The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.
Intraepithelial Effector (CD3+)/Regulatory (FoxP3+) T-Cell Ratio Predicts a Clinical Outcome of Human Colon Carcinoma
Open accessAbstract
Background & Aims Regulatory T cells (Tregs) express the forkhead box transcription factor (FoxP3) and suppress the anti-tumor immune response. We investigated whether the intratumoral densities of FoxP3+ and effector CD3+ lymphocytes are associated with prognosis of patients with colon cancer. Methods FoxP3 and CD3 expression and location were determined in stage II and III colon carcinomas (n=160) and normal mucosa (n=25) by immunohistochemistry; CD4 and FoxP3 were localized by dual immunofluorescence microscopy. T-cell markers were compared with patients’ pathological variables, DNA mismatch repair (MMR) status, and survival using Cox proportional hazards models. Results FoxP3+ and CD3+ T-cell densities increased in carcinomas compared to autologous normal mucosa (p< 0.0001). An increase in intraepithelial FoxP3+ cells was associated with poor tumor differentiation (p=0.038) and female gender (p=0.028) and advanced age of patients (p=0.042). FoxP3+ cell density was not prognostic, yet patients with tumors with reduced intraepithelial CD3+ T-cell densities had reduced disease-free survival (DFS) times (hazard ratio [HR] 1.87 [1.10, 3.16]; p=0.018). A low intraepithelial CD3+:FoxP3+ cell ratio predicted reduced DFS (46.2% vs. 66.7% survival at 5 years; HR 2.17 [1.11, 4.23]; p= 0.0205). The prognostic impact of these markers was maintained when tumors were stratified by MMR status. By multivariate analysis, a low CD3+:FoxP3+ cell ratio (p=0.0318) and low numbers of CD3+ T cells (p=0.0397) predicted shorter DFS times and were stronger prognostic variables than tumor stage or number of lymph node metastases. Conclusions A low intraepithelial CD3+:FoxP3+ cell ratio and reduced numbers of CD3+ T cells were associated with reduced patient survival time, indicating the importance of an effector to Treg cell ratio in colon cancer prognosis.
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Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome
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The immune contexture in human tumours: impact on clinical outcome
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Self-citationRegulatory T cells in cancer immunotherapy
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Towards the introduction of the ‘Immunoscore’ in the classification of malignant tumours
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Metadata
- Authors
- Sinicrope, F. A., Rego, R. L., Ansell, S. M., Knutson, K. L., Foster, N. R., & Sargent, D. J.
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2009-10
- Volume
- 137
- Issue
- 4
- Pages
- 1270-1279
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W2042965540
- Cited by
- 329
- References
- 62
- FWCI
- 8.91
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Sinicrope, F. A., Rego, R. L., Ansell, S. M., Knutson, K. L., Foster, N. R., & Sargent, D. J. (2009). Intraepithelial Effector (CD3+)/Regulatory (FoxP3+) T-Cell Ratio Predicts a Clinical Outcome of Human Colon Carcinoma. Gastroenterology. https://doi.org/10.1053/j.gastro.2009.06.053
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