Cited by 512Gastrointestinal motility and disordersPsychosomatic Disorders and Their TreatmentsAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

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Biopsychosocial Aspects of Functional Gastrointestinal Disorders: How Central and Environmental Processes Contribute to the Development and Expression of Functional Gastrointestinal Disorders

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Van Oudenhove, Lukas, Levy, Rona L., Crowell, Michael D., Drossman, Douglas A., Halpert, Albena D., Keefer, Laurie, Lackner, Jeffrey M., Murphy, Tasha B., Naliboff, Bruce D.·2016·Gastroenterology

DOI 10.1053/j.gastro.2016.02.027PMC PMC8809487

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Abstract

In this paper, we provide a general framework for understanding the functional gastrointestinal disorders (FGID) from a biopsychosocial perspective. More specifically, we provide an overview of the recent research on how the complex interactions of environmental, psychological, and biological factors contribute to the development and maintenance of the FGID. We emphasize that considering and addressing all these factors is a conditio sine qua non for appropriate treatment of these conditions. First, we provide an overview of what is currently known about how each of these factors - the environment, including the influence of those in an individual's family, the individual's own psychological states and traits, and the individual's (neuro)physiological make-up - interact to ultimately result in the generation of FGID symptoms. Second, we provide an overview of commonly used assessment tools which can assist clinicians in obtaining a more comprehensive assessment of these factors in their patients. Finally, the broader perspective outlined earlier is applied to provide an overview of centrally acting treatment strategies, both psychological and pharmacological, which have been shown to be efficacious to treat FGID.

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Authors: Van Oudenhove, L., Levy, R. L., Crowell, M. D., Drossman, D. A., Halpert, A. D., Keefer, L., Lackner, J. M., Murphy, T. B., & Naliboff, B. D.
Affiliations: University of Washington (US)
Mayo Clinic (US)
University of North Carolina at Chapel Hill (US)
Boston Medical Center (US)
Mount Sinai Hospital (US)
State University of New York (US)
University of California, Los Angeles (US)
Corresponding author: Levy, Rona L.
ORCID: Levy, Rona L.
Crowell, Michael D.
Drossman, Douglas A.
Keefer, Laurie
Lackner, Jeffrey M.
Murphy, Tasha B.
Naliboff, Bruce D.
Venue: Gastroenterology
Publisher: Elsevier BV
Published: 2016-05
Volume: 150
Issue: 6
Pages: 1355-1367.e2
ISSN: 0016-5085 (ISSN-L)
DOI: 10.1053/j.gastro.2016.02.027
PMC: PMC8809487
OpenAlex: W2344812785
Cited by: 512
References: 110
Citations by year: 2026: 49 · 2025: 58 · 2024: 54 · 2023: 52 · 2022: 59 · 2021: 63 · 2020: 51 · 2019: 47 · 2018: 35 · 2017: 38 · 2016: 6
FWCI: 45.98
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Gastroenterology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Allergan
National Institute of Diabetes and Digestive and Kidney Diseases (U01DK077738)
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords: functional gastrointestinal disorders, biopsychosocial model, environmental factors, psychological factors, family influence, psychological characteristics, neurophysiological factors, psychological assessment instruments, pharmacotherapy, psychological intervention, treatment options

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Biopsychosocial Aspects of Functional Gastrointestinal Disorders: How Central and Environmental Processes Contribute to the Development and Expression of Functional Gastrointestinal Disorders

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