Cited by 496Gastrointestinal motility and disordersGut microbiota and healthInfant Health and Development

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Brain gut microbiome interactions and functional bowel disorders

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Mayer, Emeran A., Savidge, Tor, Shulman, Robert J.·2014·Gastroenterology

DOI 10.1053/j.gastro.2014.02.037PMC PMC4114504

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Abstract

Alterations in the bidirectional interactions between the intestine and the nervous system have important roles in the pathogenesis of irritable bowel syndrome (IBS). A body of largely preclinical evidence suggests that the gut microbiota can modulate these interactions. A small and poorly defined role for dysbiosis in the development of IBS symptoms has been established through characterization of altered intestinal microbiota in IBS patients and reported improvement of subjective symptoms after its manipulation with prebiotics, probiotics, or antibiotics. It remains to be determined whether IBS symptoms are caused by alterations in brain signaling from the intestine to the microbiota or primary disruption of the microbiota, and whether they are involved in altered interactions between the brain and intestine during development. We review the potential mechanisms involved in the pathogenesis of IBS in different groups of patients. Studies are needed to better characterize alterations to the intestinal microbiome in large cohorts of well-phenotyped patients, and to correlate intestinal metabolites with specific abnormalities in gut-brain interactions.

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Authors: Mayer, E. A., Savidge, T., & Shulman, R. J.
Affiliations: University of California, Los Angeles (US)
Baylor College of Medicine (US)
Corresponding author: Mayer, Emeran A.
ORCID: Mayer, Emeran A.
Savidge, Tor
Shulman, Robert J.
Venue: Gastroenterology
Publisher: Elsevier BV
Published: 2014-05
Volume: 146
Issue: 6
Pages: 1500-1512
ISSN: 0016-5085 (ISSN-L)
DOI: 10.1053/j.gastro.2014.02.037
PMC: PMC4114504
OpenAlex: W2014965759
Cited by: 496
References: 146
Citations by year: 2026: 23 · 2025: 38 · 2024: 36 · 2023: 39 · 2022: 55 · 2021: 50 · 2020: 48 · 2019: 48 · 2018: 42 · 2017: 39 · 2016: 31 · 2015: 37 · 2014: 10
FWCI: 6.37
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Gastroenterology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: National Institutes of Health (DK 64531, DK 48351)
National Institute of Nursing Research (13497, AI100914, DK56338)
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Health and Development
Keywords: gut-brain axis, gut microbiota, irritable bowel syndrome, dysbiosis, functional bowel disorders, prebiotics, probiotics, antibiotics, intestinal metabolites, pathogenesis
MeSH terms: Animals, Anti-Inflammatory Agents, Anti-Bacterial Agents, Bacteria, Brain, Humans, Intestinal Mucosa, Intestines, Neural Pathways, Inflammatory Bowel Diseases, Signal Transduction, Probiotics, Host-Pathogen Interactions, Microbiota, Dysbiosis

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