Cited by 298Colorectal Cancer Screening and DetectionGenetic factors in colorectal cancerColorectal Cancer Surgical Treatments

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An Update on the Epidemiology, Molecular Characterization, Diagnosis, and Screening Strategies for Early-Onset Colorectal Cancer

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Burnett-Hartman, Andrea N., Lee, Jeffrey K., Demb, Joshua, Gupta, Samir·2021·Gastroenterology

DOI 10.1053/j.gastro.2020.12.068PMC PMC8273929

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Abstract

Rising trends in the incidence and mortality of early-onset CRC in those who are ages less than 50 years have been well-established. These trends have spurred intense investigation focused on elucidating the epidemiology and characteristics of early-onset CRC, as well on identifying strategies for early detection and prevention. In this review, we provide a contemporary update on early-onset CRC with a particular focus on epidemiology, molecular characterization, red flag signs and symptoms, and screening for early-onset CRC.

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Colorectal cancer statistics, 2020
Siegel, R. L., Miller, K. D., Sauer, A. G., Fedewa, S. A., Butterly, L. F., Anderson, J. C., Cercek, A., Smith, R. A., & Jemal, A. (2020) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21601 · Cited by 5,080
Role of nrf2 in oxidative stress and toxicity
Ma, Q. (2013) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-011112-140320 · Cited by 4,903
The repertoire of mutational signatures in human cancer
Alexandrov, L. B., Kim, J., Haradhvala, N. J., Huang, M. N., Tian Ng, A. W., Wu, Y., Boot, A., Covington, K. R., Gordenin, D. A., Bergstrom, E. N., et al. (2020) · Nature · doi:10.1038/s41586-020-1943-3 · Cited by 3,496
CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer
Weisenberger, D. J., Siegmund, K. D., Campan, M., Young, J. P., Long, T. I., Faasse, M. A., Kang, G. H., Widschwendter, M., Weener, D., Buchanan, D. D., et al. (2006) · Nature Genetics · doi:10.1038/ng1834 · Cited by 1,990
Colorectal cancer screening for average‐risk adults: 2018 guideline update from the American Cancer Society
Wolf, A. M. D., Fontham, E. T. H., Church, T. R., Flowers, C. R., Guerra, C. E., LaMonte, S. J., Etzioni, R., McKenna, M. T., Oeffinger, K. C., Shih, Y. T., et al. (2018) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21457 · Cited by 1,944
Increasing Disparities in the Age-Related Incidences of Colon and Rectal Cancers in the United States, 1975-2010
Bailey, C. E., Hu, C., You, Y. N., Bednarski, B. K., Rodrı́guez-Bigas, M. A., Skibber, J. M., Cantor, S. B., & Chang, G. J. (2014) · JAMA Surgery · doi:10.1001/jamasurg.2014.1756 · Cited by 1,081
Global patterns and trends in colorectal cancer incidence in young adults
Siegel, R. L., Torre, L. A., Soerjomataram, I., Hayes, R. B., Bray, F., Weber, T. K., & Jemal, A. (2019) · Gut · doi:10.1136/gutjnl-2019-319511 · Cited by 979
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Mauri, G., Bianchi, A. S., Russo, A. G., Marsoni, S., Bardelli, A., & Siena, S. (2018) · Molecular Oncology · doi:10.1002/1878-0261.12417 · Cited by 653

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Zhu, Q., Rao, B., Chen, Y., Jia, P., Wang, X., Zhang, B., Wang, L., Zhao, W., Hu, C., Tang, M., et al. (2023) · PubMed Central · Cited by 3
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Liu, G., Zhao, Q., Li, Y., Zhu, D., & Peng, H. (2025) · Molecular and Cellular Probes · doi:10.1016/j.mcp.2025.102017 · Cited by 1
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Authors: Burnett-Hartman, A. N., Lee, J. K., Demb, J., & Gupta, S.
Affiliations: Kaiser Permanente (US)
University of California San Diego (US)
Corresponding author: Lee, Jeffrey K.
ORCID: Lee, Jeffrey K.
Demb, Joshua
Gupta, Samir
Venue: Gastroenterology
Publisher: Elsevier BV
Published: 2021-03
Volume: 160
Issue: 4
Pages: 1041-1049
ISSN: 0016-5085 (ISSN-L)
DOI: 10.1053/j.gastro.2020.12.068
PMC: PMC8273929
OpenAlex: W3119321686
Semantic Scholar: 8244c2b40e175dc72040bb05f875308e37bfb4c4
Cited by: 298
References: 79
Citations by year: 2026: 27 · 2025: 60 · 2024: 88 · 2023: 71 · 2022: 43 · 2021: 9
FWCI: 6.39
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Gastroenterology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: National Cancer Institute (U24 CA 221936, R01 CA196337)
Topics: Health Sciences › Medicine › Oncology › Colorectal Cancer Screening and Detection
Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
Health Sciences › Medicine › Oncology › Colorectal Cancer Surgical Treatments
Keywords: early-onset colorectal cancer, colorectal cancer incidence, molecular characterization, colorectal cancer screening, early detection, cancer prevention, young adults
MeSH terms: Humans, Mass Screening, Risk Factors, Triage, Biomarkers, Tumor, Colorectal Neoplasms, Practice Guidelines as Topic, Age of Onset, Microsatellite Instability, Early Detection of Cancer, Precision Medicine

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An Update on the Epidemiology, Molecular Characterization, Diagnosis, and Screening Strategies for Early-Onset Colorectal Cancer

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