Cited by 315Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismCardiovascular Disease and Adiposity

Glucose Uptake and Perfusion in Subcutaneous and Visceral Adipose Tissue during Insulin Stimulation in Nonobese and Obese Humans

Virtanen, Kirsi A., Lönnroth, Peter, Parkkola, Riitta, Peltoniemi, Pauliina, Asola, Markku, Viljanen, Tapio, Tolvanen, Tuula, Knuuti, Juhani +3 more·2002·The Journal of Clinical Endocrinology & Metabolism

Abstract

To elucidate the role of adipose tissue glucose uptake in whole-body metabolism, sc and visceral adipose tissue glucose uptake and perfusion were measured in 10 nonobese and 10 age-matched obese men with positron emission tomography using [(18)F]-2-fluoro-2-deoxy-D-glucose, and [(15)O]-labeled water during normoglycemic hyperinsulinemia. Whole-body and skeletal muscle glucose uptake rates per kilogram were lower in obese than in nonobese subjects (P < 0.01). Compared with nonobese, the obese subjects had 67% lower abdominal sc and 58% lower visceral adipose tissue glucose uptake per kilogram of fat. In both groups, insulin stimulated glucose uptake per kilogram fat was significantly higher in visceral fat depots than in sc regions (P < 0.01). Both sc and visceral adipose tissue blood flow expressed per kilogram and minute was impaired in the obese subjects, compared with the nonobese (P < 0.05). Fat masses measured with magnetic resonance images were higher in obese than in nonobese individuals. If regional glucose uptake rates were expressed as per total fat mass, total glucose uptake rates per depot were similar in obese and nonobese subjects and represented 4.1% of whole-body glucose uptake in obese and 2.6% in nonobese subjects (P < 0.02 between the groups). In conclusion, insulin-stimulated glucose uptake per kilogram fat is higher in visceral than in sc adipose tissue. Glucose uptake and blood flow in adipose tissue exhibit insulin resistance in obesity, but because of the larger fat mass, adipose tissue does not seem to contribute substantially to the reduced insulin stimulated whole-body glucose uptake in obesity.

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Crossref · 10.1210/jcem.87.8.8761

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  • Adipose tissue is poorly oxygenated in the obese state in humans.

    “This has been verified by recent clinical observations in humans, which suggest that AT is poorly oxygenated in the obese state (20,21).”

    From Adipose tissue remodeling and obesity (2011) · cites this paper as [21]

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Authors
Virtanen, K. A., Lönnroth, P., Parkkola, R., Peltoniemi, P., Asola, M., Viljanen, T., Tolvanen, T., Knuuti, J., Rönnemaa, T., Huupponen, R., & Nuutila, P.
Affiliations
  • University of Turku (FI)
  • University of Gothenburg (SE)
  • Turku PET Centre (FI)
Corresponding author
Nuutila, Pirjo
Venue
The Journal of Clinical Endocrinology & Metabolism
Published
2002-08
Volume
87
Issue
8
Pages
3902-3910
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
OpenAlex
W2117731142
Cited by
315
References
0
Citations by year
2026: 8 · 2025: 6 · 2024: 13 · 2023: 14 · 2022: 20 · 2021: 14 · 2020: 19 · 2019: 13 · 2018: 14 · 2017: 23 · 2016: 12 · 2015: 11 · 2014: 19 · 2013: 18 · 2012: 13
FWCI
5.81
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords
adipose tissue glucose uptake, subcutaneous adipose tissue, visceral adipose tissue, insulin resistance, obesity, hyperinsulinemic-euglycemic clamp, skeletal muscle glucose uptake, whole-body glucose uptake, adipose tissue blood flow, fat mass
MeSH terms
Abdomen, Adipose Tissue, Adult, Glucose, Homeostasis, Humans, Hypoglycemic Agents, Insulin, Insulin Resistance, Magnetic Resonance Imaging, Male, Obesity, Regional Blood Flow, Skin, Tomography, Emission-Computed, Muscle, Skeletal, Radiopharmaceuticals, Fluorodeoxyglucose F18

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