The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Viral and immunological determinants of hepatitis C virus clearance, persistence, and disease
Open accessAbstract
To define the early events that determine the outcome of acute hepatitis C virus (HCV) infection, we compared the course of viremia with the peripheral and intrahepatic T cell response and intrahepatic cytokine profile in six acutely infected chimpanzees. Three different outcomes were observed after peak viral titers were reached: sustained viral clearance, transient viral clearance followed by chronic infection, and chronic infection that persisted at initial peak titers. The results indicate that HCV spread outpaces the T cell response and that HCV rapidly induces but is not controlled by IFN-α/β; that viral clearance follows the entry and accumulation of HCV-specific IFN-γ-producing T cells in the liver; and that it may not require the destruction of infected cells.
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Cites
Isolation of a cDNA cLone Derived from a Blood-Borne Non-A, Non-B Viral Hepatitis Genome
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Self-citationDeterminants of Viral Clearance and Persistence during Acute Hepatitis C Virus Infection
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Self-citationGenomic analysis of the host response to hepatitis C virus infection
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Self-citationIntracellular Inactivation of the Hepatitis B Virus by Cytotoxic T Lymphocytes
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Self-citationCross-Presentation, Dendritic Cells, Tolerance and Immunity
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Analysis of a Successful Immune Response against Hepatitis C Virus
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Cited by
Immunology of hepatitis B virus and hepatitis C virus infection
Rehermann, B., & Nascimbeni, M. (2005) · Nature Reviews Immunology · doi:10.1038/nri1573 · Cited by 1,627
The Liver as an Immunological Organ
Racanelli, V., & Rehermann, B. (2006) · Hepatology · doi:10.1002/hep.21060 · Cited by 1,377
Genomic analysis of the host response to hepatitis C virus infection
Su, A. I., Pezacki, J. P., Wodicka, L., Brideau, A. D., Supekova, L., Thimme, R., Wieland, S., Bukh, J., Purcell, R. H., Schultz, P. G., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.202608199 · Cited by 1,161
Self-citationDomingo, E., Sheldon, J., & Perales, C. (2012) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.05023-11 · Cited by 1,009
HCV Persistence and Immune Evasion in the Absence of Memory T Cell Help
Grakoui, A., Shoukry, N. H., Woollard, D. J., Han, J.-H., Hanson, H. L., Ghrayeb, J., Murthy, K. K., Rice, C. M., & Walker, C. M. (2003) · Science · doi:10.1126/science.1088774 · Cited by 830
Metadata
- Authors
- Thimme, R., Bukh, J., Spangenberg, H. C., Wieland, S., Pemberton, J., Steiger, C., Govindarajan, S., Purcell, R. H., & Chisari, F. V.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2002-11-19
- Volume
- 99
- Issue
- 24
- Pages
- 15661-15668
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2097224767
- Cited by
- 639
- References
- 42
- FWCI
- 23.70
- Type
- journal article
- Language
- en
- Open access
- green
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- Thimme, R., Bukh, J., Spangenberg, H. C., Wieland, S., Pemberton, J., Steiger, C., Govindarajan, S., Purcell, R. H., & Chisari, F. V. (2002). Viral and immunological determinants of hepatitis C virus clearance, persistence, and disease. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.202608299
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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