The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Interferon-γ inhibits replication of subgenomic and genomic hepatitis C virus RNAs
Abstract
Persistent infection with hepatitis C virus (HCV) is a major cause of chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. All treatments known so far rely on the antiviral activity of interferon alfa (IFN-α) that is given alone or in combination with ribavirin. Unfortunately, only a fraction of the patients clear the virus during therapy and for those who do not respond there is currently no alternative treatment. Selectable subgenomic HCV RNAs (replicons) have been recently used to investigate the effect of IFN-α on HCV replication. However, it has not yet been analyzed whether other cytokines also play a role in the innate immune response against HCV. Here we show that IFN-γ inhibits protein synthesis and RNA replication of subgenomic and genomic HCV replicons. We further show that the inhibitory action of IFN-γ does not rely on the production of nitric oxide or the depletion of tryptophan. In conclusion, our results suggest that cytotoxic T cells and natural killer cells may contribute to HCV clearance not only by cell killing but also by producing IFN-γ, thereby enhancing the intracellular inhibition of viral replication.
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Citations
Cites
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Peginterferon Alfa-2a in Patients with Chronic Hepatitis C
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Interferons: cell signalling, immune modulation, antiviral response and virus countermeasures
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Cited by
Mechanism of action of interferon and ribavirin in treatment of hepatitis C
Feld, J. J., & Hoofnagle, J. H. (2005) · Nature · doi:10.1038/nature04082 · Cited by 992
Adaptive immune responses in acute and chronic hepatitis C virus infection
Bowen, D. G., & Walker, C. M. (2005) · Nature · doi:10.1038/nature04079 · Cited by 756
Memory CD8 + T Cells Are Required for Protection from Persistent Hepatitis C Virus Infection
Shoukry, N. H., Grakoui, A., Houghton, M., Chien, D. Y., Ghrayeb, J., Reimann, K. A., & Walker, C. M. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030239 · Cited by 656
Viral and immunological determinants of hepatitis C virus clearance, persistence, and disease
Thimme, R., Bukh, J., Spangenberg, H. C., Wieland, S., Pemberton, J., Steiger, C., Govindarajan, S., Purcell, R. H., & Chisari, F. V. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.202608299 · Cited by 639
Marcello, T., Grakoui, A., Barba–Spaeth, G., Machlin, E. S., Kotenko, S. V., Macdonald, M. R., & Rice, C. M. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.09.052 · Cited by 561
Metadata
- Authors
- Frese, M., Schwärzle, V., Barth, K., Krieger, N., Lohmann, V., Mihm, S., Haller, O., & Bartenschlager, R.
- Venue
- Hepatology
- Published
- 2002-03
- Volume
- 35
- Issue
- 3
- Pages
- 694-703
- ISSN
- 0270-9139 (ISSN-L)
- OpenAlex
- W2045733748
- Cited by
- 314
- References
- 50
- FWCI
- 18.02
- Type
- journal article
- Language
- en
- Open access
- closed
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- Frese, M., Schwärzle, V., Barth, K., Krieger, N., Lohmann, V., Mihm, S., Haller, O., & Bartenschlager, R. (2002). Interferon-γ inhibits replication of subgenomic and genomic hepatitis C virus RNAs. Hepatology. https://doi.org/10.1053/jhep.2002.31770
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
