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Cited by 127Gastrointestinal motility and disordersAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesPsychosomatic Disorders and Their Treatments

Psychological Dysfunction Is Associated With Symptom Severity but Not Disease Etiology or Degree of Gastric Retention in Patients With Gastroparesis

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Hasler, William L, Parkman, Henry P, Wilson, Laura A, Pasricha, Pankaj J, Koch, Kenneth L, Abell, Thomas L, Snape, William J, Farrugia, Gianrico +4 more·2010·American Journal of Gastroenterology
DOI 10.1038/ajg.2010.253PMC PMC3070288
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Abstract

OBJECTIVES: Gastroparesis patients may have associated psychological distress. This study aimed to measure depression and anxiety in gastroparesis in relation to disease severity, etiology, and gastric retention. METHODS: Beck Depression Inventory (BDI) and State-Trait Anxiety Inventory (STAI) scores for state (Y1) and trait (Y2) anxiety were obtained from 299 gastroparesis patients from 6 centers of the National Institute of Diabetes and Digestive and Kidney Diseases Gastroparesis Clinical Research Consortium. Severity was investigator graded as grades 1, 2, or 3 and patient reported by Gastroparesis Cardinal Symptom Index (GCSI) scores. Antiemetic/prokinetic medication use, anxiolytic and antidepressant medication use, supplemental feedings, and hospitalizations were recorded. BDI, Y1, and Y2 scores were compared in diabetic vs. idiopathic etiologies and mild (≤20%) vs. moderate (>20-35%) vs. severe (>35-50%) vs. very severe (>50%) gastric retention at 4 h. RESULTS: BDI, Y1, and Y2 scores were greater with increasing degrees of investigator-rated gastroparesis severity (P<0.05). BDI, Y1, and Y2 scores were higher for GCSI >3.1 vs. ≤3.1 (P<0.05). Antiemetic and prokinetic use and ≥6 hospitalizations/year were more common with BDI ≥20 vs. <20 (P<0.05). Anxiolytic use was more common with Y1≥46; antidepressant use and ≥6 hospitalizations/year were more common with Y2≥44 (P<0.05). BDI, Y1, and Y2 scores were not different in diabetic and idiopathic gastroparesis and did not relate to degree of gastric retention. On logistic regression, GCSI >3.1 was associated with BDI ≥20 and Y1≥46; antiemetic/prokinetic use was associated with BDI≥20; anxiolytic use was associated with Y1≥46; and antidepressant use was associated with Y2≥44. CONCLUSIONS: Higher depression and anxiety scores are associated with gastroparesis severity on investigator- and patient-reported assessments. Psychological dysfunction does not vary by etiology or degree of gastric retention. Psychological features should be considered in managing gastroparesis.

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  • Psychological factors (anxiety, depression, and somatization) may modulate symptom severity despite similar objective findings.

    “while psychological factors (anxiety, depression, and somatization) may modulate symptom severity despite similar objective findings [4, 18–20].”

    From Diabetic gastroparesis: pathophysiology and impact on insulin timing choices (2026) · cites this paper as [20]

    The Discussion reports that depression and anxiety correlate with gastroparesis symptom severity but not with the degree of gastric retention, supporting the claim’s contrast with objective findings. It mentions somatization in irritable bowel syndrome, not as a measured factor in gastroparesis. The authors also say their study cannot determine whether psychological abnormalities cause or result from severe symptoms, so modulation remains a possibility rather than an established finding. (LLM, conf=0.87)

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  1. [13]Andrykowski MA Jacobsen PB Marks E Prevalence, predictors, and course of anticipatory nausea in women receiving adjuvant chemotherapy for breast cancer. Cancer 1988 62 2607 13 3191461
  2. [19]Abell TL Bernstein RK Cutts T Treatment of gastroparesis: a multidisciplinary clinical review. Neurogastroenterol Motil 2006 18 263 83 16553582

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Authors
Hasler, W. L., Parkman, H. P., Wilson, L. A., Pasricha, P. J., Koch, K. L., Abell, T. L., Snape, W. J., Farrugia, G., Lee, L., Tonascia, J., Unalp-Arida, A., & Hamilton, F.
Affiliations
  • University of Michigan (US)
  • Temple University (US)
  • Johns Hopkins University (US)
  • Stanford University (US)
  • Wake Forest University (US)
  • University of Mississippi (US)
  • California Pacific Medical Center (US)
  • Mayo Clinic (US)
  • National Institute of Diabetes and Digestive and Kidney Diseases (US)
Corresponding author
Hasler, William L
ORCID
Venue
American Journal of Gastroenterology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2010-11
Volume
105
Issue
11
Pages
2357-2367
ISSN
0002-9270 (ISSN-L)
DOI
10.1038/ajg.2010.253
PMC
PMC3070288
OpenAlex
W1970865543
Cited by
127
References
40
Citations by year
2026: 4 · 2025: 10 · 2024: 6 · 2023: 9 · 2022: 5 · 2021: 4 · 2020: 15 · 2019: 6 · 2018: 13 · 2017: 8 · 2016: 8 · 2015: 5 · 2014: 7 · 2013: 5 · 2012: 7
FWCI
8.90
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (unspecified)
Locations
  • The American Journal of Gastroenterology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Diabetes and Digestive and Kidney Diseases (U01DK074008, U01DK073985, U01DK073974, U01DK074007, U01DK073983, U01DK073975, U01DK074035)
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
Keywords
depression, anxiety, psychological distress, symptom severity, etiology, diabetic gastroparesis, idiopathic gastroparesis, gastric retention, Gastroparesis Cardinal Symptom Index, anxiolytics, antidepressants, hospitalization, quality of life, psychosocial management
MeSH terms
Adult, Anxiety, Depression, Female, Gastric Emptying, Humans, Male, Middle Aged, Surveys and Questionnaires, Severity of Illness Index, Logistic Models, Gastroparesis

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