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Cited by 79Gallbladder and Bile Duct DisordersCholangiocarcinoma and Gallbladder Cancer StudiesBiliary and Gastrointestinal Fistulas

Association between screen-detected gallstone disease and cancer in a cohort study

Shabanzadeh, Daniel Mønsted, Sørensen, Lars Tue, Jørgensen, Torben·2017·Gastroenterology
DOI 10.1053/j.gastro.2017.02.013
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Abstract

Background & aims Knowledge of temporal associations between screen-detected gallstone disease and specific cancers is limited. The objective of this study was to determine if screen-detected gallstones or cholecystectomy are associated with occurrence of gastrointestinal and nongastrointestinal cancers.Methods We performed a cohort study of 3 randomly selected groups from the general population of Copenhagen. Participants (N = 5928) were examined from 1982 through 1992 and underwent abdominal ultrasound examination to detect gallstone disease, but were not informed of their gallstone status. Participants were followed for the occurrence of cancers through national registers until December 2014. We performed multivariable Cox regression analyses to identify factors associated with development of cancer.Results Gallstone disease was identified in 10% of participants (591 of 5928); of these, 6.8% had gallstones and 3.2% had cholecystectomy at baseline. The population was followed for a median of 24.7 years (interquartile range, 18.9-32.4 years) with 1% lost. Pooled gastrointestinal cancers were associated with gallstone disease (11.2% of patients with gallstone disease vs 6.64% without; hazard ratio, 1.50; 95% confidence interval, 1.12-2.01). Right-side colon cancer was also associated with gallstone disease (2.57% of patients with gallstone disease vs 0.96% without; hazard ratio, 2.04; 95% confidence interval, 1.10-3.78). Pancreatic, esophageal, gastric, pooled colorectal, left-side colon, sigmoid colon, and rectal cancers were not associated with gallstone disease. Breast cancer had a weak association with gallstone disease depending on other factors (10.6% of patients with gallstone disease vs 7.41% without; hazard ratio, 1.44; 95% confidence interval, 0.99-2.11). Pooled nongastrointestinal and prostate cancers were not associated with gallstone disease.Conclusions Screen-detected gallstone disease in the general population is associated with pooled gastrointestinal and right-side colon cancers. These associations are not due to detection bias or cholecystectomy. Further studies are needed to determine the mechanism of this association.

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Crossref · 10.1053/j.gastro.2017.02.013

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  • People with gallstone disease and cholecystectomy have an increased risk of colorectal cancer.

    “Patients with gallstone disease and cholecystectomy, who are believed to have higher concentrations of secondary bile acids due to continuous flow of bile acids to the bowel, have an increased risk of CRC.159”

    From Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer (2020) · cites this paper as [159]

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Authors
Shabanzadeh, D. M., Sørensen, L. T., & Jørgensen, T.
Affiliations
  • Bispebjerg Hospital (DK)
  • University of Copenhagen (DK)
Corresponding author
Shabanzadeh, Daniel Mønsted
ORCID
Venue
Gastroenterology
Publisher
Elsevier BV
Published
2017-06
Volume
152
Issue
8
Pages
1965-1974.e1
ISSN
0016-5085 (ISSN-L)
DOI
10.1053/j.gastro.2017.02.013
OpenAlex
W2591208865
Cited by
79
References
64
Citations by year
2026: 6 · 2025: 9 · 2024: 13 · 2023: 6 · 2022: 7 · 2021: 9 · 2020: 9 · 2019: 7 · 2018: 6 · 2017: 6
FWCI
6.32
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Gastroenterology (publishedVersion)
  • PubMed (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
  • VBN Forskningsportal (Aalborg Universitet) (submittedVersion)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Gallbladder and Bile Duct Disorders
  • Health Sciences › Medicine › Surgery › Cholangiocarcinoma and Gallbladder Cancer Studies
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Biliary and Gastrointestinal Fistulas
Keywords
gallstone disease, cholecystectomy, cancer risk, gastrointestinal cancer, right-sided colon cancer, breast cancer, abdominal ultrasound, temporal association, detection bias
MeSH terms
Adult, Aged, Breast Neoplasms, Cholecystectomy, Denmark, Female, Gastrointestinal Neoplasms, Humans, Male, Mass Screening, Middle Aged, Registries, Risk Factors, Time Factors, Ultrasonography, Incidence, Multivariate Analysis, Proportional Hazards Models, Treatment Outcome, Risk Assessment, Gallstones

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