CoChat
Sign Up
Cited by 47Medical Imaging Techniques and ApplicationsRadiopharmaceutical Chemistry and ApplicationsLung Cancer Diagnosis and Treatment

Altered biodistribution on FDG-PET with emphasis on brown fat and insulin effect

Cohade, Christian·2010·Seminars in Nuclear Medicine
DOI 10.1053/j.semnuclmed.2010.02.001
Open this paper in CoChat — free account

Abstract

(18)F-fluorodeoxyglucose (FDG) is the radiotracer used in the vast majority of positron emission tomography (PET) cancer studies. FDG is a powerful radiotracer that provides valuable data in many cancer types. Normal FDG biodistribution is easily identified. In the PET-only era, physiological uptake provided important anatomical landmarks. However, the normal biodistribution of FDG is often variable and can be altered by intrinsic or iatrogenic factors. Recognizing these patterns of altered biodistribution is important for optimal FDG-PET interpretation. Altered FDG uptake in muscles, brown adipose tissue, bone marrow, the urinary tract, and the bowel is demonstrated in a significant proportion of patients, which can hide underlying malignant foci or mimic malignant lesions. The introduction of PET/computed tomography revolutionized PET imaging, bringing much-needed anatomical information. This modality allowed better characterization of some types of uptake, particularly brown adipose tissue FDG uptake. Different approaches to minimize interference from altered FDG biodistribution should be considered when performing PET scans. Otherwise, careful review and correlation of metabolic (FDG-PET) and anatomical (computed tomography) data should be performed to accurately characterize the foci of increased FDG uptake.

Integrity signals

Registry

Crossref · 10.1053/j.semnuclmed.2010.02.001

Cites

71 of 71 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Many noncancerous tissues, including the brain, are FDG-PET avid, showing that high glucose uptake is not unique to tumors.

    “Notably, many noncancerous tissues, including the brain, are FDG-PET avid (Berti et al., 2014; Cohade, 2010), illustrating that high glucose uptake is not a unique feature of tumors and offering a potential explanation for the relative lack of success in directly targeting glucose metabolism for cancer treatment.”

    From Targeting Metabolism for Cancer Therapy (2017) · cites this paper as Cohade, 2010

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Cohade, C.
Affiliations
Centre Hospitalier de l’Université de Montréal (CA)
Corresponding author
Cohade, Christian
Venue
Seminars in Nuclear Medicine
Publisher
Elsevier BV
Published
2010-07
Volume
40
Issue
4
Pages
283-293
ISSN
0001-2998 (ISSN-L)
DOI
10.1053/j.semnuclmed.2010.02.001
OpenAlex
W2001847653
Cited by
47
References
71
Citations by year
2026: 2 · 2024: 2 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 3 · 2018: 1 · 2017: 4 · 2016: 1 · 2015: 4 · 2014: 5 · 2013: 6 · 2012: 3
FWCI
0.78
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Seminars in Nuclear Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Radiopharmaceutical Chemistry and Applications
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Diagnosis and Treatment
Keywords
18F-fluorodeoxyglucose, brown adipose tissue, physiological FDG uptake, PET/CT, tumor imaging, bone marrow uptake, muscle uptake
MeSH terms
Adipose Tissue, Brown, Humans, Insulin, Tissue Distribution, Artifacts, Radiopharmaceuticals, Fluorodeoxyglucose F18, Positron-Emission Tomography

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review