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Cited by 411Gastrointestinal motility and disordersGastrointestinal Bleeding Diagnosis and TreatmentGastroesophageal reflux and treatments

Gastroparesis

Camilleri, Michael, Chedid, Victor, Ford, Alexander C., Haruma, Ken, Horowitz, Michael, Jones, Karen L., Low, Phillip A., Park, Seon-Young +2 more·2018·Nature Reviews Disease Primers
DOI 10.1038/s41572-018-0038-z
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Abstract

Gastroparesis is a disorder characterized by delayed gastric emptying of solid food in the absence of a mechanical obstruction of the stomach, resulting in the cardinal symptoms of early satiety, postprandial fullness, nausea, vomiting, belching and bloating. Gastroparesis is now recognized as part of a broader spectrum of gastric neuromuscular dysfunction that includes impaired gastric accommodation. The overlap between upper gastrointestinal symptoms makes the distinction between gastroparesis and other disorders, such as functional dyspepsia, challenging. Thus, a confirmed diagnosis of gastroparesis requires measurement of delayed gastric emptying via an appropriate test, such as gastric scintigraphy or breath testing. Gastroparesis can have idiopathic, diabetic, iatrogenic, post-surgical or post-viral aetiologies. The management of gastroparesis involves: correcting fluid, electrolyte and nutritional deficiencies; identifying and treating the cause of delayed gastric emptying (for example, diabetes mellitus); and suppressing or eliminating symptoms with pharmacological agents as first-line therapies. Several novel pharmacologic agents and interventions are currently in the pipeline and show promise to help tailor individualized therapy for patients with gastroparesis.

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Crossref · 10.1038/s41572-018-0038-z

Cites

14 of 14 references verified0 citation errors · 0 not checkable

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  • Diabetes can affect motility along the entire gut, producing gastroparesis often with antral hypomotility and pyloric dysfunction, rapid gastric emptying, impaired gastric accommodation, diarrhea, constipation, and fecal incontinence.

    “Diabetes can affect motility along the entire gut, producing gastroparesis (often with antral hypomotility and pyloric dysfunction), rapid gastric emptying, impaired gastric accommodation, diarrhea, constipation, and fecal incontinence (Camilleri et al., 2018; Chedid et al., 2019).”

    From Autonomic nervous system and gastrointestinal manifestations with an emphasis on gastric dysfunction (2026) · cites this paper as Camilleri et al., 2018

  • Emerging evidence suggests that macrophage phenotypes within the gut wall influence susceptibility to oxidative stress in diabetes.

    “Pathologic correlates include ‘autovagotomy’ (loss of unmyelinated axons) and loss of interstitial cells of Cajal, with emerging evidence that macrophage phenotypes within the gut wall influence susceptibility to oxidative stress (Camilleri et al., 2018).”

    From Autonomic nervous system and gastrointestinal manifestations with an emphasis on gastric dysfunction (2026) · cites this paper as Camilleri et al., 2018

  • Pathologic correlates of diabetic GI dysfunction include autovagotomy, loss of unmyelinated axons, and loss of interstitial cells of Cajal.

    “Pathologic correlates include ‘autovagotomy’ (loss of unmyelinated axons) and loss of interstitial cells of Cajal, with emerging evidence that macrophage phenotypes within the gut wall influence susceptibility to oxidative stress (Camilleri et al., 2018).”

    From Autonomic nervous system and gastrointestinal manifestations with an emphasis on gastric dysfunction (2026) · cites this paper as Camilleri et al., 2018

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Authors
Camilleri, M., Chedid, V., Ford, A. C., Haruma, K., Horowitz, M., Jones, K. L., Low, P. A., Park, S.-Y., Parkman, H. P., & Stanghellini, V.
Affiliations
  • Mayo Clinic (US)
  • University of Leeds (GB)
  • Kawasaki Medical School (JP)
  • Royal Adelaide Hospital (AU)
  • National Health and Medical Research Council (AU)
  • Chonnam National University (KR)
  • Temple University (US)
  • IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola (IT)
Corresponding author
Camilleri, Michael
ORCID
Venue
Nature Reviews Disease Primers
Publisher
Springer Science and Business Media LLC
Published
2018-11-01
Volume
4
Issue
1
Pages
41-41
ISSN
2056-676X (ISSN-L)
DOI
10.1038/s41572-018-0038-z
OpenAlex
W4211124962
Cited by
411
References
14
Citations by year
2026: 47 · 2025: 60 · 2024: 59 · 2023: 64 · 2022: 51 · 2021: 65 · 2020: 55 · 2019: 10
FWCI
5.81
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Nature Reviews Disease Primers (publishedVersion)
  • PubMed (publishedVersion)
  • Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
  • Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal Bleeding Diagnosis and Treatment
  • Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
Keywords
gastroparesis, delayed gastric emptying, functional dyspepsia, gastric emptying scintigraphy, breath test, diabetic gastroparesis, postoperative gastroparesis, nausea and vomiting
MeSH terms
Diabetes Mellitus, Humans, Quality of Life, Radionuclide Imaging, Risk Factors, Syndrome, Gastroparesis

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