood pressure and BMI in non-dialysis CKD patients: evidence from a meta-analysis (2019) · cites this paper as [17]
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Lipotoxicity and Diabetic Nephropathy: Novel Mechanistic Insights and Therapeutic Opportunities
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- Authors
- Van Craenenbroeck, A. H., Van Craenenbroeck, E. M., Van Ackeren, K., Vrints, C. J., Conraads, V. M., Verpooten, G. A., Kouidi, E., & Couttenye, M. M.
- Affiliations
- University of Antwerp (BE)
- Aristotle University of Thessaloniki (GR)
- Antwerp University Hospital (BE)
- Venue
- American Journal of Kidney Diseases
- Publisher
- Elsevier BV
- Published
- 2015-08
- Volume
- 66
- Issue
- 2
- Pages
- 285-296
- ISSN
- 0272-6386 (ISSN-L)
- OpenAlex
- W1578168337
- Cited by
- 115
- References
- 3
- Citations by year
- 2026: 12 · 2025: 5 · 2024: 12 · 2023: 9 · 2022: 14 · 2021: 16 · 2020: 12 · 2019: 12 · 2018: 5 · 2017: 12 · 2016: 3 · 2015: 3
- FWCI
- 5.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Kidney Diseases (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Keywords
- aerobic exercise training, chronic kidney disease, endothelial function, arterial stiffness, vascular function, peak oxygen uptake, endothelial progenitor cells, osteoprogenitor cells, health-related quality of life, flow-mediated dilation, pulse wave velocity
- MeSH terms
- Adult, Aged, Cardiovascular Diseases, Cell Count, Cell Movement, Endothelium, Vascular, Exercise Therapy, Female, Humans, Male, Middle Aged, Oxygen Consumption, Quality of Life, Vasodilation, Exercise, Renal Insufficiency, Chronic, Vascular Stiffness, Pulse Wave Analysis, Endothelial Progenitor Cells
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