Insulin resistance, dietary cholesterol, and cholesterol concentration in postmenopausal women
Abstract
Questions remain concerning the effect of variations in cholesterol intake on plasma cholesterol concentration, as well as on the role of factors modulating the metabolic impact of this dietary intervention. To define the impact of wide variations in dietary cholesterol intake on plasma total and low-density lipoprotein (LDL) cholesterol concentrations, as well as testing the hypothesis that resistance to insulin-mediated glucose disposal would accentuate the increase in plasma total and LDL cholesterol concentrations in response to a given increment in dietary cholesterol intake, we performed a prospective, randomized study comparing diets varying in cholesterol content in 65 healthy, postmenopausal women, 31 defined as insulin-resistant and 34 as insulin-sensitive. The changes in total and LDL cholesterol in response to increments in dietary cholesterol of up to approximately 800 mg/day were modest in magnitude, without evidence of a statistically significant diet-induced increase in cholesterol concentration, or of any difference in the responses of insulin-resistant as compared with insulin-sensitive women. These results indicate that relatively large increments in dietary cholesterol intake had little effect on total or LDL cholesterol concentrations in healthy, postmenopausal women, irrespective of whether they were insulin-resistant or insulin-sensitive.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Five RCTs reported egg consumption did not significantly alter TC, HDL-C, TC:HDL-C, or endothelial function.
“A meta-analysis showed that eggs increase TC, HDL-C, and TC:HDL-C,(188) but five RCTs subsequently reported that egg consumption did not significantly alter these parameters (189–191) or endothelial function (192,193).”
From Food Consumption and its Impact on Cardiovascular Disease: Importance of Solutions Focused on the Globalized Food System (2015) · cites this paper as [189]
Cites
Immunoassay of insulin with insulin-antibody precipitate
Hales, C. N., & Pj, R. (1963) · Biochemical Journal · doi:10.1042/bj0880137 · Cited by 2,640 · see citing works
A biometric study of basal metabolism in man
Harris, J. A., & Benedict, F. G. (2014) · Medical Entomology and Zoology · Cited by 1,847 · see citing works
Quantitative Effects of Dietary Fat on Serum Cholesterol in Man
Hegsted, D. M., McGandy, R. B., Myers, M. L., & Stare, F. J. (1965) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/17.5.281 · Cited by 1,589 · see citing works
Serum cholesterol response to changes in the diet
Keys, A. B., Anderson, J. T., & Grande, F. (1965) · Metabolism · doi:10.1016/0026-0495(65)90002-8 · Cited by 969 · see citing works
A New and Rapid Method for the Determination of Glucose by Measurement of Rate of Oxygen Consumption
Kadish, A. H., Litle, R. L., & Sternberg, J. (1968) · Clinical Chemistry · doi:10.1093/clinchem/14.2.116 · Cited by 746 · see citing works
Dietary lipids and blood cholesterol: quantitative meta-analysis of metabolic ward studies
Clarke, R. C., Frost, C. D., Collins, R., Appleby, P. N., & Peto, R. (1997) · BMJ · doi:10.1136/bmj.314.7074.112 · Cited by 645 · see citing works
Plasma lipid and lipoprotein responses to dietary fat and cholesterol: a meta-analysis
Howell, W., McNamara, D., Tosca, M., Smith, B., & Gaines, J. (1997) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/65.6.1747 · Cited by 343 · see citing works
Evaluation of octreotide to assess insulin-mediated glucose disposal by the insulin suppression test
Pei, D., Jones, C. N. O., Bhargava, R., Chen, Y. I., & Reaven, G. M. (1994) · Diabetologia · doi:10.1007/bf00404344 · Cited by 209 · see citing works
Self-citationThe Epidemiology of Cardiovascular Disease in Postmenopausal Women
Bush, T. L. (1990) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1990.tb30338.x · Cited by 174 · see citing works
CHARACTERISTICS OF HUMAN HYPO- AND HYPERRESPONDERS TO DIETARY CHOLESTEROL
Katan, M., & Beynen, A. C. (1987) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a114545 · Cited by 162 · see citing works
Quantification of cholesterol in all lipoprotein classes by the VAP-II method.
Kulkarni, K. R., Garber, D. W., Marcovina, S. M., & Segrest, J. P. (1994) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)40123-3 · Cited by 136 · see citing works
Self-citationGinsberg, H. N., Karmally, W., Siddiqui, M., Holleran, S., Tall, A. R., Rumsey, S. C., Deckelbaum, R. J., Blaner, W. S., & Ramakrishnan, R. (1994) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.14.4.576 · Cited by 132 · see citing works
Ginsberg, H. N., Karmally, W., Siddiqui, M., Holleran, S., Tall, A. R., Blaner, W. S., & Ramakrishnan, R. (1995) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.15.2.169 · Cited by 91 · see citing works
Sheu, W. H., Shieh, S.-M., Fuh, M. M.-T., Shen, D. D., Jeng, C. Y., Chen, Y. I., & Reaven, G. M. (1993) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.13.3.367 · Cited by 88 · see citing works
Self-citationKnopp, R. H., Retzlaff, B. M., Walden, C. E., Dowdy, A. A., Tsunehara, C. H., Austin, M. A., & Nguyen, T. (1997) · Journal of the American College of Nutrition · doi:10.1080/07315724.1997.10718719 · Cited by 54 · see citing works
Differences between men and women in the response of serum cholesterol to dietary changes
Weggemans, Zock, P. L., Urgert, & Katan, M. (1999) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.1999.00524.x · Cited by 47 · see citing works
Plasma lipoproteins in hyperlipidemic subjects eating iodine-enriched eggs.
Garber, D. W., Henkin, Y., Osterlund, L., Darnell, B. E., & Segrest, J. P. (1992) · Journal of the American College of Nutrition · doi:10.1080/07315724.1992.10718230 · Cited by 11 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Anand, S. S., Hawkes, C., de Souza, R. J., Mente, A., Dehghan, M., Nugent, R., Zulyniak, M. A., Weis, T., Bernstein, A. M., Krauss, R. M., et al. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.07.050 · Cited by 507 · see citing works
Reduced or modified dietary fat for preventing cardiovascular disease.
Hooper, L., Summerbell, C., Thompson, R. L., Sills, D., Roberts, F. G., Moore, H., & Smith, G. D. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002137.pub3 · Cited by 206 · see citing works
Dietary cholesterol and cardiovascular disease: a systematic review and meta-analysis
Berger, S., Raman, G., Vishwanathan, R., Jacques, P. F., & Johnson, E. J. (2015) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.100305 · Cited by 356 · see citing works
Dietary Cholesterol and Cardiovascular Risk: A Science Advisory From the American Heart Association
Carson, J. A. S., Lichtenstein, A. H., Anderson, C. A. M., Appel, L. J., Kris‐Etherton, P. M., Meyer, K. A., Petersen, K. H., Polonsky, T. S., & Horn, L. V. (2019) · Circulation · doi:10.1161/cir.0000000000000743 · Cited by 333 · see citing works
Reduction in saturated fat intake for cardiovascular disease.
Hooper, L., Martin, N., Jimoh, O., Kirk, C., Foster, E., & Abdelhamid, A. (2020) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011737.pub3 · Cited by 42 · see citing works
Shin, J. Y., Xun, P., Nakamura, Y., & He, K. (2013) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.051318 · Cited by 289 · see citing works
Dietary Cholesterol and the Lack of Evidence in Cardiovascular Disease
Soliman, G. A. (2018) · Nutrients · doi:10.3390/nu10060780 · Cited by 255 · see citing works
Reduction in saturated fat intake for cardiovascular disease
Hooper, L., Martin, N., Jimoh, O. F., Kirk, C., Foster, E., & Abdelhamid, A. S. (2020) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011737.pub2 · Cited by 228 · see citing works
Reduction in saturated fat intake for cardiovascular disease
Hooper, L., Martin, N., Abdelhamid, A., & Davey Smith, G. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011737 · Cited by 704 · see citing works
Effects of total fat intake on body weight
Hooper, L., Abdelhamid, A. S., Bunn, D. K., Brown, T. J., Summerbell, C. D., & Skeaff, C. M. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011834 · Cited by 159 · see citing works
Egg consumption and risk of cardiovascular diseases and diabetes: A meta-analysis
Li, Y., Zhou, C., Zhou, X., & Li, L. (2013) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2013.04.003 · Cited by 138 · see citing works
Reduced or modified dietary fat for preventing cardiovascular disease
Hooper, L., Summerbell, C., Thompson, R., Sills, D., Roberts, F. G., Moore, H. J., & Smith, G. D. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002137.pub2 · Cited by 304 · see citing works
Pearce, K. L., Clifton, P. M., & Noakes, M. (2010) · British Journal Of Nutrition · doi:10.1017/s0007114510003983 · Cited by 106 · see citing works
Effects of Insulin Resistance and Obesity on Lipoproteins and Sensitivity to Egg Feeding
Knopp, R. H., Retzlaff, B. M., Fish, B. E., Walden, C. E., Wallick, S., Anderson, M., Aikawa, K., & Kahn, S. E. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000082461.77557.c7 · Cited by 100 · see citing works
Dietary cholesterol, eggs and coronary heart disease risk in perspective
Lee, A., & Griffin, B. A. (2006) · Nutrition Bulletin · doi:10.1111/j.1467-3010.2006.00543.x · Cited by 51 · see citing works
Ratliff, J. C., Mutungi, G., Puglisi, M. J., Volek, J. S., & Fernández, M. L. (2009) · Nutrition Research · doi:10.1016/j.nutres.2009.03.007 · Cited by 48 · see citing works
Mazidi, M., Katsiki, N., Mikhailidis, D. P., Pencina, M. J., & Banach, M. (2019) · Journal of the American College of Nutrition · doi:10.1080/07315724.2018.1534620 · Cited by 41 · see citing works
Kishimoto, Y., Taguchi, C., Saita, E., Sugihara, N., Nishiyama, H., Wei, W., Masuda, Y., & Kondo, K. N. (2017) · Food Research International · doi:10.1016/j.foodres.2017.03.003 · Cited by 37 · see citing works
Petersen, K. S., Bowen, K. J., Tindall, A. M., Sullivan, V. K., Johnston, E. A., Fleming, J. A., & Kris‐Etherton, P. M. (2020) · Current Developments in Nutrition · doi:10.1093/cdn/nzaa160 · Cited by 21 · see citing works
Mazidi, M., Mikhailidis, D. P., & Banach, M. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.03.035 · Cited by 14 · see citing works
Egg yolk, source of bad cholesterol and good lipids?
Rosenson, R. S., & Song, W. (2019) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqz105 · Cited by 12 · see citing works
Kim, J. K., Kim, J., Kim, H., Chung, H. W., & Chang, N. (2013) · Journal of Nutrition and Health · doi:10.4163/kjn.2013.46.1.15 · Cited by 4 · see citing works
Self-citationEgg Consumption and Risk of Cardiovascular Disease: a Critical Review
Hahn, J., Dehghan, M., Drouin‐Chartier, J., Mentz, R. J., Jneid, H. M., Virani, S. S., Tang, W. H. W., & Krittanawong, C. (2021) · Current Emergency and Hospital Medicine Reports · doi:10.1007/s40138-021-00225-w · Cited by 4 · see citing works
Effects of Egg Consumption on Subjects with SLD or Hypertension: A MICOL Study
Tatoli, R., Bonfiglio, C., Cuccaro, F., Campanella, A., Coletta, S., Pesole, P. L., Giannelli, G., & Donghia, R. (2024) · Nutrients · doi:10.3390/nu16030430 · Cited by 2 · see citing works
Nutrition and cholesterol metabolism
Soliman, G. A. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-85857-1.00020-1 · Cited by 2 · see citing works
Consumo de huevo y diabetes mellitus tipo 2: una revisión de la literatura científica
Catalina Dussaillant, K., Echeverría, G., Rozowski, J., Velasco, N., Arteaga, A., & Rigotti, A. (2017) · Revista chilena de nutrición · doi:10.4067/s0717-75182017000400393 · Cited by 2 · see citing works
Egg Cholesterol is not related with Heart Disease : A Review
Kang, G.-H., Kim, D., Kim, H. K., Jang, A., Cho, S., Seong, P., & Park, B.-Y. (2013) · Korean Journal of Poultry Science · doi:10.5536/kjps.2013.40.4.337 · Cited by 1 · see citing works
Self-citationPrediction of Global Cardiovascular Risk in Hypertension
Wilson, P. W. F. (2007) · Elsevier eBooks · doi:10.1016/b978-1-4160-3053-9.50022-6 · Cited by 1 · see citing works
Clifton, P. M. (2023) · Contemporary diabetes · doi:10.1007/978-3-031-26681-2_21 · Cited by 1 · see citing works
Clifton, P. M. (2013) · Contemporary diabetes · doi:10.1007/978-1-4614-7554-5_16
Women's Health LiteratureWatch
(2001) · Journal of Women s Health & Gender-Based Medicine · doi:10.1089/15246090152543193
- Authors
- Reaven, G. M., Abbasi, F., Bernhart, S., Coulston, A., Darnell, B., Dashti, N., Kim, H.-S., Kulkarni, K., Lamendola, C., McLaughlin, T., Osterlund, L., Schaff, P., & Segrest, J.
- Affiliations
- University of Alabama at Birmingham (US)
- Venue
- Metabolism
- Publisher
- Elsevier BV
- Published
- 2001-05
- Volume
- 50
- Issue
- 5
- Pages
- 594-597
- ISSN
- 0026-0495 (ISSN-L)
- OpenAlex
- W2032572215
- Cited by
- 31
- References
- 17
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 4 · 2019: 3 · 2018: 1 · 2017: 2 · 2015: 4 · 2013: 5 · 2012: 1
- FWCI
- 0.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Center for Research Resources (RR 00 070, RR 00032, M01RR000070)
- Topics
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- insulin resistance, dietary cholesterol, serum cholesterol, LDL cholesterol, postmenopausal women, glucose disposal, dietary intervention, hypercholesterolemia
- MeSH terms
- Apolipoproteins A, Apolipoproteins B, Cholesterol, Cholesterol, Dietary, Female, Humans, Insulin Resistance, Lipids, Lipoproteins, Cholesterol, HDL, Cholesterol, LDL, Middle Aged, Triglycerides, Cholesterol, VLDL, Body Mass Index, Lipoprotein(a), Postmenopause
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
