Redundant Sources of Wnt Regulate Intestinal Stem Cells and Promote Formation of Paneth Cells

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

Sato, T., Vries, R. G., Snippert, H. J., van de Wetering, M., Barker, N., Stange, D. E., van Es, J. H., Abo, A., Kujala, P., Peters, P. J., et al. (2009) · Nature · doi:10.1038/nature07935 · Cited by 7,204

Identification of stem cells in small intestine and colon by marker gene Lgr5

Barker, N., van Es, J. H., Kuipers, J., Kujala, P., van den Born, M., Cozijnsen, M., Haegebarth, A., Korving, J., Begthel, H., Peters, P. J., et al. (2007) · Nature · doi:10.1038/nature06196 · Cited by 5,687

Generalized lacZ expression with the ROSA26 Cre reporter strain

Soriano, P. (1999) · Nature Genetics · doi:10.1038/5007 · Cited by 5,237

Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett’s epithelium

Sato, T., Stange, D. E., Ferrante, M., Vries, R. G. J., van Es, J. H., van den Brink, S., van Houdt, W. J., Pronk, A., van Gorp, J., Siersema, P. D., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.07.050 · Cited by 3,753

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

Sato, T., van Es, J. H., Snippert, H. J., Stange, D. E., Vries, R. G., van den Born, M., Barker, N., Shroyer, N. F., van de Wetering, M., & Clevers, H. (2011) · Nature · doi:10.1038/nature09637 · Cited by 2,510

The β-Catenin/TCF-4 Complex Imposes a Crypt Progenitor Phenotype on Colorectal Cancer Cells

van de Wetering, M., Sancho, E., Verweij, C., de Lau, W., Oving, I., Hurlstone, A., van der Horn, K., Batlle, E., Coudreuse, D., Haramis, A.-P., et al. (2002) · Cell · doi:10.1016/s0092-8674(02)01014-0 · Cited by 2,030

Stem Cells, Self-Renewal, and Differentiation in the Intestinal Epithelium

van der Flier, L. G., & Clevers, H. C. (2008) · Annual Review of Physiology · doi:10.1146/annurev.physiol.010908.163145 · Cited by 1,994

Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4

Kořínek, V., Barker, N., Moerer, P., van Donselaar, E. V., Huls, G., Peters, P., & Clevers, H. (1998) · Nature Genetics · doi:10.1038/1270 · Cited by 1,704

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

de Lau, W., Barker, N., Low, T. Y., Koo, B., Li, V. S. W., Teunissen, H., Kujala, P., Haegebarth, A., Peters, P. J., van de Wetering, M., et al. (2011) · Nature · doi:10.1038/nature10337 · Cited by 1,302

Bmi1 is expressed in vivo in intestinal stem cells

Sangiorgi, E., & Capecchi, M. R. (2008) · Nature Genetics · doi:10.1038/ng.165 · Cited by 1,245

Mechanisms for intestinal regeneration

Dubrovsky, G., & Dunn, J. (2018) · Current Opinion in Pediatrics · doi:10.1097/mop.0000000000000630 · Cited by 14

Growth factors of stem cell niche extend the life-span of precision-cut intestinal slices in culture: A proof-of-concept study

Bigaeva, E., Bomers, J. J. M., Biel, C., Mutsaers, H. A. M., de Graaf, I. A. M., Boersema, M., & Olinga, P. (2019) · Toxicology in Vitro · doi:10.1016/j.tiv.2019.05.024 · Cited by 15

Extracellular vesicles: General features and usefulness in diagnosis and therapeutic management of colorectal cancer

Mammes, A., Pasquier, J., Mammes, O., Conti, M., Douard, R., & Loric, S. (2021) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v13.i11.1561 · Cited by 16

Proteomic Profiling of Enteroid Cultures Skewed toward Development of Specific Epithelial Lineages

Luu, L., Matthews, Z. J., Armstrong, S. D., Powell, P. P., Wileman, T., Wastling, J. M., & Coombes, J. L. (2018) · PROTEOMICS · doi:10.1002/pmic.201800132 · Cited by 14

Epigenetic Signatures and Plasticity of Intestinal and Other Stem Cells

Saxena, M., & Shivdasani, R. A. (2020) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021119-034520 · Cited by 14

Leveraging Temporal Wnt Signal for Efficient Differentiation of Intestinal Stem Cells in an Organoid Model

Li, Y., Wang, X., Zhao, G., Deng, L., & Yin, X. (2023) · Stem Cells and Development · doi:10.1089/scd.2023.0186 · Cited by 14

Death receptor 5 is required for intestinal stem cell activity during intestinal epithelial renewal at homoeostasis

Liu, J., Liu, K., Wang, Y., Shi, Z., Xu, R., Zhang, Y., Li, J., Liu, C., & Xue, B. (2024) · Cell Death and Disease · doi:10.1038/s41419-023-06409-4 · Cited by 13

WNT2B Deficiency Causes Enhanced Susceptibility to Colitis Due to Increased Inflammatory Cytokine Production

O’Connell, A. E., Raveenthiraraj, S., Oliveira, L. F. S., Adegboye, C., Dasuri, V. S., Qi, W., Khetani, R. S., Singh, A., Sundaram, N., Lin, J., et al. (2024) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2024.04.006 · Cited by 14

Modeling Human Organ Development and Diseases With Fetal Tissue–Derived Organoids

Liang, J., Li, X., Dong, Y., & Zhao, B. T. (2022) · Cell Transplantation · doi:10.1177/09636897221124481 · Cited by 13

Intestinal stem cells and gut microbiota therapeutics: hype or hope?

Sophien, A. N. A., Jusop, A. S., Tye, G. J., Tan, Y.-F., Zaman, W. S. W. K., & Nordin, F. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1195374 · Cited by 14

Small molecule and RNAi induced phenotype transition of expanded and primary colonic epithelial cells

Sharbati, J., Hanisch, C., Pieper, R., Einspanier, R., & Sharbati, S. (2015) · Scientific Reports · doi:10.1038/srep12681 · Cited by 13

Using 3D Organoid Cultures to Model Intestinal Physiology and Colorectal Cancer

Short, S. P., Costacurta, P. W., & Williams, C. S. (2017) · Current Colorectal Cancer Reports · doi:10.1007/s11888-017-0363-8 · Cited by 14

Wnt Ligands as a Part of the Stem Cell Niche in the Intestine and the Liver

Değirmenci, B., Hausmann, G., Valenta, T., & Basler, K. (2018) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2017.11.011 · Cited by 14

Short‐term and long‐term human or mouse organoid units generate tissue‐engineered small intestine without added signalling molecules

Hou, X., Chang, D. F., Trecartin, A., Barthel, E. R., Schlieve, C. R., Frey, M. R., Fowler, K. L., & Grikscheit, T. C. (2018) · Experimental Physiology · doi:10.1113/ep086990 · Cited by 13

A contemporary snapshot of intestinal stem cells and their regulation

Seishima, R., & Barker, N. (2019) · Differentiation · doi:10.1016/j.diff.2019.01.004 · Cited by 13

5-Aminolevulinic acid-mediated photodynamic activity in patient-derived cholangiocarcinoma organoids

Fujiwara, H., Takahara, N., Tateishi, K., Tanaka, M. H., Kanai, S., Kato, H., Nakatsuka, T., Yamamoto, K., Kogure, H., Arita, J., et al. (2020) · Surgical Oncology · doi:10.1016/j.suronc.2020.10.011 · Cited by 13

Unveiling the Roles of Low-Density Lipoprotein Receptor-Related Protein 6 in Intestinal Homeostasis, Regeneration and Oncogenesis

Raisch, J., Côté-Biron, A., Langlois, M., Leblanc, C., & Rivard, N. (2021) · Cells · doi:10.3390/cells10071792 · Cited by 13

Impact of gut microbiota on host stem cells across the gastrointestinal tract

Jeong, H., Lee, Y., & Nam, K. T. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2606477 · Cited by 15

Cellular Plasticity in Gut and Liver Regeneration

Kim, M., Park, Y., Kim, Y. S., & Ko, S. (2024) · Gut and Liver · doi:10.5009/gnl240005 · Cited by 12

Modulation of β-Catenin promotes WNT expression in macrophages and mitigates intestinal injury

Chugh, R. M., Bhanja, P., Zitter, R., Gunewardena, S., Badkul, R., & Saha, S. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02065-7 · Cited by 15

Small intestinal stem cells

King, S. L., & Dekaney, C. M. (2013) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e32835cf253 · Cited by 12

Loss-of-function SLC30A2 mutants are associated with gut dysbiosis and alterations in intestinal gene expression in preterm infants

Kelleher, S. L., Alam, S., Rivera, O. C., Barber-Zucker, S., Zarivach, R., Wagatsuma, T., Kambe, T., Soybel, D. I., Wright, J., & Lamendella, R. (2021) · Gut Microbes · doi:10.1080/19490976.2021.2014739 · Cited by 13

Disruption of the crypt niche promotes outgrowth of mutated colorectal tumor stem cells

Klingler, S., Hsu, K., Hua, G., Martín, M. L., Adileh, M., Baslan, T., Zhang, Z., Paty, P. B., FUKS, Z. Y., Brown, A. M. C., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.153793 · Cited by 13

Role of Wnt signaling in the maintenance and regeneration of the intestinal epithelium

Gasnier, M., Lim, H. Y. G., & Barker, N. (2023) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2023.01.001 · Cited by 14

Stem Cell Niche

Wen, P., Sun, P., & Xi, R. (2010) · Springer eBooks · doi:10.1007/978-90-481-9075-1_3 · Cited by 12

Adult Bovine-Derived Small and Large Intestinal Organoids: In Vitro Development and Maintenance

Kawasaki, M., Dykstra, G. D., McConnel, C. S., Burbick, C. R., & Ambrosini, Y. M. (2023) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1155/2023/3095002 · Cited by 11

Homeostasis, injury, and recovery dynamics at multiple scales in a self-organizing mouse intestinal crypt

Gall, L., Duckworth, C. A., Jardí, F., Lammens, L., Parker, A., Bianco, A., Kimko, H. H. C., Pritchard, D. M., & Pin, C. (2023) · eLife · doi:10.7554/elife.85478 · Cited by 12

Spatial gene expression profile of Wnt-signaling components in the murine enteric nervous system

Scharr, M., Hirt, B., & Neckel, P. H. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1302488 · Cited by 13

Single-cell analysis defines the lineage plasticity of stem cells in cervix epithelium

Zhao, Z., Wang, Y., Wu, Y., Li, D., Zhang, T., Ma, Y., Teng, X., & Zuo, W. (2021) · Cell Regeneration · doi:10.1186/s13619-021-00096-2 · Cited by 11

Perturbation of intestinal stem cell homeostasis and radiation enteritis recovery via dietary titanium dioxide nanoparticles

Zhang, L., He, Y., Dong, L., Liu, C., Su, L. C., Guo, R., Luo, Q., Gan, B., Cao, F., Wang, Y., et al. (2023) · Cell Proliferation · doi:10.1111/cpr.13427 · Cited by 11

The Central Role of Wnt Signaling and Organoid Technology in Personalizing Anticancer Therapy

Vincan, E., Schwab, R., Flanagan, D. J., Moselen, J. M., Tran, B. M., Barker, N., & Phesse, T. J. (2017) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2017.11.009 · Cited by 12

Insights Into Human Development and Disease From Human Pluripotent Stem Cell Derived Intestinal Organoids

Daoud, A., & Múnera, J. O. (2019) · Frontiers in Medicine · doi:10.3389/fmed.2019.00297 · Cited by 11

Babao Dan Alleviates 5-Fluorouracil-Induced Intestinal Damage via Wnt/β-Catenin Pathway

Gui, M., Huang, B., Peng, J., Chen, X., Muthu, R., Gao, Y., Wang, R., & Lin, J. (2021) · Chinese Journal of Integrative Medicine · doi:10.1007/s11655-021-3282-0 · Cited by 11

Wnt/β-catenin signaling cascade down-regulation following massive small bowel resection in a rat

Sukhotnik, I., Roitburt, A., Pollak, Y., Dorfman, T., Matter, I., Mogilner, J. G., Bejar, J., & Coran, A. G. (2013) · Pediatric Surgery International · doi:10.1007/s00383-013-3447-9 · Cited by 11

Non-canonical Wnt signaling triggered by WNT2B drives adrenal aldosterone productionPreprint

Borges, K. S., Little, D. W., Magalhães, T. D. A., Ribeiro, C. H. T., Dumontet, T., LaPensee, C. R., Basham, K. J., Seth, A., Azova, S., Guagliardo, N. A., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.23.609423 · Cited by 12

Non-enzymatic role of SOD1 in intestinal stem cell growth

Wang, Y., Leng, X.-X., Zhou, C., Lu, S., Tsang, C. K., Xu, J., Zhang, M., Chen, H., & Fang, J. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05267-w · Cited by 12

p21 Regulates Wnt-Notch balance via DREAM/MMB/Rb-E2F1 and maintains intestinal stem cell homeostasis

Jiang, L., Tian, J., Yang, J. H., Luo, R., Zhang, Y., Shao, C., Guo, B., Wu, X., Dan, J., & Luo, Y. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-02192-z · Cited by 10

Tcf4 regulates secretory cell fate decisions in the small intestine and colon tumors: insights from transcriptomic, histological, and microbiome analyses

Janečková, L., Šťastná, M., Hrčkulák, D., Berková, L., Kubovčiak, J., Onhajzer, J., Křı́ž, V., Dostalikova, S., Mullerova, T., Večerková, K., et al. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04280-y · Cited by 10

Prenatal supplementation with the gut-derived tryptophan metabolite indole-3-propionic acid alleviates colitis susceptibility in maternal immune-activated offspring mice

He, Y., Ding, C., Zhang, B., Bao, B., Liu, Y., Yun, D., Chen, X., Guo, R. C., She, Y., & Liu, Z. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.05.051 · Cited by 11

The gut-heart axis: a correlation between Paneth cells’ dysfunction, microbiome dysbiosis, and cardiovascular diseases

Rezabakhsh, A., Habtemariam, S., Parvizi, R., Meddahi‐Pellé, A., Rodriguez‐Ruiz, V., Pavon‐Djavid, G., & Barzgari, A. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02335-4 · Cited by 11

Paneth cells drive intestinal stem cell competition and clonality in aging and calorie restriction

Annunziata, F., Rasa, S. M. M., Křepelová, A., Lu, J. N., Minetti, A., Omrani, O., Nunna, S., Adam, L., Käppel, S., & Neri, F. (2022) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2022.151282 · Cited by 10

Visualization of Differentiated Cells in 3D and 2D Intestinal Organoid Cultures

Hanyu, H., Sugimoto, S., & Sato, T. (2023) · Methods in molecular biology · doi:10.1007/978-1-0716-3076-1_12 · Cited by 10

Circulating Wnt Ligands Activate the Wnt Signaling Pathway in Mature Erythrocytes

Siman-Tov, R., Zelikson, N., Caspi, M., Levi, Y., Perry, C., Khair, F., Stauber, H., Sznitman, J., & Rosin-Arbesfeld, R. (2021) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.315413 · Cited by 10

Taking a Step Back: Insights into the Mechanisms Regulating Gut Epithelial Dedifferentiation

Ouladan, S., & Gregorieff, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22137043 · Cited by 9

An update on the biological characteristics and functions of tuft cells in the gut

Du, Y., Gao, H., He, C., Xin, S., Wang, B., Zhang, S., Gong, F., Yu, X., Pan, L., Sun, F., et al. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1102978 · Cited by 10

Intrinsic Control of Surface Immune and Epithelial Homeostasis by Tissue-Resident Gut Stromal Cells

Kurashima, Y., Tokuhara, D., Kamioka, M., Inagaki, Y., & Kiyono, H. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01281 · Cited by 10

Organoid Derivation and Orthotopic Xenotransplantation for Studying Human Intestinal Stem Cell Dynamics

Sugimoto, S., Fujii, M., & Sato, T. (2020) · Methods in molecular biology · doi:10.1007/978-1-0716-0747-3_21 · Cited by 10

A novel group of secretory cells regulates development of the immature intestinal stem cell niche through repression of the main signaling pathways driving proliferation

Li, J., Dedloff, M. R., Stevens, K., Maney, L., Prochaska, M. K., Hongay, C. F., & Wallace, K. N. (2019) · Developmental Biology · doi:10.1016/j.ydbio.2019.08.005 · Cited by 9

Evaluation of Potential Probiotic Properties of Limosilactobacillus fermentum Derived from Piglet Feces and Influence on the Healthy and E. coli-Challenged Porcine Intestine

Qian, M., Zhou, X., Xu, T., Li, M., Yang, Z., & Han, X. (2023) · Microorganisms · doi:10.3390/microorganisms11041055 · Cited by 9

The TMEM63B Channel Facilitates Intestinal Motility and Enhances Proliferation of Intestinal Stem Cells

Tu, J.-J., Zang, Y., Shi, Y. S., & Teng, X. (2024) · Cells · doi:10.3390/cells13211784 · Cited by 10

Frizzled5 controls murine intestinal epithelial cell plasticity through organization of chromatin accessibility

Deng, L., He, X., Chen, S., Zhang, N., Deng, F., Scott, A. R., He, Y., Tsuchiya, D., Smith, S. E., Epp, M., et al. (2024) · Developmental Cell · doi:10.1016/j.devcel.2024.10.021 · Cited by 8

Long-range organization of intestinal 2D-crypts using exogenous Wnt3a micropatterning

Larrañaga, E., Marín-Riera, M., Abad‐Lázaro, A., Bartolomé-Català, D., Otero-Tarrazón, A., Fernández‐Majada, V., Batlle, E., Sharpe, J. A., Ojosnegros, S., Comelles, J., et al. (2025) · Nature Communications · doi:10.1038/s41467-024-55651-7 · Cited by 9

Impairment of stromal-epithelial regenerative cross-talk in Hirschsprung disease primes for the progression to enterocolitis

Zhang, Z., Lee, D., Liu, L., Xiong, Y., Lee, C. M., Kim, J., Chusilp, S., Lau, E., Tian, Y., Feizi, M., et al. (2025) · Science Translational Medicine · doi:10.1126/scitranslmed.adp4679 · Cited by 8

Stromal DLK1 promotes proliferation and inhibits differentiation of the intestinal epithelium during development

Ichinose, M., Suzuki, N., Wang, T., Wright, J. A., Lannagan, T. R. M., Vrbanac, L., Kobayashi, H., Gieniec, K. A., Ng, J. Q., Hayakawa, Y., et al. (2021) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00445.2020 · Cited by 9

Update on small intestinal stem cells

Tesori, V. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i29.4671 · Cited by 9

Establishment of porcine enterocyte/myofibroblast co-cultures for the growth of porcine rota- and coronaviruses

Cui, T., Theuns, S., Desmarets, L. M. B., Xie, J., Gryse, G. M. A. D., Yang, B., Broeck, W. V. D., & Nauwynck, H. (2018) · Scientific Reports · doi:10.1038/s41598-018-33305-1 · Cited by 9

Stratified layer analysis reveals intrinsic leptin stimulates cryptal mesenchymal cells for controlling mucosal inflammation

Matsumura, S., Kurashima, Y., Murasaki, S., Morimoto, M., Arai, F., Saito, Y., Katayama, N., Kim, D., Inagaki, Y., Kudo, T., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-75186-3 · Cited by 8

Cathelicidin-WA Protects Against LPS-Induced Gut Damage Through Enhancing Survival and Function of Intestinal Stem Cells

Wang, S., Kai, L., Zhu, L., Xu, B., Chen, N., Valencak, T. G., Wang, Y., & Shan, T. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.685363 · Cited by 9

Study of the colonic epithelial-mesenchymal dialogue through establishment of two activated or not mesenchymal cell lines: Activated and resting ones differentially modulate colonocytes in co-culture

Plaisancié, P., Buisson, C., Fouché, E., Martin, P., Noirot, C., Maslo, C., Dupuy, J., Guéraud, F., & Pierre, F. H. F. (2022) · PLoS ONE · doi:10.1371/journal.pone.0273858 · Cited by 9

Wnt of the Two Horizons: Putting Stem Cell Self-Renewal and Cell Fate Determination into Context

Serio, R. N. (2014) · Stem Cells and Development · doi:10.1089/scd.2014.0055 · Cited by 12

Intestinal Stem Cells

Stange, D. E. (2013) · Digestive Diseases · doi:10.1159/000355231 · Cited by 9

Suppression of intestinal tumors by targeting the mitotic spindle of intestinal stem cells

Yao, R., Oyanagi, J., Natsume, Y., Kusama, D., Kato, Y., Nagayama, S., & Noda, T. (2016) · Oncogene · doi:10.1038/onc.2016.148 · Cited by 9

Dissecting Functional, Structural, and Molecular Requirements for Serotonin Release from Mouse Enterochromaffin CellsPreprint

Shaaban, A., Maaß, F., Schwarze, V., Lund, M. L., Beuermann, S., Chan, M., Harenberg, C., Bewick, G. A., Keating, D. J., Benseler, F., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.05.28.446100 · Cited by 8

Cellular landscape of avian intestinal organoids revealed by single cell transcriptomics

Sun, J., Borowska, D., Furniss, J. J., Sutton, K., Macqueen, D. J., & Vervelde, L. (2025) · Scientific Reports · doi:10.1038/s41598-025-95721-4 · Cited by 8

Telocytes deliver essential Wnts directly to murine intestinal stem cells via synapse-like contacts

Greicius, G., Mittermeier, L., Liang, R., Sigmundsson, K., Chan, Y. K., Liao, P.-J., Ludwig, A., & Virshup, D. M. (2025) · Developmental Cell · doi:10.1016/j.devcel.2025.06.040 · Cited by 8

RIP140 Represses Intestinal Paneth Cell Differentiation and Interplays with SOX9 Signaling in Colorectal Cancer

Gleizes, A. R., Triki, M., Bonnet, S., Baccari, N., Jiménez-Domínguez, G., Covinhes, A., Pirot, N., Blache, P., Yuan, R., Győrffy, B., et al. (2021) · Cancers · doi:10.3390/cancers13133192 · Cited by 8

Study Transportation of Drugs within Newly Established Murine Colon Organoid Systems

Davoudi, Z., Atherly, T. A., Borcherding, D. C., Jergens, A. E., Wannemuehler, M. J., Barrett, T. A., & Wang, Q. (2023) · Advanced Biology · doi:10.1002/adbi.202300103 · Cited by 8

Dual function of angiogenin-4 inducing intestinal stem cells and apoptosis

Abo, H., Sultana, M. F., & Kawashima, H. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1181145 · Cited by 9

Cellular plasticity and fate determination in gastric carcinogenesis

He, Z., Hu, X.-H., He, T.-Y., & Zhao, T. (2024) · iScience · doi:10.1016/j.isci.2024.109465 · Cited by 8

Epithelial Src homology region 2 domain–containing phosphatase‐1 restrains intestinal growth, secretory cell differentiation, and tumorigenesis

Leblanc, C., Langlois, M., Coulombe, G., Vaillancourt‐Lavigueur, V., Jones, C. M., Carrier, J. C., Boudreau, F., & Rivard, N. (2017) · The FASEB Journal · doi:10.1096/fj.201601378r · Cited by 8

Epimorphin regulates the intestinal stem cell niche via effects on the stromal microenvironment

Vishy, C. E., Swietlicki, E. A., Gazit, V. A., Amara, S., Heslop, G., Lu, J., Levin, M. S., & Rubin, D. C. (2018) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00224.2017 · Cited by 8

Histological study on regional specificity of the mucosal nerve network in the rat large intestine

Nakanishi, S., MANTANI, Y., Ohno, N., Morishita, R., YOKOYAMA, T., & Hoshi, N. (2022) · Journal of Veterinary Medical Science · doi:10.1292/jvms.22-0433 · Cited by 8

Characterization and Expression of Holothurian Wnt Signaling Genes during Adult Intestinal Organogenesis

Auger, N. A., Medina-Feliciano, J. G., Quispe-Parra, D. J., Colon-Marrero, S., Ortiz‐Zuazaga, H., & García‐Arrarás, J. E. (2023) · Genes · doi:10.3390/genes14020309 · Cited by 8

Expanding intestinal stem cells in culture

Heo, I., & Clevers, H. C. (2015) · Cell Research · doi:10.1038/cr.2015.83 · Cited by 8

Roads to the Fountain of Youth? Rejuvenating Intestinal Stem Cells

Larrick, J. W., & Mendelsohn, A. R. (2019) · Rejuvenation Research · doi:10.1089/rej.2019.2251 · Cited by 9

Tissue Engineering Functional Gastrointestinal Regions: The Importance of Stem and Progenitor CellsPreprint

Trecartin, A., & Grikscheit, T. C. (2017) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a025700 · Cited by 8

Intestinal Wnt in the transition from physiology to oncology

Swoboda, J., Mittelsdorf, P., Chen, Y., Weiskirchen, R., Stallhofer, J., Schüle, S., & Gaßler, N. (2022) · World Journal of Clinical Oncology · doi:10.5306/wjco.v13.i3.168 · Cited by 8

Epigenetic control of cellular crosstalk defines gastrointestinal organ fate and function

Smith, R. J., Liang, M., Loe, A. K. H., Yung, T. M., Kim, J., Hudson, M., Wilson, M. D., & Kim, T.-H. (2023) · Nature Communications · doi:10.1038/s41467-023-36228-2 · Cited by 8

Tissue-Predisposition to Cancer Driver Mutations

Peters, L., Venkatachalam, A., & Ben‐Neriah, Y. (2024) · Cells · doi:10.3390/cells13020106 · Cited by 7

Preclinical testing of oncolytic adenovirus sensitivity in patient-derived tumor organoids

Pascual-Sabater, S., Raimondi, G., Mato-Berciano, A., Vaquero, E. C., Ausania, F., & Fillat, C. (2021) · STAR Protocols · doi:10.1016/j.xpro.2021.101017 · Cited by 7

Glycoprotein (GP)96 Is Essential for Maintaining Intestinal Epithelial Architecture by Supporting Its Self-Renewal Capacity

Häfliger, J., Schwarzfischer, M., Atrott, K., Stanzel, C., Morsy, Y., Wawrzyniak, M., Lang, S., Valenta, T., Basler, K., Rogler, G., et al. (2022) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2022.12.004 · Cited by 8

Defining key concepts of intestinal and epithelial cancer biology through the use of mouse models

Phesse, T. J., Durban, V. M., & Sansom, O. J. (2017) · Carcinogenesis · doi:10.1093/carcin/bgx080 · Cited by 7

Identification of liver‐derived bone morphogenetic protein (BMP)‐9 as a potential new candidate for treatment of colorectal cancer

Cai, C., Itzel, T., Gaitantzi, H., Torre, C. D. L., Birgin, E., Betge, J., Gretz, N., Teufel, A., Rahbari, N. N., Ebert, M. P., et al. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17084 · Cited by 7

Correction: A more physiological approach to lipid metabolism alterations in cancer: CRC-like organoids assessment

Cruz-Gil, S., Sánchez‐Martínez, R., Wagner, S., Stange, D. E., Schölch, S., Pape, K., & de Molina, A. R. (2019) · PLoS ONE · doi:10.1371/journal.pone.0222819 · Cited by 7

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Lei, Q., Fan, M., Lin, X., Cai, Z., Li, H., Wang, H., Wang, J., Yin, R., Nan, S., Abouelfetouh, M. M., et al. (2025) · Journal of Dairy Science · doi:10.3168/jds.2025-26256 · Cited by 6

Defining the mucosal ecosystem: epithelial–mesenchymal interdependence in gastrointestinal health and disease

England, F. J., Lin, M., Sigal, M. J., & Leedham, S. J. (2025) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-025-01113-4 · Cited by 6

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Jiao, C., Karakaya, O. F., Dadgar, N., Wehrle, C. J., Massoud, Z., Hong, H., Fairchild, R. L., Leipzig, N. D., Aucejo, F., Ma, W. W., et al. (2026) · MedComm · doi:10.1002/mco2.70571 · Cited by 9

MTGR1 is required to maintain small intestinal stem cell populations

Short, S. P., Brown, R. E., Chen, Z., Pilat, J. M., McElligott, B. A., Meenderink, L. M., Bickart, A. C., Blunt, K. M., Jacobse, J., Wang, J., et al. (2024) · Cell Death and Differentiation · doi:10.1038/s41418-024-01346-x · Cited by 6

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Varga, J., & Greten, F. R. (2016) · Cell stem cell · doi:10.1016/j.stem.2015.12.008 · Cited by 6

Intestinal Stem Cells and Their Niche at Homeostasis and Under Stress

Peduto, L., Sansonetti, P. J., & Nigro, G. (2018) · Advances in stem cells and their niches · doi:10.1016/bs.asn.2017.12.002 · Cited by 6

The phosphatase PRL-3 affects intestinal homeostasis by altering the crypt cell composition

Rubio, T., Weyershaeuser, J., Montero, M. G., Hoffmann, A., Luján, P., Jechlinger, M., Sotillo, R., & Köhn, M. (2021) · Journal of Molecular Medicine · doi:10.1007/s00109-021-02097-9 · Cited by 6

Epithelial Wnt secretion drives the progression of inflammation-induced colon carcinoma in murine model

Değirmenci, B., Dinçer, C., Demirel, H. C., Berková, L., Moor, A. E., Kahraman, A., Hausmann, G., Aguet, M., Tunçbağ, N., Valenta, T., et al. (2021) · iScience · doi:10.1016/j.isci.2021.103369 · Cited by 6

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Cruz-Gil, S., Sánchez‐Martínez, R., Wagner, S., Stange, D. E., Schölch, S., Pape, K., & de Molina, A. R. (2019) · PLoS ONE · doi:10.1371/journal.pone.0219944 · Cited by 6

Clonal Evolution of Stem Cells in the Gastrointestinal Tract

Fink, J., & Koo, B. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-41388-4_2 · Cited by 6

Notch inhibition counteracts Paneth cell death in absence of caspase-8

Jeon, M., Kaemmerer, E., Schneider, U., Schiffer, M., Klaus, C., Hennings, J., Clahsen, T., Ackerstaff, T., Niggemann, M., Schippers, A., et al. (2018) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-018-2368-3 · Cited by 7

Establishment of a refined culture method for rat colon organoids

Isshiki, H., Arimura, Y., Nagaishi, K., Kawakami, K., Onodera, K., Yamashita, K., Naishiro, Y., Fujimiya, M., Imai, K., & Shinomura, Y. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.05.142 · Cited by 5

Multi-Class Segmentation and Classification of Intestinal Organoids: YOLO Stand-Alone vs. Hybrid Machine Learning Pipelines

Conte, L., Nunzio, G. D., Raso, G., & Cascio, D. (2025) · Applied Sciences · doi:10.3390/app152111311 · Cited by 5

The Function of Lgr5+ Cells in the Gastric Antrum Does Not Require Fzd7 or Myc In Vivo

Flanagan, D. J., Barker, N., Ernst, M., Vincan, E., & Phesse, T. J. (2019) · Biomedicines · doi:10.3390/biomedicines7030050 · Cited by 5

Myeloid vitamin D receptor regulates Paneth cells and microbial homeostasis

Bakke, D., Zhang, J., Zhang, Y., Ogbu, D., Xia, Y., & Sun, J. (2023) · The FASEB Journal · doi:10.1096/fj.202202169rr · Cited by 5

Abstract 5931: PDGFRα+ pericryptal stromal cells are the critical source of Wnts and RSPO3 for murine intestinal stem cells in vivo

Greicius, G., Kabiri, Z., Sigmundsson, K., Liang, C., Bunte, R. M., Singh, M. K., & Virshup, D. M. (2018) · Cancer Research · doi:10.1158/1538-7445.am2018-5931 · Cited by 1

Wnt Secretion from Epithelial Cells and Subepithelial Myofibroblasts Is Not Required in the Mouse Intestinal Stem Cell Niche In Vivo

Roman, A. K. S., Jayewickreme, C. D., Murtaugh, L. C., & Shivdasani, R. A. (2014) · Stem Cell Reports · doi:10.1016/j.stemcr.2013.12.012 · Cited by 133

Stroma provides an intestinal stem cell niche in the absence of epithelial Wnts

Kabiri, Z., Greicius, G., Madan, B., Biechele, S., Zhong, Z. A., Zaribafzadeh, H., Edison, Aliyev, J., Wu, Y., Bunte, R. M., et al. (2014) · Development · doi:10.1242/dev.104976 · Cited by 351

Visualization of a short-range Wnt gradient in the intestinal stem-cell niche

Farin, H. F., Jordens, I., Mosa, M. H., Basak, O., Korving, J., Tauriello, D. V. F., de Punder, K., Angers, S., Peters, P. J., Maurice, M. M., et al. (2016) · Nature · doi:10.1038/nature16937 · Cited by 525

Wnt Signaling in 3D: Recent Advances in the Applications of Intestinal Organoids

Merenda, A., Fenderico, N., & Maurice, M. M. (2019) · Trends in Cell Biology · doi:10.1016/j.tcb.2019.10.003 · Cited by 117