Cited by 298Colorectal Cancer Screening and DetectionGenetic factors in colorectal cancerColorectal Cancer Surgical Treatments

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An Update on the Epidemiology, Molecular Characterization, Diagnosis, and Screening Strategies for Early-Onset Colorectal Cancer

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Burnett-Hartman, Andrea N., Lee, Jeffrey K., Demb, Joshua, Gupta, Samir·2021·Gastroenterology

DOI 10.1053/j.gastro.2020.12.068PMC PMC8273929

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Abstract

Rising trends in the incidence and mortality of early-onset CRC in those who are ages less than 50 years have been well-established. These trends have spurred intense investigation focused on elucidating the epidemiology and characteristics of early-onset CRC, as well on identifying strategies for early detection and prevention. In this review, we provide a contemporary update on early-onset CRC with a particular focus on epidemiology, molecular characterization, red flag signs and symptoms, and screening for early-onset CRC.

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Colorectal cancer statistics, 2020
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Additional file 1 of Colorectal cancer pre-diagnostic symptoms are associated with anatomic cancer site
Briggs, N. L., Ton, M., Malen, R. C., Reedy, A. M., Cohen, S. A., Phipps, A. I., Burnett‐Hartman, A. N., & Newcomb, P. A. (2024) · Figshare · doi:10.6084/m9.figshare.25150525
Self-citation
Additional file 3 of Identification of specific susceptibility loci for the early-onset colorectal cancer
Wang, H., Cai, Y., Jin, M., Huang, C. Q., Ning, C., Niu, S., Fan, L., Li, B., Zhang, M., Lu, Z., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22619566
Additional file 1 of Identification of enterotype and its predictive value for patients with colorectal cancer
Qingbo, L., Jing, Z., Zhanbo, Q., Jian, C., Yifei, S., Wu, Y., & Han, S. (2024) · Figshare · doi:10.6084/m9.figshare.25303079
Additional file 2 of Identification of specific susceptibility loci for the early-onset colorectal cancer
Wang, H., Cai, Y., Jin, M., Huang, C. Q., Ning, C., Niu, S., Fan, L., Li, B., Zhang, M., Lu, Z., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22619563
Additional file 3 of Burden of early-onset colorectal cancer along with attributable risk factors from 1990 to 2019: a comparative study between China and other G20 countries
Li, Q., Yu, M., Lv, H., Zhang, L., Deng, Y., & Yu, H. (2023) · Figshare · doi:10.6084/m9.figshare.23812652
Additional file 2 of Association between metabolic syndrome and early-stage colorectal cancer
Zhang, C., Zhang, L., Tian, Y., Guan, B., & Li, S. (2024) · Figshare · doi:10.6084/m9.figshare.24425797
Additional file 1 of Association between metabolic syndrome and early-stage colorectal cancer
Zhang, C., Zhang, L., Tian, Y., Guan, B., & Li, S. (2023) · Figshare · doi:10.6084/m9.figshare.24425696
Additional file 1 of Burden of early-onset colorectal cancer along with attributable risk factors from 1990 to 2019: a comparative study between China and other G20 countries
Li, Q., Yu, M., Lv, H., Zhang, L., Deng, Y., & Yu, H. (2023) · Figshare · doi:10.6084/m9.figshare.23812646
Additional file 1 of The association between the body roundness index and the risk of colorectal cancer: a cross-sectional study
Gao, W., Jin, L., Li, D., Zhang, Y., Zhao, W., Zhao, Y., Gao, J., Zhou, L., Chen, P., & Dong, G. (2023) · Figshare · doi:10.6084/m9.figshare.22655477
Additional file 2 of The association between the body roundness index and the risk of colorectal cancer: a cross-sectional study
Gao, W., Jin, L., Li, D., Zhang, Y., Zhao, W., Zhao, Y., Gao, J., Zhou, L., Chen, P., & Dong, G. (2023) · Figshare · doi:10.6084/m9.figshare.22655480
Additional file 2 of Colorectal cancer pre-diagnostic symptoms are associated with anatomic cancer site
Briggs, N. L., Ton, M., Malen, R. C., Reedy, A. M., Cohen, S. A., Phipps, A. I., Burnett‐Hartman, A. N., & Newcomb, P. A. (2024) · Figshare · doi:10.6084/m9.figshare.25150739
Self-citation
Additional file 1 of Identification of specific susceptibility loci for the early-onset colorectal cancer
Wang, H., Cai, Y., Jin, M., Huang, C. Q., Ning, C., Niu, S., Fan, L., Li, B., Zhang, M., Lu, Z., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22619560
Additional file 3 of Association between metabolic syndrome and early-stage colorectal cancer
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Authors: Burnett-Hartman, A. N., Lee, J. K., Demb, J., & Gupta, S.
Affiliations: Kaiser Permanente (US)
University of California San Diego (US)
Corresponding author: Lee, Jeffrey K.
ORCID: Lee, Jeffrey K.
Demb, Joshua
Gupta, Samir
Venue: Gastroenterology
Publisher: Elsevier BV
Published: 2021-03
Volume: 160
Issue: 4
Pages: 1041-1049
ISSN: 0016-5085 (ISSN-L)
DOI: 10.1053/j.gastro.2020.12.068
PMC: PMC8273929
OpenAlex: W3119321686
Semantic Scholar: 8244c2b40e175dc72040bb05f875308e37bfb4c4
Cited by: 298
References: 79
Citations by year: 2026: 27 · 2025: 60 · 2024: 88 · 2023: 71 · 2022: 43 · 2021: 9
FWCI: 6.39
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Gastroenterology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: National Cancer Institute (U24 CA 221936, R01 CA196337)
Topics: Health Sciences › Medicine › Oncology › Colorectal Cancer Screening and Detection
Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
Health Sciences › Medicine › Oncology › Colorectal Cancer Surgical Treatments
Keywords: early-onset colorectal cancer, colorectal cancer incidence, molecular characterization, colorectal cancer screening, early detection, cancer prevention, young adults
MeSH terms: Humans, Mass Screening, Risk Factors, Triage, Biomarkers, Tumor, Colorectal Neoplasms, Practice Guidelines as Topic, Age of Onset, Microsatellite Instability, Early Detection of Cancer, Precision Medicine

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An Update on the Epidemiology, Molecular Characterization, Diagnosis, and Screening Strategies for Early-Onset Colorectal Cancer

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