The DOI matches its Crossref record; 166 of the 166 references it cites were found in a registry or an index.
Pancreatic Cancer: Pathogenesis, Screening, Diagnosis, and Treatment
Open accessAbstract
Pancreatic ductal adenocarcinoma (PDAC) is a clinically challenging cancer, due to both its late stage at diagnosis and its resistance to chemotherapy. However, recent advances in our understanding of the biology of PDAC have revealed new opportunities for early detection and targeted therapy of PDAC. In this review, we discuss the pathogenesis of PDAC, including molecular alterations in tumor cells, cellular alterations in the tumor microenvironment, and population-level risk factors. We review the current status of surveillance and early detection of PDAC, including populations at high risk and screening approaches. We outline the diagnostic approach to PDAC and highlight key treatment considerations, including how therapeutic approaches change with disease stage and targetable subtypes of PDAC. Recent years have seen significant improvements in our approaches to detect and treat PDAC, but large-scale, coordinated efforts will be needed to maximize the clinical impact for patients and improve overall survival.
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Self-citationGenomic analyses identify molecular subtypes of pancreatic cancer
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Cited by
Zhao, L., Zhang, H., Li, N., Chen, J., Xu, H., Wang, Y., & Liang, Q. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116306 · Cited by 963
Werba, G., Weissinger, D., Kawaler, E. A., Zhao, E., Kalfakakou, D., Dhara, S., Wang, L., Lim, H. B., Oh, G., Jing, X., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-36296-4 · Cited by 283
Self-citationMasugi, Y., Takamatsu, M., Tanaka, M., Hara, K., Inoue, Y., Hamada, T., Suzuki, T., Arita, J., Hirose, Y., Kawaguchi, Y., et al. (2023) · The Journal of Pathology: Clinical Research · doi:10.1002/cjp2.323 · Cited by 23
Metadata
- Authors
- Wood, L. D., Canto, M. I., Jaffee, E. M., & Simeone, D. M.
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2022-08
- Volume
- 163
- Issue
- 2
- Pages
- 386-402.e1
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W4223640931
- Cited by
- 865
- References
- 166
- FWCI
- 65.98
- Type
- journal article
- Language
- en
- Open access
- green
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- Wood, L. D., Canto, M. I., Jaffee, E. M., & Simeone, D. M. (2022). Pancreatic Cancer: Pathogenesis, Screening, Diagnosis, and Treatment. Gastroenterology. https://doi.org/10.1053/j.gastro.2022.03.056
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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