Human and viral interleukin-6 and other cytokines in Kaposi sarcoma herpesvirus-associated multicentric Castleman disease
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Key Points: Human IL-6 and a viral IL-6 homolog encoded by KSHV/HHV8 can independently or together lead to flares of KSHV-associated MCD. KSHV-MCD disease flares were more severe where both human and viral IL-6 were elevated, suggesting they jointly contribute to severity.
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In HHV-8-associated multicentric Castleman's disease, uncontrolled HHV-8 infection leads to cytokine storm driven primarily by excessive production of human interleukin-6 and viral interleukin-6 by HHV-8-infected plasmablasts.
“In this disorder, uncontrolled infection with HHV-8 (also known as Kaposi’s sarcoma herpesvirus) leads to a cytokine storm driven primarily by excessive production of human interleukin-6 and viral interleukin-6 by HHV-8–infected plasmablasts.68”
From Cytokine storm (2020) · cites this paper as [68]
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- Authors
- Polizzotto, M. N., Uldrick, T. S., Wang, V., Aleman, K., Wyvill, K. M., Marshall, V., Pittaluga, S., O’Mahony, D., Whitby, D., Tosato, G., Steinberg, S. M., Little, R. F., & Yarchoan, R.
- Affiliations
- National Cancer Institute (US)
- Frederick National Laboratory for Cancer Research (US)
- Laboratory of Pathology,
- Laboratory of Cellular Oncology, and
- ORCID
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2013-12-19
- Volume
- 122
- Issue
- 26
- Pages
- 4189-4198
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- PMC
- PMC3868925
- OpenAlex
- W2044588509
- Cited by
- 158
- References
- 53
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 12 · 2023: 7 · 2022: 14 · 2021: 17 · 2020: 17 · 2019: 11 · 2018: 8 · 2017: 14 · 2016: 12 · 2015: 17 · 2014: 14
- FWCI
- 7.68
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Blood (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
- Health Sciences › Medicine › Surgery › Lymphadenopathy Diagnosis and Analysis
- Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
- Keywords
- Kaposi's sarcoma-associated herpesvirus, multicentric Castleman disease, viral interleukin-6, cytokines, disease flares, viral load, IL-10, TNF-α, IL-1β, C-reactive protein, hyponatremia, lymphoproliferative disorders, IL-6 signaling
- MeSH terms
- Adult, Female, Castleman Disease, Humans, Interferon-gamma, Male, Middle Aged, Prospective Studies, Sarcoma, Kaposi, Tumor Necrosis Factor-alpha, Interleukin-6, Cytokines, Interleukin-8, Interleukin-10, Interleukin-12, Herpesvirus 8, Human, Interleukin-1beta
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