Cited by 155Viral-associated cancers and disordersHerpesvirus Infections and TreatmentsCytomegalovirus and herpesvirus research

The DOI matches its Crossref record; 209 of the 209 references it cites were found in a registry or an index.

Kaposi Sarcoma–Associated Herpesvirus-Associated Malignancies: Epidemiology, Pathogenesis, and Advances in Treatment

Open access

Bhutani, Manisha, Polizzotto, Mark N., Uldrick, Thomas S., Yarchoan, Robert·2015·Seminars in Oncology

DOI 10.1053/j.seminoncol.2014.12.027PMC PMC6309362

Open this paper in CoChat — free account

Abstract

Kaposi sarcoma associated herpesvirus (KSHV), a γ2-herpesvirus, also known as human herpesvirus-8, is the etiologic agent of three virally associated tumors: Kaposi sarcoma, a plasmablastic form of multicentric Castleman disease (KSHV-MCD), and primary effusion lymphoma. These malignancies are predominantly seen in people with acquired immunodeficiencies, including acquired immunodeficiency syndrome and iatrogenic immunosuppression in the setting of organ transplantation, but can also develop in the elderly. Kaposi sarcoma (KS) is most frequent in regions with high KSHV seroprevalence, such as sub-Saharan Africa and some Mediterranean countries. In the era of combination antiviral therapy, inflammatory manifestations associated with KSHV-infection, including KSHV-MCD, a recently described KSHV-associated inflammatory cytokine syndrome and KS immune reconstitution syndrome also are increasingly appreciated. Our understanding of viral and immune mechanisms of oncogenesis continues to expand and lead to improved molecular diagnostics, as well as novel therapeutic strategies that employ immune modulatory agents, manipulations of the tumor microenvironment, virus-activated cytotoxic therapy, or agents that target interactions between specific virus-host cell signaling pathways. This review focuses on the epidemiology and advances in molecular and clinical research that reflects the current understanding of viral oncogenesis, clinical manifestations, and therapeutics for KSHV-associated tumors.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1053/j.seminoncol.2014.12.027

Cites

209 of 209 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

RETRACTED: KSHV vFLIP Is Essential for the Survival of Infected Lymphoma Cells
Guasparri, I., Keller, S. A., & Cesarman, E. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20031467 · Cited by 325
Retracted
Identification of Herpesvirus-Like DNA Sequences in AIDS-Sssociated Kaposi's Sarcoma
Chang, Y., Cesarman, E., Pessin, M. S., Lee, F., Culpepper, J., Knowles, D. M., & Moore, P. S. (1994) · Science · doi:10.1126/science.7997879 · Cited by 5,608
A review of human carcinogens—Part B: biological agents
Bouvard, V., Baan, R., Straif, K., Grosse, Y., Secretan, B., Ghissassi, F. E., Benbrahim-Tallaa, L., Guha, N., Freeman, C., Galichet, L., et al. (2009) · The Lancet Oncology · doi:10.1016/s1470-2045(09)70096-8 · Cited by 2,935
Kaposi's Sarcoma–Associated Herpesvirus-Like DNA Sequences in AIDS-Related Body-Cavity–Based Lymphomas
Cesarman, E., Chang, Y., Moore, P. S., et al. (1995) · New England Journal of Medicine · doi:10.1056/nejm199505043321802 · Cited by 2,853
Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's disease.
Soulier, J., Grollet, L., Oksenhendler, E., Cacoub, P., Cazals-Hatem, D., Babinet, P., d'Agay, M., Clauvel, J., Raphael, M., Degos, L., et al. (1995) · Blood · doi:10.1182/blood.v86.4.1276.bloodjournal8641276 · Cited by 2,296
Spectrum of cancer risk among US solid organ transplant recipients
Engels, E. A., Pfeiffer, R. M., Fraumeni, J. F., Kasiske, B. L., Israni, A. K., Snyder, J. J., Wolfe, R. A., Goodrich, N. P., Bayakly, A. R., Clarke, C. A., et al. (2011) · JAMA · doi:10.1001/jama.2011.1592 · Cited by 1,524
Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors
Thome, M., Schneider, P., Hofmann, K., Fickenscher, H., Meinl, E., Neipel, F., Mattmann, C., Burns, K., Bodmer, J.-L., Schröter, M., et al. (1997) · Nature · doi:10.1038/386517a0 · Cited by 1,316
Primary effusion lymphoma: a distinct clinicopathologic entity associated with the Kaposi's sarcoma-associated herpes virus
Nador, R., Cesarman, E., Chadburn, A., et al. (1996) · Blood · doi:10.1182/blood.v88.2.645.bloodjournal882645 · Cited by 1,172
Detection of Herpesvirus-Like DNA Sequences in Kaposi's Sarcoma in Patients with and Those without HIV Infection
Moore, P. S., & Chang, Y. (1995) · New England Journal of Medicine · doi:10.1056/nejm199505043321801 · Cited by 1,095
Kaposi's sarcoma and Pneumocystis pneumonia among homosexual men--New York City and California.
Friedman‐Kien, A. E., Laubenstein, L. J., Marmor, M. F., Hymes, K. B., Green, J., Ragaz, A., Gottleib, J., Muggia, F. M., Demopoulos, R. I., & Weintraub, M. R. (1981) · PubMed · Cited by 1,091
Estimated HIV Incidence in the United States, 2006–2009
Prejean, J., Song, R., Hernandez, A., Ziebell, R., Green, T., Walker, F., Lin, L. S., An, Q., Mermin, J., Lansky, A., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017502 · Cited by 1,071
Kaposi's sarcoma among persons with AIDS: a sexually transmitted infection?
Beral, V., Peterman, T. A., Berkelman, R. L., & Jaffe, H. W. (1990) · The Lancet · doi:10.1016/0140-6736(90)90001-l · Cited by 1,046
Sirolimus for Kaposi's Sarcoma in Renal-Transplant Recipients
Stallone, G., Schena, A., Infante, B., Paolo, S. D., Loverre, A., Maggio, G., Ranieri, E., Gesualdo, L., Schena, F. P., & Grandaliano, G. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa042831 · Cited by 982
Molecular Mimicry of Human Cytokine and Cytokine Response Pathway Genes by KSHV
Moore, P. S., Boshoff, C., Weiss, R. A., & Chang, Y. (1996) · Science · doi:10.1126/science.274.5293.1739 · Cited by 900
Detection of Kaposi sarcoma associated herpesvirus in peripheral blood of HIV-infected individuals and progression to Kaposi's sarcoma
Whitby, D., Boshoff, C., Hatzioannou, T., et al. (1995) · The Lancet · doi:10.1016/s0140-6736(95)91619-9 · Cited by 883
G-protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator
Bais, C., Santomasso, B., Coso, O. A., Arvanitakis, L., Geras‐Raaka, E., Gutkind, J. S., Asch, A. S., Cesarman, E., Gerhengorn, M. C., & Mesri, E. A. (1998) · Nature · doi:10.1038/34193 · Cited by 829
KSHV antibodies among Americans, Italians and Ugandans with and without Kaposi's sarcoma
Gao, S., Kingsley, L., Li, M. O., Zheng, W., Parravicini, C., Ziegler, J. L., Newton, R., Rinaldo, C. R., Saah, A. J., Phair, J., et al. (1996) · Nature Medicine · doi:10.1038/nm0896-925 · Cited by 793
Cancer Burden in the HIV-Infected Population in the United States
Shiels, M. S., Pfeiffer, R. M., Gail, M. H., Hall, H. I., Li, J., Chaturvedi, A. K., Bhatia, K. G., Uldrick, T. S., Yarchoan, R., Goedert, J. J., et al. (2011) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djr076 · Cited by 778
Self-citation
Trends in cancer risk among people with AIDS in the United States 1980–2002
Engels, E. A., Pfeiffer, R. M., Goedert, J. J., Virgo, P., McNeel, T. S., Scoppa, S. M., & Biggar, R. J. (2006) · AIDS · doi:10.1097/01.aids.0000238411.75324.59 · Cited by 773
The seroepidemiology of human herpesvirus 8 (Kaposi's sarcoma–associated herpesvirus): Distribution of infection in KS risk groups and evidence for sexual transmission
Kedes, D. H., Operskalski, E. A., Busch, M. P., et al. (1996) · Nature Medicine · doi:10.1038/nm0896-918 · Cited by 760
Sexual Transmission and the Natural History of Human Herpesvirus 8 Infection
Martin, J. N., Ganem, D. E., Osmond, D. H., Page, K. A., Macrae, D., & Kedes, D. H. (1998) · New England Journal of Medicine · doi:10.1056/nejm199804023381403 · Cited by 712
p53 inhibition by the LANA protein of KSHV protects against cell death
Friborg, J., Kong, W., Hottiger, M. O., et al. (1999) · Nature · doi:10.1038/47266 · Cited by 707
Efficient Persistence of Extrachromosomal KSHV DNA Mediated by Latency-Associated Nuclear Antigen
Ballestas, M. E., Chatis, P. A., & Kaye, K. M. (1999) · Science · doi:10.1126/science.284.5414.641 · Cited by 697
Human herpesvirus KSHV encodes a constitutively active G-protein-coupled receptor linked to cell proliferation
Arvanitakis, L., Geras‐Raaka, E., Varma, A., Gershengorn, M. C., & Cesarman, E. (1997) · Nature · doi:10.1038/385347a0 · Cited by 670
DETECTION OF HERPESVIRUS-LIKE DNA SEQUENCES IN KAPOSI'S SARCOMA IN PATIENTS WITH AND THOSE WITHOUT HIV INFECTION
Oore, P. A. S. M., & Hang, Y. (1995) · Cited by 667
Kaposi's sarcoma-associated herpesvirus gene expression in endothelial (spindle) tumor cells
Staskus, K. A., Zhong, W., Gebhard, K. H., HERNDIER, B. G., Wang, H., Renne, R., Beneke, J., Pudney, J. A., Anderson, D. J., Ganem, D., et al. (1997) · Journal of Virology · doi:10.1128/jvi.71.1.715-719.1997 · Cited by 654
Pegylated-liposomal doxorubicin versus doxorubicin, bleomycin, and vincristine in the treatment of AIDS-related Kaposi's sarcoma: results of a randomized phase III clinical trial.
Northfelt, D., Dezube, B. J., Thommes, J. A., Miller, B., Fischl, M. A., Friedman‐Kien, A. E., Kaplan, L. D., Mond, C. D., Mamelok, R. D., & Henry, D. H. (1998) · Journal of Clinical Oncology · doi:10.1200/jco.1998.16.7.2445 · Cited by 646
Prevalence of Kaposi's sarcoma associated herpesvirus infection measured by antibodies to recombinant capsid protein and latent immunofluorescence antigen
Simpson, G. R., Schulz, T. F., Whitby, D., et al. (1996) · The Lancet · doi:10.1016/s0140-6736(96)07560-5 · Cited by 629
A viral gene that activates lytic cycle expression of Kaposi’s sarcoma-associated herpesvirus
Sun, R., Lin, S., Gradoville, L., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.18.10866 · Cited by 596
Seroconversion to Antibodies against Kaposi's Sarcoma–Associated Herpesvirus–Related Latent Nuclear Antigens before the Development of Kaposi's Sarcoma
Gao, S., Kingsley, L., Hoover, D. R., Spira, T. J., Rinaldo, C. R., Saah, A. J., Phair, J., Detels, R., Parry, P., Chang, Y., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199607253350403 · Cited by 594
Mucosal Shedding of Human Herpesvirus 8 in Men
Pauk, J. S., Huang, M.-L. W., Brodie, S. J., et al. (2000) · New England Journal of Medicine · doi:10.1056/nejm200011093431904 · Cited by 505
Herpes-Like Sequences in HIV-Infected and Uninfected Kaposi's Sarcoma Patients
Ambroziak, J. A., Blackbourn, D. J., HERNDIER, B. G., et al. (1995) · Science · doi:10.1126/science.7725108 · Cited by 504
The latent nuclear antigen of Kaposi sarcoma-associated herpesvirus targets the retinoblastoma–E2F pathway and with the oncogene Hras transforms primary rat cells
Radkov, S. A., Kellam, P., & Boshoff, C. (2000) · Nature Medicine · doi:10.1038/80459 · Cited by 489
Oral Ganciclovir for Patients with Cytomegalovirus Retinitis Treated with a Ganciclovir Implant
Martin, D. F., Kuppermann, B. D., Wolitz, R. A., Palestine, A. G., Li, H., & Robinson, C. A. (1999) · New England Journal of Medicine · doi:10.1056/nejm199904083401402 · Cited by 480
Kaposi's sarcoma in the acquired immune deficiency syndrome: a proposal for uniform evaluation, response, and staging criteria. AIDS Clinical Trials Group Oncology Committee.
Krown, S. E., Metroka, C. E., & Wernz, J. (1989) · Journal of Clinical Oncology · doi:10.1200/jco.1989.7.9.1201 · Cited by 479
Angiogenesis and hematopoiesis induced by Kaposi's sarcoma-associated herpesvirus-encoded interleukin-6.
Aoki, Y., Jaffe, E., Chang, Y., Jones, K., Teruya-Feldstein, J., Moore, P., & Tosato, G. (1999) · Blood · doi:10.1182/blood.v93.12.4034.412k38_4034_4043 · Cited by 475
Angiogenic and HIV-Inhibitory Functions of KSHV-Encoded Chemokines
BOSHOFF, C. H., Endo, Y., COLLINS, P. D., et al. (1997) · Science · doi:10.1126/science.278.5336.290 · Cited by 474
The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1alpha.
Sodhi, A., Montaner, S., Patel, V., Zohar, M., Bais, C., Mesri, E. A., & Gutkind, J. S. (2000) · PubMed · Cited by 452
Transcription Mapping of the Kaposi’s Sarcoma-Associated Herpesvirus (Human Herpesvirus 8) Genome in a Body Cavity-Based Lymphoma Cell Line (BC-1)
Sarid, R., Flore, O., Bohenzky, R. A., et al. (1998) · Journal of Virology · doi:10.1128/jvi.72.2.1005-1012.1998 · Cited by 440
Randomized phase III trial of liposomal daunorubicin versus doxorubicin, bleomycin, and vincristine in AIDS-related Kaposi's sarcoma.
Gill, P. S., Wernz, J., Scadden, D. T., Cohen, P., Mukwaya, G., Roenn, J. H. V., Jacobs, M., Kempin, S. J., Silverberg, I. J., Gonzales, G., et al. (1996) · Journal of Clinical Oncology · doi:10.1200/jco.1996.14.8.2353 · Cited by 438
Transgenic Expression of the Chemokine Receptor Encoded by Human Herpesvirus 8 Induces an Angioproliferative Disease Resembling Kaposi's Sarcoma
Yang, T., Chen, S., Leach, M. W., Manfra, D. J., Homey, B., Wiekowski, M., Sullivan, L., Jenh, C., Narula, S. K., Chensue, S. W., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.3.445 · Cited by 416
Cloning and Identification of a MicroRNA Cluster within the Latency-Associated Region of Kaposi's Sarcoma-Associated Herpesvirus
Samols, M. A., Hu, J., Skalsky, R. L., & Renne, R. (2005) · Journal of Virology · doi:10.1128/jvi.79.14.9301-9305.2005 · Cited by 408
FLIP-mediated autophagy regulation in cell death control
Lee, J.-S., Li, Q., Lee, J.-Y., Lee, S.-H., Jeong, J. H., Lee, H.-R., Chang, H., Zhou, F.-C., Gao, S.-J., Liang, C., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1980 · Cited by 406
Transformation of primary human endothelial cells by Kaposi's sarcoma-associated herpesvirus
Flore, O., Rafii, S., Ely, S. A., O’Leary, J. J., Hyjek, E. M., & Cesarman, E. (1998) · Nature · doi:10.1038/29093 · Cited by 399
Kaposi's sarcoma-associated herpesvirus contains G protein-coupled receptor and cyclin D homologs which are expressed in Kaposi's sarcoma and malignant lymphoma
Cesarman, E., Nádor, R. G., Bai, F., et al. (1996) · Journal of Virology · doi:10.1128/jvi.70.11.8218-8223.1996 · Cited by 394
Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma–associated herpesvirus
Hong, Y.-K., Foreman, K. E., Shin, J. W., Hirakawa, S., Curry, C. L., Sage, D. R., Libermann, T. A., Dezube, B. J., Fingeroth, J. D., & Detmar, M. J. (2004) · Nature Genetics · doi:10.1038/ng1383 · Cited by 374
Herpesvirus-like DNA sequences in patients with Mediterranean Kaposi's sarcoma
Dupin, N., Grandadam, M., Cálvez, V., Aubin, J., Huraux, J., Agut, H., Dupin, N., Gorin, I., Havard, S., Lamy, F., et al. (1995) · The Lancet · doi:10.1016/s0140-6736(95)90642-8 · Cited by 372
Kaposi sarcoma-associated herpesvirus infects monotypic (IgM lambda) but polyclonal naive B cells in Castleman disease and associated lymphoproliferative disorders.
Du, M.-Q., Liu, H.-X., Diss, T., Ye, H., Hamoudi, R., Dupin, N., Meignin, V., Oksenhendler, E., Boshoff, C., & Isaacson, P. (2001) · Blood · doi:10.1182/blood.v97.7.2130 · Cited by 371
Multicentric Castlemanʼs disease in HIV infection
Oksenhendler, É., Duarte, M., Soulier, J., Cacoub, P., Welker, Y., Cadranel, J. L., Cazals-Hatem, D. L., Autran, B., Clauvel, J., & Raphaël, M. (1996) · AIDS · doi:10.1097/00002030-199601000-00009 · Cited by 356
KSHV ORF K9 (vIRF) is an oncogene which inhibits the interferon signaling pathway
Gao, S., Boshoff, C., Jayachandra, S., Weiss, R. A., Chang, Y., & Moore, P. S. (1997) · Oncogene · doi:10.1038/sj.onc.1201571 · Cited by 356
Randomized comparative trial of pegylated liposomal doxorubicin versus bleomycin and vincristine in the treatment of AIDS-related Kaposi's sarcoma. International Pegylated Liposomal Doxorubicin Study Group.
Stewart, S., Jablonowski, H., Goebel, F. D., Arastéh, K., Spittle, M. F., Ríos, A., Aboulafia, D. M., Galleshaw, J. A., & Dezube, B. J. (1998) · Journal of Clinical Oncology · doi:10.1200/jco.1998.16.2.683 · Cited by 356
AIDS-Related Cancer and Severity of Immunosuppression in Persons With AIDS
Biggar, R. J., Chaturvedi, A. K., Goedert, J., et al. (2007) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djm010 · Cited by 354
High levels of human herpesvirus 8 viral load, human interleukin-6, interleukin-10, and C reactive protein correlate with exacerbation of multicentric Castleman disease in HIV-infected patients
Oksenhendler, É., Carcelain, G., Aoki, Y., Boulanger, E., Maillard, A. M., Clauvel, J., & Agbalika, F. (2000) · Blood · doi:10.1182/blood.v96.6.2069 · Cited by 351
Sensitivity of Kaposi's sarcoma-associated herpesvirus replication to antiviral drugs. Implications for potential therapy.
Kedes, D. H., & Ganem, D. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119380 · Cited by 320
KSHV-Positive Solid Lymphomas Represent an Extra-Cavitary Variant of Primary Effusion Lymphoma
Chadburn, A., Hyjek, E. M., Mathew, S., et al. (2004) · The American Journal of Surgical Pathology · doi:10.1097/01.pas.0000138177.10829.5c · Cited by 314
Prognostic Factors and Outcome of Human Herpesvirus 8–Associated Primary Effusion Lymphoma in Patients With AIDS
Boulanger, E., Gérard, L., Gabarre, J., et al. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.07.084 · Cited by 314
A novel viral mechanism for dysregulation of β-catenin in Kaposi's sarcoma–associated herpesvirus latency
Fujimuro, M., Wu, F. Y., Aprhys, C., Kajumbula, H., Young, D. B., Hayward, G. S., & Hayward, S. D. (2003) · Nature Medicine · doi:10.1038/nm829 · Cited by 309
AIDS-related Kaposi's sarcoma: prospective validation of the AIDS Clinical Trials Group staging classification. AIDS Clinical Trials Group Oncology Committee.
Krown, S. E., Testa, M. A., & Huang, J. (1997) · Journal of Clinical Oncology · doi:10.1200/jco.1997.15.9.3085 · Cited by 305
An Interleukin‐6–Related Systemic Inflammatory Syndrome in Patients Co‐Infected with Kaposi Sarcoma–Associated Herpesvirus and HIV but without Multicentric Castleman Disease
Uldrick, T. S., Wang, V., O’Mahony, D., Aleman, K. O., Wyvill, K. M., Marshall, V. A., Steinberg, S. M., Pittaluga, S., Marić, I., Whitby, D., et al. (2010) · Clinical Infectious Diseases · doi:10.1086/654798 · Cited by 304
Self-citation
Transmission of Human Herpesvirus 8 Infection from Renal-Transplant Donors to Recipients
Regamey, N., Tamm, M., Wernli, M., Witschi, A. T., Thiel, G. T., Cathomas, G., & Erb, P. (1998) · New England Journal of Medicine · doi:10.1056/nejm199811053391903 · Cited by 303
Whole-exome sequencing-based discovery of STIM1 deficiency in a child with fatal classic Kaposi sarcoma
Byun, M., Abhyankar, A., Lelarge, V., Plancoulaine, S., Palandüz, A., Telhan, L., Boisson, B., Pïcard, C., Dewell, S. B., Zhao, C., et al. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20101597 · Cited by 297
Kaposi's Sarcoma-Associated Herpesvirus LANA2 Is a B-Cell-Specific Latent Viral Protein That Inhibits p53
Rivas, C., Thlick, A.-E., Parravicini, C., Moore, P. S., & Chang, Y. (2001) · Journal of Virology · doi:10.1128/jvi.75.1.429-438.2001 · Cited by 295
HIV Infection, Immunodeficiency, Viral Replication, and the Risk of Cancer
Silverberg, M. J., Chao, C., Leyden, W. A., Xu, L., Horberg, M. A., Klein, D. B., Towner, W. J., Dubrow, R., Quesenberry, C. P., Neugebauer, R. S., et al. (2011) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-11-0777 · Cited by 293
Activity of Thalidomide in AIDS-Related Kaposi’s Sarcoma
Little, R. F., Wyvill, K. M., Pluda, J. M., et al. (2000) · Journal of Clinical Oncology · doi:10.1200/jco.2000.18.13.2593 · Cited by 291
The cyclin encoded by Kaposi's sarcoma-associated herpesvirus stimulates cdk6 to phosphorylate the retinoblastoma protein and histone H1
Godden-Kent, D., Talbot, S. J., Boshoff, C., Chang, Y., Moore, P. S., Weiss, R. A., & Mittnacht, S. (1997) · Journal of Virology · doi:10.1128/jvi.71.6.4193-4198.1997 · Cited by 289
Modulation of the NF-κB pathway by virally encoded Death Effector Domains-containing proteins
Chaudhary, P. M., Jasmin, A., Eby, M. T., & Hood, L. (1999) · Oncogene · doi:10.1038/sj.onc.1202976 · Cited by 287
A Kaposi's Sarcoma-associated Herpesvirus-encoded Cytokine Homolog (vIL-6) Activates Signaling through the Shared gp130 Receptor Subunit
Molden, J., Chang, Y., You, Y., Moore, P. S., & Goldsmith, M. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.31.19625 · Cited by 281
Antibodies against Human Herpesvirus 8 in Black South African Patients with Cancer
Sitas, F., Carrara, H., Beral, V., et al. (1999) · New England Journal of Medicine · doi:10.1056/nejm199906173402403 · Cited by 268
Gene expression profile analysis of AIDS-related primary effusion lymphoma (PEL) suggests a plasmablastic derivation and identifies PEL-specific transcripts
Klein, U. (2003) · Blood · doi:10.1182/blood-2002-10-3090 · Cited by 267
Kaposi's Sarcoma–Associated Herpesvirus DNA Sequences in Prostate Tissue and Human Semen
Monini, P., Lellis, L. D., Fabris, M., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199605023341805 · Cited by 264
Metabolic epidemiology of large bowel cancer. Fecal bulk and constituents of high-risk North American and low-risk finnish population
Reddy, B. S., Hedges, A. R., Laakso, K., & Wynder, E. L. (1978) · Cancer · doi:10.1002/1097-0142(197812)42:6 · Cited by 257
Hypoxia induces lytic replication of Kaposi sarcoma–associated herpesvirus
Davis, D. A., Rinderknecht, A. S., Zoeteweij, J. P., Aoki, Y., Read-Connole, E., Tosato, G., Blauvelt, A., & Yarchoan, R. (2001) · Blood · doi:10.1182/blood.v97.10.3244 · Cited by 254
Self-citation
Human Herpesvirus 8 Seroprevalence in Blood Donors and Lymphoma Patients From Different Regions of Italy
Whitby, D., BOSHOFF, C. H., Weiss, R. A., et al. (1998) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/90.5.395 · Cited by 253
Identification of Kaposin (Open Reading Frame K12) as a Human Herpesvirus 8 (Kaposi’s Sarcoma-Associated Herpesvirus) Transforming Gene
Muralidhar, S., Pumfery, A. M., Hassani, M., et al. (1998) · Journal of Virology · doi:10.1128/jvi.72.6.4980-4988.1998 · Cited by 246
The Kaposin B Protein of KSHV Activates the p38/MK2 Pathway and Stabilizes Cytokine mRNAs
McCormick, C., & Ganem, D. (2005) · Science · doi:10.1126/science.1105779 · Cited by 242
Transmission of Human Herpesvirus 8 by Blood Transfusion
Hladik, W., Dollard, S. C., Mermin, J., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa055009 · Cited by 240
Prospective Study of Rituximab in Chemotherapy-Dependent Human Immunodeficiency Virus–Associated Multicentric Castleman's Disease: ANRS 117 CastlemaB Trial
Gérard, L., BEREZNE, A., Galicier, L., Meignin, V., Obadia, M., Castro, N. D., Jacomet, C., Verdon, R., Madelaine, I., Boulanger, E., et al. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2007.10.6732 · Cited by 233
Kaposi's sarcoma and Pneumocystis pneumonia among homosexual men--New York City and California.
(1981) · PubMed · Cited by 225
Viral IL-6-Induced Cell Proliferation and Immune Evasion of Interferon Activity
Chatterjee, M., Osborne, J., Bestetti, G., Chang, Y., & Moore, P. S. (2002) · Science · doi:10.1126/science.1074883 · Cited by 219
Modulation of Cellular and Viral Gene Expression by the Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus
Renne, R., Barry, C., Dittmer, D. P., et al. (2001) · Journal of Virology · doi:10.1128/jvi.75.1.458-468.2001 · Cited by 217
Kaposi's Sarcoma in the Acquired Immune Deficiency Syndrome: A Proposal for Uniform Evaluation, Response, and Staging Criteria
Krown, S. E., Metroka, C. E., & Wernz, J. (1989) · Cited by 217
Post-transplant Kaposi sarcoma originates from the seeding of donor-derived progenitors
Barozzi, P., Luppi, M., Facchetti, F., et al. (2003) · Nature Medicine · doi:10.1038/nm862 · Cited by 215
Human Herpesvirus 8 in Brazilian Amerindians: A Hyperendemic Population with a New Subtype
Biggar, R. J., Whitby, D., Marshall, V. A., et al. (2000) · The Journal of Infectious Diseases · doi:10.1086/315456 · Cited by 214
Seroconversion for human herpesvirus 8 during HIV infection is highly predictive of Kaposiʼs sarcoma
Renwick, N. M., Halaby, T., Weverling, G. J., et al. (1998) · AIDS · doi:10.1097/00002030-199818000-00018 · Cited by 209
The geographical distribution of Kaposi's sarcoma and of lymphomas in Africa before the AIDS epidemic
Cook-Mozaffari, P., Newton, R., Beral, V., et al. (1998) · British Journal of Cancer · doi:10.1038/bjc.1998.717 · Cited by 207
Treatment of HIV-associated Kaposi's sarcoma with paclitaxel
Saville, M. W., Lietzau, J., Pluda, J. M., Wilson, W. H., Humphrey, R. W., Feigel, E., Steinberg, S. M., Broder, S., Yarchoan, R., Odom, J., et al. (1995) · The Lancet · doi:10.1016/s0140-6736(95)92654-2 · Cited by 206
Self-citation
Risk of Kaposi's sarcoma and sexual practices associated with faecal contact in homosexual or bisexual men with AIDS
Beral, V., Bull, D., Darby, S. C., et al. (1992) · The Lancet · doi:10.1016/0140-6736(92)90793-3 · Cited by 206
Kaposi's Sarcoma-Associated Herpesvirus-Encoded Latency-Associated Nuclear Antigen Inhibits Lytic Replication by Targeting Rta: a Potential Mechanism for Virus-Mediated Control of Latency
Lan, K., Kuppers, D. A., Verma, S. C., et al. (2004) · Journal of Virology · doi:10.1128/jvi.78.12.6585-6594.2004 · Cited by 206
Trends in the incidence of cancer in Kampala, Uganda 1991-2010
Wabinga, H. R., Nambooze, S., Amulen, P. M., Okello, C., Mbus, L. N., & Parkin, D. M. (2013) · International Journal of Cancer · doi:10.1002/ijc.28661 · Cited by 203
Cumulative incidence of cancer among individuals with acquired immunodeficiency syndrome in the United States
Simard, E. P., Pfeiffer, R. M., & Engels, E. A. (2010) · Cancer · doi:10.1002/cncr.25547 · Cited by 196
Brief Communication: Rituximab in HIV-Associated Multicentric Castleman Disease
Bower, M., Powles, T., Williams, S., Davis, T. N., Atkins, M., Montoto, S., Orkin, C. M., Webb, A., Fisher, M., Nelson, M. R., et al. (2007) · Annals of Internal Medicine · doi:10.7326/0003-4819-147-12-200712180-00003 · Cited by 196
The TSC2/mTOR pathway drives endothelial cell transformation induced by the Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor
Sodhi, A., Chaisuparat, R., Hu, J., Ramsdell, A. K., Manning, B. D., Sausville, E. A., Sawai, E. T., Molinolo, A., Gutkind, J. S., & Montaner, S. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.05.026 · Cited by 195
Clinical Manifestations of Kaposi Sarcoma Herpesvirus Lytic Activation: Multicentric Castleman Disease (KSHV–MCD) and the KSHV Inflammatory Cytokine Syndrome
Polizzotto, M. N., Uldrick, T. S., Hu, D., & Yarchoan, R. (2012) · Frontiers in Microbiology · doi:10.3389/fmicb.2012.00073 · Cited by 195
Self-citation
Kaposi's sarcoma-associated herpesvirus-infected primary effusion lymphoma has a plasma cell gene expression profile
Jenner, R. G., Maillard, K. I., Cattini, N., Weiss, R. A., Boshoff, C., Wooster, R., & Kellam, P. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1630810100 · Cited by 193
Blood-Borne and Sexual Transmission of Human Herpesvirus 8 in Women with or at Risk for Human Immunodeficiency Virus Infection
Cannon, M. J., Dollard, S. C., Smith, D. K., Klein, R. S., Schuman, P. C., Rich, J. D., Vlahov, D., & Pellett, P. E. (2001) · New England Journal of Medicine · doi:10.1056/nejm200103013440904 · Cited by 191
Kaposi’s Sarcoma-Associated Herpesvirus G Protein-Coupled Receptor Constitutively Activates NF-κB and Induces Proinflammatory Cytokine and Chemokine Production Via a C-Terminal Signaling Determinant
Schwarz, M., & Murphy, P. M. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.1.505 · Cited by 187
Paclitaxel Is Safe and Effective in the Treatment of Advanced AIDS-Related Kaposi's Sarcoma
Gill, P. S., Tulpule, A., Espina, B. M., et al. (1999) · Journal of Clinical Oncology · doi:10.1200/jco.1999.17.6.1876 · Cited by 186
Kaposi's Sarcoma-Associated Herpesvirus and Kaposi's Sarcoma in Africa
Chang, Y. (1996) · Archives of Internal Medicine · doi:10.1001/archinte.1996.00440020112014 · Cited by 179
Phase II trial with dose titration of paclitaxel for the therapy of human immunodeficiency virus-associated Kaposi's sarcoma.
Welles, L., Saville, M. W., Lietzau, J., et al. (1998) · Journal of Clinical Oncology · doi:10.1200/jco.1998.16.3.1112 · Cited by 174
Randomized trial of paclitaxel versus pegylated liposomal doxorubicin for advanced human immunodeficiency virus‐associated Kaposi sarcoma
Cianfrocca, M. E., Lee, S., Roenn, J. V., Tulpule, A., Dezube, B. J., Aboulafia, D. M., Ambinder, R. F., Lee, J. Y., Krown, S. E., & Sparano, J. A. (2010) · Cancer · doi:10.1002/cncr.25362 · Cited by 173
AIDS-Related Kaposi’s Sarcoma: Evaluation of Potential New Prognostic Factors and Assessment of the AIDS Clinical Trial Group Staging System in the Haart Era—the Italian Cooperative Group on AIDS and Tumors and the Italian Cohort of Patients Naïve From Antiretrovirals
Nasti, G., Talamini, R., Antinori, A., et al. (2003) · Journal of Clinical Oncology · doi:10.1200/jco.2003.10.162 · Cited by 173
NF-κB is essential for the progression of KSHV- and EBV-infected lymphomas in vivo
Keller, S. A., Hernandez-Hopkins, D., Vider, J., Ponomarev, V., Hyjek, E. M., Schattner, E. J., & Cesarman, E. (2005) · Blood · doi:10.1182/blood-2005-07-2730 · Cited by 172
Highly active anti-retroviral therapy (HAART) prolongs time to treatment failure in Kaposi‚s sarcoma
Bower, M., Fox, P., Fife, K. M., et al. (1999) · AIDS · doi:10.1097/00002030-199910220-00014 · Cited by 170
The role of immune suppression and HHV-8 in the increasing incidence of HIV-associated multicentric Castleman’s disease
Powles, T. B., Stebbing, J., Bazeos, A., Hatzimichael, E. C., Mandalia, S., Nelson, M. R., Gazzard, B., & Bower, M. (2009) · Annals of Oncology · doi:10.1093/annonc/mdn697 · Cited by 170
Randomized Phase II Trial of Matrix Metalloproteinase Inhibitor COL-3 in AIDS-Related Kaposi's Sarcoma: An AIDS Malignancy Consortium Study
Dezube, B. J., Krown, S. E., Lee, J. Y., et al. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2005.04.2614 · Cited by 169
Erratum: G-protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator (Nature (1998) 391 (86-89))
Bais, C., Santomasso, B., Coso, O. A., Arvanitakis, L., Geras‐Raaka, E., Gutkind, J. S., Asch, A. S., Cesarman, E., Gershengorn, M. C., & Mesri, E. A. (1998) · Nature · Cited by 164
Multicenter trial of low‐dose paclitaxel in patients with advanced AIDS‐related Kaposi sarcoma
Tulpule, A., Groopman, J. E., Saville, M. W., et al. (2002) · Cancer · doi:10.1002/cncr.10634 · Cited by 159
Risk Factors for Human Herpesvirus 8 Infection among Adults in the United States and Evidence for Sexual Transmission
Engels, E. A., Atkinson, J., Graubard, B. I., et al. (2007) · The Journal of Infectious Diseases · doi:10.1086/518791 · Cited by 159
Human and viral interleukin-6 and other cytokines in Kaposi sarcoma herpesvirus-associated multicentric Castleman disease
Polizzotto, M. N., Uldrick, T. S., Wang, V., Aleman, K., Wyvill, K. M., Marshall, V., Pittaluga, S., O’Mahony, D., Whitby, D., Tosato, G., et al. (2013) · Blood · doi:10.1182/blood-2013-08-519959 · Cited by 158
Self-citation
Risk Factors for Human Herpesvirus 8 Seropositivity and Seroconversion in a Cohort of Homosexula Men
Dukers–Muijrers, N. H. T. M., Renwick, N. M., Prins, M., et al. (2000) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a010195 · Cited by 158
Inherited human OX40 deficiency underlying classic Kaposi sarcoma of childhood
Byun, M., Ma, C. S., Akçay, A., Pedergnana, V., Palendira, U., Myoung, J., Avery, D. T., Liu, Y., Abhyankar, A., Lorenzo, L., et al. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20130592 · Cited by 153
A Randomized Controlled Trial of Highly Active Antiretroviral Therapy Versus Highly Active Antiretroviral Therapy and Chemotherapy in Therapy-Naive Patients With HIV-Associated Kaposi Sarcoma in South Africa
Mosam, A., Shaik, F., Uldrick, T. S., Esterhuizen, T. M., FRIEDLAND, G. H., Scadden, D. T., Aboobaker, J., & Coovadia, H. M. (2012) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e318251aedd · Cited by 152
Self-citation
High-dose zidovudine plus valganciclovir for Kaposi sarcoma herpesvirus-associated multicentric Castleman disease: a pilot study of virus-activated cytotoxic therapy
Uldrick, T. S., Polizzotto, M. N., Aleman, K. O., O’Mahony, D., Wyvill, K. M., Wang, V., Marshall, V. A., Pittaluga, S., Steinberg, S. M., Tosato, G., et al. (2011) · Blood · doi:10.1182/blood-2010-11-317610 · Cited by 152
Self-citation
Modulation of p27Kip1 levels by the cyclin encoded by Kaposi's sarcoma‐associated herpesvirus
Mann, D. J., Child, E. S., Swanton, C., Laman, H., & Jones, N. (1999) · The EMBO Journal · doi:10.1093/emboj/18.3.654 · Cited by 149
Acquired immune deficiency syndrome (AIDS) trends in the United States, 1978–1982
Selik, R. M., Haverkos, H. W., & Curran, J. W. (1984) · The American Journal of Medicine · doi:10.1016/0002-9343(84)90669-7 · Cited by 144
An IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in men infected with human immunodeficiency virus
Foster, C. B., Lehrnbecher, T., Samuels, S., Stein, S., Mol, F., Metcalf, J. A., Wyvill, K. M., Steinberg, S. M., Kovacs, J. A., Blauvelt, A., et al. (2000) · Blood · doi:10.1182/blood.v96.7.2562 · Cited by 143
Self-citation
Human Herpesvirus 8 Infects and Replicates in Primary Cultures of Activated B Lymphocytes through DC-SIGN
Rappocciolo, G., Hensler, H. R., Jais, M., Reinhart, T. A., Pegu, A., Jenkins, F. J., & Rinaldo, C. R. (2008) · Journal of Virology · doi:10.1128/jvi.01587-07 · Cited by 142
Kaposi's Sarcoma-Associated Herpesvirus MicroRNAs Target IRAK1 and MYD88, Two Components of the Toll-Like Receptor/Interleukin-1R Signaling Cascade, To Reduce Inflammatory-Cytokine Expression
Abend, J. R., Ramalingam, D., Kieffer-Kwon, P., Uldrick, T. S., Yarchoan, R., & Ziegelbauer, J. M. (2012) · Journal of Virology · doi:10.1128/jvi.01147-12 · Cited by 135
Self-citation
Pivotal Advance: Kaposi’s sarcoma-associated herpesvirus (KSHV)-encoded microRNA specifically induce IL-6 and IL-10 secretion by macrophages and monocytes
Qin, Z., Kearney, P., Plaisance‐Bonstaff, K., & Parsons, C. H. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0409251 · Cited by 134
Low T Cell Responses to Human Herpesvirus 8 in Patients with AIDS‐Related and Classic Kaposi Sarcoma
Guihot, A., Dupin, N., Marcelin, A., et al. (2006) · The Journal of Infectious Diseases · doi:10.1086/507648 · Cited by 134
Intracellular Tat of Human Immunodeficiency Virus Type 1 Activates Lytic Cycle Replication of Kaposi's Sarcoma-Associated Herpesvirus: Role of JAK/STAT Signaling
Zeng, Y., Zhang, X., Huang, Z., Cheng, L., Yao, S., Qin, D., Chen, X., Tang, Q., Lv, Z., Zhang, L., et al. (2006) · Journal of Virology · doi:10.1128/jvi.02024-06 · Cited by 132
HHV-8-encoded viral IL-6 collaborates with mouse IL-6 in the development of multicentric Castleman disease in mice.
Suthaus, J., Stuhlmann-Laeisz, C., Tompkins, V., Rosean, T. R., Klapper, W., Tosato, G., Janz, S., Scheller, J., & Rose-John, S. (2012) · Blood · doi:10.1182/blood-2011-09-377705 · Cited by 131
Frequent and Asymptomatic Oropharyngeal Shedding of Human Herpesvirus 8 among Immunocompetent Men
Casper, C., Krantz, E. M., Selke, S., Kuntz, S. R., Wang, J., Huang, M.-L. W., Pauk, J. S., Corey, L., & Wald, A. (2006) · The Journal of Infectious Diseases · doi:10.1086/509621 · Cited by 131
Kaposi's sarcoma-associated herpesvirus and Kaposi's sarcoma in Africa. Uganda Kaposi's Sarcoma Study Group
Chang, Y. (1996) · Archives of Internal Medicine · doi:10.1001/archinte.156.2.202 · Cited by 131
Multicentric Castleman's disease in HIV infection: a systematic review of the literature.
Mylona, E. E., Baraboutis, I. G., Lekakis, L. J., et al. (2008) · PubMed · Cited by 130
Genotypic analysis at multiple loci across Kaposi's sarcoma herpesvirus (KSHV) DNA molecules: clustering patterns, novel variants and chimerism
Zong, J., Ciufo, D. M., Viscidi, R. P., et al. (2002) · Journal of Clinical Virology · doi:10.1016/s1386-6532(01)00205-0 · Cited by 130
Activity of thalidomide in AIDS-related Kaposi's sarcoma and correlation with HHV8 titre
Fife, K., Phillips, R. H., Howard, M. R., et al. (1998) · International Journal of STD & AIDS · doi:10.1258/0956462981921512 · Cited by 125
Rituximab plus liposomal doxorubicin in HIV-infected patients with KSHV-associated multicentric Castleman disease
Uldrick, T. S., Polizzotto, M. N., Aleman, K. O., Wyvill, K. M., Marshall, V. A., Whitby, D., Wang, V., Pittaluga, S., O’Mahony, D., Steinberg, S. M., et al. (2014) · Blood · doi:10.1182/blood-2014-07-586800 · Cited by 124
Self-citation
Phase II Study of Bevacizumab in Patients With HIV-Associated Kaposi's Sarcoma Receiving Antiretroviral Therapy
Uldrick, T. S., Wyvill, K. M., Kumar, P. P., O’Mahony, D., Bernstein, W., Aleman, K. O., Polizzotto, M. N., Steinberg, S. M., Pittaluga, S., Marshall, V. A., et al. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2011.39.6853 · Cited by 124
Self-citation
Kaposi's sarcoma-associated herpesvirus encoded vFLIP induces cellular IL-6 expression: the role of the NF-κB and JNK/AP1 pathways
An, J., Sun, Y., Sun, R., & Rettig, M. B. (2003) · Oncogene · doi:10.1038/sj.onc.1206407 · Cited by 120
The viral interferon-regulatory factor-3 is required for the survival of KSHV-infected primary effusion lymphoma cells
Wies, E., Mori, Y., Hahn, A. S., Kremmer, E., Stürzl, M., Fleckenstein, B., & Neipel, F. (2007) · Blood · doi:10.1182/blood-2007-05-092288 · Cited by 110
Rituximab decreases the risk of lymphoma in patients with HIV-associated multicentric Castleman disease
Gérard, L., Michot, J., Burcheri, S., Fieschi, C., Longuet, P., DELCEY, V., Meignin, V., Agbalika, F., Chevret, S., Oksenhendler, É., et al. (2012) · Blood · doi:10.1182/blood-2011-08-376012 · Cited by 109
Phase II Trial of Imatinib in AIDS-Associated Kaposi's Sarcoma: AIDS Malignancy Consortium Protocol 042
Koon, H. B., Krown, S. E., Lee, J. Y., Honda, K. S., Rapisuwon, S., Wang, Z., Aboulafia, D. M., Reid, E. G., Rudek, M. A., Dezube, B. J., et al. (2013) · Journal of Clinical Oncology · doi:10.1200/jco.2012.48.6365 · Cited by 108
Prevalence of Kaposi Sarcoma–Associated Herpesvirus Infection in Homosexual Men at Beginning of and During the HIV Epidemic
Osmond, D. H. (2002) · JAMA · doi:10.1001/jama.287.2.221 · Cited by 102
HHV-8–associated Kaposi sarcoma in a child with IFNγR1 deficiency
Çamcıoğlu, Y., Pïcard, C., Lacoste, V., et al. (2004) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2003.11.012 · Cited by 100
Kaposi's Sarcoma–Associated Herpesvirus Viral IFN Regulatory Factor 3 Stabilizes Hypoxia-Inducible Factor-1α to Induce Vascular Endothelial Growth Factor Expression
Shin, Y. C., Joo, C.-H., Gack, M. U., Lee, H.-R., & Jung, J. U. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-2766 · Cited by 99
Recent advances in Kaposi sarcoma herpesvirus-associated multicentric Castleman disease
Uldrick, T., Polizzotto, M., & Yarchoan, R. (2012) · Current Opinion in Oncology · doi:10.1097/cco.0b013e328355e0f3 · Cited by 97
Self-citation
Oxidative Stress Induces Reactivation of Kaposi's Sarcoma-Associated Herpesvirus and Death of Primary Effusion Lymphoma Cells
Li, X., Feng, J., & Sun, R. (2010) · Journal of Virology · doi:10.1128/jvi.01742-10 · Cited by 96
Kaposi Sarcoma–Associated Herpesvirus (KSHV) Seroprevalence in Population‐Based Samples of African Children: Evidence for At Least 2 Patterns of KSHV Transmission
Butler, L., Dorsey, G., Hladik, W., et al. (2009) · The Journal of Infectious Diseases · doi:10.1086/600103 · Cited by 93
Viral and cellular cytokines in AIDS-related malignant lymphomatous effusions
Aoki, Y., Yarchoan, R., Braun, J., et al. (2000) · Blood · doi:10.1182/blood.v96.4.1599.h8001599_1599_1601 · Cited by 90
Self-citation
Remission from Kaposi's sarcoma on HAART is associated with suppression of HIV replication and is independent of protease inhibitor therapy
Martinez, V., Caumes, É., Gambotti, L., et al. (2006) · British Journal of Cancer · doi:10.1038/sj.bjc.6603056 · Cited by 89
Incidence of Primary and Second Cancers in Renal Transplant Recipients: A Multicenter Cohort Study
Tessari, G., Naldi, L., Boschiero, L., Minetti, E., Sandrini, S., Nacchia, F., Valerio, F., Rugiu, C., Sassi, F., Gotti, E., et al. (2012) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2012.04294.x · Cited by 86
The Impact of Preexisting or Acquired Kaposi Sarcoma Herpesvirus Infection in Kidney Transplant Recipients on Morbidity and Survival
Francès, C., Marcelin, A., Legendre, C., Chevret, S., Dussaix, É., Lejeune, J., Euvrard, S., Bigorie, A., Schulz, T. F., Agbalika, F., et al. (2009) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2009.02816.x · Cited by 86
Serum viral interleukin-6 in AIDS-related multicentric Castleman disease
Aoki, Y., Tosato, G., Fonville, T. W., et al. (2001) · Blood · doi:10.1182/blood.v97.8.2526 · Cited by 86
A Randomized, Double-Blind Study of Pegylated Liposomal Doxorubicin for the Treatment of AIDS-Related Kaposi's Sarcoma
Cooley, T. P., Henry, D. H., Tonda, M. E., et al. (2007) · The Oncologist · doi:10.1634/theoncologist.12-1-114 · Cited by 85
Nucleophosmin Phosphorylation by v-Cyclin-CDK6 Controls KSHV Latency
Sarek, G., Järviluoma, A., Moore, H. M., Tojkander, S., Vartia, S., Biberfeld, P., Laiho, M., & Ojala, P. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000818 · Cited by 84
Heterogeneity and Breadth of Host Antibody Response to KSHV Infection Demonstrated by Systematic Analysis of the KSHV Proteome
Labò, N., Miley, W., Marshall, V. A., Gillette, W., Esposito, D., Bess, M., Turano, A., Uldrick, T. S., Polizzotto, M. N., Wyvill, K. M., et al. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004046 · Cited by 83
Self-citation
CD30 targeting with brentuximab vedotin: a novel therapeutic approach to primary effusion lymphoma
Bhatt, S., Ashlock, B. M., Natkunam, Y., et al. (2013) · Blood · doi:10.1182/blood-2013-01-481713 · Cited by 83
Shedding of Human Herpesvirus 8 in Oral and Genital Secretions from HIV‐1–Seropositive and –Seronegative Kenyan Women
Taylor, M. M., Chohan, B. H., Lavreys, L., et al. (2004) · The Journal of Infectious Diseases · doi:10.1086/421466 · Cited by 83
Detection of antibodies to Kaposi's sarcoma-associated herpesvirus: A new approach using K8.1 ELISA and a newly developed recombinant LANA ELISA
Mbisa, G. L., Miley, W., Gamache, C. J., et al. (2010) · Journal of Immunological Methods · doi:10.1016/j.jim.2010.02.015 · Cited by 82
Correlates of Prevalent and Incident Kaposi’s Sarcoma–Associated Herpesvirus Infection in Men Who Have Sex with Men
Casper, C., Wald, A., Pauk, J. S., et al. (2002) · The Journal of Infectious Diseases · doi:10.1086/339605 · Cited by 82
Immunosenescence is associated with presence of Kaposi's sarcoma in antiretroviral treated HIV infection
Unemori, P., Leslie, K. S., Hunt, P. W., Sinclair, E., Epling, L., Mitsuyasu, R. T., Effros, R. B., Dock, J., Dollard, S., Deeks, S. G., et al. (2013) · AIDS · doi:10.1097/qad.0b013e3283601144 · Cited by 81
Human Herpesvirus 8 Infection and Transfusion History in Children With Sickle-Cell Disease in Uganda
Mbulaiteye, S. M. (2003) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djg039 · Cited by 81
Prospective randomized trial of two dose levels of interferon alfa with zidovudine for the treatment of Kaposi's sarcoma associated with human immunodeficiency virus infection: a Canadian HIV Clinical Trials Network study.
Shepherd, F. A., Beaulieu, R., Gelmon, K. E., et al. (1998) · Journal of Clinical Oncology · doi:10.1200/jco.1998.16.5.1736 · Cited by 79
Efficacy of Low-Dose Interferon with Antiretroviral Therapy in Kaposi's Sarcoma: A Randomized Phase II AIDS Clinical Trials Group Study
Krown, S. E., Li, P., Roenn, J. H. V., et al. (2002) · Journal of Interferon & Cytokine Research · doi:10.1089/107999002753675712 · Cited by 79
Identifying Human Herpesvirus 8 Infection: Performance Characteristics of Serologic Assays
Engels, E. A., Whitby, D., Goebel, P. B., et al. (2000) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/00126334-200004010-00011 · Cited by 78
Virologic, hematologic, and immunologic risk factors for classic Kaposi sarcoma
Brown, E. E., Whitby, D., Vitale, F. M., et al. (2006) · Cancer · doi:10.1002/cncr.22236 · Cited by 77
γ-Herpesvirus-encoded miRNAs and their roles in viral biology and pathogenesis
Zhu, Y., Häecker, I., Yang, Y., Gao, S., & Renne, R. (2013) · Current Opinion in Virology · doi:10.1016/j.coviro.2013.05.013 · Cited by 76
Water, Socioeconomic Factors, and Human Herpesvirus 8 Infection in Ugandan Children and Their Mothers
Mbulaiteye, S. M., Biggar, R. J., Pfeiffer, R. M., et al. (2005) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/01.qai.0000132495.89162.c0 · Cited by 75
Human Herpesvirus 8 (HHV8) Transmission and Related Morbidity in Organ Recipients
Lebbé, C., Porcher, R., Marcelin, A., et al. (2012) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2012.04290.x · Cited by 70
Viral IFN-Regulatory Factors Inhibit Activation-Induced Cell Death Via Two Positive Regulatory IFN-Regulatory Factor 1-Dependent Domains in the CD95 Ligand Promoter
Kirchhoff, S., Sebens, T., Baumann, S., Krueger, A., Zawatzky, R., Li‐Weber, M., Meinl, E., Neipel, F., Fleckenstein, B., & Krammer, P. H. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.3.1226 · Cited by 70
Intracellular Signaling Mechanisms and Activities of Human Herpesvirus 8 Interleukin-6
Chen, D., Sandford, G., & Nicholas, J. (2008) · Journal of Virology · doi:10.1128/jvi.01517-08 · Cited by 70
Primary effusion lymphoma: genomic profiling revealed amplification of SELPLG and CORO1C encoding for proteins important for cell migration
Luan, S., Boulanger, E., Ye, H., et al. (2010) · The Journal of Pathology · doi:10.1002/path.2752 · Cited by 69
Lymph Nodes Involved by Multicentric Castleman Disease Among HIV-positive Individuals are Often Involved by Kaposi Sarcoma
Naresh, K. N., Rice, A. J., & Bower, M. (2008) · The American Journal of Surgical Pathology · doi:10.1097/pas.0b013e318160ed97 · Cited by 66
Rapamycin With Antiretroviral Therapy in AIDS-Associated Kaposi Sarcoma
Krown, S. E., Roy, D., Lee, J. Y., et al. (2011) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e31823e7884 · Cited by 66
Risk Factors for Seropositivity to Kaposi Sarcoma–Associated Herpesvirus Among Children in Uganda
Wakeham, K., Webb, E. L., Sebina, I., et al. (2013) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e31828a7056 · Cited by 66
Kaposi sarcoma herpesvirus–encoded vFLIP and vIRF1 regulate antigen presentation in lymphatic endothelial cells
Lagos, D., Trotter, M. W. B., Vart, R. J., Wang, H., Matthews, N. C., Hansen, A., Flore, O., Gotch, F. M., & Boshoff, C. (2006) · Blood · doi:10.1182/blood-2006-05-024034 · Cited by 64
Phase II Evaluation of Low-Dose Oral Etoposide for the Treatment of Relapsed or Progressive AIDS-Related Kaposi’s Sarcoma: An AIDS Clinical Trials Group Clinical Study
Evans, S. R., Krown, S. E., Testa, M. A., et al. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.2002.12.038 · Cited by 64
Kaposin-B Enhances the PROX1 mRNA Stability during Lymphatic Reprogramming of Vascular Endothelial Cells by Kaposi's Sarcoma Herpes Virus
Yoo, J., Kang, J., Lee, H. N., Aguilar, B., Kafka, D., Lee, S., Choi, I., Lee, J., Ramu, S., Haas, J., et al. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001046 · Cited by 64
No evidence of sexual transmission of Kaposi's sarcoma herpes virus in a heterosexual South African population
Malope‐Kgokong, B., MacPhail, P., Mbisa, G. L., et al. (2008) · AIDS · doi:10.1097/qad.0b013e3282f46582 · Cited by 63
Correlates of human herpesvirus 8 seropositivity among heterosexual men in Kenya
Baeten, J. M., Chohan, B. H., Lavreys, L., et al. (2002) · AIDS · doi:10.1097/00002030-200210180-00013 · Cited by 63
Histone Deacetylase Classes I and II Regulate Kaposi's Sarcoma-Associated Herpesvirus Reactivation
Shin, H. J., DeCotiis, J., Giron, M., Palmeri, D., & Lukac, D. M. (2013) · Journal of Virology · doi:10.1128/jvi.02665-13 · Cited by 63
Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 3 Inhibits Gamma Interferon and Major Histocompatibility Complex Class II Expression
Schmidt, K., Wies, E., & Neipel, F. (2011) · Journal of Virology · doi:10.1128/jvi.02123-10 · Cited by 62
Primary and Reactivated HHV8 Infection and Disease After Liver Transplantation: A Prospective Study
Pietrosi, G., Vizzini, G. B., Pipitone, L., et al. (2011) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2011.03769.x · Cited by 61
Associations of Classic Kaposi Sarcoma with Common Variants in Genes that Modulate Host Immunity
Brown, E. E., Fallin, M. D., Ruczinski, I., Hutchinson, A. A., Staats, B. J., Vitale, F. M., Lauria, C., Serraino, D., Rezza, G., Mbisa, G. L., et al. (2006) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-05-0791 · Cited by 61
Kaposi's sarcoma herpesvirus-encoded latency-associated nuclear antigen stabilizes intracellular activated Notch by targeting the Sel10 protein
Lan, K., Verma, S. C., Murakami, M., Bajaj, B. G., Kaul, R., & Robertson, E. S. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703508104 · Cited by 59
High-attenuation lymphadenopathy in AIDS patients: significance of findings at CT.
Herts, B. R., Megibow, A. J., Birnbaum, B. A., et al. (1992) · Radiology · doi:10.1148/radiology.185.3.1438762 · Cited by 59
Vinorelbine Is an Effective and Safe Drug for AIDS-Related Kaposi’s Sarcoma: Results of a Phase II Study
Nasti, G., Errante, D., Talamini, R., et al. (2000) · Journal of Clinical Oncology · doi:10.1200/jco.2000.18.7.1550 · Cited by 58
Proteomic Screening of Human Targets of Viral microRNAs Reveals Functions Associated with Immune Evasion and Angiogenesis
Gallaher, A., Das, S., Xiao, Z., Andrésson, Þ., Kieffer-Kwon, P., Happel, C., & Ziegelbauer, J. M. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003584 · Cited by 56
Viral and cellular cytokines in AIDS-related malignant lymphomatous effusions
Aoki, Y., Yarchoan, R., Braun, J., et al. (2000) · Blood · doi:10.1182/blood.v96.4.1599 · Cited by 55
Self-citation
Malignancies in South African Children With HIV
Davidson, A., Wainwright, R., Stones, D. K., et al. (2014) · Journal of Pediatric Hematology/Oncology · doi:10.1097/mph.0b013e31829cdd49 · Cited by 51
The National Heart, Lung, and Blood Institute Retrovirus Epidemiology Donor Studies (Retrovirus Epidemiology Donor Study and Retrovirus Epidemiology Donor Study-II): Twenty Years of Research to Advance Blood Product Safety and Availability
Kleinman, S. H., King, M. R., Busch, M. P., Murphy, E. L., & Glynn, S. A. (2012) · Transfusion Medicine Reviews · doi:10.1016/j.tmrv.2012.04.004 · Cited by 50
Histological characterization of regression in acquired immunodeficiency syndrome‐related Kaposi's sarcoma
Pantanowitz, L., Dezube, B. J., Pinkus, G. S., et al. (2003) · Journal of Cutaneous Pathology · doi:10.1046/j.0303-6987.2004.0132.x · Cited by 50
Distinct Roles of Kaposi's Sarcoma-Associated Herpesvirus-Encoded Viral Interferon Regulatory Factors in Inflammatory Response and Cancer
Baresova, P., Pitha, P. M., & Lubyová, B. (2013) · Journal of Virology · doi:10.1128/jvi.03315-12 · Cited by 49
Treatment Response and Mortality among Patients Starting Antiretroviral Therapy with and without Kaposi Sarcoma: A Cohort Study
Maskew, M., Fox, M. P., Cutsem, G. V., Chu, K., MacPhail, P., Boulle, A., Egger, M., & Africa, F. I. S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064392 · Cited by 47
Interferon-α2b With Protease Inhibitor-Based Antiretroviral Therapy in Patients With AIDS-Associated Kaposi Sarcoma
Krown, S. E., Lee, J. Y., Lin, L., et al. (2006) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/01.qai.0000194237.15831.23 · Cited by 45
Development of hemophagocytic lymphohistiocytosis in triplets infected with HHV-8
Grossman, W. J., Radhi, M., Schauer, D. W., et al. (2005) · Blood · doi:10.1182/blood-2005-03-0950 · Cited by 45
Kaposi’s sarcoma in a child with Wiskott-Aldrich syndrome
Pïcard, C., Mellouli, F., Duprez, R., et al. (2006) · European Journal of Pediatrics · doi:10.1007/s00431-006-0107-2 · Cited by 44
Risk of Kaposi's Sarcoma and Oroanal Sexual Contact
Grulich, A. E., Kaldor, J. M., Hendry, O., et al. (1997) · American Journal of Epidemiology · doi:10.1093/aje/145.8.673 · Cited by 43
Immunohistochemistry in Kaposi’s sarcoma
Pantanowitz, L., Otis, C. N., & Dezube, B. J. (2009) · Clinical and Experimental Dermatology · doi:10.1111/j.1365-2230.2009.03707.x · Cited by 42
Prostratin and Bortezomib are Novel Inducers of Latent Kaposi'S Sarcoma-Associated Herpesvirus
Brown, H. J., McBride, W. H., Zack, J. A., & Sun, R. (2005) · Antiviral Therapy · doi:10.1177/135965350501000609 · Cited by 42
Gene Regulation and Functional Alterations Induced by Kaposi's Sarcoma-Associated Herpesvirus-Encoded ORFK13/vFLIP in Endothelial Cells
Sakakibara, S., Pise-Masison, C. A., Brady, J. N., & Tosato, G. (2008) · Journal of Virology · doi:10.1128/jvi.01871-08 · Cited by 41
Four-Antigen Mixture Containing V-Cyclin for Serological Screening of Human Herpesvirus 8 Infection
Burbelo, P. D., Leahy, H. P., Groot, S., et al. (2009) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00474-08 · Cited by 39
Sequence Analysis of Kaposi Sarcoma–Associated Herpesvirus (KSHV) MicroRNAs in Patients with Multicentric Castleman Disease and KSHV-Associated Inflammatory Cytokine Syndrome
Ray, A. K., Marshall, V. A., Uldrick, T. S., et al. (2012) · The Journal of Infectious Diseases · doi:10.1093/infdis/jis249 · Cited by 39
Self-citation
Targeting the mammalian target of Rapamycin to inhibit VEGF and cytokines for the treatment of primary effusion lymphoma
Gasperini, P., & Tosato, G. (2009) · Leukemia · doi:10.1038/leu.2009.117 · Cited by 38
Hypoxia Enhances the Phosphorylation and Cytotoxicity of Ganciclovir and Zidovudine in Kaposi's Sarcoma-Associated Herpesvirus–Infected Cells
Davis, D. A., Singer, K. E., Reynolds, I. P., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0939 · Cited by 36
Human Herpesvirus-8 and Other Viral Infections, Papua New Guinea
Rezza, G., Danaya, R. T., Wagner, T. M., et al. (2001) · Emerging infectious diseases · doi:10.3201/eid0705.017522 · Cited by 35
Role of Human Herpesvirus 8 Interleukin-6-Activated gp130 Signal Transducer in Primary Effusion Lymphoma Cell Growth and Viability
Cousins, E., & Nicholas, J. (2013) · Journal of Virology · doi:10.1128/jvi.02047-13 · Cited by 35
High prevalence of human herpesvirus 8 (HHV‐8) infection in south Texas children
Baillargeon, J., Leach, C. T., Deng, J., et al. (2002) · Journal of Medical Virology · doi:10.1002/jmv.10136 · Cited by 34
Clinical and pharmacokinetic study of oral etoposide in patients with AIDS-related Kaposi's sarcoma with no prior exposure to cytotoxic therapy.
Schwartsmann, G., Sprinz, E., Kromfield, M., et al. (1997) · Journal of Clinical Oncology · doi:10.1200/jco.1997.15.5.2118 · Cited by 32

Research works printed but not linked: 1

2012, Estimated HIV incidence in the United States, 2007–2010, HIV Surveillance Supplemental Report

Sorted by citations

Pomalidomide for Symptomatic Kaposi's Sarcoma in People With and Without HIV Infection: A Phase I/II Study
Polizzotto, M. N., Uldrick, T. S., Wyvill, K. M., Aleman, K., Peer, C. J., Bevans, M., Sereti, I., Maldarelli, F., Whitby, D., Marshall, V., et al. (2016) · Journal of Clinical Oncology · doi:10.1200/jco.2016.69.3812 · Cited by 138
Self-citation
Cancer therapies based on targeted protein degradation — lessons learned with lenalidomide
Jan, M., Sperling, A. S., & Ebert, B. L. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-021-00479-z · Cited by 137

See all 155

Authors: Bhutani, M., Polizzotto, M. N., Uldrick, T. S., & Yarchoan, R.
Affiliations: National Cancer Institute (US)
Corresponding author: Yarchoan, Robert
ORCID: Bhutani, Manisha
Polizzotto, Mark N.
Uldrick, Thomas S.
Yarchoan, Robert
Venue: Seminars in Oncology
Publisher: Elsevier BV
Published: 2015-04
Volume: 42
Issue: 2
Pages: 223-246
ISSN: 0093-7754 (ISSN-L)
DOI: 10.1053/j.seminoncol.2014.12.027
PMC: PMC6309362
OpenAlex: W2154435586
Cited by: 155
References: 209
Citations by year: 2026: 6 · 2025: 11 · 2024: 8 · 2023: 13 · 2022: 9 · 2021: 12 · 2020: 13 · 2019: 13 · 2018: 10 · 2017: 27 · 2016: 25 · 2015: 8
FWCI: 2.51
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Seminars in Oncology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, public-domain)
Funders: National Institutes of Health
National Cancer Institute (ZIABC010885, ZIABC010888)
Topics: Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
Health Sciences › Medicine › Infectious Diseases › Herpesvirus Infections and Treatments
Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
Keywords: Kaposi's sarcoma-associated herpesvirus, human herpesvirus 8, Kaposi's sarcoma, multicentric Castleman disease, primary effusion lymphoma, viral oncogenesis, immunodeficiency, HIV/AIDS, organ transplantation, antiviral therapy, tumor microenvironment, immunomodulatory therapy, molecular diagnosis
MeSH terms: Herpesviridae Infections, Humans, Neoplasms, Seroepidemiologic Studies, Herpesvirus 8, Human

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Kaposi Sarcoma–Associated Herpesvirus-Associated Malignancies: Epidemiology, Pathogenesis, and Advances in Treatment

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks