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Brain gut microbiome interactions and functional bowel disorders
Open accessAbstract
Alterations in the bidirectional interactions between the intestine and the nervous system have important roles in the pathogenesis of irritable bowel syndrome (IBS). A body of largely preclinical evidence suggests that the gut microbiota can modulate these interactions. A small and poorly defined role for dysbiosis in the development of IBS symptoms has been established through characterization of altered intestinal microbiota in IBS patients and reported improvement of subjective symptoms after its manipulation with prebiotics, probiotics, or antibiotics. It remains to be determined whether IBS symptoms are caused by alterations in brain signaling from the intestine to the microbiota or primary disruption of the microbiota, and whether they are involved in altered interactions between the brain and intestine during development. We review the potential mechanisms involved in the pathogenesis of IBS in different groups of patients. Studies are needed to better characterize alterations to the intestinal microbiome in large cohorts of well-phenotyped patients, and to correlate intestinal metabolites with specific abnormalities in gut-brain interactions.
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“Both neural (vagus) and hormonal (HPA axis) lines of communication combine to allow brain to influence the activities of intestinal functional effector cells, such as immune cells, epithelial cells, enteric neurons, smooth muscle cells, interstitial cells of Cajal, and enterochromaffin cells (32).”
From Vagus Nerve as Modulator of the Brain–Gut Axis in Psychiatric and Inflammatory Disorders (2018) · cites this paper as [32]
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“Mechanistic data provided mainly by animal studies highlight that probiotics exert a direct antinociceptive action through the modulation of bacterial metabolites production (i.e., neurotransmitters, neuroactive substances including GABA and serotonin) on sensitive nerve endings in the gut mucosa [2631,130]”
From Gut microbiota role in irritable bowel syndrome: New therapeutic strategies (2016) · cites this paper as [130]
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Cites
Diet rapidly and reproducibly alters the human gut microbiome
David, L. A., Maurice, C. F., Carmody, R. N., Gootenberg, D. B., Button, J. E., Wolfe, B. E., Ling, A. V., Devlin, A. S., Varma, Y., Fischbach, M. A., et al. (2014) · Nature · doi:10.1038/nature12820 · Cited by 10,100
Linking long-term dietary patterns with gut microbial enterotypes
Wu, G. D., Chen, J., Hoffmann, C., Bittinger, K., Chen, Y.-Y., Keilbaugh, S. A., Bewtra, M., Knights, D., Walters, W. A., Knight, R., et al. (2011) · Science · doi:10.1126/science.1208344 · Cited by 6,513
De Filippo, C., Cavalieri, D., Di Paola, M., Ramazzotti, M., Poullet, J. B., Massart, S., Collini, S., Pieraccini, G., & Lionetti, P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005963107 · Cited by 5,579
The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic T reg Cell Homeostasis
Smith, P. M., Howitt, M. R., Panikov, N., Michaud, M., Gallini, C. A., Bohlooly-Y, M., Glickman, J. N., & Garrett, W. S. (2013) · Science · doi:10.1126/science.1241165 · Cited by 5,413
The gut microbiota shapes intestinal immune responses during health and disease
Round, J. L., & Mazmanian, S. K. (2009) · Nature Reviews Immunology · doi:10.1038/nri2515 · Cited by 5,029
Richness of human gut microbiome correlates with metabolic markers
Le Chatelier, E., Nielsen, T., Qin, J., Prifti, E., Hildebrand, F., Falony, G., Almeida, M., Arumugam, M., Batto, J.-M., Kennedy, S., et al. (2013) · Nature · doi:10.1038/nature12506 · Cited by 4,662
Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour
Cryan, J. F., & Dinan, T. G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3346 · Cited by 4,572
Bravo, J. A., Forsythe, P., Chew, M. V., Escaravage, E., Savignac, H. M., Dinan, T. G., Bienenstock, J., & Cryan, J. F. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102999108 · Cited by 3,888
Normal gut microbiota modulates brain development and behavior
Heijtz, R. D., Wang, S., Anuar, F., Qian, Y., Björkholm, B., Samuelsson, A., Hibberd, M. L., Forssberg, H., & Pettersson, S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010529108 · Cited by 3,228
Short chain fatty acids in human large intestine, portal, hepatic and venous blood
Cummings, J. H., Pomare, E. W., Branch, W. J., Naylor, C. P., & Macfarlane, G. T. (1987) · Gut · doi:10.1136/gut.28.10.1221 · Cited by 3,119
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Association of Gut Hormones and Microbiota with Vascular Dysfunction in Obesity
Rovella, V., Rodia, G., Daniele, F. D., Cardillo, C., Campia, U., Noce, A., Candi, E., Della‐Morte, D., & Tesauro, M. (2021) · Nutrients · doi:10.3390/nu13020613 · Cited by 24
Zhang, X., Svn, Z., Liv, M., Yan, Y., Zeng, R., Huang, Q., & Sun, Q. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.720958 · Cited by 25
Xinzhou, W., Cheng, L., Liu, Y., Zhang, R., Wu, Z., Weng, P., Zhang, P., & Zhang, X. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.807076 · Cited by 24
Recent findings within the microbiota–gut–brain–endocrine metabolic interactome
Obrenovich, M. E., Mana, T. S. C., Rai, H., Shola, D. T. N., Sass, C., McCloskey, B., & Levison, B. S. (2017) · Pathology and Laboratory Medicine International · doi:10.2147/plmi.s121487 · Cited by 24
Influences of environmental factors during preeclampsia
Dasinger, J. H., Abais‐Battad, J. M., & Mattson, D. L. (2020) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00020.2020 · Cited by 26
Yuan, M., Zhang, Z., Liu, T., Hua, F., Liu, Y., & Chen, K. (2024) · Foods · doi:10.3390/foods13132157 · Cited by 23
Atanasova, K., Lotter, T., Reindl, W., & Lis, S. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.680878 · Cited by 26
Impact of Probiotics in Modulation of Gut Microbiome
Nourizadeh, R., Sepehri, B., Abbasi, A., Sayyed, R. Z., & Khalili, L. (2022) · Springer eBooks · doi:10.1007/978-981-16-1626-6_20 · Cited by 23
Therapeutic implications of SARS-CoV-2 dysregulation of the gut-brain-lung axis
Johnson, S. D., Olwenyi, O. A., Bhyravbhatla, N., Thurman, M., Pandey, K., Klug, E., Johnston, M., Dyavar, S. R., Acharya, A., Podany, A. T., et al. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i29.4763 · Cited by 24
Microbial influences on gut development and gut-brain communication
Ye, L., & Rawls, J. F. (2021) · Development · doi:10.1242/dev.194936 · Cited by 22
Wang, G. N., Zhang, K., Xiong, Y. Y., & Liu, S. (2023) · Pediatric Research · doi:10.1038/s41390-023-02711-1 · Cited by 22
Gut-Brain Axis and its Neuro-Psychiatric Effects: A Narrative Review
Shaik, L., Kashyap, R., Thotamgari, S. R., Singh, R., & Khanna, S. (2020) · Cureus · doi:10.7759/cureus.11131 · Cited by 22
Stachelska, M. A., Karpiński, P., & Kruszewski, B. (2024) · Nutrients · doi:10.3390/nu17010009 · Cited by 26
Jeon, S., Kim, H., Kim, J., Seol, D., Jo, J., Choi, Y., Cho, S., & Kim, H. (2022) · Microbiology Spectrum · doi:10.1128/spectrum.01815-21 · Cited by 20
A multi-omic brain gut microbiome signature differs between IBS subjects with different bowel habits
Sarnoff, R. P., Bhatt, R. R., Osadchiy, V., Dong, T. S., Labus, J. S., Kilpatrick, L. A., Chen, Z., Subramanyam, V., Zhang, Y., Ellingson, B. M., et al. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109381 · Cited by 22
Self-citationWu, L., Gao, L., Jin, X., Chen, Z., Qiao, X., Cui, X., Gao, J., & Zhang, L. (2023) · Foods · doi:10.3390/foods12051101 · Cited by 22
Gut instincts: Unveiling the connection between gut microbiota and Alzheimer's disease
Peddinti, V., Avaghade, M. M., Suthar, S. U., Rout, B., Gomte, S. S., Agnihotri, T. G., & Jain, A. (2024) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2024.02.019 · Cited by 24
Ma, J., Li, J., Qian, M., He, N., Cao, Y. J., Liu, Y., Wu, K., & He, S. (2019) · The FASEB Journal · doi:10.1096/fj.201901489r · Cited by 21
Xia, T., Huang, F., Yun, F., Liu, Y., Wang, T., Wang, S., Jin, S., Ma, X., Wang, W., He, J., et al. (2024) · Current Research in Food Science · doi:10.1016/j.crfs.2024.100924 · Cited by 22
Gut virome: New key players in the pathogenesis of inflammatory bowel disease
Hetta, . F., Ahmed, R. F., Ramadan, Y. N., Fathy, H., Khorshid, M., Mabrouk, M. M., & Hashem, M. (2024) · World Journal of Methodology · doi:10.5662/wjm.v15.i2.92592 · Cited by 21
Peter, J., Tran, U. S., Michalski, M., & Moser, G. (2018) · PLoS ONE · doi:10.1371/journal.pone.0202538 · Cited by 22
Boonma, P., Shapiro, J. M., Hollister, E. B., Badu, S., Wu, Q., Weidler, E. M., Abraham, B. P., Devaraj, S., Luna, R. A., Versalovic, J. A., et al. (2021) · Frontiers in Pain Research · doi:10.3389/fpain.2021.691689 · Cited by 20
Self-citationZhang, K., Liu, G., Wu, Y., Zhang, T., Guo, M., Yu, L., Cao, X., Suo, L., Brügger, D., Wang, X., et al. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.02955-22 · Cited by 23
Collyer, R., Clancy, A., & Borody, T. (2020) · Medicine in Microecology · doi:10.1016/j.medmic.2020.100029 · Cited by 19
Louka, E., & Koumandou, V. L. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46050286 · Cited by 20
Golden bifid might improve diarrhea-predominant irritable bowel syndrome via microbiota modulation
Luo, M., Liu, Q., Xiao, L., & Xiong, L. (2022) · Journal of Health Population and Nutrition · doi:10.1186/s41043-022-00302-0 · Cited by 19
Mehrzadi, S., Sheibani, M., Koosha, F., Alinaghian, N., Pourhanifeh, M. H., Tabaeian, S. P., Reiter, R. J., & Hosseinzadeh, A. (2023) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2023.2267439 · Cited by 19
Seong, G., Lee, S., Min, Y., Jang, Y., Park, S.-Y., Kim, C.-H., Lee, C., Hong, S., & Chang, D. (2020) · Nutrients · doi:10.3390/nu12103205 · Cited by 17
Analysis of the gut microbiota composition of myostatin mutant cattle prepared using CRISPR/Cas9
Wen, T., Mao, C., & Gao, L. (2022) · PLoS ONE · doi:10.1371/journal.pone.0264849 · Cited by 18
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Giorgio, V., Margiotta, G., Stella, G., Cicco, F. D., Leoni, C., Proli, F., Zampino, G., Gasbarrini, A., & Onesimo, R. (2022) · Nutrients · doi:10.3390/nu14081578 · Cited by 21
Muraleedharan, A., & Ray, S. K. (2024) · Brain Sciences · doi:10.3390/brainsci14010096 · Cited by 20
Pancreatic Diseases and Microbiota: A Literature Review and Future Perspectives
Gesualdo, M., Rizzi, F., Bonetto, S., Rizza, S., Cravero, F., Saracco, G. M., & Angelis, C. G. D. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9113535 · Cited by 17
Auto-Brewery as an Emerging Syndrome: Three Representative Case Studies
(2015) · Journal of Clinical & Medical Case Reports · doi:10.13188/2332-4120.1000013 · Cited by 19
The Gut Microbiome During Pregnancy
Jiang, G., Zhou, Z., Li, X., Qian, Y., & Wang, K. (2021) · Maternal-Fetal Medicine · doi:10.1097/fm9.0000000000000091 · Cited by 21
Raj, K., Singh, S., Chib, S., & Mallan, S. (2022) · Current Pharmaceutical Design · doi:10.2174/1381612828666221003112300 · Cited by 16
Kaplan, A. I., Mazor, Y., Prott, G. M., Sequeira, C., Jones, M., & Malcolm, A. (2022) · Neurogastroenterology & Motility · doi:10.1111/nmo.14524 · Cited by 16
Effects of natural products on functional constipation: analysis of active ingredient and mechanism
Zhou, P., Wang, X., Sun, M., & Yan, S. (2023) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-023-02786-x · Cited by 16
Gupta, S., Dinesh, S., & Sharma, S. (2024) · Central Nervous System Agents in Medicinal Chemistry · doi:10.2174/0118715249271548231115071021 · Cited by 18
A clinical primer of the role of gut microbiome in health and disease
Yang, A. L., & Kashyap, P. (2015) · Tropical Gastroenterology · doi:10.7869/tg.238 · Cited by 16
Trasplante de microbiota fecal
de Paredes, A. G. G., de Santiago, E. R., Aguilera, L., Ferre‐Aracil, C., & López–Sanromán, A. (2014) · Gastroenterología y Hepatología · doi:10.1016/j.gastrohep.2014.07.010 · Cited by 17
Feng, Y., Fan, H., Liang, X., Wang, X., Gao, G., & Gun, S. (2022) · PeerJ · doi:10.7717/peerj.13068 · Cited by 17
Liu, L., Du, C., Liu, Y., & Gao, L. (2022) · Frontiers in Veterinary Science · doi:10.3389/fvets.2022.860540 · Cited by 16
Sensory Processing Sensitivity and Gastrointestinal Symptoms in Japanese Adults
Iimura, S., & Takasugi, S. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19169893 · Cited by 16
Network analysis of temporal functionalities of the gut induced by perturbations in new-born piglets
Benis, N., Schokker, D., Diez, M. S., dos Santos, V. A. P. M., Smidt, H., & Smits, M. A. (2015) · BMC Genomics · doi:10.1186/s12864-015-1733-8 · Cited by 15
The Unknown Effect of Antibiotic-Induced Dysbiosis on the Gut Microbiota
Birg, A., Ritz, N. L., & Lin, H. C. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-815249-2.00020-8 · Cited by 16
Targeted Biomedical Treatment for Autism Spectrum Disorders
Pacheva, I. H., & Ivanov, I. S. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666191205091312 · Cited by 17
Giang, J., Lan, X., Crichton, M., Marx, W., & Marshall, S. (2021) · Nutrition & Dietetics · doi:10.1111/1747-0080.12672 · Cited by 16
The Gastrointestinal Microbiome
(2016) · doi:10.1128/9781555819071.ch11 · Cited by 15
Opekun, A. R., Balesh, A. M., & Shelby, H. T. (2016) · BioMed Research International · doi:10.1155/2016/7952891 · Cited by 15
Kazemian, N., & Pakpour, S. (2024) · Microbial Biotechnology · doi:10.1111/1751-7915.70030 · Cited by 17
Gut Microbiome and Autism: Recent Advances and Future Perspectives
Liu, J., Zhang, M., & Kong, X. (2016) · North American Journal of Medicine and Science · Cited by 14
Guo, M., Cao, X., Zhang, K., Pan, M., Wu, Y., Suo, L., Yang, Y., Chen, Y., Gui, B., & Ma, B. (2022) · Veterinary Sciences · doi:10.3390/vetsci9040169 · Cited by 14
Rezazadegan, M., Shahdadian, F., Soheilipour, M., Tarrahi, M. J., & Amani, R. (2022) · Scientific Reports · doi:10.1038/s41598-022-15080-2 · Cited by 14
Human microbiome: From the bathroom to the bedside
Malnick, S. D. H., & Melzer, E. (2015) · World Journal of Gastrointestinal Pathophysiology · doi:10.4291/wjgp.v6.i3.79 · Cited by 15
Jang, S.-H., Ryu, H.-S., Choi, S. C., & Lee, S.-Y. (2017) · Psychiatry Investigation · doi:10.4306/pi.2017.14.4.434 · Cited by 14
Lackner, J. (2020) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2020.1780118 · Cited by 11
Kurakin, A. V., & Bredesen, D. E. (2020) · Aging · doi:10.18632/aging.103883 · Cited by 15
The Role of Livestock Antibiotic Use in Microbiota Dysbiosis and Neuroinflammation
Silvestro, S., Biondo, C., Midiri, A., Lucia, B. P. A., & Mancuso, G. (2025) · Antibiotics · doi:10.3390/antibiotics14060608 · Cited by 17
Anzà, S., Schneider, D., Daniel, R., Heistermann, M., Sangmaneedet, S., Ostner, J., & Schülke, O. (2023) · Microbiome · doi:10.1186/s40168-023-01596-w · Cited by 14
Irritable Bowel Syndrome in Terms of Changes in the Microbiota
Ivashkin, V. T., & Zolnikova, O. Y. (2019) · Russian Journal of Gastroenterology Hepatology Coloproctology · doi:10.22416/1382-4376-2019-29-1-84-92 · Cited by 13
Cognitive Functions and Depression in Patients with Irritable Bowel Syndrome
Farup, P. G., & Hestad, K. A. (2015) · Gastroenterology Research and Practice · doi:10.1155/2015/438329 · Cited by 13
Long-Term Impact of Childhood Adversity on the Gut Microbiome of Nursing Students
Kazemian, N., Zhou, T., Chalasani, N., Narayan, A., Laurent, J. G. C., Alvarez, H. A. O., & Pakpour, S. (2024) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph21010068 · Cited by 12
Neuropathy in COVID-19 associated with dysbiosis-related inflammation
Aktaş, B., & Aslım, B. (2021) · TURKISH JOURNAL OF BIOLOGY · doi:10.3906/biy-2105-53 · Cited by 12
Kheloui, S., Smith, A., & Ismail, N. (2022) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2022.101041 · Cited by 15
Benis, N., Wells, J. M., Smits, M. A., Kar, S. K., van der Hee, B., dos Santos, V. A. P. M., Diez, M. S., & Schokker, D. (2019) · BMC Genomics · doi:10.1186/s12864-019-6390-x · Cited by 12
The link between gut microbiota and multiple sclerosis from the perspective of barrier function
Ren, J., Niu, Z., Wang, J., Guo, J., Hao, H.-J., Gao, F., Liu, R., & Wang, Z. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1652796 · Cited by 13
Intriguing Role of Gut-Brain Axis on Cognition with an Emphasis on Interaction with Papez Circuit
Xavier, J., Anu, M., Fathima, A. S., Ravichandiran, V., & Kumar, N. (2022) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527321666220614124145 · Cited by 11
Drug discovery approaches to irritable bowel syndrome
Hornby, P. J. (2015) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2015.1049528 · Cited by 11
The Costs of Living Together: Immune Responses to the Microbiota and Chronic Gut Inflammation
Kirschman, L. J., & Milligan‐McClellan, K. (2018) · Applied and Environmental Microbiology · doi:10.1128/aem.02147-18 · Cited by 11
Die Rolle Der Psychotherapie Beim Reizdarmsyndrom
Weibert, E., & Stengel, A. (2019) · PPmP - Psychotherapie · Psychosomatik · Medizinische Psychologie · doi:10.1055/a-0829-6990 · Cited by 11
Role and impact of the gut microbiota in a Drosophila model for parkinsonismPreprint
Feltzin, V., Wan, K. H., Celniker, S., & Bonini, N. M. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/718825 · Cited by 14
Mărginean, C. M., Popescu, M., Drocaș, A. I., Cazacu, S. M., Mitruţ, R., Mărginean, I. C., Iacob, G. A., Popescu, M. S., Docea, A. O., & Mitruț, P. (2023) · Gastrointestinal Disorders · doi:10.3390/gidisord5040043 · Cited by 10
New treatment options for irritable bowel syndrome with predominant diarrhea
Weber, H. C. (2016) · Current Opinion in Endocrinology, Diabetes & Obesity · doi:10.1097/med.0000000000000302 · Cited by 9
Liu, J., Ren, H., Yuan, F., Shao, M., & Luo, H.-S. (2022) · PeerJ · doi:10.7717/peerj.14390 · Cited by 10
Dai, Y., Shen, Z., Khachatryan, L., Vadiyan, D. E., Karampoor, S., & Mirzaei, R. (2023) · Pathology - Research and Practice · doi:10.1016/j.prp.2023.154740 · Cited by 10
Ho, S.-M., Tsai, W.-H., Lai, C., Chiang, M.-H., Lee, W.-P., Wu, H.-Y., Bai, P.-Y., Wu, T., & Wu, C. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2316533 · Cited by 11
Functional Abdominal Pain and Related Syndromes.
Herzlinger, M., & Cerezo, C. (2018) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2017.08.006 · Cited by 10
Sometti, D., Ballan, C., Wang, H., Braun, C., & Enck, P. (2021) · Scientific Reports · doi:10.1038/s41598-021-83994-4 · Cited by 11
Lv, Y., Wen, J., Fang, Y., Zhang, H., & Zhang, J. (2021) · Peptides · doi:10.1016/j.peptides.2021.170705 · Cited by 10
Can irritable bowel syndrome be detected by ultrasound?
Okawa, Y. (2020) · Drug Discoveries & Therapeutics · doi:10.5582/ddt.2020.03082 · Cited by 10
Irritable bowel syndrome and functional dyspepsia: what can epidemiology tell us about etiology?
Talley, N. J., & Holtmann, G. (2018) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2018.1476136 · Cited by 10
Vedantam, S., Graff, E., Khakoo, N. S., Khakoo, N. S., & Pearlman, M. Y. (2023) · Current Gastroenterology Reports · doi:10.1007/s11894-023-00861-0 · Cited by 11
Targeted pharmacotherapy of irritable bowel syndrome.
Arokiadoss, A., & Weber, H. (2021) · Current Opinion in Endocrinology, Diabetes & Obesity · doi:10.1097/med.0000000000000618 · Cited by 9
The Maternal Gut Microbiome During Pregnancy
(2017) · MCN The American Journal of Maternal/Child Nursing · doi:10.1097/nmc.0000000000000398 · Cited by 9
Lambiase, C., Rettura, F., Sciumè, G. D., Tedeschi, R., Grosso, A., Cancelli, L., Bottari, A., Fornai, M., Antonioli, L., de Bortoli, N., et al. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1677037 · Cited by 8
Sun, X., Zhang, S., & Zhou, X. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1430280 · Cited by 9
The Influence of the Gut Microbiome in Paediatric Cancer Origin and Treatment
Sági, V., Makra, N., Csoszánszki, N., Decmann, Á., Szabó, D., & Garami, M. (2022) · Antibiotics · doi:10.3390/antibiotics11111521 · Cited by 9
Shulman, R. J., Öhman, L., Stridsberg, M., Cain, K. C., Simrén, M., & Heitkemper, M. M. (2018) · Neurogastroenterology & Motility · doi:10.1111/nmo.13486 · Cited by 8
Self-citationGut Microbiota Dysbiosis and COVID-19: Possible Links
Aktaş, B. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819265-8.00072-3 · Cited by 7
The gut microbiota-neuroimmune crosstalk and neuropathic pain: a scoping review
Nawarathna, G. S., Fakhruddin, K. S., Shorbagi, A., & Samaranayake, L. P. (2023) · Gut Microbiome · doi:10.1017/gmb.2023.7 · Cited by 7
Iimura, S., Takasugi, S., Yasuda, M., Saito, Y., & Morifuji, M. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.07.016 · Cited by 7
Gut microbiota and exercise-induced fatigue: unraveling the connections
Li, Q., Wen, X. L., Wang, G., Wang, Z., & Tian, P. (2024) · Food Science of Animal Products · doi:10.26599/fsap.2024.9240061 · Cited by 7
Mechanism-Oriented Therapy of Irritable Bowel Syndrome
Malagelada, J. R., & Malagelada, C. (2016) · Advances in Therapy · doi:10.1007/s12325-016-0336-3 · Cited by 7
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Metadata
- Authors
- Mayer, E. A., Savidge, T., & Shulman, R. J.
- Affiliations
- University of California, Los Angeles (US)
- Baylor College of Medicine (US)
- Corresponding author
- Mayer, Emeran A.
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2014-05
- Volume
- 146
- Issue
- 6
- Pages
- 1500-1512
- ISSN
- 0016-5085 (ISSN-L)
- PMC
- PMC4114504
- OpenAlex
- W2014965759
- Cited by
- 496
- References
- 146
- Citations by year
- 2026: 23 · 2025: 38 · 2024: 36 · 2023: 39 · 2022: 55 · 2021: 50 · 2020: 48 · 2019: 48 · 2018: 42 · 2017: 39 · 2016: 31 · 2015: 37 · 2014: 10
- FWCI
- 6.37
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health (DK 64531, DK 48351)
- National Institute of Nursing Research (13497, AI100914, DK56338)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Health and Development
- Keywords
- gut-brain axis, gut microbiota, irritable bowel syndrome, dysbiosis, functional bowel disorders, prebiotics, probiotics, antibiotics, intestinal metabolites, pathogenesis
- MeSH terms
- Animals, Anti-Inflammatory Agents, Anti-Bacterial Agents, Bacteria, Brain, Humans, Intestinal Mucosa, Intestines, Neural Pathways, Inflammatory Bowel Diseases, Signal Transduction, Probiotics, Host-Pathogen Interactions, Microbiota, Dysbiosis
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