Mucosal Protection by Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibition
Robinson, Andreas, Keely, Simon, Karhausen, Jörn, Gerich, Mark E., Furuta, Glenn T., Colgan, Sean P.·2008·Gastroenterology
Cited by (369)
Items 101–200 of 369
- Coumarin Derivatives in Inflammatory Bowel DiseaseLuiz Cláudio Di Stasi · 2021 · Molecules
- Selective induction of integrin βi by hypoxia‐inducible factor: implications for wound healingSimon Keely, Louise Elaine Glover, Christopher F. MacManus, Eric L. Campbell, Melanie M. Scully, Glenn T. Furuta, Sean P. Colgan · 2008 · The FASEB Journal
- Targeting Hypoxia Signaling for Perioperative Organ InjuryXiaoyi Yuan, Jae W. Lee, Jessica L. Bowser, Viola Neudecker, Srikanth Sridhar, Holger K. Eltzschig · 2017 · Anesthesia & Analgesia
- Hypoxia. Regulation of NFκB signalling during inflammation: the role of hydroxylasesKathryn M. Oliver, Cormac T. Taylor, Eoin P. Cummins · 2009 · Arthritis Research & Therapy
- Activation of hypoxia-inducible factors ameliorates hypoxic distal tubular injury in the isolated perfused rat kidneyChristian Rosenberger, Seymour Rosen, Ahuva Shina, Ulrich A. Frei, Kai‐Uwe Eckardt, Lee A. Flippin, Michael Arend, S J Klaus, Samuel Noam Heyman · 2008 · Nephrology Dialysis Transplantation
- Cucurbitacin I Induces Protective Autophagy in Glioblastoma in Vitro and in VivoYuan, Guang, Yan, Shao-Feng, Xue, Hao, Zhang, Ping, Sun, Jin-Tang, Li, Gang · 2014 · Journal of Biological Chemistry
- MicroRNA‐146a‐mediated downregulation of IRAK1 protects mouse and human small intestine against ischemia/reperfusion injuryCécilia Chassin, Cordelia Hempel, Silvia Stockinger, Aline Dupont, Joachim F. Kübler, Jochen Wedemeyer, Alain Vandewalle, Mathias Walter Hornef · 2012 · EMBO Molecular Medicine
- The role of hypoxia in intestinal inflammationYatrik Madhukar Shah · 2016 · Molecular and Cellular Pediatrics
- Hypoxia and inflammatory bowel diseaseEoin P. Cummins, Daniel Crean · 2016 · Microbes and Infection
- HIF-1α mediates the induction of IL-8 and VEGF expression on infection with Afa/Dr diffusely adheringE. coliand promotes EMT-like behaviourGaëlle Cane, Amandine Ginouvès, Sandrine Marchetti, Roser Buscà, Jacques Pouysségur, Edurne Berra, Paul M Hofman, Valérie Vouret‐Craviari · 2009 · Cellular Microbiology
- Activation of hypoxia-inducible factor-1 protects airway epithelium against oxidant-induced barrier dysfunctionNels C. Olson, Milena Hristova, Nicholas H. Heintz, Karen M. Lounsbury, Albert van der Vliet · 2011 · American Journal of Physiology-Lung Cellular and Molecular Physiology
- A double‐edged sword: Role of butyrate in the oral cavity and the gutXiaoyuan Guan, Wenjing Li, Huanxin Meng · 2020 · Molecular Oral Microbiology
- Biological functions of ecto-enzymes in regulating extracellular adenosine levels in neoplastic and inflammatory disease statesMaria Serena Longhi, Simon Christopher Robson, Steven H. Bernstein, Sara Serra, Silvia Deaglio · 2013 · Journal of Molecular Medicine
- Pharmacological Characterization of 1-(5-Chloro-6-(trifluoromethoxy)-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic Acid (JNJ-42041935), a Potent and Selective Hypoxia-Inducible Factor Prolyl Hydroxylase InhibitorBarrett, Terrance D., Palomino, Heather L., Brondstetter, Theresa I., Kanelakis, Kimon C., Wu, Xiaodong, Haug, Peter V., Yan, Wen, Young, Andrew, Hua, Hong, Hart, Juliet C. et al. · 2011 · Molecular Pharmacology
- Macrophage polarization: an effective approach to targeted therapy of inflammatory bowel diseaseYaoyao Du, Lan Rong, Yuanhua Cong, Lan Shen, Ning Zhang, Bing Wang · 2021 · Expert Opinion on Therapeutic Targets
- Therapeutic Manipulation of the HIF HydroxylasesSimon Nagel, Nick P. Talbot, Jasmin Mecinović, Thomas G. Smith, Alastair Mitchell Buchan, Christopher John Schofield · 2009 · Antioxidants and Redox Signaling
- Switching off CD73: a way to boost the activity of conventional and targeted antineoplastic therapiesLuca Antonioli, Sergey V. Novitskiy, Kris F. Sachsenmeier, Matteo Fornai, Corrado Blandizzi, György Haskó · 2017 · Drug Discovery Today
- The role of mucosal barriers in human gut healthKangseok Seo, Jeong-Mi Seo, Jiyoun Yeun, Haebin Choi, Young‐In Kim, Sun-Young Chang · 2021 · Archives of Pharmacal Research
- Non-hypoxic Stabilization of Hypoxia-Inducible Factor Alpha (HIF-α): Relevance in Neural Progenitor/Stem CellsJavorina Milošević, Irena Adler, Anatol Manaenko, Sigrid C. Schwarz, Gail Walkinshaw, Michael Arend, Lee A. Flippin, Alexander Storch, Johannes Schwarz · 2009 · Neurotoxicity Research
- Hydroxylase Inhibition Abrogates TNF-α–Induced Intestinal Epithelial Damage by Hypoxia-Inducible Factor-1–Dependent Repression of FADDHindryckx, Pieter, De Vos, Martine, Jacques, Peggy, Ferdinande, Liesbeth, Peeters, Harald, Olievier, Kim, Bogaert, Sara, Brinkman, Brigitta, Vandenabeele, Peter, Elewaut, Dirk et al. · 2010 · The Journal of Immunology
- Interplay of Hypoxia and A2B Adenosine Receptors in Tissue ProtectionMichael Koeppen, Tobias de la Garza Eckle, Holger K. Eltzschig · 2011 · Advances in pharmacology
- Hypoxia-inducible factor plays a gut-injurious role in intestinal ischemia reperfusion injuryKolenkode B. Kannan, Iriana Colorado, Diego C. Reino, David Palange, Qi Lu, Xiaofa Qin, Billy Abungu, Anthony C. Watkins, Francis J. Caputo, Da-Zhong Xu et al. · 2010 · American Journal of Physiology-Gastrointestinal and Liver Physiology
- Pharmacological intervention studies using mouse models of the inflammatory bowel diseasesIurii Koboziev, Fridrik J. Karlsson, Songlin Zhang, Matthew B. Grisham · 2011 · Inflammatory Bowel Diseases
- Hypoxia-Inducible Factor/MAZ-Dependent Induction of Caveolin-1 Regulates Colon Permeability through Suppression of Occludin, Leading to Hypoxia-Induced InflammationLiwei Xie, Xiang Xue, Matthew J. Taylor, Sadeesh Kumar Ramakrishnan, Kenjiro Nagaoka, Cathy Hao, Frank J. Gonzalez, Yatrik Madhukar Shah · 2014 · Molecular and Cellular Biology
- Targeted delivery of the hydroxylase inhibitor DMOG provides enhanced efficacy with reduced systemic exposure in a murine model of colitisMurtaza M. Tambuwala, Mario C. Manresa, Eoin P. Cummins, Vincenzo Aversa, Ivan S. Coulter, Cormac T. Taylor · 2015 · Journal of Controlled Release
- Hypoxia-inducible factor 1 in autoimmune diseasesWei Deng, Xuebing Feng, Xia Li, Dandan Wang, Lingyun Sun · 2016 · Cellular Immunology
- HIF-1 in T cells ameliorated dextran sodium sulfate-induced murine colitisHigashiyama, Masaaki, Hokari, Ryota, Hozumi, Hideaki, Kurihara, Chie, Ueda, Toshihide, Watanabe, Chikako, Tomita, Kengo, Nakamura, Mitsuyasu, Komoto, Shunsuke, Okada, Yoshikiyo et al. · 2012 · Journal of Leukocyte Biology
- Inhibition of Prolyl Hydroxylase Domain-Containing Protein Suppressed Lipopolysaccharide-Induced TNF-α ExpressionKotaro Takeda, Toshihiro Ichiki, Eriko Narabayashi, Keita Inanaga, Ryohei Miyazaki, Toru Hashimoto, Hirohide Matsuura, Jiro Ikeda, Toshio Miyata, Kenji Sunagawa · 2009 · Arteriosclerosis Thrombosis and Vascular Biology
- Recent Advances in Developing Inhibitors for Hypoxia-Inducible Factor Prolyl Hydroxylases and Their Therapeutic ImplicationsSo Yeon Kim, Eun Yang · 2015 · Molecules
- Elongation Factor 2 Kinase Is Regulated by Proline Hydroxylation and Protects Cells during HypoxiaClaire E. Moore, Halina Mikolajek, Sergio Regufe da Mota, Wang Xuemin, Justin W. Kenney, Jörn M. Werner, Christopher G. Proud · 2015 · Molecular and Cellular Biology
- Results of the 2nd Scientific Workshop of the ECCO (III): Basic mechanisms of intestinal healingFlorian Rieder, Thomas Karrasch, Shomron Ben‐Horin, Anja Schirbel, Robert Ehehalt, Jan Wehkamp, Colin G. de Haar, Dominique Velin, Giovanni Latella, Franco Scaldaferri et al. · 2011 · Journal of Crohn s and Colitis
- PHD3 Stabilizes the Tight Junction Protein Occludin and Protects Intestinal Epithelial Barrier FunctionYing Chen, Hai-Sheng Zhang, Guo‐Hua Fong, Qiulei Xi, Guohao Wu, Chenguang Bai, Zhi‐Qiang Ling, Fan Li, Yiming Xu, Yan-qing Qin et al. · 2015 · Journal of Biological Chemistry
- Mononuclear phagocytes orchestrate prolyl hydroxylase inhibition-mediated renoprotection in chronic tubulointerstitial nephritisGunnar Schley, Bernd Klanke, Joanna Maria Kalucka, Valentin Schatz, Christoph Daniel, Marleen Mayer, Margarete Goppelt‐Struebe, Martin Herrmann i, Margrét Þorsteinsdóttir, Runólfur Pálsson et al. · 2019 · Kidney International
- Hypoxic Environment Promotes Barrier Formation in Human Intestinal Epithelial Cells through Regulation of MicroRNA 320a ExpressionStephanie Muenchau, Rosalie Deutsch, Inês J. de Castro, Thomas Hielscher, Nora Heber, Beate Niesler, Marina Lušić, Megan Lynn Stanifer, Steeve Boulant · 2019 · Molecular and Cellular Biology
- Hypoxia-sensitive pathways in inflammation-driven fibrosisMario C. Manresa, Catherine Godson, Cormac T. Taylor · 2014 · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- The Hypoxia–Adenosine Link during Intestinal InflammationJessica L. Bowser, Luan Hai Phan, Holger K. Eltzschig · 2018 · The Journal of Immunology
- HIF-1α is required for hematopoietic stem cell mobilization and 4-prolyl hydroxylase inhibitors enhance mobilization by stabilizing HIF-1αCatherine E. Forristal, Bianca Nowlan, Rebecca N. Jacobsen, Valérie Barbier, Gail Walkinshaw, Carl R. Walkley, Ingrid G. Winkler, Jean-Pierre Lévesque · 2015 · Leukemia
- Hypoxia-Inducible Factor Activation Protects the Kidney from Gentamicin-Induced Acute InjuryJeong-myung Ahn, Sun Jin You, Yun Mi Lee, Se Won Oh, Shin Young Ahn, Sejoong Kim, Ho Jun Chin, Dong‐Wan Chae, Ki Young Na · 2012 · PLoS ONE
- New Insights into Protein Hydroxylation and Its Important Role in Human DiseasesGiada Zurlo, Jianping Guo, Mamoru Takada, Wenyi Wei, Qing Hua Zhang · 2016 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
- Hypoxia signaling during intestinal ischemia and inflammationAlmut Grenz, Eric T. Clambey, Holger K. Eltzschig · 2012 · Current Opinion in Critical Care
- Exploring the HIFs, buts and maybes of hypoxia signalling in disease: lessons from zebrafish modelsPhilip M. Elks, Stephen A. Renshaw, Annemarie H. Meijer, Sarah R. Walmsley, Fredericus J. van Eeden · 2015 · Disease Models & Mechanisms
- Cyclooxygenase-2 and Hypoxia-Inducible Factor-1α protein expression is related to inflammation, and up-regulated since the early steps of colorectal carcinogenesisFrancesco Mariani, Paola Sena, Laura Marzona, Massimo Riccio, Rita Adriana Fano, Paola Manni, Carmela Di Gregorio, Annalisa Pezzi, Maurizio Ponz de Leòn, Sebastiano Monni et al. · 2009 · Cancer Letters
- Reducing radiation-induced gastrointestinal toxicity — the role of the PHD/HIF axisMonica M. Olcina, Amato J. Giaccia · 2016 · Journal of Clinical Investigation
- Hypoxia-inducible factor-2α plays a role in mediating oesophagitis in GORDXiaofang Huo, Agoston T. Agoston, Kerry B. Dunbar, Daisha Jane Cipher, Xi Zhang, Chunhua Yu, Edaire Cheng, Qiuyang Zhang, Thai H. Pham, Uttam K. Tambar et al. · 2016 · Gut
- Transmembrane prolyl 4-hydroxylase is a fourth prolyl 4-hydroxylase regulating EPO production and erythropoiesisLaitala, Anu, Aro, Ellinoora, Walkinshaw, Gail, Mäki, Joni M., Rossi, Maarit, Heikkilä, Minna, Savolainen, Eeva-Riitta, Arend, Michael, Kivirikko, Kari I., Koivunen, Peppi et al. · 2012 · Blood
- Oral Delivery of Prolyl Hydroxylase InhibitorEllen Marks, Bridie J. Goggins, Jocelle Cardona, Siobhan Cole, Kyra Minahan, Sean W. Mateer, Marjorie M. Walker, Robert A. Shalwitz, Simon Keely · 2015 · Inflammatory Bowel Diseases
- Local Stabilization of Hypoxia-Inducible Factor-1α Controls Intestinal Inflammation via Enhanced Gut Barrier Function and Immune RegulationYoung‐In Kim, Eun-Je Yi, Young‐Dae Kim, A Reum Lee, Jiwoung Chung, Hae Chan Ha, Joong Myung Cho, Seong-Ryeol Kim, Hyun‐Jeong Ko, Jae Hee Cheon et al. · 2021 · Frontiers in Immunology
- A possible role for hypoxia-induced apelin expression in enteric cell proliferationSong Han, Guiyun Wang, Qi Xiang, Heung M. Lee, Ella W. Englander, George H. Greeley · 2008 · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Proresolution effects of hydrogen sulfide during colitis are mediated through hypoxia‐inducible factor‐1αKyle L. Flannigan, Terence A. Agbor, Jean‐Paul Motta, José G. Ferraz, Rui Wang, André G. Buret, John Lawrence Wallace · 2014 · The FASEB Journal
- An Endogenously Anti-Inflammatory Role for Methylation in Mucosal Inflammation Identified through Metabolite ProfilingDouglas J. Kominsky, Simon Keely, Christopher F. MacManus, Louise Elaine Glover, Melanie M. Scully, Colm B. Collins, Brittelle Bowers, Eric L. Campbell, Sean P. Colgan · 2011 · The Journal of Immunology
- Nix-Mediated Mitophagy Modulates Mitochondrial Damage During Intestinal InflammationGarret Vincent, Elizabeth A. Novak, Vei Shaun Siow, Kellie E. Cunningham, Brian D. Griffith, Thomas E. Comerford, Heather L. Mentrup, Donna Beer Stolz, Patricia Loughran, Sarangarajan Ranganathan et al. · 2020 · Antioxidants and Redox Signaling
- Targeting the A2B adenosine receptor during gastrointestinal ischemia and inflammationHolger K. Eltzschig, Jesús Rivera–Nieves, Sean P. Colgan · 2009 · Expert Opinion on Therapeutic Targets
- Metabolic Host–Microbiota Interactions in Autophagy and the Pathogenesis of Inflammatory Bowel Disease (IBD)Alexander S. Dowdell, Sean P. Colgan · 2021 · Pharmaceuticals
- The Therapeutic Effect of Chelidonic Acid on Ulcerative ColitisDae‐Seung Kim, Su Jin Kim, Min-Cheol Kim, Yong‐Deok Jeon, Jae‐Young Um, Seung‐Heon Hong · 2012 · Biological and Pharmaceutical Bulletin
- Hypoxia and Integrin-Mediated Epithelial Restitution during Mucosal InflammationBridie J. Goggins, Ciaran Chaney, Graham L Radford‐Smith, Jay Christopher Horvat, Simon Keely · 2013 · Frontiers in Immunology
- The hypoxia–inflammation link and potential drug targetsMichael Koeppen, Tobias de la Garza Eckle, Holger K. Eltzschig · 2011 · Current Opinion in Anaesthesiology
- Ex Vivo Intestinal Sacs to Assess Mucosal Permeability in Models of Gastrointestinal DiseaseSean W. Mateer, Jocelle Cardona, Ellen Marks, Bridie J. Goggin, Susan Hua, Simon Keely · 2016 · Journal of Visualized Experiments
- Signaling hypoxia by hypoxia-inducible factor protein hydroxylases: a historical overview and future perspectivesPeter Peter Ratcliffe, Tammie Bishop · 2014 · Hypoxia
- Neutrophil priming by hypoxic preconditioning protects against epithelial barrier damage and enteric bacterial translocation in intestinal ischemia/reperfusionYen‐Zhen Lu, Chi-Chin Wu, Yi-Chen Huang, Ching-Ying Huang, Chung-Yi Yang, Tsung‐Chun Lee, Chau-Fong Chen, Linda Chia‐Hui Yu · 2012 · Laboratory Investigation
- The Inflammatory Tissue Microenvironment in IBDSean P. Colgan, Valerie F. Curtis, Eric L. Campbell · 2013 · Inflammatory Bowel Diseases
- Anti‐inflammatory actions of adrenomedullin through fine tuning of HIF stabilizationChristopher F. MacManus, Eric L. Campbell, Simon Keely, Adrianne Burgess, Douglas J. Kominsky, Sean P. Colgan · 2011 · The FASEB Journal
- Betulinic acid hydroxamate prevents colonic inflammation and fibrosis in murine models of inflammatory bowel diseaseMaría E. Prados, Adela García‐Martín, Juan Diego Unciti-Broceta, Belén Palomares, Juan Antonio Collado, Alberto Minassi, Marco A. Calzado, Giovanni Appendino, Eduardo Muñóz · 2020 · Acta Pharmacologica Sinica
- Metabolic regulation of intestinal epithelial barrier during inflammationSean P. Colgan, Valerie F. Curtis, Jordi M. Lanis, Louise Elaine Glover · 2014 · Tissue Barriers
- Targeting Hypoxia-Inducible Factor-1 (HIF-1) Signaling in Therapeutics: Implications for the Treatment of Inflammatory Bowel DiseaseSimon Andrew Hirota, Paul L. Beck, Justin A. MacDonald · 2009 · Recent Patents on Inflammation & Allergy Drug Discovery
- Neutrophils and inflammatory resolution in the mucosaSean P. Colgan · 2015 · Seminars in Immunology
- Yak milk–derived exosomal microRNAs regulate intestinal epithelial cells on proliferation in hypoxic environmentHang Gao, Fazheng Ren, Pengcheng Wen, L.X. Xie, Rui Wang, Z.N. Yang, Y.X. Li · 2020 · Journal of Dairy Science
- Hypoxia and hypoxia-inducible factors in myeloid cell-driven host defense and tissue homeostasisJantsch, Jonathan, Schödel, Johannes · 2015 · Immunobiology
- Hydroxylase-dependent regulation of the NF-κB pathwayCarsten C. Scholz, Cormac T. Taylor · 2013 · Biological Chemistry
- Hypoxia-adaptive pathways: A pharmacological target in fibrotic disease?Moritz J. Strowitzki, Alina S. Ritter, Gwendolyn Kimmer, Martin A. Schneider · 2019 · Pharmacological Research
- Hydroxylases as therapeutic targets in inflammatory bowel diseaseEoin P. Cummins, Glen A. Doherty, Cormac T. Taylor · 2013 · Laboratory Investigation
- Molecular Mechanisms of Action and Therapeutic Uses of Pharmacological Inhibitors of HIF–Prolyl 4-Hydroxylases for Treatment of Ischemic DiseasesVaithinathan Selvaraju, Narasimham L. Parinandi, Ram Sudheer Adluri, Joshua W. Goldman, Naveed Hussain, Juan A. Sánchez, Nilanjana Maulik · 2013 · Antioxidants and Redox Signaling
- Activation of HIF-1α does not increase intestinal tumorigenesisXiang Xue, Sadeesh Kumar Ramakrishnan, Yatrik Madhukar Shah · 2014 · American Journal of Physiology-Gastrointestinal and Liver Physiology
- Regulation of IL-12p40 by HIF controls Th1/Th17 responses to prevent mucosal inflammationEllen Marks, Crystal R. Naudin, Garry P. Nolan, Bridie J. Goggins, Grace L. Burns, Sean W. Mateer, J.K. Latimore, Kyra Minahan, Maximilian W. Plank, Paul S. Foster et al. · 2017 · Mucosal Immunology
- Neutrophils as Components of Mucosal HomeostasisCaroline H. T. Hall, Eric L. Campbell, Sean P. Colgan · 2017 · Cellular and Molecular Gastroenterology and Hepatology
- Loss of PHLPP protects against colitis by inhibiting intestinal epithelial cell apoptosisYang‐An Wen, Xin Li, Tatiana Goretsky, Heidi L. Weiss, Terrence A. Barrett, Tianyan Gao · 2015 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Hypoxia-inducible factor as a bridge between healthy barrier function, wound healing, and fibrosisCalen A. Steiner, Ian M. Cartwright, Cormac T. Taylor, Sean P. Colgan · 2022 · American Journal of Physiology-Cell Physiology
- Involvement of HIF-1α in MLCK-dependent Endothelial Barrier Dysfunction in HypoxiaHuabing Qi, Pei Wang, Chen Liu, Mu Li, Shiliang Wang, Yuesheng Huang, Fengjun Wang · 2011 · Cellular Physiology and Biochemistry
- Anti-Inflammatory Effects of Hyperbaric Oxygenation during DSS-Induced Colitis in BALB/c Mice Include Changes in Gene Expression ofHIF-1α, Proinflammatory Cytokines, and Antioxidative EnzymesSanja Novak, Ines Drenjančević, Rosemary Vuković, Zoltán Kellermayer, Anita Ćosić, Maja Tolušić Levak, Péter Balogh, Filip Čulo, Martina Mihalj · 2016 · Mediators of Inflammation
- In Vivo and In Vitro Evidence of the Involvement of CXCL1, a Keratinocyte-Derived Chemokine, in Equine LaminitisRafael Resende Faleiros, Britta Sigrid Leise, Trina L. Westerman, Cailing Yin, Gerard James Nuovo, James K. Belknap · 2009 · Journal of Veterinary Internal Medicine
- Targeting the Hypoxia-Sensing Pathway in Clinical HematologyCatherine E. Forristal, Jean-Pierre Lévesque · 2013 · Stem Cells Translational Medicine
- Hypoxia‐sensitive pathways in intestinal inflammationEric Brown, Cormac T. Taylor · 2017 · The Journal of Physiology
- Protective effect of decursin and decursinol angelate-rich Angelica gigas Nakai extract on dextran sulfate sodium-induced murine ulcerative colitisSarang Oh, Seon Ok, Tae-Sung Jung, Sang-Ok Jeon, Ji-Min Park, Ji-Wook Jung, Deok‐Seon Ryu · 2017 · Asian Pacific Journal of Tropical Medicine
- Hypoxia-inducible factor-1α: a promising therapeutic target for autoimmune diseasesShi‐Yang Guan, Rui‐Xue Leng, Jin-Hui Tao, Xiang-Pei Li, Dong‐Qing Ye, Nancy J. Olsen, Song Guo Zheng, Hai‐Feng Pan · 2017 · Expert Opinion on Therapeutic Targets
- MiR-155 contributes to intestinal barrier dysfunction in DSS-induced mice colitis via targeting HIF-1α/TFF-3 axisYujin Liu, Feng Zhu, Huarong Li, Heng Fan, Hui Wu, Yalan Dong, Si Chu, Chen Tan, Quansheng Wang, Hongxia He et al. · 2020 · Aging
- In vivo functions of the prolyl‐4‐hydroxylase domain oxygen sensors: direct route to the treatment of anaemia and the protection of ischaemic tissuesDörthe Magdalena Katschinski · 2008 · Acta Physiologica
- Non-canonical HIF-1 stabilization contributes to intestinal tumorigenesisNadine Rohwer, Sandra Jumpertz, Merve Erdem, Antje Egners, Klaudia Theresa Warzecha, Athanassios Fragoulis, Anja Andrea Kühl, Rafael Kramann, Sabine Neuß, Ines Rudolph et al. · 2019 · Oncogene
- Haematopoietic prolyl hydroxylase‐1 deficiency promotes M2 macrophage polarization and is both necessary and sufficient to protect against experimental colitisSophie Van Welden, Martine De Vos, Ben Wielockx, Simon Jan Tavernier, Mélissa Dullaers, Sara Neyt, Benedicte Descamps, Lindsey Devisscher, Sarah Devriese, Lien Van den Bossche et al. · 2016 · The Journal of Pathology
- Dynamics of Prolyl Hydroxylases Levels During Disease Progression in Experimental ColitisHamid A. Bakshi, Vijay Kumar Mishra, Saurabh Satija, Meenu Mehta, Faruk L. Hakkim, Prashant Kesharwani, Kamal Dua, Dinesh Kumar Chellappan, Nitin B. Charbe, Garima Shrivastava et al. · 2019 · Inflammation
- Blockade of hypoxia-inducible factor-1α by YC-1 attenuates interferon-γ and tumor necrosis factor-α-induced intestinal epithelial barrier dysfunctionHang Liu, Mu Li, Pei Wang, Fengjun Wang · 2011 · Cytokine
- 1,2,4-Triazolo-[1,5-a]pyridine HIF Prolylhydroxylase Domain-1 (PHD-1) Inhibitors With a Novel Monodentate Binding InteractionSaleh Ahmed, Andrew Ayscough, Greg R. Barker, Hannah E. Canning, Richard Davenport, Robert Downham, David Harrison, Kerry Jenkins, Natasha Kinsella, David G. Livermore et al. · 2017 · Journal of Medicinal Chemistry
- Immunologic Consequences of Hypoxia during Critical IllnessHarmke D. Kiers, Gert‐Jan Scheffer, Johannes G. van der Hoeven, Holger K. Eltzschig, Peter Pickkers, Matthijs Kox · 2016 · Anesthesiology
- Oxygen sensing in intestinal mucosal inflammationKatharina Flück, Joachim Fandrey · 2015 · Pflügers Archiv - European Journal of Physiology
- Pharmacologic stabilization of hypoxia-inducible transcription factors protects developing mouse brain from hypoxia-induced apoptotic cell deathRegina Trollmann, Melvyn Richter, Susan Jung, Gail Walkinshaw, Florian A. Brackmann · 2014 · Neuroscience
- On the role of ischemia in the pathogenesis of IBDChristopher B. Ibrahim, Olga C. Aroniadis, Lawrence J. Brandt · 2009 · Inflammatory Bowel Diseases
- Hypoxia-inducible factor prolyl-4-hydroxylase-1 is a convergent point in the reciprocal negative regulation of NF-κB and p53 signaling pathwaysKarim Ullah, Ann-Helen Rosendahl, Valerio Izzi, Ulrich Bergmann, Taina A. Pihlajaniemi, Joni M. Mäki, Johanna Myllyharju · 2017 · Scientific Reports
- Mitochondrial dysfunctions in T cells: focus on inflammatory bowel diseaseHoyul Lee, Jae‐Han Jeon, Eun Soo Kim · 2023 · Frontiers in Immunology
- Randomised clinical trial: a phase 1b study of GB004, an oral HIF‐1α stabiliser, for treatment of ulcerative colitisSilvio Danese, Barrett G. Levesque, Brian G. Feagan, Alina Jucov, Bal Raj Bhandari, Rish K. Pai, Kristen Taylor Meadows, Brian J. Kirby, Jean‐Marie Bruey, Allan David Olson et al. · 2022 · Alimentary Pharmacology & Therapeutics
- Therapeutic Effects and Molecular Mechanism of Chlorogenic Acid on Polycystic Ovarian Syndrome: Role of HIF-1alphaZhenghong Zhang, Congjian Shi, Zhengchao Wang · 2023 · Nutrients
- Joint Involvement Associated with Inflammatory Bowel DiseaseMartine De Vos · 2009 · Digestive Diseases
- Hypoxia-Induced Signaling in Gut and Liver PathobiologySumeet A. Solanki, Yatrik Madhukar Shah · 2023 · Annual Review of Pathology Mechanisms of Disease