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Cited by 339

The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.

Proliferative Activity of Intrahepatic Colorectal Metastases After Preoperative Hemihepatic Portal Vein Embolization

Open access
Kokudo, Norihiro, Tada, Keiichiro, Seki, Makoto, Ohta, Hirotoshi, Azekura, Kaoru, Ueno, Masashi, Ohta, Keiichiro, Yamaguchi, Toshiharu, Matsubara, Toshiki, Takahashi, Takashi, Nakajima, Toshifusa, Muto, Tetsuichiro, Ikari, Takaaki, Yanagisawa, Akio, Kato, Yo·2001·Hepatology
DOI 10.1053/jhep.2001.26513
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Abstract

Although hemihepatic portal vein embolization (PVE) has been used preoperatively to extend indications for hepatectomy in patients with colorectal metastases, the effects of this procedure on tumor growth and outcome remain controversial. To address this issue, we assessed the proliferative activity of intrahepatic metastases after PVE and the long–term outcome of this procedure. Eighteen patients with colorectal metastases underwent preoperative PVE between 1996 and 2000 (PVE group). Twenty–nine patients who underwent major hepatic resection without PVE served as control (non–PVE group). The hepatic parenchymal fraction of the left lobe had significantly increased from 38.1 ± 3.2% to 45.9 ± 2.9% 3 weeks after PVE (+20.5%, P < .0001). Tumor volume and percent tumor volume had also significantly increased from 223 ± 89 mL to 270 ± 97 mL (+20.8%, P = .016) and from 13.7 + 4.3% to 16.2 + 4.9% (+18.5%, P = .014), respectively. There was no apparent correlation between the increase in parenchymal volume and that in tumor volume. The Ki–67 labeling index of metastatic lesions was 46.6 ± 7.2% in the PVE group and 35.4 ± 12.6% in the non–PVE group (P = .013). Long–term survival was similar in the PVE and non–PVE groups, however, disease–free survival was significantly poorer in the PVE group than in the non–PVE group (P = .004). We conclude that PVE increases tumor growth and probably is associated with enhanced recurrence of disease. Although PVE is effective in extending indications for surgery, patient selection for PVE should be cautious.

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Metadata

Authors
Kokudo, N., Tada, K., Seki, M., Ohta, H., Azekura, K., Ueno, M., Ohta, K., Yamaguchi, T., Matsubara, T., Takahashi, T., Nakajima, T., Muto, T., Ikari, T., Yanagisawa, A., & Kato, Y.
Venue
Hepatology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2001-08
Volume
34
Issue
2
Pages
267-272
ISSN
0270-9139 (ISSN-L)
DOI
10.1053/jhep.2001.26513
OpenAlex
W2152826859
Cited by
339
References
17
FWCI
2.71
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Proliferative Activity of Intrahepatic Colorectal Metastases After Preoperative Hemihepatic Portal Vein Embolization. https://app.cochat.ai/papers/10.1053/jhep.2001.26513
The paper
Kokudo, N., Tada, K., Seki, M., Ohta, H., Azekura, K., Ueno, M., Ohta, K., Yamaguchi, T., Matsubara, T., Takahashi, T., Nakajima, T., Muto, T., Ikari, T., Yanagisawa, A., & Kato, Y. (2001). Proliferative Activity of Intrahepatic Colorectal Metastases After Preoperative Hemihepatic Portal Vein Embolization. Hepatology. https://doi.org/10.1053/jhep.2001.26513

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.