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Cited by 142Gastrointestinal motility and disordersGastrointestinal Bleeding Diagnosis and TreatmentGastroesophageal reflux and treatments

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Epidemiology, Etiology, and Treatment of Gastroparesis: Real-World Evidence From a Large US National Claims Database

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Ye, Yizhou, Yin, Yu, Huh, Susanna Y., Almansa, Cristina, Bennett, Dimitri, Camilleri, Michael·2022·Gastroenterology
DOI 10.1053/j.gastro.2021.09.064
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Abstract

Background & aims Although gastroparesis carries a considerable health care and patient burden, associated epidemiological data are limited. To provide new real-world evidence for gastroparesis, we estimated disease prevalence, and investigated patient demographics and disease etiology in a large US claims database. Methods This retrospective, cross-sectional analysis used de-identified, longitudinal patient-level enrollment and billing data for adults from the Optum Clinformatics Data Mart database, a large US national administrative health insurance claims database. Prevalence was age-, sex-, and geographical region-standardized using the 2018 US census. Descriptive analyses of demographic and clinical variables and underlying disease etiologies were performed. Results The overall standardized prevalence of gastroparesis was 267.7 (95% confidence interval [CI] 264.8-270.7) per 100,000 US adults, whereas prevalence of "definite" gastroparesis (individuals diagnosed within 3 months of gastric emptying scintigraphy testing with persistent symptoms for more than 3 months) was 21.5 (95% CI 20.6-22.4) per 100,000 persons. Patients with gastroparesis had an overall Charlson Comorbidity Index score of 4.2, indicating substantial comorbidity burden. The most frequently documented comorbidities were chronic pulmonary disease (46.4%), diabetes with chronic complication (37.3%), and peripheral vascular disease (30.4%). Patients most commonly had a diabetic etiology (57.4%; type 1, 5.7%…

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Metadata

Authors
Ye, Y., Yin, Y., Huh, S. Y., Almansa, C., Bennett, D., & Camilleri, M.
Affiliations
  • Takeda (United States) (US)
  • Mayo Clinic (US)
Corresponding author
Bennett, Dimitri
ORCID
Venue
Gastroenterology
Publisher
Elsevier BV
Published
2022-01
Volume
162
Issue
1
Pages
109-121.e5
ISSN
0016-5085 (ISSN-L)
DOI
10.1053/j.gastro.2021.09.064
OpenAlex
W3204205013
Cited by
142
References
0
Citations by year
2026: 31 · 2025: 35 · 2024: 35 · 2023: 24 · 2022: 16
FWCI
17.36
Type
journal article
Language
en
Open access
Licence
Locations
  • Gastroenterology (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
Takeda Pharmaceutical Co Ltd
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal Bleeding Diagnosis and Treatment
  • Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
Keywords
gastroparesis, prevalence, etiology, diabetic gastroparesis, type 2 diabetes, type 1 diabetes, postoperative gastroparesis, idiopathic gastroparesis, comorbidities, Charlson Comorbidity Index, gastric emptying scintigraphy, healthcare burden, patient demographics
MeSH terms
Administrative Claims, Healthcare, Adolescent, Adult, Age Factors, Aged, Cross-Sectional Studies, Female, Gastric Emptying, Humans, Male, Middle Aged, Predictive Value of Tests, Retrospective Studies, Risk Factors, Sex Factors, Time Factors, United States, Comorbidity, Prevalence, Databases, Factual, Treatment Outcome, Risk Assessment, Gastroparesis, Young Adult

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